Experiment set5S611 for Mycobacterium tuberculosis H37Rv

200 most important genes:

gene	name	fitness	t score	description
Rv0497		-3.1	-2.7	Probable conserved transmembrane protein
Rv3033		-3.0	-0.9	Unknown protein
Rv0928		-2.8	-4.8	Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1)
Rv3101c		-2.4	-3.1	Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter)
Rv0949		-2.2	-1.1	Probable ATP-dependent DNA helicase II UvrD1
Rv0930		-2.1	-6.4	Probable phosphate-transport integral membrane ABC transporter PstA1
Rv1062		-2.1	-1.2	Conserved hypothetical protein
Rv0820		-1.8	-4.3	Probable phosphate-transport ATP-binding protein ABC transporter PhoT
Rv0819		-1.8	-2.5	GCN5-related N-acetyltransferase, MshD
Rv0757		-1.8	-1.8	Possible two component system response transcriptional positive regulator PhoP
Rv1620c		-1.7	-3.8	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC
Rv1010		-1.6	-1.2	Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase)
Rv0954		-1.6	-6.1	Probable conserved transmembrane protein
Rv0437c		-1.5	-1.5	Possible phosphatidylserine decarboxylase Psd (PS decarboxylase)
Rv3277		-1.4	-0.7	Probable conserved transmembrane protein
Rv1131		-1.4	-3.5	Probable methylcitrate synthase PrpC
Rv2869c		-1.4	-2.3	Membrane bound metalloprotease
Rv2365c		-1.4	-1.0	Conserved hypothetical protein
Rv0642c		-1.3	-2.3	Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase)
Rv0929		-1.3	-1.8	Phosphate-transport integral membrane ABC transporter PstC2
Rv0199		-1.3	-3.9	Probable conserved membrane protein
Rv3658c		-1.3	-1.1	Probable conserved transmembrane protein
Rv3249c		-1.3	-0.9	Possible transcriptional regulatory protein (probably TetR-family)
Rv0867c		-1.3	-0.5	Possible resuscitation-promoting factor RpfA
Rv3650		-1.3	-0.8	PE family protein PE33
Rv1798		-1.2	-1.1	ESX conserved component EccA5. ESX-5 type VII secretion system protein.
Rv0675		-1.2	-0.7	Probable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv3193c		-1.2	-1.5	Probable conserved transmembrane protein
Rv1621c		-1.2	-2.8	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD
Rv2382c		-1.2	-0.6	Polyketide synthetase MbtC (polyketide synthase)
Rv1751		-1.2	-1.6	Probable oxidoreductase
Rv2317		-1.2	-1.0	Probable sugar-transport integral membrane protein ABC transporter UspB
Rv0452		-1.2	-3.3	Possible transcriptional regulatory protein
Rv0093c		-1.2	-0.9	Probable conserved membrane protein
Rv0323c		-1.2	-1.3	Conserved hypothetical protein
Rv2230c		-1.2	-1.4	Conserved protein
Rv1821		-1.1	-3.5	Possible preprotein translocase ATPase SecA2
Rv1836c		-1.1	-2.2	Conserved protein
Rv3306c		-1.1	-1.4	Probable amidohydrolase AmiB1 (aminohydrolase)
Rv0893c		-1.1	-1.8	Possible S-adenosylmethionine-dependent methyltransferase
Rv0007		-1.1	-0.7	Possible conserved membrane protein
Rv3563		-1.1	-1.0	Probable acyl-CoA dehydrogenase FadE32
Rv1159		-1.1	-2.1	Mannosyltransferase PimE
Rv1930c		-1.1	-0.8	Conserved hypothetical protein
Rv2224c		-1.1	-6.4	Probable carboxylesterase CaeA
Rv3005c		-1.1	-6.7	Conserved hypothetical protein
Rv2691		-1.0	-4.4	TRK system potassium uptake protein CeoB
Rv3477		-1.0	-1.1	PE family protein PE31
Rv2237A		-1.0	-1.1	Conserved protein
Rv2709		-1.0	-4.3	Probable conserved transmembrane protein
Rv0940c		-1.0	-1.4	Possible oxidoreductase
Rv3715c		-1.0	-2.3	Probable recombination protein RecR
Rv3492c		-1.0	-2.0	Conserved hypothetical Mce associated protein
Rv0955		-1.0	-1.0	Probable conserved integral membrane protein
Rv0758		-1.0	-2.0	Possible two component system response sensor kinase membrane associated PhoR
Rv1420		-1.0	-1.8	Probable excinuclease ABC (subunit C-nuclease) UvrC
Rv2680		-1.0	-1.6	Conserved protein
Rv0653c		-1.0	-3.6	Possible transcriptional regulatory protein (probably TetR-family)
Rv0313		-0.9	-1.6	Conserved protein
Rv3513c		-0.9	-0.6	Probable fatty-acid-CoA ligase FadD18 (fragment) (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Rv0472c		-0.9	-1.9	Probable transcriptional regulatory protein (possibly TetR-family)
Rv3610c		-0.9	-2.6	Membrane-bound protease FtsH (cell division protein)
Rv2170		-0.9	-1.4	GCN5-related N-acetyltransferase
Rv1209		-0.9	-4.0	Conserved protein
Rv0242c		-0.9	-2.4	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase)
Rv2945c		-0.9	-5.2	Probable conserved lipoprotein LppX
Rv2468c		-0.9	-2.4	Conserved protein
Rv2647		-0.9	-1.1	Hypothetical protein
Rv0615		-0.9	-1.0	Probable integral membrane protein
Rv3102c		-0.9	-2.1	Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter)
Rv2855		-0.9	-1.9	NADPH-dependent mycothiol reductase Mtr
Rv1127c		-0.9	-0.6	Probable pyruvate, phosphate dikinase PpdK
Rv3716c		-0.8	-0.6	Conserved protein
Rv2249c		-0.8	-2.6	Probable glycerol-3-phosphate dehydrogenase GlpD1
Rv2232		-0.8	-1.8	Protein tyrosine kinase transcriptional regulatory protein PtkA
Rv3614c		-0.8	-2.5	ESX-1 secretion-associated protein EspD
Rv0918		-0.8	-2.4	Conserved protein
Rv3204		-0.8	-0.4	Possible DNA-methyltransferase (modification methylase)
Rv1459c		-0.8	-1.0	Possible conserved integral membrane protein
Rv1111c		-0.8	-2.7	Conserved hypothetical protein
Rv3843c		-0.8	-1.4	Probable conserved transmembrane protein
Rv2292c		-0.8	-0.9	Hypothetical protein
Rv1173		-0.8	-1.5	Probable F420 biosynthesis protein FbiC
Rv1013		-0.8	-4.4	Putative polyketide synthase Pks16
Rv0016c		-0.8	-4.5	Probable penicillin-binding protein PbpA
Rv3445c		-0.8	-1.2	ESAT-6 like protein EsxU
Rv1908c		-0.8	-1.1	Catalase-peroxidase-peroxynitritase T KatG
Rv0818		-0.8	-2.5	Transcriptional regulatory protein
Rv2938		-0.8	-5.5	Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC
Rv0624		-0.8	-2.5	Possible toxin VapC30. Contains PIN domain.
Rv1055		-0.8	-0.7	Possible integrase (fragment)
Rv2360c		-0.8	-2.2	Unknown protein
Rv0680c		-0.8	-1.3	Probable conserved transmembrane protein
Rv2919c		-0.8	-1.2	Probable nitrogen regulatory protein P-II GlnB
Rv0018c		-0.8	-1.8	Phosphoserine/threonine phosphatase PstP
Rv0245		-0.8	-1.5	Possible oxidoreductase
Rv1244		-0.8	-2.8	Probable lipoprotein LpqZ
Rv2696c		-0.8	-1.5	Conserved alanine and glycine and valine rich protein
Rv2048c		-0.8	-3.0	Polyketide synthase Pks12
Rv0354c		-0.8	-1.8	PPE family protein PPE7
Rv1608c		-0.7	-2.0	Probable peroxidoxin BcpB
Rv1053c		-0.7	-0.6	Hypothetical protein
Rv3066		-0.7	-2.8	Probable transcriptional regulatory protein (probably DeoR-family)
Rv1860		-0.7	-2.2	Alanine and proline rich secreted protein Apa (fibronectin attachment protein) (immunogenic protein MPT32) (antigen MPT-32) (45-kDa glycoprotein) (45/47 kDa antigen)
Rv2144c		-0.7	-2.6	Probable transmembrane protein
Rv3501c		-0.7	-1.7	Conserved integral membrane protein YrbE4A. Possible ABC transporter.
Rv0050		-0.7	-1.6	Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase)
Rv0395		-0.7	-1.8	Hypothetical protein
Rv3004		-0.7	-1.4	Low molecular weight protein antigen 6 (CFP-6)
Rv2588c		-0.7	-1.3	Probable conserved membrane protein secretion factor YajC
Rv1112		-0.7	-0.7	Probable GTP binding protein
Rv1410c		-0.7	-3.9	Aminoglycosides/tetracycline-transport integral membrane protein
Rv1435c		-0.7	-2.8	Probable conserved proline, glycine, valine-rich secreted protein
Rv2630		-0.7	-0.6	Hypothetical protein
Rv1598c		-0.7	-2.0	Conserved protein
Rv3865		-0.7	-1.6	ESX-1 secretion-associated protein EspF
Rv1160		-0.7	-1.2	Probable mutator protein MutT2 (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase)
Rv0047c		-0.7	-1.9	Conserved protein
Rv2661c		-0.7	-0.8	Hypothetical protein
Rv0088		-0.7	-0.7	Possible polyketide cyclase/dehydrase
Rv2302		-0.7	-0.9	Conserved protein
Rv0333		-0.7	-2.6	Unknown protein
Rv0324		-0.7	-1.8	Possible transcriptional regulatory protein (possibly ArsR-family)
Rv1243c		-0.7	-3.2	PE-PGRS family protein PE_PGRS23
Rv0241c		-0.7	-1.7	Probable 3-hydroxyacyl-thioester dehydratase HtdX
Rv0523c		-0.7	-1.1	Conserved protein
Rv1324		-0.7	-0.6	Possible thioredoxin
Rv3499c		-0.7	-3.7	Mce-family protein Mce4A
Rv0184		-0.7	-1.9	Conserved hypothetical protein
Rv2762c		-0.7	-1.0	Conserved hypothetical protein
Rv2937		-0.7	-5.0	Daunorubicin-dim-transport integral membrane protein ABC transporter DrrB
Rv3140		-0.7	-3.0	Probable acyl-CoA dehydrogenase FadE23
Rv2429		-0.7	-0.9	Alkyl hydroperoxide reductase D protein AhpD (alkyl hydroperoxidase D)
Rv0622		-0.7	-1.1	Possible membrane protein
Rv3584		-0.7	-1.4	Possible conserved lipoprotein LpqE
Rv3346c		-0.7	-2.3	Conserved transmembrane protein
Rv0056		-0.7	-0.8	50S ribosomal protein L9 RplI
Rv3747		-0.7	-1.8	Conserved protein
Rv3171c		-0.7	-0.5	Possible non-heme haloperoxidase Hpx
Rv3527		-0.6	-1.0	Hypothetical protein
Rv1331		-0.6	-1.1	Conserved hypothetical protein
Rv1232c		-0.6	-1.2	Conserved protein
Rv0863		-0.6	-2.3	Conserved hypothetical protein
Rv0655		-0.6	-3.3	Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl
Rv3209		-0.6	-2.3	Conserved hypothetical threonine and proline rich protein
Rv1884c		-0.6	-1.3	Probable resuscitation-promoting factor RpfC
Rv2731		-0.6	-3.0	Conserved alanine and arginine rich protein
Rv1411c		-0.6	-1.7	Conserved lipoprotein LprG
Rv2046		-0.6	-1.2	Probable lipoprotein LppI
Rv2732c		-0.6	-1.7	Probable conserved transmembrane protein
Rv2873		-0.6	-2.0	Cell surface lipoprotein Mpt83 (lipoprotein P23)
Rv3085		-0.6	-0.7	Probable short-chain type dehydrogenase/reductase
Rv0310c		-0.6	-1.2	Conserved protein
Rv2694c		-0.6	-0.9	Conserved protein
Rv2993c		-0.6	-0.9	Possible 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase)
Rv3389c		-0.6	-1.7	Probable 3-hydroxyacyl-thioester dehydratase HtdY
Rv0587		-0.6	-1.4	Conserved hypothetical integral membrane protein YrbE2A
Rv2316		-0.6	-1.7	Probable sugar-transport integral membrane protein ABC transporter UspA
Rv3267		-0.6	-2.2	Conserved protein (CPSA-related protein)
Rv1422		-0.6	-0.7	Conserved hypothetical protein
Rv1019		-0.6	-4.0	Probable transcriptional regulatory protein (probably TetR-family)
Rv2379c		-0.6	-2.1	Peptide synthetase MbtF (peptide synthase)
Rv3438		-0.6	-1.3	Conserved protein
Rv3194c		-0.6	-2.7	Possible conserved secreted protein
Rv3655c		-0.6	-1.1	Conserved hypothetical protein
Rv2708c		-0.6	-1.5	Conserved hypothetical protein
Rv3723		-0.6	-1.1	Probable conserved transmembrane protein
Rv0999		-0.6	-1.2	Unknown protein
Rv3353c		-0.6	-1.2	Conserved hypothetical protein
Rv1570		-0.6	-1.5	Dethiobiotin synthetase BioD
Rv3237c		-0.6	-2.5	Conserved protein
Rv1336		-0.6	-3.1	Cysteine synthase B CysM (CSASE B) (O-phosphoserine sulfhydrylase B) (O-phosphoserine (thiol)-lyase B)
Rv3672c		-0.6	-1.0	Conserved hypothetical protein
Rv3637		-0.6	-1.1	Possible transposase
Rv1400c		-0.6	-0.6	Probable lipase LipH
Rv3041c		-0.6	-1.8	Probable conserved ATP-binding protein ABC transporter
Rv3657c		-0.6	-1.1	Possible conserved alanine rich membrane protein
Rv1059		-0.6	-2.0	Conserved protein
Rv2942		-0.6	-4.4	Conserved transmembrane transport protein MmpL7
Rv2779c		-0.6	-2.0	Possible transcriptional regulatory protein (probably Lrp/AsnC-family)
Rv2331A		-0.6	-0.5	Hypothetical protein
Rv1912c		-0.6	-1.2	Possible oxidoreductase FadB5
Rv2206		-0.6	-2.2	Probable conserved transmembrane protein
Rv0243		-0.6	-2.7	Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase)
Rv1107c		-0.6	-0.6	Probable exodeoxyribonuclease VII (small subunit) XseB (exonuclease VII small subunit)
Rv2798c		-0.6	-1.2	Conserved hypothetical protein
Rv2812		-0.6	-1.3	Probable transposase
Rv2936		-0.6	-4.2	Daunorubicin-dim-transport ATP-binding protein ABC transporter DrrA
Rv2722		-0.6	-2.1	Conserved hypothetical protein
Rv1829		-0.6	-2.3	Conserved protein
Rv3200c		-0.6	-1.3	Possible transmembrane cation transporter
Rv1046c		-0.6	-1.0	Hypothetical protein
Rv3855		-0.5	-1.9	Transcriptional regulatory repressor protein (TetR-family) EthR
Rv3495c		-0.5	-3.2	Possible Mce-family lipoprotein LprN (Mce-family lipoprotein Mce4E)
Rv3261		-0.5	-1.5	Probable F420 biosynthesis protein FbiA
Rv0821c		-0.5	-1.2	Probable phosphate-transport system transcriptional regulatory protein PhoY2
Rv3497c		-0.5	-3.3	Mce-family protein Mce4C
Rv0994		-0.5	-2.7	Probable molybdopterin biosynthesis protein MoeA1
Rv0444c		-0.5	-2.9	Anti-sigma factor RskA (regulator of sigma K)
Rv3905c		-0.5	-1.6	Putative ESAT-6 like protein EsxF (hypothetical alanine and glycine rich protein) (ESAT-6 like protein 13)

Specific Phenotypes

None in this experiment

For Mycobacterium tuberculosis H37Rv in stress experiments

For stress Tetracycline hydrochloride across organisms