Experiment set5S615 for Mycobacterium tuberculosis H37Rv

200 most important genes:

gene	name	fitness	t score	description
Rv2989		-3.5	-1.1	Probable transcriptional regulatory protein
Rv3650		-2.8	-1.3	PE family protein PE33
Rv2044c		-2.7	-0.9	Conserved hypothetical protein
Rv0867c		-2.7	-0.9	Possible resuscitation-promoting factor RpfA
Rv2348c		-2.7	-1.2	Hypothetical protein
Rv3716c		-2.6	-1.2	Conserved protein
Rv0451c		-2.6	-1.4	Probable conserved membrane protein MmpS4
Rv3182		-2.4	-1.1	Conserved hypothetical protein
Rv1072		-2.2	-2.8	Probable conserved transmembrane protein
Rv2661c		-1.9	-1.4	Hypothetical protein
Rv3413c		-1.9	-1.0	Unknown alanine and proline rich protein
Rv1324		-1.8	-1.8	Possible thioredoxin
Rv2272		-1.8	-1.0	Probable conserved transmembrane protein
Rv3013		-1.7	-1.6	Conserved protein
Rv2055c		-1.7	-1.6	30S ribosomal protein S18 RpsR2
Rv3819		-1.6	-0.7	Unknown protein
Rv2377c		-1.5	-2.4	Putative conserved protein MbtH
Rv0929		-1.4	-2.2	Phosphate-transport integral membrane ABC transporter PstC2
Rv2173		-1.4	-2.9	Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase)
Rv1121		-1.4	-1.9	Probable glucose-6-phosphate 1-dehydrogenase Zwf1 (G6PD)
Rv2237A		-1.4	-1.5	Conserved protein
Rv0375c		-1.4	-1.8	Probable carbon monoxyde dehydrogenase (medium chain)
Rv1459c		-1.3	-1.5	Possible conserved integral membrane protein
Rv3066		-1.3	-5.0	Probable transcriptional regulatory protein (probably DeoR-family)
Rv0868c		-1.3	-1.9	Probable molybdenum cofactor biosynthesis protein D 2 MoaD2 (molybdopterin converting factor small subunit) (molybdopterin [MPT] converting factor, subunit 1)
Rv1284		-1.3	-0.8	Beta-carbonic anhydrase
Rv0395		-1.3	-2.1	Hypothetical protein
Rv3492c		-1.3	-2.4	Conserved hypothetical Mce associated protein
Rv2099c		-1.3	-2.0	PE family protein PE21
Rv0819		-1.2	-2.7	GCN5-related N-acetyltransferase, MshD
Rv3897c		-1.2	-0.5	Conserved hypothetical protein
Rv3910		-1.2	-1.5	Probable conserved transmembrane protein
Rv0242c		-1.2	-2.9	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase)
Rv3817		-1.2	-1.9	Possible phosphotransferase
Rv1350		-1.2	-1.1	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase)
Rv2938		-1.2	-7.5	Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC
Rv0018c		-1.1	-3.1	Phosphoserine/threonine phosphatase PstP
Rv2945c		-1.1	-7.6	Probable conserved lipoprotein LppX
Rv0955		-1.1	-1.3	Probable conserved integral membrane protein
Rv3843c		-1.1	-1.9	Probable conserved transmembrane protein
Rv2942		-1.1	-7.9	Conserved transmembrane transport protein MmpL7
Rv3672c		-1.1	-1.5	Conserved hypothetical protein
Rv2553c		-1.1	-0.9	Probable conserved membrane protein
Rv0989c		-1.1	-5.8	Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase)
Rv1421		-1.1	-3.1	Conserved protein
Rv2691		-1.0	-4.7	TRK system potassium uptake protein CeoB
Rv2936		-1.0	-7.4	Daunorubicin-dim-transport ATP-binding protein ABC transporter DrrA
Rv0437c		-1.0	-1.0	Possible phosphatidylserine decarboxylase Psd (PS decarboxylase)
Rv0019c		-1.0	-3.7	Conserved protein with FHA domain, FhaB
Rv1127c		-1.0	-1.1	Probable pyruvate, phosphate dikinase PpdK
Rv1836c		-1.0	-1.3	Conserved protein
Rv1821		-1.0	-2.7	Possible preprotein translocase ATPase SecA2
Rv2899c		-1.0	-1.0	Possible FdhD protein homolog
Rv3085		-1.0	-1.0	Probable short-chain type dehydrogenase/reductase
Rv0646c		-1.0	-2.3	Probable lipase/esterase LipG
Rv2887		-1.0	-1.3	Probable transcriptional regulatory protein
Rv0200		-0.9	-1.6	Possible conserved transmembrane protein
Rv0472c		-0.9	-2.5	Probable transcriptional regulatory protein (possibly TetR-family)
Rv0680c		-0.9	-1.5	Probable conserved transmembrane protein
Rv3101c		-0.9	-1.1	Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter)
Rv0452		-0.9	-2.0	Possible transcriptional regulatory protein
Rv0928		-0.9	-2.3	Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1)
Rv2937		-0.9	-5.9	Daunorubicin-dim-transport integral membrane protein ABC transporter DrrB
Rv3759c		-0.9	-2.1	Possible osmoprotectant (glycine betaine/carnitine/choline/L-proline) binding lipoprotein ProX
Rv2558		-0.9	-2.1	Conserved protein
Rv0653c		-0.9	-3.3	Possible transcriptional regulatory protein (probably TetR-family)
Rv1662		-0.9	-2.6	Probable polyketide synthase Pks8
Rv0135c		-0.9	-2.1	Possible transcriptional regulatory protein
Rv3171c		-0.9	-0.7	Possible non-heme haloperoxidase Hpx
Rv3610c		-0.9	-1.7	Membrane-bound protease FtsH (cell division protein)
Rv2919c		-0.9	-1.3	Probable nitrogen regulatory protein P-II GlnB
Rv2621c		-0.9	-1.1	Possible transcriptional regulatory protein
Rv3389c		-0.9	-1.5	Probable 3-hydroxyacyl-thioester dehydratase HtdY
Rv1745c		-0.9	-3.2	Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase)
Rv2140c		-0.9	-1.3	Conserved protein TB18.6
Rv1131		-0.9	-2.3	Probable methylcitrate synthase PrpC
Rv1140		-0.9	-1.8	Probable integral membrane protein
Rv2322c		-0.8	-0.9	Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase)
Rv3140		-0.8	-3.3	Probable acyl-CoA dehydrogenase FadE23
Rv3081		-0.8	-0.8	Conserved hypothetical protein
Rv3855		-0.8	-4.0	Transcriptional regulatory repressor protein (TetR-family) EthR
Rv0581		-0.8	-2.2	Possible antitoxin VapB26
Rv1934c		-0.8	-2.5	Probable acyl-CoA dehydrogenase FadE17
Rv2047c		-0.8	-4.5	Conserved hypothetical protein
Rv3311		-0.8	-2.7	Conserved protein
Rv2709		-0.8	-2.9	Probable conserved transmembrane protein
Rv3277		-0.8	-0.5	Probable conserved transmembrane protein
Rv0563		-0.8	-2.0	Probable protease transmembrane protein heat shock protein HtpX
Rv0820		-0.8	-2.3	Probable phosphate-transport ATP-binding protein ABC transporter PhoT
Rv3278c		-0.8	-3.7	Probable conserved transmembrane protein
Rv0383c		-0.8	-0.7	Possible conserved secreted protein
Rv0674		-0.8	-0.5	Conserved hypothetical protein
Rv3919c		-0.8	-1.9	Probable glucose-inhibited division protein B Gid
Rv2236c		-0.8	-1.7	Probable cobalamin biosynthesis transmembrane protein CobD
Rv1262c		-0.8	-1.5	Hypothetical hit-like protein
Rv3335c		-0.8	-1.6	Probable conserved integral membrane protein
Rv0805		-0.8	-0.6	Class III cyclic nucleotide phosphodiesterase (cNMP PDE)
Rv0841		-0.8	-1.6	Probable conserved transmembrane protein
Rv3865		-0.8	-2.1	ESX-1 secretion-associated protein EspF
Rv2706c		-0.8	-1.0	Hypothetical protein
Rv1351		-0.8	-0.9	Hypothetical protein
Rv0313		-0.7	-1.3	Conserved protein
Rv0734		-0.7	-2.1	Methionine aminopeptidase MapA (map) (peptidase M) (MetAP)
Rv1013		-0.7	-4.1	Putative polyketide synthase Pks16
Rv3200c		-0.7	-2.0	Possible transmembrane cation transporter
Rv1930c		-0.7	-0.6	Conserved hypothetical protein
Rv3658c		-0.7	-0.8	Probable conserved transmembrane protein
Rv1049		-0.7	-1.2	Probable transcriptional repressor protein
Rv0436c		-0.7	-1.3	Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase)
Rv0978c		-0.7	-2.6	PE-PGRS family protein PE_PGRS17
Rv3050c		-0.7	-2.3	Probable transcriptional regulatory protein (probably AsnC-family)
Rv1851		-0.7	-1.0	Urease accessory protein UreF
Rv1102c		-0.7	-1.0	Toxin MazF3
Rv3856c		-0.7	-1.3	Conserved hypothetical protein
Rv0081		-0.7	-1.1	Probable transcriptional regulatory protein
Rv2181		-0.7	-3.7	Alpha(1->2)mannosyltransferase
Rv1332		-0.7	-0.6	Probable transcriptional regulatory protein
Rv2702		-0.7	-0.6	Polyphosphate glucokinase PpgK (polyphosphate-glucose phosphotransferase)
Rv0564c		-0.7	-1.0	Probable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA1 (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase) (NAD(P)H-dependent dihydroxyacetone-phosphate reductase)
Rv0930		-0.7	-2.7	Probable phosphate-transport integral membrane ABC transporter PstA1
Rv1159		-0.7	-1.3	Mannosyltransferase PimE
Rv0392c		-0.7	-0.6	Probable membrane NADH dehydrogenase NdhA
Rv1272c		-0.7	-3.4	Probable drugs-transport transmembrane ATP-binding protein ABC transporter
Rv0675		-0.7	-0.5	Probable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv0893c		-0.7	-1.3	Possible S-adenosylmethionine-dependent methyltransferase
Rv2206		-0.7	-2.3	Probable conserved transmembrane protein
Rv3220c		-0.7	-1.1	Probable two component sensor kinase
Rv3664c		-0.7	-1.3	Probable dipeptide-transport integral membrane protein ABC transporter DppC
Rv3661		-0.7	-2.4	Conserved hypothetical protein
Rv0497		-0.7	-1.1	Probable conserved transmembrane protein
Rv3668c		-0.7	-1.8	Possible protease
Rv1898		-0.7	-1.4	Conserved hypothetical protein
Rv1010		-0.7	-0.4	Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase)
Rv0949		-0.7	-0.5	Probable ATP-dependent DNA helicase II UvrD1
Rv2506		-0.7	-1.8	Probable transcriptional regulatory protein (probably TetR-family)
Rv2028c		-0.7	-0.7	Universal stress protein family protein
Rv0937c		-0.7	-1.4	DNA end-binding protein, Mku
Rv0939		-0.7	-0.3	Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase
Rv0396		-0.6	-0.7	Hypothetical protein
Rv1291c		-0.6	-1.1	Conserved hypothetical secreted protein
Rv2970A		-0.6	-1.7	Conserved hypothetical protein
Rv3550		-0.6	-1.6	Probable enoyl-CoA hydratase EchA20 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv2444c		-0.6	-1.2	Possible ribonuclease E Rne
Rv3067		-0.6	-2.9	Conserved hypothetical protein
Rv2366c		-0.6	-1.3	Probable conserved transmembrane protein
Rv1620c		-0.6	-1.9	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC
Rv0508		-0.6	-2.5	Conserved hypothetical protein
Rv2048c		-0.6	-3.4	Polyketide synthase Pks12
Rv3652		-0.6	-2.7	PE-PGRS family-related protein PE_PGRS60
Rv2766c		-0.6	-2.2	Probable short-chain type dehydrogenase/reductase
Rv2275		-0.6	-0.8	Conserved hypothetical protein
Rv0241c		-0.6	-1.4	Probable 3-hydroxyacyl-thioester dehydratase HtdX
Rv1100		-0.6	-2.5	Conserved protein
Rv0250c		-0.6	-1.1	Conserved protein
Rv2529		-0.6	-2.5	Hypothetical protein
Rv3174		-0.6	-1.0	Probable short-chain dehydrogenase/reductase
Rv2021c		-0.6	-1.3	Transcriptional regulatory protein
Rv1209		-0.6	-2.0	Conserved protein
Rv2708c		-0.6	-1.2	Conserved hypothetical protein
Rv3433c		-0.6	-1.4	Conserved protein
Rv2762c		-0.6	-0.9	Conserved hypothetical protein
Rv1672c		-0.6	-1.9	Probable conserved integral membrane transport protein
Rv1218c		-0.6	-2.0	Probable tetronasin-transport ATP-binding protein ABC transporter
Rv3569c		-0.6	-1.0	4,9-DHSA hydrolase
Rv0504c		-0.6	-0.8	Conserved protein
Rv0017c		-0.6	-1.9	Probable cell division protein RodA
Rv0863		-0.6	-2.1	Conserved hypothetical protein
Rv0598c		-0.6	-2.0	Possible toxin VapC27. Contains PIN domain.
Rv2742c		-0.6	-3.3	Conserved hypothetical arginine rich protein
Rv0622		-0.6	-1.0	Possible membrane protein
Rv3763		-0.6	-1.3	19 kDa lipoprotein antigen precursor LpqH
Rv1329c		-0.6	-2.1	Probable ATP-dependent helicase DinG
Rv3149		-0.5	-3.0	Probable NADH dehydrogenase I (chain E) NuoE (NADH-ubiquinone oxidoreductase chain E)
Rv3622c		-0.5	-2.4	PE family protein PE32
Rv3426		-0.5	-1.8	PPE family protein PPE58
Rv3427c		-0.5	-1.1	Possible transposase
Rv3633		-0.5	-2.0	Conserved protein
Rv0444c		-0.5	-2.2	Anti-sigma factor RskA (regulator of sigma K)
Rv0050		-0.5	-1.3	Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase)
Rv3723		-0.5	-1.8	Probable conserved transmembrane protein
Rv3631		-0.5	-0.5	Possible transferase (possibly glycosyltransferase)
Rv1138c		-0.5	-2.3	Possible oxidoreductase
Rv2774c		-0.5	-0.5	Hypothetical protein
Rv2622		-0.5	-1.2	Possible methyltransferase (methylase)
Rv1091		-0.5	-3.3	PE-PGRS family protein PE_PGRS22
Rv0696		-0.5	-2.2	Probable membrane sugar transferase
Rv2618		-0.5	-1.6	Conserved hypothetical protein
Rv0460		-0.5	-1.0	Conserved hydrophobic protein
Rv3542c		-0.5	-1.1	Conserved hypothetical protein
Rv0069c		-0.5	-0.9	Probable L-serine dehydratase SdaA (L-serine deaminase) (SDH) (L-SD)
Rv3559c		-0.5	-0.7	Probable oxidoreductase
Rv0944		-0.5	-1.1	Possible formamidopyrimidine-DNA glycosylase (FAPY-DNA glycosylase)
Rv2136c		-0.5	-1.2	Possible conserved transmembrane protein
Rv0521		-0.5	-1.9	Possible methyltransferase/methylase (fragment)
Rv0188		-0.5	-1.7	Probable conserved transmembrane protein
Rv0954		-0.5	-1.2	Probable conserved transmembrane protein
Rv1070c		-0.5	-2.1	Probable enoyl-CoA hydratase EchA8 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv3192		-0.5	-1.6	Conserved hypothetical alanine and proline-rich protein
Rv2232		-0.5	-0.9	Protein tyrosine kinase transcriptional regulatory protein PtkA
Rv2307D		-0.5	-1.3	Hypothetical protein

Specific Phenotypes

None in this experiment

For Mycobacterium tuberculosis H37Rv in stress experiments

For stress Dibucaine across organisms