Experiment set5S618 for Mycobacterium tuberculosis H37Rv

200 most important genes:

gene	name	fitness	t score	description
Rv0929		-4.8	-3.3	Phosphate-transport integral membrane ABC transporter PstC2
Rv1930c		-4.5	-1.3	Conserved hypothetical protein
Rv2989		-3.5	-1.1	Probable transcriptional regulatory protein
Rv3513c		-2.8	-1.4	Probable fatty-acid-CoA ligase FadD18 (fragment) (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Rv0949		-2.8	-1.2	Probable ATP-dependent DNA helicase II UvrD1
Rv3102c		-2.5	-4.8	Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter)
Rv3101c		-2.5	-2.7	Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter)
Rv0928		-2.4	-3.2	Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1)
Rv0757		-2.4	-2.2	Possible two component system response transcriptional positive regulator PhoP
Rv1421		-2.4	-3.6	Conserved protein
Rv1908c		-2.2	-2.4	Catalase-peroxidase-peroxynitritase T KatG
Rv0472c		-2.2	-3.6	Probable transcriptional regulatory protein (possibly TetR-family)
Rv2696c		-2.1	-2.8	Conserved alanine and glycine and valine rich protein
Rv3306c		-2.1	-1.7	Probable amidohydrolase AmiB1 (aminohydrolase)
Rv3277		-2.1	-0.9	Probable conserved transmembrane protein
Rv1821		-2.0	-4.6	Possible preprotein translocase ATPase SecA2
Rv2224c		-2.0	-11.6	Probable carboxylesterase CaeA
Rv1411c		-2.0	-3.9	Conserved lipoprotein LprG
Rv1620c		-2.0	-3.7	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC
Rv2553c		-1.9	-1.1	Probable conserved membrane protein
Rv1159		-1.9	-3.2	Mannosyltransferase PimE
Rv0820		-1.8	-5.8	Probable phosphate-transport ATP-binding protein ABC transporter PhoT
Rv1621c		-1.8	-3.6	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD
Rv2630		-1.8	-1.5	Hypothetical protein
Rv1127c		-1.8	-1.5	Probable pyruvate, phosphate dikinase PpdK
Rv3188		-1.7	-2.1	Conserved hypothetical protein
Rv0930		-1.7	-7.5	Probable phosphate-transport integral membrane ABC transporter PstA1
Rv1025		-1.6	-0.8	Conserved protein
Rv2170		-1.6	-1.5	GCN5-related N-acetyltransferase
Rv0642c		-1.6	-1.8	Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase)
Rv3650		-1.5	-0.9	PE family protein PE33
Rv2650c		-1.5	-0.8	Possible PhiRv2 prophage protein
Rv1010		-1.5	-1.1	Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase)
Rv1410c		-1.5	-5.5	Aminoglycosides/tetracycline-transport integral membrane protein
Rv3717		-1.5	-3.9	Conserved hypothetical protein
Rv3249c		-1.5	-1.2	Possible transcriptional regulatory protein (probably TetR-family)
Rv1798		-1.5	-1.2	ESX conserved component EccA5. ESX-5 type VII secretion system protein.
Rv1459c		-1.4	-1.4	Possible conserved integral membrane protein
Rv0452		-1.4	-3.5	Possible transcriptional regulatory protein
Rv0954		-1.4	-5.5	Probable conserved transmembrane protein
Rv2976c		-1.4	-1.3	Probable uracil-DNA glycosylase Ung (UDG)
Rv0819		-1.4	-3.1	GCN5-related N-acetyltransferase, MshD
Rv2240c		-1.4	-1.9	Unknown protein
Rv1013		-1.4	-5.6	Putative polyketide synthase Pks16
Rv3267		-1.4	-4.1	Conserved protein (CPSA-related protein)
Rv3817		-1.4	-1.9	Possible phosphotransferase
Rv3850		-1.3	-1.3	Conserved protein
Rv3200c		-1.3	-2.8	Possible transmembrane cation transporter
Rv2879c		-1.3	-1.4	Conserved hypothetical protein
Rv2003c		-1.3	-1.3	Conserved hypothetical protein
Rv3005c		-1.2	-7.3	Conserved hypothetical protein
Rv2732c		-1.2	-2.7	Probable conserved transmembrane protein
Rv3182		-1.2	-0.7	Conserved hypothetical protein
Rv3492c		-1.2	-2.2	Conserved hypothetical Mce associated protein
Rv3177		-1.2	-1.0	Possible peroxidase (non-haem peroxidase)
Rv0242c		-1.2	-1.9	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase)
Rv0395		-1.2	-1.6	Hypothetical protein
Rv2237A		-1.2	-1.0	Conserved protein
Rv2691		-1.2	-5.0	TRK system potassium uptake protein CeoB
Rv0674		-1.2	-0.7	Conserved hypothetical protein
Rv2051c		-1.1	-3.5	Polyprenol-monophosphomannose synthase Ppm1
Rv2869c		-1.1	-1.4	Membrane bound metalloprotease
Rv2044c		-1.1	-0.4	Conserved hypothetical protein
Rv0204c		-1.1	-2.8	Probable conserved transmembrane protein
Rv0999		-1.1	-1.5	Unknown protein
Rv3818		-1.1	-4.4	Unknown protein
Rv2047c		-1.1	-4.7	Conserved hypothetical protein
Rv0994		-1.1	-5.2	Probable molybdopterin biosynthesis protein MoeA1
Rv0018c		-1.1	-2.0	Phosphoserine/threonine phosphatase PstP
Rv1291c		-1.1	-1.5	Conserved hypothetical secreted protein
Rv1657		-1.1	-1.7	Probable arginine repressor ArgR (AHRC)
Rv0989c		-1.0	-5.3	Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase)
Rv0680c		-1.0	-1.5	Probable conserved transmembrane protein
Rv1158c		-1.0	-1.9	Conserved hypothetical ala-, pro-rich protein
Rv1055		-1.0	-0.8	Possible integrase (fragment)
Rv1019		-1.0	-4.4	Probable transcriptional regulatory protein (probably TetR-family)
Rv3498c		-1.0	-4.0	Mce-family protein Mce4B
Rv2366c		-1.0	-2.2	Probable conserved transmembrane protein
Rv0007		-1.0	-0.6	Possible conserved membrane protein
Rv1860		-1.0	-3.2	Alanine and proline rich secreted protein Apa (fibronectin attachment protein) (immunogenic protein MPT32) (antigen MPT-32) (45-kDa glycoprotein) (45/47 kDa antigen)
Rv0019c		-1.0	-3.3	Conserved protein with FHA domain, FhaB
Rv2171		-1.0	-1.8	Probable conserved lipoprotein LppM
Rv3723		-1.0	-3.5	Probable conserved transmembrane protein
Rv2365c		-1.0	-0.7	Conserved hypothetical protein
Rv3810		-1.0	-2.1	Exported repetitive protein precursor PirG (cell surface protein) (EXP53)
Rv0990c		-1.0	-0.7	Hypothetical protein
Rv0497		-1.0	-0.9	Probable conserved transmembrane protein
Rv0200		-1.0	-2.0	Possible conserved transmembrane protein
Rv0040c		-1.0	-5.3	Secreted proline rich protein Mtc28 (proline rich 28 kDa antigen)
Rv2945c		-1.0	-5.3	Probable conserved lipoprotein LppX
Rv2232		-0.9	-1.8	Protein tyrosine kinase transcriptional regulatory protein PtkA
Rv1791		-0.9	-1.1	PE family protein PE19
Rv0531		-0.9	-1.1	Possible conserved membrane protein
Rv0016c		-0.9	-3.6	Probable penicillin-binding protein PbpA
Rv0460		-0.9	-1.6	Conserved hydrophobic protein
Rv0219		-0.9	-2.8	Probable conserved transmembrane protein
Rv1273c		-0.9	-2.7	Probable drugs-transport transmembrane ATP-binding protein ABC transporter
Rv0758		-0.9	-1.7	Possible two component system response sensor kinase membrane associated PhoR
Rv0740		-0.9	-2.2	Conserved hypothetical protein
Rv2039c		-0.9	-1.6	Probable sugar-transport integral membrane protein ABC transporter
Rv0959		-0.9	-1.0	Conserved hypothetical protein
Rv1693		-0.9	-1.1	Conserved hypothetical protein
Rv2942		-0.9	-6.6	Conserved transmembrane transport protein MmpL7
Rv2525c		-0.9	-5.5	Conserved hypothetical protein. Secreted; predicted to be a substrate of the twin arginine translocation (tat) export system.
Rv2429		-0.9	-1.2	Alkyl hydroperoxide reductase D protein AhpD (alkyl hydroperoxidase D)
Rv0436c		-0.9	-1.1	Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase)
Rv0563		-0.9	-1.0	Probable protease transmembrane protein heat shock protein HtpX
Rv3814c		-0.9	-3.6	Possible acyltransferase
Rv2938		-0.9	-5.3	Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC
Rv2993c		-0.8	-1.6	Possible 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase)
Rv3311		-0.8	-2.9	Conserved protein
Rv1561		-0.8	-2.2	Possible toxin VapC11
Rv2799		-0.8	-4.3	Probable membrane protein
Rv0955		-0.8	-0.9	Probable conserved integral membrane protein
Rv2190c		-0.8	-2.4	Conserved hypothetical protein
Rv1624c		-0.8	-2.2	Probable conserved membrane protein
Rv0655		-0.8	-2.0	Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl
Rv3494c		-0.8	-4.0	Mce-family protein Mce4F
Rv1244		-0.8	-2.3	Probable lipoprotein LpqZ
Rv0070c		-0.8	-1.2	Serine hydroxymethyltransferase GlyA2 (serine methylase 2) (SHMT 2)
Rv0202c		-0.8	-3.5	Probable conserved transmembrane transport protein MmpL11
Rv1209		-0.8	-2.9	Conserved protein
Rv1336		-0.8	-3.3	Cysteine synthase B CysM (CSASE B) (O-phosphoserine sulfhydrylase B) (O-phosphoserine (thiol)-lyase B)
Rv3496c		-0.8	-4.9	Mce-family protein Mce4D
Rv2046		-0.8	-2.3	Probable lipoprotein LppI
Rv2048c		-0.8	-2.9	Polyketide synthase Pks12
Rv1745c		-0.8	-2.2	Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase)
Rv2937		-0.8	-5.4	Daunorubicin-dim-transport integral membrane protein ABC transporter DrrB
Rv1072		-0.8	-1.5	Probable conserved transmembrane protein
Rv1422		-0.8	-0.7	Conserved hypothetical protein
Rv2548		-0.8	-1.3	Possible toxin VapC19
Rv0344c		-0.8	-1.8	Probable lipoprotein LpqJ
Rv0310c		-0.8	-1.2	Conserved protein
Rv3610c		-0.8	-1.7	Membrane-bound protease FtsH (cell division protein)
Rv2728c		-0.7	-2.1	Conserved alanine rich protein
Rv0738		-0.7	-0.8	Conserved protein
Rv2581c		-0.7	-0.9	Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II)
Rv0294		-0.7	-1.5	Probable trans-aconitate methyltransferase Tam
Rv3414c		-0.7	-2.7	Probable alternative RNA polymerase sigma-D factor SigD
Rv1836c		-0.7	-1.3	Conserved protein
Rv3658c		-0.7	-0.8	Probable conserved transmembrane protein
Rv0190		-0.7	-1.9	Conserved protein
Rv0590		-0.7	-1.4	Mce-family protein Mce2B
Rv2865		-0.7	-1.1	Antitoxin RelF
Rv1435c		-0.7	-3.1	Probable conserved proline, glycine, valine-rich secreted protein
Rv1030		-0.7	-2.6	Probable potassium-transporting P-type ATPase B chain KdpB (potassium-translocating ATPase B chain) (ATP phosphohydrolase [potassium-transporting] B chain) (potassium binding and translocating subunit B)
Rv1111c		-0.7	-1.7	Conserved hypothetical protein
Rv2936		-0.7	-4.8	Daunorubicin-dim-transport ATP-binding protein ABC transporter DrrA
Rv2206		-0.7	-2.8	Probable conserved transmembrane protein
Rv1982c		-0.7	-1.3	Possible toxin VapC36. Contains PIN domain.
Rv0612		-0.7	-1.2	Conserved hypothetical protein
Rv3204		-0.7	-0.3	Possible DNA-methyltransferase (modification methylase)
Rv1096		-0.7	-0.6	Possible glycosyl hydrolase
Rv2335		-0.7	-1.0	Probable serine acetyltransferase CysE (sat)
Rv0049		-0.7	-1.3	Conserved hypothetical protein
Rv3500c		-0.7	-3.7	Conserved integral membrane protein YrbE4B. Possible ABC transporter.
Rv2694c		-0.7	-1.7	Conserved protein
Rv3495c		-0.7	-4.1	Possible Mce-family lipoprotein LprN (Mce-family lipoprotein Mce4E)
Rv3314c		-0.7	-0.9	Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase)
Rv2382c		-0.7	-0.6	Polyketide synthetase MbtC (polyketide synthase)
Rv0470c		-0.7	-1.0	Mycolic acid synthase PcaA (cyclopropane synthase)
Rv3499c		-0.7	-3.3	Mce-family protein Mce4A
Rv2686c		-0.7	-1.9	Antibiotic-transport integral membrane leucine and alanine and valine rich protein ABC transporter
Rv0047c		-0.7	-2.7	Conserved protein
Rv1401		-0.7	-0.8	Possible membrane protein
Rv2476c		-0.7	-1.9	Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase)
Rv3501c		-0.7	-2.2	Conserved integral membrane protein YrbE4A. Possible ABC transporter.
Rv1068c		-0.7	-1.9	PE-PGRS family protein PE_PGRS20
Rv3416		-0.7	-0.8	Transcriptional regulatory protein WhiB-like WhiB3. Contains [4FE-4S] cluster.
Rv2028c		-0.7	-0.8	Universal stress protein family protein
Rv0154c		-0.7	-1.5	Probable acyl-CoA dehydrogenase FadE2
Rv2529		-0.7	-1.9	Hypothetical protein
Rv0201c		-0.7	-1.2	Conserved protein
Rv1679		-0.6	-0.5	Possible acyl-CoA dehydrogenase FadE16
Rv0523c		-0.6	-0.9	Conserved protein
Rv1840c		-0.6	-1.2	PE-PGRS family protein PE_PGRS34
Rv1898		-0.6	-1.2	Conserved hypothetical protein
Rv1235		-0.6	-1.9	Probable sugar-binding lipoprotein LpqY
Rv0745		-0.6	-2.4	Conserved hypothetical protein
Rv1884c		-0.6	-1.2	Probable resuscitation-promoting factor RpfC
Rv1364c		-0.6	-1.7	Possible sigma factor regulatory protein
Rv2410c		-0.6	-1.7	Conserved protein
Rv2173		-0.6	-1.4	Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase)
Rv3139		-0.6	-1.7	Probable acyl-CoA dehydrogenase FadE24
Rv0950c		-0.6	-2.5	Conserved hypothetical protein
Rv1941		-0.6	-0.9	Probable short-chain type dehydrogenase/reductase
Rv1502		-0.6	-1.0	Hypothetical protein
Rv3768		-0.6	-1.5	Unknown protein
Rv2331A		-0.6	-0.5	Hypothetical protein
Rv2680		-0.6	-0.8	Conserved protein
Rv0017c		-0.6	-2.0	Probable cell division protein RodA
Rv3898c		-0.6	-2.2	Conserved hypothetical protein
Rv1351		-0.6	-0.7	Hypothetical protein
Rv0653c		-0.6	-2.4	Possible transcriptional regulatory protein (probably TetR-family)
Rv2144c		-0.6	-1.6	Probable transmembrane protein
Rv3584		-0.6	-1.1	Possible conserved lipoprotein LpqE
Rv3282		-0.6	-1.0	Conserved hypothetical protein
Rv2679		-0.6	-1.2	Probable enoyl-CoA hydratase EchA15 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv3335c		-0.6	-2.8	Probable conserved integral membrane protein
Rv0199		-0.6	-1.5	Probable conserved membrane protein

Specific Phenotypes

None in this experiment

For Mycobacterium tuberculosis H37Rv in stress experiments

For stress Tetrazolium violet across organisms