Experiment set5S608 for Mycobacterium tuberculosis H37Rv

Compare to:

7H9 with Doxycycline hyclate 0.0035 mM

200 most important genes:

  gene name fitness t score description  
Rv0949 -4.4 -1.4 Probable ATP-dependent DNA helicase II UvrD1 compare
Rv0819 -3.2 -4.6 GCN5-related N-acetyltransferase, MshD compare
Rv3850 -3.1 -2.3 Conserved protein compare
Rv0758 -2.9 -3.9 Possible two component system response sensor kinase membrane associated PhoR compare
Rv0247c -2.9 -0.9 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) compare
Rv1851 -2.7 -1.9 Urease accessory protein UreF compare
Rv3182 -2.5 -1.1 Conserved hypothetical protein compare
Rv1621c -2.3 -4.3 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD compare
Rv0928 -2.3 -3.6 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv1010 -2.1 -1.3 Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase) compare
Rv3650 -2.1 -1.1 PE family protein PE33 compare
Rv0018c -2.0 -4.1 Phosphoserine/threonine phosphatase PstP compare
Rv1411c -2.0 -3.7 Conserved lipoprotein LprG compare
Rv2989 -1.9 -0.8 Probable transcriptional regulatory protein compare
Rv2001 -1.9 -0.8 Conserved hypothetical protein compare
Rv0820 -1.9 -5.9 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv1963c -1.9 -2.1 Probable transcriptional repressor (probably TetR-family) Mce3R compare
Rv1798 -1.9 -1.4 ESX conserved component EccA5. ESX-5 type VII secretion system protein. compare
Rv2774c -1.8 -1.1 Hypothetical protein compare
Rv1127c -1.8 -1.6 Probable pyruvate, phosphate dikinase PpdK compare
Rv0757 -1.8 -2.1 Possible two component system response transcriptional positive regulator PhoP compare
Rv2224c -1.6 -9.7 Probable carboxylesterase CaeA compare
Rv0642c -1.6 -1.7 Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase) compare
Rv1410c -1.6 -7.6 Aminoglycosides/tetracycline-transport integral membrane protein compare
Rv0929 -1.5 -2.1 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv0930 -1.5 -5.9 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv1620c -1.5 -3.5 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC compare
Rv3262 -1.5 -2.0 Probable F420 biosynthesis protein FbiB compare
Rv0452 -1.5 -3.0 Possible transcriptional regulatory protein compare
Rv3085 -1.4 -1.0 Probable short-chain type dehydrogenase/reductase compare
Rv3102c -1.4 -3.2 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv3005c -1.4 -7.6 Conserved hypothetical protein compare
Rv0007 -1.4 -0.8 Possible conserved membrane protein compare
Rv2331A -1.4 -0.9 Hypothetical protein compare
Rv0437c -1.4 -1.5 Possible phosphatidylserine decarboxylase Psd (PS decarboxylase) compare
Rv3277 -1.4 -0.7 Probable conserved transmembrane protein compare
Rv1013 -1.3 -8.0 Putative polyketide synthase Pks16 compare
Rv1930c -1.3 -0.9 Conserved hypothetical protein compare
Rv0313 -1.2 -1.5 Conserved protein compare
Rv3193c -1.2 -1.3 Probable conserved transmembrane protein compare
Rv0312 -1.2 -2.3 Conserved hypothetical proline and threonine rich protein compare
Rv1821 -1.2 -3.3 Possible preprotein translocase ATPase SecA2 compare
Rv3101c -1.2 -1.9 Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter) compare
Rv2899c -1.2 -1.0 Possible FdhD protein homolog compare
Rv2624c -1.2 -1.2 Universal stress protein family protein compare
Rv1745c -1.2 -2.5 Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase) compare
Rv2237A -1.2 -1.3 Conserved protein compare
Rv0989c -1.2 -6.8 Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) compare
Rv2869c -1.1 -1.6 Membrane bound metalloprotease compare
Rv3874 -1.1 -0.7 10 kDa culture filtrate antigen EsxB (LHP) (CFP10) compare
Rv2322c -1.1 -1.1 Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) compare
Rv0050 -1.1 -3.0 Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase) compare
Rv0392c -1.1 -0.8 Probable membrane NADH dehydrogenase NdhA compare
Rv2762c -1.1 -1.4 Conserved hypothetical protein compare
Rv2691 -1.1 -4.8 TRK system potassium uptake protein CeoB compare
Rv0841 -1.1 -1.7 Probable conserved transmembrane protein compare
Rv2173 -1.1 -3.1 Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) compare
Rv3438 -1.1 -2.1 Conserved protein compare
Rv2694c -1.1 -3.3 Conserved protein compare
Rv0983 -1.1 -4.7 Probable serine protease PepD (serine proteinase) (MTB32B) compare
Rv3715c -1.1 -2.4 Probable recombination protein RecR compare
Rv1324 -1.0 -0.8 Possible thioredoxin compare
Rv1577c -1.0 -0.8 Probable PhiRv1 phage protein compare
Rv0245 -1.0 -1.7 Possible oxidoreductase compare
Rv2170 -1.0 -1.5 GCN5-related N-acetyltransferase compare
Rv2680 -1.0 -1.1 Conserved protein compare
Rv3282 -1.0 -1.0 Conserved hypothetical protein compare
Rv0765c -1.0 -1.2 Probable oxidoreductase compare
Rv3658c -1.0 -1.0 Probable conserved transmembrane protein compare
Rv0571c -1.0 -2.4 Conserved protein compare
Rv1072 -1.0 -1.6 Probable conserved transmembrane protein compare
Rv3631 -1.0 -0.8 Possible transferase (possibly glycosyltransferase) compare
Rv3267 -1.0 -1.8 Conserved protein (CPSA-related protein) compare
Rv2583c -1.0 -2.5 Probable GTP pyrophosphokinase RelA (ATP:GTP 3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase) compare
Rv3856c -0.9 -1.4 Conserved hypothetical protein compare
Rv3419c -0.9 -1.3 Probable O-sialoglycoprotein endopeptidase Gcp (glycoprotease) compare
Rv3045 -0.9 -2.4 Probable NADP-dependent alcohol dehydrogenase AdhC compare
Rv0954 -0.9 -3.3 Probable conserved transmembrane protein compare
Rv3817 -0.9 -1.5 Possible phosphotransferase compare
Rv1946c -0.9 -1.8 Possible lipoprotein compare
Rv2553c -0.9 -0.7 Probable conserved membrane protein compare
Rv0324 -0.9 -1.9 Possible transcriptional regulatory protein (possibly ArsR-family) compare
Rv0472c -0.9 -2.5 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv1433 -0.9 -3.0 Possible conserved exported protein compare
Rv1053c -0.9 -0.7 Hypothetical protein compare
Rv3196A -0.9 -1.3 Unknown protein compare
Rv0674 -0.9 -0.6 Conserved hypothetical protein compare
Rv0016c -0.9 -3.0 Probable penicillin-binding protein PbpA compare
Rv0204c -0.9 -2.1 Probable conserved transmembrane protein compare
Rv2171 -0.9 -2.2 Probable conserved lipoprotein LppM compare
Rv2798c -0.9 -1.9 Conserved hypothetical protein compare
Rv3717 -0.9 -2.5 Conserved hypothetical protein compare
Rv0994 -0.8 -4.8 Probable molybdopterin biosynthesis protein MoeA1 compare
Rv1459c -0.8 -1.0 Possible conserved integral membrane protein compare
Rv2206 -0.8 -2.0 Probable conserved transmembrane protein compare
Rv3723 -0.8 -2.6 Probable conserved transmembrane protein compare
Rv0019c -0.8 -3.4 Conserved protein with FHA domain, FhaB compare
Rv0939 -0.8 -0.5 Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase compare
Rv2993c -0.8 -1.2 Possible 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) compare
Rv3073c -0.8 -1.1 Conserved hypothetical protein compare
Rv0991c -0.8 -0.7 Conserved serine rich protein compare
Rv2140c -0.8 -1.5 Conserved protein TB18.6 compare
Rv2274c -0.8 -1.7 Possible toxin MazF8 compare
Rv2232 -0.8 -1.3 Protein tyrosine kinase transcriptional regulatory protein PtkA compare
Rv2009 -0.8 -1.0 Antitoxin VapB15 compare
Rv1640c -0.8 -4.8 Lysyl-tRNA synthetase 2 LysX compare
Rv1570 -0.8 -1.6 Dethiobiotin synthetase BioD compare
Rv2661c -0.8 -0.9 Hypothetical protein compare
Rv0444c -0.8 -4.1 Anti-sigma factor RskA (regulator of sigma K) compare
Rv0468 -0.8 -0.8 3-hydroxybutyryl-CoA dehydrogenase FadB2 (beta-hydroxybutyryl-CoA dehydrogenase) (BHBD) compare
Rv0690c -0.8 -1.7 Conserved hypothetical protein compare
Rv3642c -0.8 -0.9 Hypothetical protein compare
Rv3538 -0.8 -0.6 Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase. compare
Rv3672c -0.8 -1.0 Conserved hypothetical protein compare
Rv2525c -0.8 -5.7 Conserved hypothetical protein. Secreted; predicted to be a substrate of the twin arginine translocation (tat) export system. compare
Rv2047c -0.8 -3.5 Conserved hypothetical protein compare
Rv1282c -0.8 -2.2 Probable oligopeptide-transport integral membrane protein ABC transporter OppC compare
Rv0818 -0.8 -2.3 Transcriptional regulatory protein compare
Rv2887 -0.7 -0.9 Probable transcriptional regulatory protein compare
Rv3496c -0.7 -4.8 Mce-family protein Mce4D compare
Rv0270 -0.7 -2.8 Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv1957 -0.7 -1.0 Hypothetical protein compare
Rv2793c -0.7 -0.9 Probable tRNA pseudouridine synthase B TruB (tRNA pseudouridine 55 synthase) (PSI55 synthase) (pseudouridylate synthase) (uracil hydrolyase) compare
Rv0383c -0.7 -0.7 Possible conserved secreted protein compare
Rv3569c -0.7 -1.0 4,9-DHSA hydrolase compare
Rv0081 -0.7 -1.1 Probable transcriptional regulatory protein compare
Rv0504c -0.7 -0.7 Conserved protein compare
Rv1346 -0.7 -2.6 Acyl-CoA dehydrogenase MbtN compare
Rv0632c -0.7 -1.7 Probable enoyl-CoA hydratase EchA3 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv3771c -0.7 -1.2 Conserved hypothetical protein compare
Rv2055c -0.7 -0.7 30S ribosomal protein S18 RpsR2 compare
Rv1159 -0.7 -1.2 Mannosyltransferase PimE compare
Rv1890c -0.7 -0.9 Hypothetical protein compare
Rv0354c -0.7 -1.9 PPE family protein PPE7 compare
Rv3493c -0.7 -2.2 Conserved hypothetical Mce associated alanine and valine rich protein compare
Rv3610c -0.7 -2.1 Membrane-bound protease FtsH (cell division protein) compare
Rv1284 -0.7 -0.5 Beta-carbonic anhydrase compare
Rv3843c -0.7 -1.4 Probable conserved transmembrane protein compare
Rv1541c -0.7 -1.9 Possible lipoprotein LprI compare
Rv2434c -0.7 -1.9 Probable conserved transmembrane protein compare
Rv2190c -0.7 -1.9 Conserved hypothetical protein compare
Rv0451c -0.6 -0.7 Probable conserved membrane protein MmpS4 compare
Rv2365c -0.6 -0.6 Conserved hypothetical protein compare
Rv0047c -0.6 -1.3 Conserved protein compare
Rv1515c -0.6 -1.8 Conserved hypothetical protein compare
Rv3922c -0.6 -1.9 Possible hemolysin compare
Rv1035c -0.6 -0.8 Probable transposase (fragment) compare
Rv1683 -0.6 -2.3 Possible bifunctional enzyme; long-chain acyl-CoA synthase and lipase. compare
Rv0497 -0.6 -1.0 Probable conserved transmembrane protein compare
Rv2317 -0.6 -0.6 Probable sugar-transport integral membrane protein ABC transporter UspB compare
Rv0940c -0.6 -1.0 Possible oxidoreductase compare
Rv2707 -0.6 -4.8 Probable conserved transmembrane alanine and leucine rich protein compare
Rv1272c -0.6 -2.5 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv1829 -0.6 -3.3 Conserved protein compare
Rv2581c -0.6 -0.8 Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II) compare
Rv3140 -0.6 -1.7 Probable acyl-CoA dehydrogenase FadE23 compare
Rv0375c -0.6 -1.3 Probable carbon monoxyde dehydrogenase (medium chain) compare
Rv1281c -0.6 -2.0 Probable oligopeptide-transport ATP-binding protein ABC transporter OppD compare
Rv0563 -0.6 -1.6 Probable protease transmembrane protein heat shock protein HtpX compare
Rv2383c -0.6 -2.3 Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) compare
Rv0653c -0.6 -3.6 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv0955 -0.6 -0.9 Probable conserved integral membrane protein compare
Rv2945c -0.6 -3.4 Probable conserved lipoprotein LppX compare
Rv1116A -0.6 -0.6 Conserved hypothetical protein (fragment) compare
Rv2571c -0.6 -1.6 Probable transmembrane alanine and valine and leucine rich protein compare
Rv2276 -0.6 -0.7 Cytochrome P450 121 Cyp121 compare
Rv1698 -0.6 -1.2 Outer membrane protein MctB compare
Rv3810 -0.6 -1.1 Exported repetitive protein precursor PirG (cell surface protein) (EXP53) compare
Rv1435c -0.6 -2.6 Probable conserved proline, glycine, valine-rich secreted protein compare
Rv0612 -0.6 -1.2 Conserved hypothetical protein compare
Rv3481c -0.6 -0.8 Probable integral membrane protein compare
Rv1058 -0.6 -2.3 Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv0927c -0.6 -0.9 Probable short-chain type dehydrogenase/reductase compare
Rv2609c -0.6 -1.6 Probable conserved membrane protein compare
Rv1170 -0.6 -1.8 N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) compare
Rv2379c -0.6 -2.1 Peptide synthetase MbtF (peptide synthase) compare
Rv2548 -0.6 -1.1 Possible toxin VapC19 compare
Rv2702 -0.6 -0.5 Polyphosphate glucokinase PpgK (polyphosphate-glucose phosphotransferase) compare
Rv3010c -0.6 -1.9 Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) compare
Rv1836c -0.6 -1.0 Conserved protein compare
Rv0202c -0.6 -3.2 Probable conserved transmembrane transport protein MmpL11 compare
Rv2348c -0.6 -0.4 Hypothetical protein compare
Rv1531 -0.6 -0.8 Conserved protein compare
Rv2616 -0.6 -1.6 Conserved protein compare
Rv2144c -0.6 -1.7 Probable transmembrane protein compare
Rv0242c -0.6 -1.3 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase) compare
Rv0680c -0.6 -1.0 Probable conserved transmembrane protein compare
Rv0113 -0.6 -0.7 Probable sedoheptulose-7-phosphate isomerase GmhA (phosphoheptose isomerase) compare
Rv1421 -0.6 -1.2 Conserved protein compare
Rv1006 -0.6 -2.1 Unknown protein compare
Rv0173 -0.6 -2.9 Possible Mce-family lipoprotein LprK (Mce-family lipoprotein Mce1E) compare
Rv2292c -0.6 -0.7 Hypothetical protein compare
Rv2096c -0.6 -1.8 Proteasome accessory factor B PafB compare
Rv2618 -0.6 -1.2 Conserved hypothetical protein compare
Rv2936 -0.6 -4.1 Daunorubicin-dim-transport ATP-binding protein ABC transporter DrrA compare
Rv0201c -0.6 -0.7 Conserved protein compare
Rv2709 -0.6 -1.4 Probable conserved transmembrane protein compare
Rv1751 -0.5 -1.1 Probable oxidoreductase compare
Rv0978c -0.5 -1.8 PE-PGRS family protein PE_PGRS17 compare
Rv1025 -0.5 -0.4 Conserved protein compare


Specific Phenotypes

None in this experiment

For Mycobacterium tuberculosis H37Rv in stress experiments

For stress Doxycycline hyclate across organisms