Experiment set5S600 for Mycobacterium tuberculosis H37Rv

Compare to:

cholesterol 100uM carbon source

200 most important genes:

  gene name fitness t score description  
Rv1303 -4.3 -1.2 Conserved hypothetical transmembrane protein compare
Rv3513c -3.6 -1.7 Probable fatty-acid-CoA ligase FadD18 (fragment) (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv0247c -3.3 -0.9 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) compare
Rv3492c -3.3 -2.4 Conserved hypothetical Mce associated protein compare
Rv3553 -3.0 -2.1 Possible oxidoreductase compare
Rv0692 -2.8 -5.1 Conserved hypothetical protein compare
Rv3419c -2.8 -2.1 Probable O-sialoglycoprotein endopeptidase Gcp (glycoprotease) compare
Rv3501c -2.7 -5.6 Conserved integral membrane protein YrbE4A. Possible ABC transporter. compare
Rv3496c -2.6 -9.8 Mce-family protein Mce4D compare
Rv3527 -2.5 -1.6 Hypothetical protein compare
Rv3550 -2.4 -2.9 Probable enoyl-CoA hydratase EchA20 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv3570c -2.3 -5.4 Possible oxidoreductase. Possible 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione hydroxylase. compare
Rv3499c -2.3 -8.5 Mce-family protein Mce4A compare
Rv0696 -2.3 -2.9 Probable membrane sugar transferase compare
Rv0200 -2.3 -2.2 Possible conserved transmembrane protein compare
Rv3495c -2.3 -8.9 Possible Mce-family lipoprotein LprN (Mce-family lipoprotein Mce4E) compare
Rv3494c -2.2 -6.8 Mce-family protein Mce4F compare
Rv1291c -2.1 -1.7 Conserved hypothetical secreted protein compare
Rv2801c -2.1 -1.4 Toxin MazF9 compare
Rv0694 -2.1 -4.9 Possible L-lactate dehydrogenase (cytochrome) LldD1 compare
Rv3544c -2.1 -3.5 Probable acyl-CoA dehydrogenase FadE28 compare
Rv3543c -2.0 -3.9 Probable acyl-CoA dehydrogenase FadE29 compare
Rv0761c -2.0 -7.8 Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB compare
Rv3563 -1.9 -1.5 Probable acyl-CoA dehydrogenase FadE32 compare
Rv1049 -1.9 -1.7 Probable transcriptional repressor protein compare
Rv3559c -1.9 -0.7 Probable oxidoreductase compare
Rv3526 -1.9 -8.4 Oxygenase component of 3-ketosteroid-9-alpha-hydroxylase KshA compare
Rv3500c -1.9 -6.7 Conserved integral membrane protein YrbE4B. Possible ABC transporter. compare
Rv1350 -1.9 -0.9 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) compare
Rv1192 -1.8 -2.6 Unknown protein compare
Rv3498c -1.8 -6.0 Mce-family protein Mce4B compare
Rv3481c -1.8 -1.1 Probable integral membrane protein compare
Rv0655 -1.7 -3.7 Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl compare
Rv2222c -1.7 -3.4 Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) compare
Rv3693 -1.7 -1.5 Possible conserved membrane protein compare
Rv3561 -1.6 -8.2 Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv2733c -1.6 -2.4 Conserved hypothetical alanine, arginine-rich protein compare
Rv0693 -1.6 -3.3 Probable coenzyme PQQ synthesis protein E PqqE (coenzyme PQQ synthesis protein III) compare
Rv0695 -1.6 -2.0 Conserved hypothetical protein compare
Rv1259 -1.5 -1.2 Probable uracil DNA glycosylase, UdgB compare
Rv3537 -1.5 -4.7 Probable dehydrogenase compare
Rv3497c -1.5 -4.2 Mce-family protein Mce4C compare
Rv0470c -1.5 -3.3 Mycolic acid synthase PcaA (cyclopropane synthase) compare
Rv3493c -1.4 -3.3 Conserved hypothetical Mce associated alanine and valine rich protein compare
Rv3569c -1.4 -1.4 4,9-DHSA hydrolase compare
Rv3316 -1.4 -1.7 Probable succinate dehydrogenase (cytochrome B-556 subunit) SdhC (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase) compare
Rv3567c -1.4 -2.1 Possible oxidoreductase. Possible 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione hydroxylase. compare
Rv2850c -1.4 -0.7 Possible magnesium chelatase compare
Rv3502c -1.4 -3.6 Probable short-chain type dehydrogenase/reductase. Possible 17-beta-hydroxysteroid dehydrogenase. compare
Rv0391 -1.4 -4.9 Probable O-succinylhomoserine sulfhydrylase MetZ (OSH sulfhydrylase) compare
Rv3540c -1.4 -2.3 Probable lipid transfer protein or keto acyl-CoA thiolase Ltp2 compare
Rv1628c -1.4 -2.8 Conserved protein compare
Rv3571 -1.3 -4.3 Reductase component of 3-ketosteroid-9-alpha-hydroxylase KshB compare
Rv2799 -1.3 -5.4 Probable membrane protein compare
Rv2588c -1.3 -1.8 Probable conserved membrane protein secretion factor YajC compare
Rv3338 -1.3 -1.1 Conserved hypothetical protein compare
Rv2707 -1.3 -8.1 Probable conserved transmembrane alanine and leucine rich protein compare
Rv0088 -1.3 -0.8 Possible polyketide cyclase/dehydrase compare
Rv0523c -1.3 -1.1 Conserved protein compare
Rv2976c -1.3 -1.0 Probable uracil-DNA glycosylase Ung (UDG) compare
Rv1930c -1.3 -0.6 Conserved hypothetical protein compare
Rv3556c -1.2 -1.6 Probable acetyl-CoA acetyltransferase FadA6 (acetoacetyl-CoA thiolase) compare
Rv3148 -1.2 -4.5 Probable NADH dehydrogenase I (chain D) NuoD (NADH-ubiquinone oxidoreductase chain D) compare
Rv2548 -1.2 -1.6 Possible toxin VapC19 compare
Rv0939 -1.2 -0.9 Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase compare
Rv0248c -1.2 -3.3 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) compare
Rv3033 -1.2 -0.5 Unknown protein compare
Rv1148c -1.2 -1.2 Conserved hypothetical protein compare
Rv3557c -1.1 -3.5 Transcriptional regulatory protein (probably TetR-family) compare
Rv3655c -1.1 -1.1 Conserved hypothetical protein compare
Rv0929 -1.1 -1.3 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv2762c -1.1 -0.9 Conserved hypothetical protein compare
Rv0642c -1.1 -1.7 Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase) compare
Rv3395c -1.1 -1.5 Conserved hypothetical protein compare
Rv0949 -1.1 -0.7 Probable ATP-dependent DNA helicase II UvrD1 compare
Rv3222c -1.1 -0.9 Conserved hypothetical protein compare
Rv0249c -1.1 -3.1 Probable succinate dehydrogenase [membrane anchor subunit] (succinic dehydrogenase) compare
Rv3081 -1.1 -0.6 Conserved hypothetical protein compare
Rv3687c -1.1 -0.4 Anti-anti-sigma factor RsfB (anti-sigma factor antagonist) (regulator of sigma F B) compare
Rv3131 -1.1 -0.9 Conserved protein compare
Rv3149 -1.1 -3.2 Probable NADH dehydrogenase I (chain E) NuoE (NADH-ubiquinone oxidoreductase chain E) compare
Rv3614c -1.1 -2.2 ESX-1 secretion-associated protein EspD compare
Rv1112 -1.0 -0.9 Probable GTP binding protein compare
Rv3564 -1.0 -2.1 Probable acyl-CoA dehydrogenase FadE33 compare
Rv1351 -1.0 -1.1 Hypothetical protein compare
Rv2039c -1.0 -1.9 Probable sugar-transport integral membrane protein ABC transporter compare
Rv3140 -1.0 -3.2 Probable acyl-CoA dehydrogenase FadE23 compare
Rv0782 -1.0 -1.4 Probable protease II PtrBb [second part] (oligopeptidase B) compare
Rv3180c -1.0 -1.8 Hypothetical alanine rich protein compare
Rv3726 -1.0 -1.0 Possible dehydrogenase compare
Rv1627c -1.0 -3.7 Probable nonspecific lipid-transfer protein compare
Rv3545c -1.0 -3.8 Probable cytochrome P450 125 Cyp125 compare
Rv0458 -1.0 -4.8 Probable aldehyde dehydrogenase compare
Rv2644c -1.0 -2.4 Hypothetical protein compare
Rv1097c -1.0 -1.7 Probable membrane glycine and proline rich protein compare
Rv2581c -0.9 -0.5 Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II) compare
Rv0504c -0.9 -1.2 Conserved protein compare
Rv3182 -0.9 -0.6 Conserved hypothetical protein compare
Rv2975c -0.9 -0.6 Conserved hypothetical protein compare
Rv1130 -0.9 -4.1 Possible methylcitrate dehydratase PrpD compare
Rv3249c -0.9 -0.9 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv2630 -0.9 -0.8 Hypothetical protein compare
Rv2237A -0.9 -0.7 Conserved protein compare
Rv1531 -0.9 -1.3 Conserved protein compare
Rv2224c -0.9 -5.5 Probable carboxylesterase CaeA compare
Rv1053c -0.9 -0.5 Hypothetical protein compare
Rv0563 -0.9 -1.5 Probable protease transmembrane protein heat shock protein HtpX compare
Rv1513 -0.9 -1.2 Conserved protein compare
Rv0135c -0.9 -1.9 Possible transcriptional regulatory protein compare
Rv1044 -0.9 -1.2 Conserved hypothetical protein compare
Rv2623 -0.8 -2.4 Universal stress protein family protein TB31.7 compare
Rv3658c -0.8 -0.7 Probable conserved transmembrane protein compare
Rv1694 -0.8 -0.9 2'-O-methyltransferase TlyA compare
Rv0277A -0.8 -1.8 Possible antitoxin VapB25 compare
Rv3158 -0.8 -3.9 Probable NADH dehydrogenase I (chain N) NuoN (NADH-ubiquinone oxidoreductase chain N) compare
Rv1928c -0.8 -2.3 Probable short-chain type dehydrogenase/reductase compare
Rv2009 -0.8 -1.2 Antitoxin VapB15 compare
Rv3188 -0.8 -1.0 Conserved hypothetical protein compare
Rv2668 -0.8 -1.7 Possible exported alanine and valine rich protein compare
Rv2197c -0.8 -3.0 Probable conserved transmembrane protein compare
Rv2586c -0.8 -0.8 Probable protein-export membrane protein SecF compare
Rv1541c -0.8 -2.0 Possible lipoprotein LprI compare
Rv2706c -0.8 -0.6 Hypothetical protein compare
Rv3196A -0.8 -1.3 Unknown protein compare
Rv1003 -0.8 -0.4 Conserved protein compare
Rv3771c -0.8 -1.0 Conserved hypothetical protein compare
Rv3146 -0.8 -3.2 Probable NADH dehydrogenase I (chain B) NuoB (NADH-ubiquinone oxidoreductase chain B) compare
Rv2061c -0.8 -2.2 Conserved protein compare
Rv2175c -0.8 -1.5 Conserved regulatory protein compare
Rv0928 -0.8 -1.8 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv3157 -0.8 -3.9 Probable NADH dehydrogenase I (chain M) NUOK (NADH-ubiquinone oxidoreductase chain M) compare
Rv3428c -0.8 -0.7 Possible transposase compare
Rv0905 -0.8 -1.6 Possible enoyl-CoA hydratase EchA6 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv1896c -0.8 -2.4 Conserved hypothetical protein compare
Rv2331A -0.8 -0.5 Hypothetical protein compare
Rv3147 -0.8 -1.7 Probable NADH dehydrogenase I (chain C) NuoC (NADH-ubiquinone oxidoreductase chain C) compare
Rv1831 -0.8 -2.7 Hypothetical protein compare
Rv0199 -0.8 -1.7 Probable conserved membrane protein compare
Rv1055 -0.8 -0.6 Possible integrase (fragment) compare
Rv0098 -0.7 -0.9 Probable fatty acyl CoA thioesterase type III FcoT compare
Rv0312 -0.7 -1.2 Conserved hypothetical proline and threonine rich protein compare
Rv0615 -0.7 -0.6 Probable integral membrane protein compare
Rv1926c -0.7 -1.9 Immunogenic protein Mpt63 (antigen Mpt63/MPB63) (16 kDa immunoprotective extracellular protein) compare
Rv2462c -0.7 -2.8 Probable trigger factor (TF) protein Tig compare
Rv3020c -0.7 -1.4 ESAT-6 like protein EsxS compare
Rv3803c -0.7 -3.6 Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) (85C) compare
Rv2745c -0.7 -0.8 Transcriptional regulatory protein ClgR compare
Rv3232c -0.7 -3.6 Polyphosphate kinase Ppk2 (polyphosphoric acid kinase) compare
Rv3153 -0.7 -3.8 Probable NADH dehydrogenase I (chain I) NuoI (NADH-ubiquinone oxidoreductase chain I) compare
Rv0280 -0.7 -4.4 PPE family protein PPE3 compare
Rv3178 -0.7 -1.5 Conserved hypothetical protein compare
Rv0857 -0.7 -0.9 Conserved hypothetical protein compare
Rv3334 -0.7 -1.4 Probable transcriptional regulatory protein (probably MerR-family) compare
Rv3152 -0.7 -3.0 Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H) compare
Rv2491 -0.7 -1.7 Conserved hypothetical protein compare
Rv3133c -0.7 -2.2 Two component transcriptional regulatory protein DevR (probably LuxR/UhpA-family) compare
Rv3273 -0.7 -3.5 Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) compare
Rv3217c -0.7 -1.2 Probable conserved integral membrane protein compare
Rv3085 -0.7 -0.5 Probable short-chain type dehydrogenase/reductase compare
Rv2836c -0.7 -1.1 Possible DNA-damage-inducible protein F DinF compare
Rv0323c -0.7 -1.2 Conserved hypothetical protein compare
Rv1004c -0.7 -1.9 Probable membrane protein compare
Rv1528c -0.7 -2.3 Probable conserved polyketide synthase associated protein PapA4 compare
Rv3069 -0.7 -1.2 Probable conserved transmembrane protein compare
Rv2205c -0.7 -3.0 Conserved hypothetical protein compare
Rv1890c -0.7 -0.6 Hypothetical protein compare
Rv0346c -0.7 -4.3 Possible L-asparagine permease AnsP2 (L-asparagine transport protein) compare
Rv0531 -0.7 -0.7 Possible conserved membrane protein compare
Rv1332 -0.7 -0.7 Probable transcriptional regulatory protein compare
Rv2674 -0.7 -3.4 Probable peptide methionine sulfoxide reductase MsrB (protein-methionine-R-oxide reductase) (peptide met(O) reductase) compare
Rv2321c -0.7 -0.8 Probable ornithine aminotransferase (C-terminus part) RocD2 (ornithine--oxo-acid aminotransferase) compare
Rv2686c -0.7 -1.7 Antibiotic-transport integral membrane leucine and alanine and valine rich protein ABC transporter compare
Rv1519 -0.7 -2.3 Conserved hypothetical protein compare
Rv0379 -0.7 -0.5 Possible protein transport protein SecE2 compare
Rv0687 -0.7 -1.4 Probable short-chain type dehydrogenase/reductase compare
Rv3724B -0.7 -2.5 Probable cutinase [second part] Cut5b compare
Rv3040c -0.7 -1.4 Conserved protein compare
Rv2381c -0.7 -0.9 Polyketide synthetase MbtD (polyketide synthase) compare
Rv3856c -0.7 -0.7 Conserved hypothetical protein compare
Rv0544c -0.7 -0.9 Possible conserved transmembrane protein compare
Rv3546 -0.7 -1.9 Probable acetyl-CoA acetyltransferase FadA5 (acetoacetyl-CoA thiolase) compare
Rv2014 -0.7 -1.4 Transposase compare
Rv1035c -0.7 -0.6 Probable transposase (fragment) compare
Rv1839c -0.7 -1.6 Possible antitoxin VapB13 compare
Rv3154 -0.7 -2.3 Probable NADH dehydrogenase I (chain J) NuoJ (NADH-ubiquinone oxidoreductase chain J) compare
Rv0965c -0.7 -2.4 Conserved hypothetical protein compare
Rv0766c -0.7 -0.9 Probable cytochrome P450 123 Cyp123 compare
Rv1414 -0.7 -0.4 Conserved hypothetical protein compare
Rv1871c -0.7 -3.0 Conserved protein compare
Rv0235c -0.7 -1.9 Probable conserved transmembrane protein compare
Rv3715c -0.6 -0.9 Probable recombination protein RecR compare
Rv1013 -0.6 -3.3 Putative polyketide synthase Pks16 compare
Rv1916 -0.6 -1.7 Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) compare
Rv0549c -0.6 -0.6 Possible toxin VapC3 compare
Rv0250c -0.6 -1.1 Conserved protein compare
Rv3386 -0.6 -0.7 Possible transposase compare
Rv0773c -0.6 -1.0 Probable bifunctional acylase GgtA: cephalosporin acylase (GL-7ACA acylase) + gamma-glutamyltranspeptidase (GGT) compare
Rv2985 -0.6 -0.8 Possible hydrolase MutT1 compare
Rv2558 -0.6 -1.4 Conserved protein compare
Rv0397 -0.6 -1.3 Conserved 13E12 repeat family protein compare


Specific Phenotypes

For 7 genes in this experiment

For carbon source cholesterol in Mycobacterium tuberculosis H37Rv

For carbon source cholesterol across organisms