Experiment set5S607 for Mycobacterium tuberculosis H37Rv

200 most important genes:

gene	name	fitness	t score	description
Rv0949		-4.4	-1.3	Probable ATP-dependent DNA helicase II UvrD1
Rv3819		-3.1	-0.9	Unknown protein
Rv0819		-2.9	-5.2	GCN5-related N-acetyltransferase, MshD
Rv0247c		-2.9	-0.9	Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase)
Rv0757		-2.4	-2.3	Possible two component system response transcriptional positive regulator PhoP
Rv3046c		-2.4	-1.0	Conserved protein
Rv3101c		-2.2	-2.5	Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter)
Rv0805		-2.1	-0.8	Class III cyclic nucleotide phosphodiesterase (cNMP PDE)
Rv3249c		-1.8	-1.2	Possible transcriptional regulatory protein (probably TetR-family)
Rv3102c		-1.8	-3.6	Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter)
Rv2630		-1.8	-1.4	Hypothetical protein
Rv0930		-1.7	-4.5	Probable phosphate-transport integral membrane ABC transporter PstA1
Rv0615		-1.7	-1.4	Probable integral membrane protein
Rv0497		-1.6	-1.7	Probable conserved transmembrane protein
Rv3143		-1.6	-0.8	Probable response regulator
Rv1620c		-1.5	-3.4	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC
Rv2302		-1.5	-1.4	Conserved protein
Rv0452		-1.5	-3.0	Possible transcriptional regulatory protein
Rv0820		-1.5	-3.3	Probable phosphate-transport ATP-binding protein ABC transporter PhoT
Rv1401		-1.5	-1.5	Possible membrane protein
Rv1798		-1.5	-1.1	ESX conserved component EccA5. ESX-5 type VII secretion system protein.
Rv0361		-1.5	-1.0	Probable conserved membrane protein
Rv2224c		-1.5	-8.8	Probable carboxylesterase CaeA
Rv0954		-1.4	-4.2	Probable conserved transmembrane protein
Rv1821		-1.4	-4.1	Possible preprotein translocase ATPase SecA2
Rv2553c		-1.4	-1.0	Probable conserved membrane protein
Rv3843c		-1.4	-1.7	Probable conserved transmembrane protein
Rv0738		-1.4	-1.3	Conserved protein
Rv0955		-1.4	-1.3	Probable conserved integral membrane protein
Rv3717		-1.4	-3.1	Conserved hypothetical protein
Rv2374c		-1.3	-2.0	Probable heat shock protein transcriptional repressor HrcA
Rv0989c		-1.3	-7.0	Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase)
Rv0472c		-1.3	-3.3	Probable transcriptional regulatory protein (possibly TetR-family)
Rv0978c		-1.3	-3.4	PE-PGRS family protein PE_PGRS17
Rv0929		-1.3	-2.3	Phosphate-transport integral membrane ABC transporter PstC2
Rv0392c		-1.3	-0.8	Probable membrane NADH dehydrogenase NdhA
Rv0504c		-1.3	-1.3	Conserved protein
Rv0437c		-1.3	-1.4	Possible phosphatidylserine decarboxylase Psd (PS decarboxylase)
Rv2696c		-1.2	-2.2	Conserved alanine and glycine and valine rich protein
Rv1930c		-1.2	-0.8	Conserved hypothetical protein
Rv3193c		-1.2	-1.5	Probable conserved transmembrane protein
Rv0836c		-1.2	-4.0	Hypothetical protein
Rv2869c		-1.2	-2.1	Membrane bound metalloprotease
Rv1621c		-1.2	-2.6	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD
Rv3045		-1.2	-2.3	Probable NADP-dependent alcohol dehydrogenase AdhC
Rv1963c		-1.2	-1.3	Probable transcriptional repressor (probably TetR-family) Mce3R
Rv0867c		-1.2	-0.5	Possible resuscitation-promoting factor RpfA
Rv1792		-1.1	-1.0	ESAT-6 like protein EsxM
Rv0758		-1.1	-1.5	Possible two component system response sensor kinase membrane associated PhoR
Rv1013		-1.1	-5.1	Putative polyketide synthase Pks16
Rv3813c		-1.1	-2.4	Conserved protein
Rv2240c		-1.1	-1.7	Unknown protein
Rv2335		-1.1	-1.7	Probable serine acetyltransferase CysE (sat)
Rv1459c		-1.1	-1.2	Possible conserved integral membrane protein
Rv0928		-1.1	-2.3	Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1)
Rv2140c		-1.1	-1.1	Conserved protein TB18.6
Rv1421		-1.0	-2.3	Conserved protein
Rv0367c		-1.0	-0.8	Hypothetical protein
Rv0680c		-1.0	-1.5	Probable conserved transmembrane protein
Rv2281		-1.0	-2.8	Putative phosphate-transport permease PitB
Rv0242c		-1.0	-3.2	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase)
Rv2383c		-1.0	-2.2	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)
Rv1410c		-1.0	-3.9	Aminoglycosides/tetracycline-transport integral membrane protein
Rv2694c		-1.0	-2.6	Conserved protein
Rv3771c		-1.0	-1.3	Conserved hypothetical protein
Rv3005c		-1.0	-6.1	Conserved hypothetical protein
Rv3267		-1.0	-1.9	Conserved protein (CPSA-related protein)
Rv0018c		-1.0	-2.8	Phosphoserine/threonine phosphatase PstP
Rv0994		-1.0	-5.2	Probable molybdopterin biosynthesis protein MoeA1
Rv1324		-1.0	-1.0	Possible thioredoxin
Rv1159		-1.0	-1.9	Mannosyltransferase PimE
Rv3655c		-1.0	-1.8	Conserved hypothetical protein
Rv1178		-1.0	-2.7	Probable aminotransferase
Rv3631		-0.9	-0.7	Possible transferase (possibly glycosyltransferase)
Rv3477		-0.9	-1.0	PE family protein PE31
Rv3196A		-0.9	-1.1	Unknown protein
Rv3207c		-0.9	-3.4	Conserved protein
Rv1010		-0.9	-0.7	Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase)
Rv1908c		-0.9	-1.8	Catalase-peroxidase-peroxynitritase T KatG
Rv2691		-0.9	-3.4	TRK system potassium uptake protein CeoB
Rv2237A		-0.9	-0.8	Conserved protein
Rv2272		-0.9	-0.6	Probable conserved transmembrane protein
Rv2043c		-0.9	-1.0	Pyrazinamidase/nicotinamidase PncA (PZase)
Rv0983		-0.9	-2.8	Probable serine protease PepD (serine proteinase) (MTB32B)
Rv1055		-0.9	-0.7	Possible integrase (fragment)
Rv0353		-0.8	-2.6	Probable heat shock protein transcriptional repressor HspR (MerR family)
Rv3306c		-0.8	-0.6	Probable amidohydrolase AmiB1 (aminohydrolase)
Rv0451c		-0.8	-0.9	Probable conserved membrane protein MmpS4
Rv1127c		-0.8	-0.9	Probable pyruvate, phosphate dikinase PpdK
Rv1791		-0.8	-0.9	PE family protein PE19
Rv2170		-0.8	-1.3	GCN5-related N-acetyltransferase
Rv3262		-0.8	-1.3	Probable F420 biosynthesis protein FbiB
Rv1534		-0.8	-2.5	Probable transcriptional regulator
Rv0520		-0.8	-1.7	Possible methyltransferase/methylase (fragment)
Rv1068c		-0.8	-1.7	PE-PGRS family protein PE_PGRS20
Rv3413c		-0.8	-0.6	Unknown alanine and proline rich protein
Rv1662		-0.8	-1.9	Probable polyketide synthase Pks8
Rv3200c		-0.8	-2.1	Possible transmembrane cation transporter
Rv1884c		-0.8	-1.4	Probable resuscitation-promoting factor RpfC
Rv2687c		-0.8	-1.6	Antibiotic-transport integral membrane leucine and valine rich protein ABC transporter
Rv1815		-0.8	-2.2	Conserved protein
Rv0990c		-0.8	-0.6	Hypothetical protein
Rv3478		-0.8	-1.5	PE family protein PPE60
Rv3658c		-0.8	-0.8	Probable conserved transmembrane protein
Rv2709		-0.7	-3.4	Probable conserved transmembrane protein
Rv0135c		-0.7	-2.2	Possible transcriptional regulatory protein
Rv2322c		-0.7	-0.8	Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase)
Rv3695		-0.7	-2.2	Possible conserved membrane protein
Rv2548		-0.7	-1.3	Possible toxin VapC19
Rv3559c		-0.7	-0.8	Probable oxidoreductase
Rv1698		-0.7	-1.4	Outer membrane protein MctB
Rv2344c		-0.7	-4.0	Probable deoxyguanosine triphosphate triphosphohydrolase Dgt (dGTPase) (dGTP triphosphohydrolase)
Rv0050		-0.7	-1.9	Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase)
Rv2912c		-0.7	-1.6	Probable transcriptional regulatory protein (probably TetR-family)
Rv2887		-0.7	-0.8	Probable transcriptional regulatory protein
Rv1273c		-0.7	-2.5	Probable drugs-transport transmembrane ATP-binding protein ABC transporter
Rv0649		-0.7	-1.5	Possible malonyl CoA-acyl carrier protein transacylase FabD2 (MCT)
Rv0396		-0.7	-1.8	Hypothetical protein
Rv1957		-0.7	-0.9	Hypothetical protein
Rv0587		-0.7	-1.1	Conserved hypothetical integral membrane protein YrbE2A
Rv0646c		-0.7	-1.6	Probable lipase/esterase LipG
Rv0056		-0.7	-1.4	50S ribosomal protein L9 RplI
Rv3650		-0.7	-0.5	PE family protein PE33
Rv0313		-0.7	-0.7	Conserved protein
Rv2173		-0.6	-1.6	Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase)
Rv3610c		-0.6	-1.1	Membrane-bound protease FtsH (cell division protein)
Rv1500		-0.6	-2.2	Probable glycosyltransferase
Rv1435c		-0.6	-1.7	Probable conserved proline, glycine, valine-rich secreted protein
Rv0389		-0.6	-2.3	Probable phosphoribosylglycinamide formyltransferase 2 PurT (GART 2) (gar transformylase 2) (5'-phosphoribosylglycinamide transformylase 2) (formate-dependent gar transformylase)
Rv3922c		-0.6	-1.5	Possible hemolysin
Rv3855		-0.6	-2.5	Transcriptional regulatory repressor protein (TetR-family) EthR
Rv3332		-0.6	-1.2	Probable N-acetylglucosamine-6-phosphate deacetylase NagA (GlcNAc 6-P deacetylase)
Rv0838		-0.6	-1.6	Probable conserved lipoprotein LpqR
Rv0642c		-0.6	-0.8	Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase)
Rv3494c		-0.6	-3.4	Mce-family protein Mce4F
Rv2144c		-0.6	-2.4	Probable transmembrane protein
Rv3214		-0.6	-0.8	Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM)
Rv2525c		-0.6	-4.6	Conserved hypothetical protein. Secreted; predicted to be a substrate of the twin arginine translocation (tat) export system.
Rv0398c		-0.6	-0.9	Possible secreted protein
Rv2009		-0.6	-0.9	Antitoxin VapB15
Rv3259		-0.6	-1.3	Conserved hypothetical protein
Rv3334		-0.6	-1.9	Probable transcriptional regulatory protein (probably MerR-family)
Rv0017c		-0.6	-1.8	Probable cell division protein RodA
Rv1860		-0.6	-1.8	Alanine and proline rich secreted protein Apa (fibronectin attachment protein) (immunogenic protein MPT32) (antigen MPT-32) (45-kDa glycoprotein) (45/47 kDa antigen)
Rv0212c		-0.6	-2.1	Possible transcriptional regulatory protein NadR (probably AsnC-family)
Rv2377c		-0.6	-1.1	Putative conserved protein MbtH
Rv2408		-0.6	-0.7	Possible PE family-related protein PE24
Rv3085		-0.6	-0.7	Probable short-chain type dehydrogenase/reductase
Rv1839c		-0.6	-1.5	Possible antitoxin VapB13
Rv0040c		-0.6	-3.4	Secreted proline rich protein Mtc28 (proline rich 28 kDa antigen)
Rv2706c		-0.6	-0.7	Hypothetical protein
Rv2831		-0.6	-2.0	Probable enoyl-CoA hydratase EchA16 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv0051		-0.6	-3.1	Probable conserved transmembrane protein
Rv1244		-0.6	-2.3	Probable lipoprotein LpqZ
Rv2772c		-0.6	-0.9	Probable conserved transmembrane protein
Rv0818		-0.6	-2.1	Transcriptional regulatory protein
Rv2991		-0.6	-1.2	Conserved protein
Rv3173c		-0.6	-1.9	Probable transcriptional regulatory protein (probably TetR/AcrR-family)
Rv0400c		-0.6	-2.2	Acyl-CoA dehydrogenase FadE7
Rv0196		-0.6	-2.2	Possible transcriptional regulatory protein
Rv2342		-0.6	-2.4	Conserved hypothetical protein
Rv3346c		-0.6	-1.4	Conserved transmembrane protein
Rv1111c		-0.6	-1.6	Conserved hypothetical protein
Rv1565c		-0.6	-2.5	Conserved hypothetical membrane protein
Rv0964c		-0.6	-0.9	Hypothetical protein
Rv2047c		-0.6	-2.9	Conserved hypothetical protein
Rv1495		-0.6	-0.8	Possible toxin MazF4
Rv2011c		-0.6	-0.8	Conserved hypothetical protein, probable transcription repressor.
Rv2230c		-0.6	-0.8	Conserved protein
Rv1411c		-0.6	-1.5	Conserved lipoprotein LprG
Rv3399		-0.6	-2.2	Possible S-adenosylmethionine-dependent methyltransferase
Rv2766c		-0.6	-3.0	Probable short-chain type dehydrogenase/reductase
Rv3435c		-0.5	-1.0	Probable conserved transmembrane protein
Rv2680		-0.5	-0.9	Conserved protein
Rv0688		-0.5	-1.9	Putative ferredoxin reductase
Rv0204c		-0.5	-2.1	Probable conserved transmembrane protein
Rv2048c		-0.5	-2.4	Polyketide synthase Pks12
Rv3220c		-0.5	-1.4	Probable two component sensor kinase
Rv1946c		-0.5	-1.3	Possible lipoprotein
Rv3496c		-0.5	-3.4	Mce-family protein Mce4D
Rv2532c		-0.5	-2.1	Hypothetical protein
Rv3371		-0.5	-1.2	Possible triacylglycerol synthase (diacylglycerol acyltransferase)
Rv0756c		-0.5	-1.2	Unknown protein
Rv1232c		-0.5	-1.1	Conserved protein
Rv2250c		-0.5	-0.9	Possible transcriptional regulatory protein
Rv0092		-0.5	-2.8	Cation transporter P-type ATPase a CtpA
Rv2647		-0.5	-0.5	Hypothetical protein
Rv2206		-0.5	-1.6	Probable conserved transmembrane protein
Rv3386		-0.5	-0.9	Possible transposase
Rv2348c		-0.5	-0.4	Hypothetical protein
Rv0130		-0.5	-0.7	Probable 3-hydroxyl-thioester dehydratase
Rv1148c		-0.5	-0.9	Conserved hypothetical protein
Rv0999		-0.5	-1.0	Unknown protein
Rv0563		-0.5	-0.9	Probable protease transmembrane protein heat shock protein HtpX
Rv2619c		-0.5	-1.2	Conserved protein
Rv1745c		-0.5	-1.6	Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase)
Rv3170		-0.5	-1.3	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)
Rv2807		-0.5	-1.5	Conserved hypothetical protein
Rv2872		-0.5	-1.5	Possible toxin VapC43. Contains PIN domain.
Rv1973		-0.5	-0.9	Possible conserved Mce associated membrane protein

Specific Phenotypes

None in this experiment

For Mycobacterium tuberculosis H37Rv in stress experiments

For stress Doxycycline hyclate across organisms