Experiment set5S620 for Mycobacterium tuberculosis H37Rv

Compare to:

7H9 with Chlorhexidine diacetate salt hydrate 0.0021 mM

200 most important genes:

  gene name fitness t score description  
Rv0436c -3.0 -2.5 Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase) compare
Rv0247c -2.8 -0.8 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) compare
Rv3101c -2.8 -2.8 Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter) compare
Rv3513c -2.7 -1.4 Probable fatty-acid-CoA ligase FadD18 (fragment) (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv0867c -2.7 -0.8 Possible resuscitation-promoting factor RpfA compare
Rv3306c -2.6 -2.3 Probable amidohydrolase AmiB1 (aminohydrolase) compare
Rv0929 -2.6 -3.3 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv0437c -2.6 -1.9 Possible phosphatidylserine decarboxylase Psd (PS decarboxylase) compare
Rv2317 -2.5 -1.3 Probable sugar-transport integral membrane protein ABC transporter UspB compare
Rv0930 -2.4 -7.1 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv2170 -2.3 -2.1 GCN5-related N-acetyltransferase compare
Rv2650c -2.1 -0.9 Possible PhiRv2 prophage protein compare
Rv0820 -2.1 -4.7 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv3413c -2.0 -1.2 Unknown alanine and proline rich protein compare
Rv2224c -2.0 -10.9 Probable carboxylesterase CaeA compare
Rv0392c -2.0 -1.2 Probable membrane NADH dehydrogenase NdhA compare
Rv1173 -2.0 -2.5 Probable F420 biosynthesis protein FbiC compare
Rv0928 -1.9 -3.3 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv2001 -1.8 -0.8 Conserved hypothetical protein compare
Rv2581c -1.8 -1.5 Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II) compare
Rv0242c -1.8 -3.5 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase) compare
Rv0472c -1.8 -3.8 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv1096 -1.7 -1.0 Possible glycosyl hydrolase compare
Rv1003 -1.7 -0.9 Conserved protein compare
Rv0954 -1.7 -3.3 Probable conserved transmembrane protein compare
Rv0007 -1.7 -0.9 Possible conserved membrane protein compare
Rv3655c -1.7 -2.5 Conserved hypothetical protein compare
Rv3810 -1.6 -2.8 Exported repetitive protein precursor PirG (cell surface protein) (EXP53) compare
Rv3717 -1.6 -2.5 Conserved hypothetical protein compare
Rv2945c -1.6 -7.4 Probable conserved lipoprotein LppX compare
Rv0361 -1.6 -1.2 Probable conserved membrane protein compare
Rv1410c -1.6 -5.3 Aminoglycosides/tetracycline-transport integral membrane protein compare
Rv3316 -1.5 -2.4 Probable succinate dehydrogenase (cytochrome B-556 subunit) SdhC (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase) compare
Rv0989c -1.5 -7.7 Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) compare
Rv2942 -1.5 -10.5 Conserved transmembrane transport protein MmpL7 compare
Rv2237A -1.5 -1.2 Conserved protein compare
Rv2621c -1.5 -1.2 Possible transcriptional regulatory protein compare
Rv1159 -1.5 -2.6 Mannosyltransferase PimE compare
Rv1010 -1.4 -1.2 Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase) compare
Rv1121 -1.4 -1.7 Probable glucose-6-phosphate 1-dehydrogenase Zwf1 (G6PD) compare
Rv1411c -1.4 -3.5 Conserved lipoprotein LprG compare
Rv0504c -1.3 -1.2 Conserved protein compare
Rv0757 -1.3 -1.6 Possible two component system response transcriptional positive regulator PhoP compare
Rv2936 -1.3 -8.8 Daunorubicin-dim-transport ATP-binding protein ABC transporter DrrA compare
Rv0204c -1.3 -4.4 Probable conserved transmembrane protein compare
Rv3723 -1.3 -3.6 Probable conserved transmembrane protein compare
Rv3658c -1.3 -1.0 Probable conserved transmembrane protein compare
Rv2696c -1.3 -2.0 Conserved alanine and glycine and valine rich protein compare
Rv2938 -1.3 -8.3 Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC compare
Rv2171 -1.2 -1.9 Probable conserved lipoprotein LppM compare
Rv2706c -1.2 -1.2 Hypothetical protein compare
Rv0955 -1.2 -1.2 Probable conserved integral membrane protein compare
Rv0819 -1.2 -2.9 GCN5-related N-acetyltransferase, MshD compare
Rv2525c -1.2 -7.6 Conserved hypothetical protein. Secreted; predicted to be a substrate of the twin arginine translocation (tat) export system. compare
Rv3267 -1.2 -2.5 Conserved protein (CPSA-related protein) compare
Rv1459c -1.2 -1.2 Possible conserved integral membrane protein compare
Rv3262 -1.2 -1.8 Probable F420 biosynthesis protein FbiB compare
Rv3102c -1.2 -1.7 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv3910 -1.2 -1.8 Probable conserved transmembrane protein compare
Rv0642c -1.2 -2.1 Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase) compare
Rv3005c -1.2 -7.2 Conserved hypothetical protein compare
Rv1244 -1.1 -4.3 Probable lipoprotein LpqZ compare
Rv2476c -1.1 -3.8 Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase) compare
Rv1013 -1.1 -5.9 Putative polyketide synthase Pks16 compare
Rv2937 -1.1 -7.1 Daunorubicin-dim-transport integral membrane protein ABC transporter DrrB compare
Rv3193c -1.1 -1.5 Probable conserved transmembrane protein compare
Rv1420 -1.1 -2.3 Probable excinuclease ABC (subunit C-nuclease) UvrC compare
Rv3897c -1.1 -0.4 Conserved hypothetical protein compare
Rv1930c -1.1 -0.7 Conserved hypothetical protein compare
Rv0949 -1.1 -0.7 Probable ATP-dependent DNA helicase II UvrD1 compare
Rv2912c -1.1 -2.6 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv0818 -1.0 -3.8 Transcriptional regulatory protein compare
Rv1401 -1.0 -1.1 Possible membrane protein compare
Rv2707 -1.0 -7.1 Probable conserved transmembrane alanine and leucine rich protein compare
Rv2693c -1.0 -2.8 Probable conserved integral membrane alanine and leucine rich protein compare
Rv0646c -1.0 -1.6 Probable lipase/esterase LipG compare
Rv2026c -1.0 -1.2 Universal stress protein family protein compare
Rv3920c -1.0 -1.0 Conserved protein similar to jag protein compare
Rv3817 -1.0 -1.5 Possible phosphotransferase compare
Rv1821 -1.0 -2.1 Possible preprotein translocase ATPase SecA2 compare
Rv0994 -1.0 -4.0 Probable molybdopterin biosynthesis protein MoeA1 compare
Rv0609 -1.0 -1.0 Possible toxin VapC28. Contains PIN domain. compare
Rv1701 -0.9 -3.3 Probable integrase/recombinase compare
Rv3140 -0.9 -2.2 Probable acyl-CoA dehydrogenase FadE23 compare
Rv1072 -0.9 -1.7 Probable conserved transmembrane protein compare
Rv3843c -0.9 -1.2 Probable conserved transmembrane protein compare
Rv1350 -0.9 -0.8 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) compare
Rv3610c -0.9 -1.1 Membrane-bound protease FtsH (cell division protein) compare
Rv2793c -0.9 -1.0 Probable tRNA pseudouridine synthase B TruB (tRNA pseudouridine 55 synthase) (PSI55 synthase) (pseudouridylate synthase) (uracil hydrolyase) compare
Rv0078 -0.9 -1.9 Probable transcriptional regulatory protein compare
Rv3559c -0.9 -1.0 Probable oxidoreductase compare
Rv1860 -0.9 -2.7 Alanine and proline rich secreted protein Apa (fibronectin attachment protein) (immunogenic protein MPT32) (antigen MPT-32) (45-kDa glycoprotein) (45/47 kDa antigen) compare
Rv1006 -0.9 -2.6 Unknown protein compare
Rv0452 -0.9 -1.6 Possible transcriptional regulatory protein compare
Rv2173 -0.8 -2.2 Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) compare
Rv3496c -0.8 -5.2 Mce-family protein Mce4D compare
Rv0383c -0.8 -0.7 Possible conserved secreted protein compare
Rv2899c -0.8 -0.8 Possible FdhD protein homolog compare
Rv0241c -0.8 -1.9 Probable 3-hydroxyacyl-thioester dehydratase HtdX compare
Rv3919c -0.8 -1.3 Probable glucose-inhibited division protein B Gid compare
Rv0615 -0.8 -0.5 Probable integral membrane protein compare
Rv0497 -0.8 -0.8 Probable conserved transmembrane protein compare
Rv2879c -0.8 -0.9 Conserved hypothetical protein compare
Rv0018c -0.8 -2.8 Phosphoserine/threonine phosphatase PstP compare
Rv1068c -0.8 -2.3 PE-PGRS family protein PE_PGRS20 compare
Rv0208c -0.8 -1.8 Hypothetical methlytransferase (methylase) compare
Rv3200c -0.8 -2.2 Possible transmembrane cation transporter compare
Rv3386 -0.8 -1.3 Possible transposase compare
Rv3132c -0.8 -2.5 Two component sensor histidine kinase DevS compare
Rv3605c -0.8 -3.2 Probable conserved secreted protein compare
Rv0821c -0.8 -1.6 Probable phosphate-transport system transcriptional regulatory protein PhoY2 compare
Rv3818 -0.8 -3.5 Unknown protein compare
Rv0690c -0.8 -1.9 Conserved hypothetical protein compare
Rv1620c -0.8 -2.1 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC compare
Rv0201c -0.8 -1.1 Conserved protein compare
Rv0893c -0.8 -1.3 Possible S-adenosylmethionine-dependent methyltransferase compare
Rv2029c -0.8 -1.4 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) compare
Rv1414 -0.8 -0.7 Conserved hypothetical protein compare
Rv3500c -0.8 -3.7 Conserved integral membrane protein YrbE4B. Possible ABC transporter. compare
Rv2553c -0.8 -0.6 Probable conserved membrane protein compare
Rv2967c -0.7 -3.3 Probable pyruvate carboxylase Pca (pyruvic carboxylase) compare
Rv3546 -0.7 -1.4 Probable acetyl-CoA acetyltransferase FadA5 (acetoacetyl-CoA thiolase) compare
Rv3273 -0.7 -3.7 Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) compare
Rv2190c -0.7 -2.9 Conserved hypothetical protein compare
Rv1690 -0.7 -1.6 Probable lipoprotein LprJ compare
Rv2384 -0.7 -1.0 Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase compare
Rv1332 -0.7 -0.6 Probable transcriptional regulatory protein compare
Rv1565c -0.7 -2.7 Conserved hypothetical membrane protein compare
Rv3499c -0.7 -3.4 Mce-family protein Mce4A compare
Rv1127c -0.7 -0.8 Probable pyruvate, phosphate dikinase PpdK compare
Rv3340 -0.7 -2.4 Probable O-acetylhomoserine sulfhydrylase MetC (homocysteine synthase) (O-acetylhomoserine (thiol)-lyase) (OAH sulfhydrylase) (O-acetyl-L-homoserine sulfhydrylase) compare
Rv3335c -0.7 -2.8 Probable conserved integral membrane protein compare
Rv3495c -0.7 -4.9 Possible Mce-family lipoprotein LprN (Mce-family lipoprotein Mce4E) compare
Rv2321c -0.7 -0.8 Probable ornithine aminotransferase (C-terminus part) RocD2 (ornithine--oxo-acid aminotransferase) compare
Rv2260 -0.7 -1.2 Conserved hypothetical protein compare
Rv0019c -0.7 -2.3 Conserved protein with FHA domain, FhaB compare
Rv1810 -0.7 -3.7 Conserved protein compare
Rv3768 -0.7 -1.6 Unknown protein compare
Rv0426c -0.7 -1.9 Possible transmembrane protein compare
Rv0760c -0.7 -1.1 Conserved protein compare
Rv1561 -0.7 -1.7 Possible toxin VapC11 compare
Rv0090 -0.7 -2.4 Possible membrane protein compare
Rv1209 -0.7 -2.3 Conserved protein compare
Rv1663 -0.7 -2.0 Probable polyketide synthase Pks17 compare
Rv1640c -0.7 -3.6 Lysyl-tRNA synthetase 2 LysX compare
Rv3139 -0.7 -2.7 Probable acyl-CoA dehydrogenase FadE24 compare
Rv0995 -0.7 -0.9 Ribosomal-protein-alanine acetyltransferase RimJ (acetylating enzyme for N-terminal of ribosomal protein S5) compare
Rv0003 -0.7 -1.6 DNA replication and repair protein RecF (single-strand DNA binding protein) compare
Rv2096c -0.7 -2.1 Proteasome accessory factor B PafB compare
Rv0444c -0.7 -3.5 Anti-sigma factor RskA (regulator of sigma K) compare
Rv2463 -0.7 -3.4 Probable esterase/lipase LipP compare
Rv3291c -0.7 -2.7 Probable transcriptional regulatory protein LrpA (Lrp/AsnC-family) compare
Rv3013 -0.7 -0.7 Conserved protein compare
Rv0129c -0.7 -2.1 Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) compare
Rv0016c -0.7 -2.4 Probable penicillin-binding protein PbpA compare
Rv3318 -0.7 -2.4 Probable succinate dehydrogenase (flavoprotein subunit) SdhA (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase) compare
Rv0857 -0.6 -1.0 Conserved hypothetical protein compare
Rv0655 -0.6 -2.1 Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl compare
Rv2144c -0.6 -1.9 Probable transmembrane protein compare
Rv3301c -0.6 -2.3 Probable phosphate-transport system transcriptional regulatory protein PhoU homolog 1 PhoY1 compare
Rv3501c -0.6 -1.2 Conserved integral membrane protein YrbE4A. Possible ABC transporter. compare
Rv0113 -0.6 -0.8 Probable sedoheptulose-7-phosphate isomerase GmhA (phosphoheptose isomerase) compare
Rv2365c -0.6 -0.5 Conserved hypothetical protein compare
Rv1495 -0.6 -0.8 Possible toxin MazF4 compare
Rv3848 -0.6 -0.9 Probable conserved transmembrane protein compare
Rv0202c -0.6 -4.1 Probable conserved transmembrane transport protein MmpL11 compare
Rv2613c -0.6 -1.8 Conserved protein compare
Rv1282c -0.6 -1.6 Probable oligopeptide-transport integral membrane protein ABC transporter OppC compare
Rv2691 -0.6 -3.3 TRK system potassium uptake protein CeoB compare
Rv2383c -0.6 -1.6 Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) compare
Rv1049 -0.6 -0.9 Probable transcriptional repressor protein compare
Rv0805 -0.6 -0.3 Class III cyclic nucleotide phosphodiesterase (cNMP PDE) compare
Rv3652 -0.6 -1.9 PE-PGRS family-related protein PE_PGRS60 compare
Rv1030 -0.6 -1.6 Probable potassium-transporting P-type ATPase B chain KdpB (potassium-translocating ATPase B chain) (ATP phosphohydrolase [potassium-transporting] B chain) (potassium binding and translocating subunit B) compare
Rv3046c -0.6 -0.4 Conserved protein compare
Rv1278 -0.6 -1.3 Hypothetical protein compare
Rv0050 -0.6 -1.2 Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase) compare
Rv1148c -0.6 -1.0 Conserved hypothetical protein compare
Rv3177 -0.6 -0.6 Possible peroxidase (non-haem peroxidase) compare
Rv0841 -0.6 -1.3 Probable conserved transmembrane protein compare
Rv0632c -0.6 -1.5 Probable enoyl-CoA hydratase EchA3 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv0040c -0.6 -3.2 Secreted proline rich protein Mtc28 (proline rich 28 kDa antigen) compare
Rv3332 -0.6 -0.7 Probable N-acetylglucosamine-6-phosphate deacetylase NagA (GlcNAc 6-P deacetylase) compare
Rv0924c -0.6 -2.1 Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP) compare
Rv2816c -0.6 -1.2 Conserved hypothetical protein compare
Rv1925 -0.6 -3.6 Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) compare
Rv1354c -0.6 -2.0 Conserved hypothetical protein compare
Rv1836c -0.6 -1.2 Conserved protein compare
Rv0009 -0.6 -0.4 Probable iron-regulated peptidyl-prolyl cis-trans isomerase A PpiA (PPIase A) (rotamase A) compare
Rv2049c -0.6 -0.8 Conserved hypothetical protein compare
Rv1272c -0.6 -2.4 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv1670 -0.6 -1.8 Conserved hypothetical protein compare
Rv3066 -0.6 -2.9 Probable transcriptional regulatory protein (probably DeoR-family) compare
Rv3493c -0.6 -2.8 Conserved hypothetical Mce associated alanine and valine rich protein compare
Rv2644c -0.6 -1.6 Hypothetical protein compare
Rv2136c -0.6 -1.4 Possible conserved transmembrane protein compare
Rv0876c -0.6 -1.1 Possible conserved transmembrane protein compare
Rv3010c -0.6 -1.9 Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) compare
Rv2588c -0.6 -1.1 Probable conserved membrane protein secretion factor YajC compare
Rv2717c -0.6 -1.3 Conserved protein compare


Specific Phenotypes

None in this experiment

For Mycobacterium tuberculosis H37Rv in stress experiments

For stress Chlorhexidine diacetate salt hydrate across organisms