Experiment set5S628 for Mycobacterium tuberculosis H37Rv

Compare to:

no stress control

200 most important genes:

  gene name fitness t score description  
Rv1010 -5.1 -2.8 Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase) compare
Rv0929 -4.0 -3.9 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv0867c -3.4 -1.1 Possible resuscitation-promoting factor RpfA compare
Rv1159 -3.0 -3.0 Mannosyltransferase PimE compare
Rv2989 -2.4 -1.1 Probable transcriptional regulatory protein compare
Rv1621c -2.3 -3.9 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD compare
Rv0949 -2.3 -1.2 Probable ATP-dependent DNA helicase II UvrD1 compare
Rv1620c -2.2 -3.7 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC compare
Rv3513c -2.1 -1.4 Probable fatty-acid-CoA ligase FadD18 (fragment) (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv2500c -2.0 -1.4 Possible acyl-CoA dehydrogenase FadE19 (MMGC) compare
Rv0497 -1.9 -2.0 Probable conserved transmembrane protein compare
Rv1055 -1.9 -1.1 Possible integrase (fragment) compare
Rv1421 -1.8 -3.5 Conserved protein compare
Rv1745c -1.8 -5.5 Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase) compare
Rv2335 -1.7 -2.1 Probable serine acetyltransferase CysE (sat) compare
Rv2976c -1.6 -1.2 Probable uracil-DNA glycosylase Ung (UDG) compare
Rv3569c -1.6 -1.5 4,9-DHSA hydrolase compare
Rv0367c -1.5 -1.1 Hypothetical protein compare
Rv0452 -1.4 -3.7 Possible transcriptional regulatory protein compare
Rv0820 -1.4 -3.0 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv1332 -1.4 -1.1 Probable transcriptional regulatory protein compare
Rv0930 -1.4 -5.6 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv2694c -1.4 -6.3 Conserved protein compare
Rv2173 -1.3 -2.9 Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) compare
Rv2382c -1.3 -1.2 Polyketide synthetase MbtC (polyketide synthase) compare
Rv0819 -1.3 -2.2 GCN5-related N-acetyltransferase, MshD compare
Rv2912c -1.3 -3.3 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv3419c -1.2 -1.3 Probable O-sialoglycoprotein endopeptidase Gcp (glycoprotease) compare
Rv1102c -1.2 -1.2 Toxin MazF3 compare
Rv0955 -1.2 -0.8 Probable conserved integral membrane protein compare
Rv1303 -1.2 -1.0 Conserved hypothetical transmembrane protein compare
Rv3647c -1.2 -1.0 Conserved hypothetical protein compare
Rv2733c -1.2 -2.0 Conserved hypothetical alanine, arginine-rich protein compare
Rv2707 -1.2 -8.5 Probable conserved transmembrane alanine and leucine rich protein compare
Rv3850 -1.2 -1.0 Conserved protein compare
Rv3101c -1.2 -1.7 Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter) compare
Rv0989c -1.2 -6.4 Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) compare
Rv2348c -1.2 -0.7 Hypothetical protein compare
Rv0742 -1.2 -1.4 PE-PGRS family protein PE_PGRS8 compare
Rv2923c -1.1 -1.6 Conserved protein compare
Rv1420 -1.1 -1.9 Probable excinuclease ABC (subunit C-nuclease) UvrC compare
Rv2691 -1.1 -5.3 TRK system potassium uptake protein CeoB compare
Rv0609 -1.1 -1.6 Possible toxin VapC28. Contains PIN domain. compare
Rv0893c -1.1 -1.4 Possible S-adenosylmethionine-dependent methyltransferase compare
Rv2070c -1.0 -1.7 Precorrin-6X reductase CobK compare
Rv0019c -1.0 -3.8 Conserved protein with FHA domain, FhaB compare
Rv3311 -1.0 -3.1 Conserved protein compare
Rv3538 -1.0 -1.1 Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase. compare
Rv3817 -1.0 -1.8 Possible phosphotransferase compare
Rv1908c -1.0 -1.8 Catalase-peroxidase-peroxynitritase T KatG compare
Rv2630 -1.0 -1.1 Hypothetical protein compare
Rv3501c -1.0 -3.0 Conserved integral membrane protein YrbE4A. Possible ABC transporter. compare
Rv2429 -1.0 -1.4 Alkyl hydroperoxide reductase D protein AhpD (alkyl hydroperoxidase D) compare
Rv0309 -1.0 -3.2 Possible conserved exported protein compare
Rv0928 -1.0 -2.1 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv3387 -1.0 -2.0 Possible transposase compare
Rv1013 -1.0 -4.4 Putative polyketide synthase Pks16 compare
Rv2581c -1.0 -0.9 Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II) compare
Rv0395 -1.0 -2.2 Hypothetical protein compare
Rv0379 -0.9 -0.9 Possible protein transport protein SecE2 compare
Rv1072 -0.9 -1.5 Probable conserved transmembrane protein compare
Rv3816c -0.9 -0.8 Possible acyltransferase compare
Rv3193c -0.9 -1.2 Probable conserved transmembrane protein compare
Rv2384 -0.9 -1.3 Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase compare
Rv1581c -0.9 -1.2 Probable PhiRv1 phage protein compare
Rv3171c -0.9 -0.8 Possible non-heme haloperoxidase Hpx compare
Rv0312 -0.9 -1.9 Conserved hypothetical proline and threonine rich protein compare
Rv0398c -0.9 -1.0 Possible secreted protein compare
Rv0870c -0.9 -1.3 Possible conserved integral membrane protein compare
Rv3922c -0.9 -1.7 Possible hemolysin compare
Rv0991c -0.9 -1.0 Conserved serine rich protein compare
Rv3173c -0.9 -3.0 Probable transcriptional regulatory protein (probably TetR/AcrR-family) compare
Rv3691 -0.9 -1.2 Conserved protein compare
Rv2772c -0.9 -1.1 Probable conserved transmembrane protein compare
Rv3495c -0.9 -5.0 Possible Mce-family lipoprotein LprN (Mce-family lipoprotein Mce4E) compare
Rv2732c -0.9 -2.2 Probable conserved transmembrane protein compare
Rv3498c -0.8 -2.9 Mce-family protein Mce4B compare
Rv0017c -0.8 -3.4 Probable cell division protein RodA compare
Rv1137c -0.8 -1.5 Hypothetical protein compare
Rv0200 -0.8 -2.2 Possible conserved transmembrane protein compare
Rv2383c -0.8 -2.6 Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) compare
Rv2799 -0.8 -4.3 Probable membrane protein compare
Rv0311 -0.8 -2.2 Unknown protein compare
Rv3910 -0.8 -1.4 Probable conserved transmembrane protein compare
Rv2154c -0.8 -1.2 FtsW-like protein FtsW compare
Rv0345 -0.8 -3.1 Conserved hypothetical protein compare
Rv0313 -0.8 -1.0 Conserved protein compare
Rv3334 -0.8 -1.7 Probable transcriptional regulatory protein (probably MerR-family) compare
Rv2616 -0.8 -3.0 Conserved protein compare
Rv1324 -0.8 -1.1 Possible thioredoxin compare
Rv3177 -0.8 -0.7 Possible peroxidase (non-haem peroxidase) compare
Rv2567 -0.8 -3.5 Conserved hypothetical alanine and leucine rich protein compare
Rv2048c -0.8 -4.3 Polyketide synthase Pks12 compare
Rv2028c -0.8 -1.2 Universal stress protein family protein compare
Rv1680 -0.8 -3.0 Hypothetical protein compare
Rv2072c -0.8 -1.0 Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL compare
Rv3848 -0.8 -1.2 Probable conserved transmembrane protein compare
Rv2365c -0.8 -0.4 Conserved hypothetical protein compare
Rv3642c -0.8 -0.9 Hypothetical protein compare
Rv0954 -0.8 -2.2 Probable conserved transmembrane protein compare
Rv1019 -0.8 -3.6 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv1139c -0.8 -2.2 Conserved hypothetical membrane protein compare
Rv3332 -0.8 -1.5 Probable N-acetylglucosamine-6-phosphate deacetylase NagA (GlcNAc 6-P deacetylase) compare
Rv1506c -0.8 -1.0 Hypothetical protein compare
Rv3855 -0.8 -2.4 Transcriptional regulatory repressor protein (TetR-family) EthR compare
Rv0939 -0.7 -0.6 Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase compare
Rv2679 -0.7 -3.3 Probable enoyl-CoA hydratase EchA15 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv0078 -0.7 -1.3 Probable transcriptional regulatory protein compare
Rv0655 -0.7 -2.7 Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl compare
Rv0632c -0.7 -1.2 Probable enoyl-CoA hydratase EchA3 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv1112 -0.7 -0.8 Probable GTP binding protein compare
Rv2190c -0.7 -2.8 Conserved hypothetical protein compare
Rv0016c -0.7 -4.2 Probable penicillin-binding protein PbpA compare
Rv2668 -0.7 -2.3 Possible exported alanine and valine rich protein compare
Rv0865 -0.7 -2.4 Probable molybdopterin biosynthesis Mog protein compare
Rv3420c -0.7 -2.4 Ribosomal-protein-alanine acetyltransferase RimI (acetylating enzyme for N-terminal of ribosomal protein S18) compare
Rv1331 -0.7 -2.1 Conserved hypothetical protein compare
Rv1701 -0.7 -1.3 Probable integrase/recombinase compare
Rv0950c -0.7 -2.6 Conserved hypothetical protein compare
Rv2344c -0.7 -2.1 Probable deoxyguanosine triphosphate triphosphohydrolase Dgt (dGTPase) (dGTP triphosphohydrolase) compare
Rv2216 -0.7 -2.3 Conserved protein compare
Rv3200c -0.7 -1.7 Possible transmembrane cation transporter compare
Rv3565 -0.7 -1.0 Possible aspartate aminotransferase AspB (transaminase A) (ASPAT) (glutamic--oxaloacetic transaminase) (glutamic--aspartic transaminase) compare
Rv0321 -0.7 -2.1 Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase) compare
Rv1860 -0.7 -3.0 Alanine and proline rich secreted protein Apa (fibronectin attachment protein) (immunogenic protein MPT32) (antigen MPT-32) (45-kDa glycoprotein) (45/47 kDa antigen) compare
Rv2374c -0.7 -1.3 Probable heat shock protein transcriptional repressor HrcA compare
Rv1531 -0.7 -0.6 Conserved protein compare
Rv3066 -0.7 -2.6 Probable transcriptional regulatory protein (probably DeoR-family) compare
Rv2047c -0.7 -3.4 Conserved hypothetical protein compare
Rv1821 -0.7 -2.2 Possible preprotein translocase ATPase SecA2 compare
Rv1127c -0.7 -1.0 Probable pyruvate, phosphate dikinase PpdK compare
Rv2618 -0.7 -3.3 Conserved hypothetical protein compare
Rv2709 -0.7 -3.0 Probable conserved transmembrane protein compare
Rv0563 -0.7 -1.0 Probable protease transmembrane protein heat shock protein HtpX compare
Rv1364c -0.7 -2.1 Possible sigma factor regulatory protein compare
Rv3723 -0.7 -1.9 Probable conserved transmembrane protein compare
Rv0378 -0.7 -1.1 Conserved hypothetical glycine rich protein compare
Rv0204c -0.7 -2.4 Probable conserved transmembrane protein compare
Rv3188 -0.7 -1.1 Conserved hypothetical protein compare
Rv1097c -0.7 -1.5 Probable membrane glycine and proline rich protein compare
Rv3304 -0.7 -2.3 Conserved protein compare
Rv3499c -0.7 -3.9 Mce-family protein Mce4A compare
Rv2660c -0.7 -1.8 Hypothetical protein compare
Rv3497c -0.7 -4.6 Mce-family protein Mce4C compare
Rv1259 -0.7 -0.5 Probable uracil DNA glycosylase, UdgB compare
Rv2250c -0.7 -2.7 Possible transcriptional regulatory protein compare
Rv3120 -0.7 -2.7 Conserved hypothetical protein compare
Rv0392c -0.6 -0.5 Probable membrane NADH dehydrogenase NdhA compare
Rv0381c -0.6 -3.1 Hypothetical protein compare
Rv1657 -0.6 -2.0 Probable arginine repressor ArgR (AHRC) compare
Rv1709 -0.6 -2.7 Possible segregation and condensation protein ScpA compare
Rv3631 -0.6 -0.6 Possible transferase (possibly glycosyltransferase) compare
Rv2342 -0.6 -3.0 Conserved hypothetical protein compare
Rv3560c -0.6 -1.7 Probable acyl-CoA dehydrogenase FadE30 compare
Rv3301c -0.6 -2.3 Probable phosphate-transport system transcriptional regulatory protein PhoU homolog 1 PhoY1 compare
Rv0437c -0.6 -0.6 Possible phosphatidylserine decarboxylase Psd (PS decarboxylase) compare
Rv2647 -0.6 -1.2 Hypothetical protein compare
Rv1209 -0.6 -1.7 Conserved protein compare
Rv3813c -0.6 -1.7 Conserved protein compare
Rv0924c -0.6 -1.9 Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP) compare
Rv2586c -0.6 -0.9 Probable protein-export membrane protein SecF compare
Rv0744c -0.6 -1.8 Possible transcriptional regulatory protein compare
Rv2661c -0.6 -0.9 Hypothetical protein compare
Rv2236c -0.6 -1.3 Probable cobalamin biosynthesis transmembrane protein CobD compare
Rv3289c -0.6 -2.8 Possible transmembrane protein compare
Rv2872 -0.6 -2.1 Possible toxin VapC43. Contains PIN domain. compare
Rv0170 -0.6 -2.2 Mce-family protein Mce1B compare
Rv1798 -0.6 -0.5 ESX conserved component EccA5. ESX-5 type VII secretion system protein. compare
Rv0921 -0.6 -2.1 Possible resolvase compare
Rv0472c -0.6 -2.0 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv0100 -0.6 -1.0 Conserved hypothetical protein compare
Rv3496c -0.6 -4.0 Mce-family protein Mce4D compare
Rv1271c -0.6 -0.9 Conserved hypothetical secreted protein compare
Rv0242c -0.6 -1.5 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase) compare
Rv2609c -0.6 -1.1 Probable conserved membrane protein compare
Rv3500c -0.6 -3.2 Conserved integral membrane protein YrbE4B. Possible ABC transporter. compare
Rv3102c -0.6 -1.2 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv0900 -0.6 -1.4 Possible membrane protein compare
Rv0202c -0.6 -3.7 Probable conserved transmembrane transport protein MmpL11 compare
Rv3493c -0.6 -2.4 Conserved hypothetical Mce associated alanine and valine rich protein compare
Rv3005c -0.6 -3.8 Conserved hypothetical protein compare
Rv0274 -0.6 -1.8 Conserved protein compare
Rv0556 -0.6 -0.8 Probable conserved transmembrane protein compare
Rv0531 -0.6 -0.6 Possible conserved membrane protein compare
Rv1398c -0.6 -0.9 Possible antitoxin VapB10 compare
Rv0018c -0.6 -1.1 Phosphoserine/threonine phosphatase PstP compare
Rv3017c -0.6 -1.4 ESAT-6 like protein EsxQ (TB12.9) (ESAT-6 like protein 8) compare
Rv0168 -0.6 -1.7 Conserved integral membrane protein YrbE1B compare
Rv3218 -0.6 -3.4 Conserved protein compare
Rv3262 -0.6 -0.9 Probable F420 biosynthesis protein FbiB compare
Rv3039c -0.5 -1.3 Probable enoyl-CoA hydratase EchA17 (crotonase) (unsatured acyl-CoA hydratase) (enoyl hydrase) compare
Rv2302 -0.5 -0.5 Conserved protein compare
Rv2086 -0.5 -0.8 Conserved hypothetical protein compare
Rv2949c -0.5 -1.0 Chorismate pyruvate lyase compare
Rv0653c -0.5 -2.0 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv0992c -0.5 -2.8 Conserved hypothetical protein compare
Rv0361 -0.5 -0.8 Probable conserved membrane protein compare
Rv1884c -0.5 -0.8 Probable resuscitation-promoting factor RpfC compare
Rv2718c -0.5 -2.1 Probable transcriptional regulatory protein NrdR compare
Rv0661c -0.5 -0.9 Possible toxin VapC7 compare


Specific Phenotypes

None in this experiment

For Mycobacterium tuberculosis H37Rv in no stress control experiments