Experiment set5S636 for Mycobacterium tuberculosis H37Rv

Compare to:

7H9 with Spectinomycin dihydrochloride pentahydrate 0.029 mM

200 most important genes:

  gene name fitness t score description  
Rv1930c -3.5 -1.1 Conserved hypothetical protein compare
Rv2140c -2.5 -2.0 Conserved protein TB18.6 compare
Rv1258c -2.5 -11.7 Probable conserved integral membrane transport protein compare
Rv2384 -2.4 -2.6 Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase compare
Rv1621c -2.2 -3.3 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD compare
Rv0819 -2.1 -4.3 GCN5-related N-acetyltransferase, MshD compare
Rv2270 -2.0 -1.7 Probable lipoprotein LppN compare
Rv1010 -1.9 -2.1 Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase) compare
Rv1963c -1.9 -1.4 Probable transcriptional repressor (probably TetR-family) Mce3R compare
Rv0867c -1.8 -0.8 Possible resuscitation-promoting factor RpfA compare
Rv0930 -1.8 -5.3 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv0078 -1.7 -2.8 Probable transcriptional regulatory protein compare
Rv2989 -1.7 -0.9 Probable transcriptional regulatory protein compare
Rv2694c -1.6 -3.9 Conserved protein compare
Rv1851 -1.6 -1.3 Urease accessory protein UreF compare
Rv1620c -1.6 -3.2 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC compare
Rv2650c -1.6 -0.9 Possible PhiRv2 prophage protein compare
Rv2630 -1.5 -1.5 Hypothetical protein compare
Rv2680 -1.5 -1.5 Conserved protein compare
Rv3922c -1.5 -3.6 Possible hemolysin compare
Rv0949 -1.5 -1.0 Probable ATP-dependent DNA helicase II UvrD1 compare
Rv0928 -1.4 -2.9 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv1072 -1.4 -1.5 Probable conserved transmembrane protein compare
Rv2382c -1.4 -1.3 Polyketide synthetase MbtC (polyketide synthase) compare
Rv3102c -1.4 -3.0 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv0531 -1.3 -1.2 Possible conserved membrane protein compare
Rv0675 -1.3 -0.7 Probable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv0929 -1.3 -1.9 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv2709 -1.3 -5.5 Probable conserved transmembrane protein compare
Rv0241c -1.3 -3.0 Probable 3-hydroxyacyl-thioester dehydratase HtdX compare
Rv2869c -1.3 -1.4 Membrane bound metalloprotease compare
Rv2691 -1.3 -5.3 TRK system potassium uptake protein CeoB compare
Rv0321 -1.3 -2.4 Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase) compare
Rv1013 -1.2 -6.2 Putative polyketide synthase Pks16 compare
Rv0310c -1.2 -1.7 Conserved protein compare
Rv2001 -1.2 -1.3 Conserved hypothetical protein compare
Rv3920c -1.2 -0.9 Conserved protein similar to jag protein compare
Rv2707 -1.2 -8.8 Probable conserved transmembrane alanine and leucine rich protein compare
Rv0383c -1.2 -0.9 Possible conserved secreted protein compare
Rv0504c -1.2 -2.0 Conserved protein compare
Rv3306c -1.2 -1.2 Probable amidohydrolase AmiB1 (aminohydrolase) compare
Rv2706c -1.1 -1.0 Hypothetical protein compare
Rv0237 -1.1 -2.4 Probable conserved lipoprotein LpqI compare
Rv2372c -1.1 -0.9 Conserved hypothetical protein compare
Rv2154c -1.1 -2.3 FtsW-like protein FtsW compare
Rv1745c -1.1 -3.9 Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase) compare
Rv3165c -1.1 -1.4 Unknown protein compare
Rv1159 -1.1 -1.8 Mannosyltransferase PimE compare
Rv3282 -1.1 -1.8 Conserved hypothetical protein compare
Rv1836c -1.0 -2.0 Conserved protein compare
Rv3249c -1.0 -0.9 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv3173c -1.0 -2.5 Probable transcriptional regulatory protein (probably TetR/AcrR-family) compare
Rv1398c -1.0 -1.6 Possible antitoxin VapB10 compare
Rv2949c -1.0 -2.0 Chorismate pyruvate lyase compare
Rv2581c -1.0 -1.0 Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II) compare
Rv2793c -1.0 -0.8 Probable tRNA pseudouridine synthase B TruB (tRNA pseudouridine 55 synthase) (PSI55 synthase) (pseudouridylate synthase) (uracil hydrolyase) compare
Rv1821 -1.0 -2.6 Possible preprotein translocase ATPase SecA2 compare
Rv3481c -1.0 -1.4 Probable integral membrane protein compare
Rv3919c -1.0 -1.8 Probable glucose-inhibited division protein B Gid compare
Rv0245 -1.0 -1.2 Possible oxidoreductase compare
Rv2190c -1.0 -3.7 Conserved hypothetical protein compare
Rv3445c -1.0 -1.1 ESAT-6 like protein EsxU compare
Rv2028c -1.0 -1.0 Universal stress protein family protein compare
Rv0820 -1.0 -2.2 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv3658c -1.0 -0.9 Probable conserved transmembrane protein compare
Rv0680c -1.0 -1.5 Probable conserved transmembrane protein compare
Rv0556 -0.9 -1.2 Probable conserved transmembrane protein compare
Rv2829c -0.9 -1.4 Possible toxin VapC22 compare
Rv3200c -0.9 -2.6 Possible transmembrane cation transporter compare
Rv3050c -0.9 -1.3 Probable transcriptional regulatory protein (probably AsnC-family) compare
Rv0452 -0.9 -2.5 Possible transcriptional regulatory protein compare
Rv0693 -0.9 -1.9 Probable coenzyme PQQ synthesis protein E PqqE (coenzyme PQQ synthesis protein III) compare
Rv3174 -0.9 -1.2 Probable short-chain dehydrogenase/reductase compare
Rv0692 -0.9 -4.6 Conserved hypothetical protein compare
Rv3334 -0.9 -1.3 Probable transcriptional regulatory protein (probably MerR-family) compare
Rv0019c -0.9 -3.3 Conserved protein with FHA domain, FhaB compare
Rv0738 -0.9 -0.9 Conserved protein compare
Rv3492c -0.9 -1.8 Conserved hypothetical Mce associated protein compare
Rv3513c -0.9 -0.7 Probable fatty-acid-CoA ligase FadD18 (fragment) (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv0989c -0.8 -4.9 Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) compare
Rv0016c -0.8 -4.3 Probable penicillin-binding protein PbpA compare
Rv3013 -0.8 -0.8 Conserved protein compare
Rv2702 -0.8 -0.7 Polyphosphate glucokinase PpgK (polyphosphate-glucose phosphotransferase) compare
Rv1401 -0.8 -0.9 Possible membrane protein compare
Rv0398c -0.8 -1.2 Possible secreted protein compare
Rv0437c -0.8 -0.9 Possible phosphatidylserine decarboxylase Psd (PS decarboxylase) compare
Rv0098 -0.8 -1.4 Probable fatty acyl CoA thioesterase type III FcoT compare
Rv0563 -0.8 -2.0 Probable protease transmembrane protein heat shock protein HtpX compare
Rv1672c -0.8 -1.9 Probable conserved integral membrane transport protein compare
Rv1766 -0.8 -1.2 Conserved protein compare
Rv2260 -0.8 -1.2 Conserved hypothetical protein compare
Rv3101c -0.8 -1.5 Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter) compare
Rv1006 -0.8 -2.9 Unknown protein compare
Rv1710 -0.8 -0.9 Possible segregation and condensation protein ScpB compare
Rv2252 -0.8 -0.5 Diacylglycerol kinase compare
Rv0017c -0.8 -2.8 Probable cell division protein RodA compare
Rv2500c -0.8 -0.8 Possible acyl-CoA dehydrogenase FadE19 (MMGC) compare
Rv0313 -0.8 -1.2 Conserved protein compare
Rv0939 -0.8 -0.7 Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase compare
Rv2679 -0.8 -2.0 Probable enoyl-CoA hydratase EchA15 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv0924c -0.7 -3.3 Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP) compare
Rv3167c -0.7 -1.5 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv3565 -0.7 -1.1 Possible aspartate aminotransferase AspB (transaminase A) (ASPAT) (glutamic--oxaloacetic transaminase) (glutamic--aspartic transaminase) compare
Rv2044c -0.7 -0.5 Conserved hypothetical protein compare
Rv2107 -0.7 -1.4 PE family protein PE22 compare
Rv3033 -0.7 -0.4 Unknown protein compare
Rv1420 -0.7 -1.6 Probable excinuclease ABC (subunit C-nuclease) UvrC compare
Rv2616 -0.7 -2.2 Conserved protein compare
Rv3610c -0.7 -1.5 Membrane-bound protease FtsH (cell division protein) compare
Rv3065 -0.7 -1.5 Multidrugs-transport integral membrane protein Mmr compare
Rv0204c -0.7 -2.1 Probable conserved transmembrane protein compare
Rv3353c -0.7 -1.4 Conserved hypothetical protein compare
Rv0978c -0.7 -1.6 PE-PGRS family protein PE_PGRS17 compare
Rv3855 -0.7 -3.6 Transcriptional regulatory repressor protein (TetR-family) EthR compare
Rv3747 -0.7 -2.0 Conserved protein compare
Rv3098c -0.7 -1.4 Hypothetical protein compare
Rv3366 -0.7 -1.3 Probable tRNA/rRNA methylase SpoU (tRNA/rRNA methyltransferase) compare
Rv2647 -0.7 -1.1 Hypothetical protein compare
Rv0036c -0.7 -2.5 Conserved protein compare
Rv0018c -0.7 -1.7 Phosphoserine/threonine phosphatase PstP compare
Rv3856c -0.7 -1.1 Conserved hypothetical protein compare
Rv2072c -0.7 -0.9 Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL compare
Rv1468c -0.7 -1.5 PE-PGRS family protein PE_PGRS29 compare
Rv1102c -0.7 -0.9 Toxin MazF3 compare
Rv0374c -0.7 -1.6 Probable carbon monoxyde dehydrogenase (small chain) compare
Rv1046c -0.7 -0.9 Hypothetical protein compare
Rv3054c -0.7 -1.3 Conserved hypothetical protein compare
Rv1657 -0.7 -1.6 Probable arginine repressor ArgR (AHRC) compare
Rv0609 -0.7 -1.0 Possible toxin VapC28. Contains PIN domain. compare
Rv3214 -0.6 -0.7 Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) compare
Rv3133c -0.6 -1.9 Two component transcriptional regulatory protein DevR (probably LuxR/UhpA-family) compare
Rv1096 -0.6 -0.5 Possible glycosyl hydrolase compare
Rv3311 -0.6 -1.8 Conserved protein compare
Rv3089 -0.6 -1.9 Probable chain-fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) compare
Rv1025 -0.6 -0.5 Conserved protein compare
Rv3046c -0.6 -0.4 Conserved protein compare
Rv0887c -0.6 -0.9 Conserved hypothetical protein compare
Rv0942 -0.6 -1.9 Hypothetical protein compare
Rv0598c -0.6 -0.9 Possible toxin VapC27. Contains PIN domain. compare
Rv3843c -0.6 -1.0 Probable conserved transmembrane protein compare
Rv3817 -0.6 -1.2 Possible phosphotransferase compare
Rv3768 -0.6 -0.9 Unknown protein compare
Rv0954 -0.6 -2.0 Probable conserved transmembrane protein compare
Rv2732c -0.6 -1.7 Probable conserved transmembrane protein compare
Rv1459c -0.6 -0.8 Possible conserved integral membrane protein compare
Rv0573c -0.6 -2.1 Nicotinic acid phosphoribosyltransferase PncB2 compare
Rv0242c -0.6 -1.5 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase) compare
Rv3560c -0.6 -1.6 Probable acyl-CoA dehydrogenase FadE30 compare
Rv2762c -0.6 -0.6 Conserved hypothetical protein compare
Rv3726 -0.6 -0.7 Possible dehydrogenase compare
Rv1584c -0.6 -1.7 Possible PhiRv1 phage protein compare
Rv0309 -0.6 -1.6 Possible conserved exported protein compare
Rv1701 -0.6 -1.2 Probable integrase/recombinase compare
Rv2733c -0.6 -1.4 Conserved hypothetical alanine, arginine-rich protein compare
Rv2427A -0.6 -1.2 'Transcriptional regulator OxyR', pseudogene' pseudogene=unknown transl_table=11 compare
Rv1908c -0.6 -0.9 Catalase-peroxidase-peroxynitritase T KatG compare
Rv3131 -0.6 -0.6 Conserved protein compare
Rv3217c -0.6 -1.3 Probable conserved integral membrane protein compare
Rv3428c -0.6 -0.6 Possible transposase compare
Rv0571c -0.6 -1.2 Conserved protein compare
Rv2055c -0.6 -0.9 30S ribosomal protein S18 RpsR2 compare
Rv0100 -0.6 -1.3 Conserved hypothetical protein compare
Rv1019 -0.6 -2.3 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv3495c -0.6 -3.5 Possible Mce-family lipoprotein LprN (Mce-family lipoprotein Mce4E) compare
Rv2206 -0.6 -1.7 Probable conserved transmembrane protein compare
Rv0916c -0.6 -1.1 PE family protein PE7 compare
Rv0892 -0.6 -1.0 Probable monooxygenase compare
Rv1218c -0.6 -1.9 Probable tetronasin-transport ATP-binding protein ABC transporter compare
Rv0921 -0.6 -1.7 Possible resolvase compare
Rv2348c -0.6 -0.4 Hypothetical protein compare
Rv0572c -0.6 -2.9 Hypothetical protein compare
Rv0862c -0.5 -1.6 Conserved protein compare
Rv2011c -0.5 -1.1 Conserved hypothetical protein, probable transcription repressor. compare
Rv3139 -0.5 -2.4 Probable acyl-CoA dehydrogenase FadE24 compare
Rv1637c -0.5 -1.3 Conserved protein compare
Rv0653c -0.5 -1.9 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv3496c -0.5 -3.5 Mce-family protein Mce4D compare
Rv2417c -0.5 -0.7 Conserved protein compare
Rv0378 -0.5 -0.9 Conserved hypothetical glycine rich protein compare
Rv0033 -0.5 -1.1 Probable acyl carrier protein AcpA (ACP) compare
Rv2729c -0.5 -2.1 Probable conserved integral membrane alanine valine and leucine rich protein compare
Rv3823c -0.5 -4.2 Conserved integral membrane transport protein MmpL8 compare
Rv3301c -0.5 -2.0 Probable phosphate-transport system transcriptional regulatory protein PhoU homolog 1 PhoY1 compare
Rv2718c -0.5 -2.8 Probable transcriptional regulatory protein NrdR compare
Rv2970A -0.5 -1.4 Conserved hypothetical protein compare
Rv2116 -0.5 -1.8 Conserved lipoprotein LppK compare
Rv0561c -0.5 -0.8 Possible oxidoreductase compare
Rv0003 -0.5 -1.8 DNA replication and repair protein RecF (single-strand DNA binding protein) compare
Rv0569 -0.5 -0.8 Conserved protein compare
Rv0157A -0.5 -0.8 Conserved protein compare
Rv3816c -0.5 -0.5 Possible acyltransferase compare
Rv0655 -0.5 -1.6 Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl compare
Rv0629c -0.5 -1.9 Probable exonuclease V (alpha chain) RecD (exodeoxyribonuclease V alpha chain) (exodeoxyribonuclease V polypeptide) compare
Rv2625c -0.5 -1.9 Probable conserved transmembrane alanine and leucine rich protein compare
Rv3633 -0.5 -1.2 Conserved protein compare
Rv0865 -0.5 -1.5 Probable molybdopterin biosynthesis Mog protein compare
Rv1335 -0.5 -1.8 Sulfur carrier protein CysO compare
Rv0202c -0.5 -3.4 Probable conserved transmembrane transport protein MmpL11 compare
Rv2834c -0.5 -1.7 Probable Sn-glycerol-3-phosphate transport integral membrane protein ABC transporter UgpE compare
Rv0610c -0.5 -0.4 Hypothetical protein compare


Specific Phenotypes

For 1 genes in this experiment

For stress Spectinomycin dihydrochloride pentahydrate in Mycobacterium tuberculosis H37Rv

For stress Spectinomycin dihydrochloride pentahydrate across organisms