Experiment set5S645 for Mycobacterium tuberculosis H37Rv

200 most important genes:

gene	name	fitness	t score	description
Rv3102c		-2.5	-4.4	Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter)
Rv3364c		-2.5	-3.5	Conserved protein
Rv2647		-2.4	-1.1	Hypothetical protein
Rv0819		-2.3	-3.3	GCN5-related N-acetyltransferase, MshD
Rv3202c		-2.2	-9.2	Possible ATP-dependent DNA helicase
Rv2096c		-2.2	-4.8	Proteasome accessory factor B PafB
Rv2975c		-2.0	-1.4	Conserved hypothetical protein
Rv0928		-1.9	-3.5	Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1)
Rv2737c		-1.8	-6.0	RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)].
Rv0870c		-1.8	-1.8	Possible conserved integral membrane protein
Rv0930		-1.8	-4.4	Probable phosphate-transport integral membrane ABC transporter PstA1
Rv3267		-1.7	-3.9	Conserved protein (CPSA-related protein)
Rv0531		-1.7	-1.7	Possible conserved membrane protein
Rv3201c		-1.7	-5.9	Probable ATP-dependent DNA helicase
Rv3810		-1.6	-2.1	Exported repetitive protein precursor PirG (cell surface protein) (EXP53)
Rv0007		-1.5	-0.9	Possible conserved membrane protein
Rv0955		-1.5	-1.2	Probable conserved integral membrane protein
Rv2095c		-1.5	-5.6	Proteasome accessory factor C PafC
Rv2581c		-1.5	-1.5	Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II)
Rv3046c		-1.5	-0.6	Conserved protein
Rv1108c		-1.5	-3.2	Probable exodeoxyribonuclease VII (large subunit) XseA (exonuclease VII large subunit)
Rv3715c		-1.4	-2.7	Probable recombination protein RecR
Rv0361		-1.4	-0.9	Probable conserved membrane protein
Rv3486		-1.4	-2.1	Conserved protein
Rv1290A		-1.4	-0.8	Hypothetical protein
Rv2694c		-1.4	-5.8	Conserved protein
Rv2630		-1.4	-0.7	Hypothetical protein
Rv3751		-1.3	-2.0	Probable integrase (fragment)
Rv0003		-1.3	-4.0	DNA replication and repair protein RecF (single-strand DNA binding protein)
Rv2302		-1.3	-0.9	Conserved protein
Rv0820		-1.3	-3.3	Probable phosphate-transport ATP-binding protein ABC transporter PhoT
Rv3650		-1.3	-0.8	PE family protein PE33
Rv1107c		-1.3	-1.4	Probable exodeoxyribonuclease VII (small subunit) XseB (exonuclease VII small subunit)
Rv3287c		-1.2	-1.4	Anti-sigma factor RsbW (sigma negative effector)
Rv0929		-1.2	-1.7	Phosphate-transport integral membrane ABC transporter PstC2
Rv3405c		-1.2	-1.5	Possible transcriptional regulatory protein
Rv3314c		-1.2	-1.3	Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase)
Rv2216		-1.2	-2.4	Conserved protein
Rv1420		-1.1	-2.2	Probable excinuclease ABC (subunit C-nuclease) UvrC
Rv3874		-1.1	-1.4	10 kDa culture filtrate antigen EsxB (LHP) (CFP10)
Rv3358		-1.1	-1.5	Toxin RelK
Rv0130		-1.1	-1.4	Probable 3-hydroxyl-thioester dehydratase
Rv0742		-1.1	-1.8	PE-PGRS family protein PE_PGRS8
Rv3328c		-1.1	-1.9	Probable alternative RNA polymerase sigma factor (fragment) SigJ
Rv0892		-1.0	-1.6	Probable monooxygenase
Rv3273		-1.0	-5.5	Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase)
Rv0760c		-1.0	-2.0	Conserved protein
Rv2072c		-1.0	-0.8	Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL
Rv3855		-1.0	-5.1	Transcriptional regulatory repressor protein (TetR-family) EthR
Rv1102c		-1.0	-0.9	Toxin MazF3
Rv0994		-1.0	-4.7	Probable molybdopterin biosynthesis protein MoeA1
Rv2719c		-1.0	-2.4	Possible conserved membrane protein
Rv3162c		-0.9	-1.3	Possible integral membrane protein
Rv0494		-0.9	-3.3	Probable transcriptional regulatory protein (probably GntR-family)
Rv2706c		-0.9	-1.1	Hypothetical protein
Rv2331A		-0.9	-0.6	Hypothetical protein
Rv0674		-0.9	-0.8	Conserved hypothetical protein
Rv1982c		-0.9	-1.6	Possible toxin VapC36. Contains PIN domain.
Rv0078		-0.9	-1.7	Probable transcriptional regulatory protein
Rv2945c		-0.9	-5.2	Probable conserved lipoprotein LppX
Rv1411c		-0.9	-2.4	Conserved lipoprotein LprG
Rv2475c		-0.9	-2.6	Conserved protein
Rv3272		-0.9	-4.1	Conserved hypothetical protein
Rv2224c		-0.9	-5.8	Probable carboxylesterase CaeA
Rv2226		-0.9	-1.3	Conserved protein
Rv1621c		-0.8	-1.7	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD
Rv3005c		-0.8	-5.3	Conserved hypothetical protein
Rv1745c		-0.8	-1.9	Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase)
Rv2942		-0.8	-6.1	Conserved transmembrane transport protein MmpL7
Rv2171		-0.8	-1.6	Probable conserved lipoprotein LppM
Rv3850		-0.8	-1.1	Conserved protein
Rv0098		-0.8	-0.9	Probable fatty acyl CoA thioesterase type III FcoT
Rv0323c		-0.8	-1.3	Conserved hypothetical protein
Rv0394c		-0.8	-2.4	Possible secreted protein
Rv1514c		-0.8	-2.2	Conserved hypothetical protein
Rv1839c		-0.8	-1.4	Possible antitoxin VapB13
Rv2427A		-0.8	-1.4	'Transcriptional regulator OxyR', pseudogene' pseudogene=unknown transl_table=11
Rv2274c		-0.8	-1.4	Possible toxin MazF8
Rv2009		-0.8	-0.6	Antitoxin VapB15
Rv2937		-0.8	-4.7	Daunorubicin-dim-transport integral membrane protein ABC transporter DrrB
Rv1546		-0.8	-3.1	Conserved protein
Rv2691		-0.8	-3.0	TRK system potassium uptake protein CeoB
Rv2936		-0.8	-5.6	Daunorubicin-dim-transport ATP-binding protein ABC transporter DrrA
Rv3010c		-0.8	-2.6	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)
Rv2222c		-0.8	-2.2	Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II)
Rv2513		-0.7	-1.9	Hypothetical protein
Rv3346c		-0.7	-1.1	Conserved transmembrane protein
Rv2369c		-0.7	-0.8	Hypothetical protein
Rv3338		-0.7	-0.9	Conserved hypothetical protein
Rv0242c		-0.7	-1.9	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase)
Rv1019		-0.7	-4.4	Probable transcriptional regulatory protein (probably TetR-family)
Rv2517c		-0.7	-2.4	Unknown protein
Rv3360		-0.7	-1.8	Conserved hypothetical protein
Rv0677c		-0.7	-1.4	Possible conserved membrane protein MmpS5
Rv1194c		-0.7	-2.3	Conserved protein
Rv3414c		-0.7	-2.4	Probable alternative RNA polymerase sigma-D factor SigD
Rv3283		-0.7	-1.9	Probable thiosulfate sulfurtransferase SseA (rhodanese) (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase)
Rv0472c		-0.7	-2.2	Probable transcriptional regulatory protein (possibly TetR-family)
Rv3311		-0.7	-2.3	Conserved protein
Rv0243		-0.7	-3.8	Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase)
Rv3585		-0.7	-3.5	DNA repair protein RadA (DNA repair protein SMS)
Rv0782		-0.7	-2.3	Probable protease II PtrBb [second part] (oligopeptidase B)
Rv0241c		-0.7	-1.9	Probable 3-hydroxyacyl-thioester dehydratase HtdX
Rv3717		-0.7	-2.5	Conserved hypothetical protein
Rv0374c		-0.7	-1.6	Probable carbon monoxyde dehydrogenase (small chain)
Rv3306c		-0.7	-1.2	Probable amidohydrolase AmiB1 (aminohydrolase)
Rv3132c		-0.7	-2.7	Two component sensor histidine kinase DevS
Rv2938		-0.7	-4.4	Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC
Rv0563		-0.7	-1.0	Probable protease transmembrane protein heat shock protein HtpX
Rv3196A		-0.7	-1.5	Unknown protein
Rv3655c		-0.6	-1.4	Conserved hypothetical protein
Rv3033		-0.6	-0.4	Unknown protein
Rv1663		-0.6	-2.2	Probable polyketide synthase Pks17
Rv0867c		-0.6	-0.5	Possible resuscitation-promoting factor RpfA
Rv2154c		-0.6	-1.4	FtsW-like protein FtsW
Rv0184		-0.6	-2.0	Conserved hypothetical protein
Rv3700c		-0.6	-1.1	Conserved hypothetical protein
Rv0868c		-0.6	-0.9	Probable molybdenum cofactor biosynthesis protein D 2 MoaD2 (molybdopterin converting factor small subunit) (molybdopterin [MPT] converting factor, subunit 1)
Rv3305c		-0.6	-0.9	Possible N-acyl-L-amino acid amidohydrolase AmiA1 (N-acyl-L-amino acid aminohydrolase)
Rv1291c		-0.6	-1.0	Conserved hypothetical secreted protein
Rv1944c		-0.6	-1.4	Conserved protein
Rv1030		-0.6	-2.0	Probable potassium-transporting P-type ATPase B chain KdpB (potassium-translocating ATPase B chain) (ATP phosphohydrolase [potassium-transporting] B chain) (potassium binding and translocating subunit B)
Rv2799		-0.6	-3.9	Probable membrane protein
Rv2919c		-0.6	-0.9	Probable nitrogen regulatory protein P-II GlnB
Rv0885		-0.6	-1.8	Conserved hypothetical protein
Rv0200		-0.6	-1.7	Possible conserved transmembrane protein
Rv3131		-0.6	-0.8	Conserved protein
Rv0832		-0.6	-1.8	PE-PGRS family protein PE_PGRS12
Rv1931c		-0.6	-1.1	Probable transcriptional regulatory protein
Rv3501c		-0.6	-1.8	Conserved integral membrane protein YrbE4A. Possible ABC transporter.
Rv0986		-0.6	-1.6	Probable adhesion component transport ATP-binding protein ABC transporter
Rv1324		-0.6	-0.5	Possible thioredoxin
Rv3691		-0.6	-0.9	Conserved protein
Rv1351		-0.6	-0.9	Hypothetical protein
Rv3591c		-0.6	-1.0	Possible hydrolase
Rv0016c		-0.6	-3.5	Probable penicillin-binding protein PbpA
Rv0572c		-0.6	-1.6	Hypothetical protein
Rv2707		-0.6	-3.9	Probable conserved transmembrane alanine and leucine rich protein
Rv3657c		-0.6	-1.8	Possible conserved alanine rich membrane protein
Rv0579		-0.6	-2.2	Conserved hypothetical protein
Rv0009		-0.6	-0.5	Probable iron-regulated peptidyl-prolyl cis-trans isomerase A PpiA (PPIase A) (rotamase A)
Rv2144c		-0.6	-2.2	Probable transmembrane protein
Rv3237c		-0.6	-1.9	Conserved protein
Rv2276		-0.6	-0.7	Cytochrome P450 121 Cyp121
Rv3856c		-0.6	-1.0	Conserved hypothetical protein
Rv1566c		-0.6	-1.3	Possible Inv protein
Rv3706c		-0.5	-2.1	Conserved hypothetical proline rich protein
Rv1889c		-0.5	-1.0	Conserved hypothetical protein
Rv0437c		-0.5	-0.7	Possible phosphatidylserine decarboxylase Psd (PS decarboxylase)
Rv3698		-0.5	-2.2	Conserved protein
Rv2087		-0.5	-1.3	Conserved hypothetical protein
Rv2309A		-0.5	-2.3	Hypothetical protein
Rv0604		-0.5	-2.1	Probable conserved lipoprotein LpqO
Rv1823		-0.5	-2.8	Conserved protein
Rv2774c		-0.5	-0.4	Hypothetical protein
Rv1919c		-0.5	-2.1	Conserved protein
Rv3334		-0.5	-1.1	Probable transcriptional regulatory protein (probably MerR-family)
Rv0653c		-0.5	-2.3	Possible transcriptional regulatory protein (probably TetR-family)
Rv3178		-0.5	-1.1	Conserved hypothetical protein
Rv3787c		-0.5	-1.2	Conserved hypothetical protein
Rv1006		-0.5	-2.2	Unknown protein
Rv1260		-0.5	-1.9	Probable oxidoreductase
Rv1109c		-0.5	-1.3	Conserved protein
Rv1620c		-0.5	-1.5	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC
Rv1121		-0.5	-0.8	Probable glucose-6-phosphate 1-dehydrogenase Zwf1 (G6PD)
Rv1159		-0.5	-1.1	Mannosyltransferase PimE
Rv3139		-0.5	-2.6	Probable acyl-CoA dehydrogenase FadE24
Rv0185		-0.5	-2.7	Conserved hypothetical protein
Rv2923c		-0.5	-0.8	Conserved protein
Rv3249c		-0.5	-0.6	Possible transcriptional regulatory protein (probably TetR-family)
Rv0675		-0.5	-0.4	Probable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv2365c		-0.5	-0.4	Conserved hypothetical protein
Rv1013		-0.5	-3.0	Putative polyketide synthase Pks16
Rv2991		-0.5	-1.7	Conserved protein
Rv2367c		-0.5	-1.1	Conserved hypothetical protein
Rv3198A		-0.5	-2.4	Possible glutaredoxin protein
Rv0818		-0.5	-1.6	Transcriptional regulatory protein
Rv1569		-0.5	-1.5	Probable 8-amino-7-oxononanoate synthase BioF1 (AONS) (8-amino-7-ketopelargonate synthase) (7-keto-8-amino-pelargonic acid synthetase) (7-KAP synthetase) (L-alanine--pimelyl CoA ligase)
Rv3300c		-0.5	-1.8	Conserved hypothetical protein
Rv3748		-0.5	-0.9	Conserved hypothetical protein
Rv0049		-0.5	-2.0	Conserved hypothetical protein
Rv3282		-0.5	-1.0	Conserved hypothetical protein
Rv0257		-0.5	-1.7	Conserved hypothetical protein
Rv3759c		-0.5	-1.7	Possible osmoprotectant (glycine betaine/carnitine/choline/L-proline) binding lipoprotein ProX
Rv1377c		-0.5	-1.6	Putative transferase
Rv1220c		-0.5	-1.5	Probable methyltransferase
Rv2061c		-0.5	-1.7	Conserved protein
Rv1396c		-0.5	-1.6	PE-PGRS family protein PE_PGRS25
Rv1825		-0.5	-1.8	Conserved protein
Rv2704		-0.5	-2.3	Conserved protein
Rv2758c		-0.5	-0.6	Possible antitoxin VapB21
Rv2463		-0.5	-2.2	Probable esterase/lipase LipP
Rv3885c		-0.5	-1.0	ESX conserved component EccE2. ESX-2 type VII secretion system protein. Possible membrane protein.
Rv2134c		-0.5	-2.0	Conserved protein
Rv2023c		-0.5	-1.0	Hypothetical protein
Rv2625c		-0.5	-2.7	Probable conserved transmembrane alanine and leucine rich protein
Rv3694c		-0.5	-1.4	Possible conserved transmembrane protein
Rv0397		-0.5	-1.4	Conserved 13E12 repeat family protein
Rv1410c		-0.5	-2.3	Aminoglycosides/tetracycline-transport integral membrane protein
Rv2791c		-0.5	-1.0	Probable transposase

Specific Phenotypes

None in this experiment

For Mycobacterium tuberculosis H37Rv in stress experiments

For stress Lomefloxacin hydrochloride across organisms