Experiment set5S596 for Mycobacterium tuberculosis H37Rv

Compare to:

Urea 10mM nitrogen source

200 most important genes:

  gene name fitness t score description  
Rv0955 -3.4 -2.5 Probable conserved integral membrane protein compare
Rv2989 -3.4 -0.9 Probable transcriptional regulatory protein compare
Rv3850 -2.7 -2.1 Conserved protein compare
Rv2088 -2.7 -1.5 Transmembrane serine/threonine-protein kinase J PknJ (protein kinase J) (STPK J) compare
Rv2553c -2.7 -1.0 Probable conserved membrane protein compare
Rv1459c -2.6 -1.5 Possible conserved integral membrane protein compare
Rv2222c -2.6 -4.3 Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) compare
Rv2967c -2.6 -6.6 Probable pyruvate carboxylase Pca (pyruvic carboxylase) compare
Rv0018c -2.5 -4.1 Phosphoserine/threonine phosphatase PstP compare
Rv0933 -2.5 -2.0 Phosphate-transport ATP-binding protein ABC transporter PstB compare
Rv1350 -2.1 -1.1 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) compare
Rv1366A -1.9 -1.1 Conserved protein compare
Rv0561c -1.9 -1.8 Possible oxidoreductase compare
Rv0078 -1.9 -2.5 Probable transcriptional regulatory protein compare
Rv3081 -1.8 -1.0 Conserved hypothetical protein compare
Rv2702 -1.8 -0.7 Polyphosphate glucokinase PpgK (polyphosphate-glucose phosphotransferase) compare
Rv2801c -1.8 -1.4 Toxin MazF9 compare
Rv1159 -1.8 -2.5 Mannosyltransferase PimE compare
Rv0472c -1.7 -3.2 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv3277 -1.7 -1.1 Probable conserved transmembrane protein compare
Rv3810 -1.6 -1.8 Exported repetitive protein precursor PirG (cell surface protein) (EXP53) compare
Rv1962A -1.6 -1.2 Possible antitoxin VapB35 compare
Rv0929 -1.6 -1.7 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv1046c -1.6 -1.5 Hypothetical protein compare
Rv3874 -1.6 -0.6 10 kDa culture filtrate antigen EsxB (LHP) (CFP10) compare
Rv0157A -1.6 -1.8 Conserved protein compare
Rv2975c -1.5 -0.8 Conserved hypothetical protein compare
Rv0990c -1.5 -0.8 Hypothetical protein compare
Rv0675 -1.5 -1.0 Probable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv0135c -1.5 -3.5 Possible transcriptional regulatory protein compare
Rv3438 -1.5 -2.0 Conserved protein compare
Rv1053c -1.5 -0.8 Hypothetical protein compare
Rv2369c -1.5 -1.0 Hypothetical protein compare
Rv2630 -1.4 -0.7 Hypothetical protein compare
Rv0009 -1.4 -0.9 Probable iron-regulated peptidyl-prolyl cis-trans isomerase A PpiA (PPIase A) (rotamase A) compare
Rv2606c -1.3 -3.7 Possible pyridoxine biosynthesis protein SnzP compare
Rv2624c -1.3 -1.3 Universal stress protein family protein compare
Rv2270 -1.3 -1.7 Probable lipoprotein LppN compare
Rv0452 -1.3 -3.1 Possible transcriptional regulatory protein compare
Rv3013 -1.3 -1.0 Conserved protein compare
Rv1272c -1.3 -4.6 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv3658c -1.3 -1.0 Probable conserved transmembrane protein compare
Rv3033 -1.3 -0.6 Unknown protein compare
Rv3101c -1.3 -1.3 Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter) compare
Rv3610c -1.3 -2.9 Membrane-bound protease FtsH (cell division protein) compare
Rv0017c -1.3 -3.1 Probable cell division protein RodA compare
Rv2376c -1.3 -0.8 Low molecular weight antigen CFP2 (low molecular weight protein antigen 2) (CFP-2) compare
Rv3306c -1.3 -1.3 Probable amidohydrolase AmiB1 (aminohydrolase) compare
Rv3193c -1.3 -1.1 Probable conserved transmembrane protein compare
Rv0437c -1.2 -0.8 Possible phosphatidylserine decarboxylase Psd (PS decarboxylase) compare
Rv1273c -1.2 -3.0 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv3716c -1.2 -0.6 Conserved protein compare
Rv2173 -1.2 -3.1 Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) compare
Rv2551c -1.2 -1.4 Conserved hypothetical protein compare
Rv2696c -1.2 -1.7 Conserved alanine and glycine and valine rich protein compare
Rv0200 -1.2 -1.4 Possible conserved transmembrane protein compare
Rv0930 -1.2 -4.4 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv3513c -1.1 -1.0 Probable fatty-acid-CoA ligase FadD18 (fragment) (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv1420 -1.1 -2.1 Probable excinuclease ABC (subunit C-nuclease) UvrC compare
Rv1400c -1.1 -0.7 Probable lipase LipH compare
Rv1072 -1.1 -0.8 Probable conserved transmembrane protein compare
Rv2691 -1.1 -4.9 TRK system potassium uptake protein CeoB compare
Rv2869c -1.1 -1.3 Membrane bound metalloprotease compare
Rv2581c -1.1 -1.0 Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II) compare
Rv3066 -1.1 -2.6 Probable transcriptional regulatory protein (probably DeoR-family) compare
Rv1934c -1.1 -2.9 Probable acyl-CoA dehydrogenase FadE17 compare
Rv0677c -1.1 -1.3 Possible conserved membrane protein MmpS5 compare
Rv2762c -1.1 -0.9 Conserved hypothetical protein compare
Rv0867c -1.1 -0.5 Possible resuscitation-promoting factor RpfA compare
Rv0653c -1.1 -4.1 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv0825c -1.0 -1.3 Conserved protein compare
Rv0199 -1.0 -2.2 Probable conserved membrane protein compare
Rv2171 -1.0 -1.3 Probable conserved lipoprotein LppM compare
Rv2206 -1.0 -1.6 Probable conserved transmembrane protein compare
Rv3392c -1.0 -1.4 Cyclopropane-fatty-acyl-phospholipid synthase 1 CmaA1 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic acid synthase 1) compare
Rv3102c -1.0 -2.0 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv2707 -1.0 -6.5 Probable conserved transmembrane alanine and leucine rich protein compare
Rv0016c -1.0 -3.1 Probable penicillin-binding protein PbpA compare
Rv3564 -1.0 -1.5 Probable acyl-CoA dehydrogenase FadE33 compare
Rv2252 -1.0 -0.8 Diacylglycerol kinase compare
Rv1013 -1.0 -4.3 Putative polyketide synthase Pks16 compare
Rv0765c -1.0 -1.4 Probable oxidoreductase compare
Rv2993c -1.0 -1.4 Possible 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) compare
Rv3267 -1.0 -3.5 Conserved protein (CPSA-related protein) compare
Rv3073c -0.9 -0.9 Conserved hypothetical protein compare
Rv2047c -0.9 -3.7 Conserved hypothetical protein compare
Rv0995 -0.9 -0.9 Ribosomal-protein-alanine acetyltransferase RimJ (acetylating enzyme for N-terminal of ribosomal protein S5) compare
Rv1364c -0.9 -3.1 Possible sigma factor regulatory protein compare
Rv1973 -0.9 -1.4 Possible conserved Mce associated membrane protein compare
Rv1049 -0.9 -1.1 Probable transcriptional repressor protein compare
Rv0642c -0.9 -0.8 Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase) compare
Rv3803c -0.9 -4.5 Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) (85C) compare
Rv0819 -0.9 -2.5 GCN5-related N-acetyltransferase, MshD compare
Rv0245 -0.9 -1.3 Possible oxidoreductase compare
Rv0241c -0.9 -1.9 Probable 3-hydroxyacyl-thioester dehydratase HtdX compare
Rv2007c -0.9 -1.2 Ferredoxin FdxA compare
Rv3855 -0.9 -2.1 Transcriptional regulatory repressor protein (TetR-family) EthR compare
Rv3291c -0.9 -3.0 Probable transcriptional regulatory protein LrpA (Lrp/AsnC-family) compare
Rv3386 -0.8 -0.9 Possible transposase compare
Rv3922c -0.8 -1.5 Possible hemolysin compare
Rv1102c -0.8 -1.0 Toxin MazF3 compare
Rv0954 -0.8 -1.9 Probable conserved transmembrane protein compare
Rv2224c -0.8 -5.7 Probable carboxylesterase CaeA compare
Rv2048c -0.8 -2.8 Polyketide synthase Pks12 compare
Rv0019c -0.8 -1.6 Conserved protein with FHA domain, FhaB compare
Rv2004c -0.8 -1.1 Conserved protein compare
Rv1085c -0.8 -3.2 Possible hemolysin-like protein compare
Rv1410c -0.8 -3.6 Aminoglycosides/tetracycline-transport integral membrane protein compare
Rv3484 -0.8 -4.8 Possible conserved protein CpsA compare
Rv0033 -0.8 -1.5 Probable acyl carrier protein AcpA (ACP) compare
Rv3375 -0.8 -2.8 Probable amidase AmiD (acylamidase) (acylase) compare
Rv3249c -0.8 -0.8 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv3496c -0.8 -5.0 Mce-family protein Mce4D compare
Rv3472 -0.8 -2.8 Conserved protein compare
Rv3720 -0.8 -3.1 Possible fatty acid synthase compare
Rv2237A -0.8 -0.7 Conserved protein compare
Rv0081 -0.8 -1.1 Probable transcriptional regulatory protein compare
Rv0676c -0.8 -5.5 Probable conserved transmembrane transport protein MmpL5 compare
Rv2771c -0.8 -2.8 Conserved hypothetical protein compare
Rv0174 -0.7 -3.8 Mce-family protein Mce1F compare
Rv0589 -0.7 -2.6 Mce-family protein Mce2A compare
Rv1421 -0.7 -1.6 Conserved protein compare
Rv1140 -0.7 -1.0 Probable integral membrane protein compare
Rv0202c -0.7 -3.3 Probable conserved transmembrane transport protein MmpL11 compare
Rv2793c -0.7 -0.7 Probable tRNA pseudouridine synthase B TruB (tRNA pseudouridine 55 synthase) (PSI55 synthase) (pseudouridylate synthase) (uracil hydrolyase) compare
Rv0248c -0.7 -2.5 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) compare
Rv1531 -0.7 -1.1 Conserved protein compare
Rv3311 -0.7 -2.2 Conserved protein compare
Rv0820 -0.7 -1.9 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv0249c -0.7 -2.1 Probable succinate dehydrogenase [membrane anchor subunit] (succinic dehydrogenase) compare
Rv0436c -0.7 -1.2 Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase) compare
Rv0989c -0.7 -3.7 Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) compare
Rv1773c -0.7 -1.3 Probable transcriptional regulatory protein compare
Rv2344c -0.7 -3.2 Probable deoxyguanosine triphosphate triphosphohydrolase Dgt (dGTPase) (dGTP triphosphohydrolase) compare
Rv2586c -0.7 -0.8 Probable protein-export membrane protein SecF compare
Rv0865 -0.7 -2.3 Probable molybdopterin biosynthesis Mog protein compare
Rv3491 -0.7 -2.6 Unknown protein compare
Rv1940 -0.7 -0.9 Probable riboflavin biosynthesis protein RibA1 (GTP cyclohydrolase II) compare
Rv0037c -0.7 -4.2 Probable conserved integral membrane protein compare
Rv2137c -0.7 -1.6 Conserved hypothetical protein compare
Rv0530A -0.7 -1.8 Conserved protein compare
Rv2912c -0.7 -1.2 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv2061c -0.7 -1.9 Conserved protein compare
Rv2089c -0.7 -1.4 Dipeptidase PepE compare
Rv0088 -0.7 -0.6 Possible polyketide cyclase/dehydrase compare
Rv0426c -0.7 -1.5 Possible transmembrane protein compare
Rv2478c -0.6 -3.4 Conserved hypothetical protein compare
Rv0586 -0.6 -1.5 Probable transcriptional regulatory protein Mce2R (GntR-family) compare
Rv3000 -0.6 -1.5 Possible conserved transmembrane protein compare
Rv0112 -0.6 -2.0 Possible GDP-mannose 4,6-dehydratase Gca (GDP-D-mannose dehydratase) compare
Rv3828c -0.6 -1.5 Possible resolvase compare
Rv0391 -0.6 -2.7 Probable O-succinylhomoserine sulfhydrylase MetZ (OSH sulfhydrylase) compare
Rv2248 -0.6 -1.2 Conserved hypothetical protein compare
Rv1693 -0.6 -0.9 Conserved hypothetical protein compare
Rv0610c -0.6 -0.4 Hypothetical protein compare
Rv3316 -0.6 -1.3 Probable succinate dehydrogenase (cytochrome B-556 subunit) SdhC (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase) compare
Rv0964c -0.6 -1.1 Hypothetical protein compare
Rv0514 -0.6 -1.1 Possible transmembrane protein compare
Rv2452c -0.6 -1.6 Hypothetical protein compare
Rv3171c -0.6 -0.5 Possible non-heme haloperoxidase Hpx compare
Rv0190 -0.6 -1.8 Conserved protein compare
Rv1247c -0.6 -1.3 Antitoxin RelB compare
Rv3200c -0.6 -1.3 Possible transmembrane cation transporter compare
Rv3492c -0.6 -1.1 Conserved hypothetical Mce associated protein compare
Rv0885 -0.6 -1.5 Conserved hypothetical protein compare
Rv3813c -0.6 -1.4 Conserved protein compare
Rv2502c -0.6 -2.0 Probable acetyl-/propionyl-CoA carboxylase (beta subunit) AccD1 compare
Rv3315c -0.6 -1.9 Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) compare
Rv3173c -0.6 -1.3 Probable transcriptional regulatory protein (probably TetR/AcrR-family) compare
Rv3188 -0.6 -0.5 Conserved hypothetical protein compare
Rv3428c -0.6 -0.6 Possible transposase compare
Rv1657 -0.6 -1.7 Probable arginine repressor ArgR (AHRC) compare
Rv3590c -0.6 -2.6 PE-PGRS family protein PE_PGRS58 compare
Rv3493c -0.6 -2.3 Conserved hypothetical Mce associated alanine and valine rich protein compare
Rv3747 -0.6 -1.6 Conserved protein compare
Rv0786c -0.6 -1.5 Conserved protein compare
Rv3499c -0.6 -3.0 Mce-family protein Mce4A compare
Rv1884c -0.6 -0.8 Probable resuscitation-promoting factor RpfC compare
Rv0243 -0.6 -2.4 Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase) compare
Rv3495c -0.6 -3.3 Possible Mce-family lipoprotein LprN (Mce-family lipoprotein Mce4E) compare
Rv3771c -0.6 -0.7 Conserved hypothetical protein compare
Rv3555c -0.6 -1.6 Conserved protein compare
Rv0040c -0.6 -2.6 Secreted proline rich protein Mtc28 (proline rich 28 kDa antigen) compare
Rv1227c -0.6 -1.5 Probable transmembrane protein compare
Rv0818 -0.6 -2.3 Transcriptional regulatory protein compare
Rv2277c -0.6 -1.2 Possible glycerolphosphodiesterase compare
Rv0381c -0.6 -3.1 Hypothetical protein compare
Rv0324 -0.6 -1.3 Possible transcriptional regulatory protein (possibly ArsR-family) compare
Rv3353c -0.6 -0.8 Conserved hypothetical protein compare
Rv1513 -0.6 -1.1 Conserved protein compare
Rv2858c -0.6 -2.0 Probable aldehyde dehydrogenase AldC compare
Rv0994 -0.6 -2.8 Probable molybdopterin biosynthesis protein MoeA1 compare
Rv3278c -0.6 -2.1 Probable conserved transmembrane protein compare
Rv1062 -0.6 -0.4 Conserved hypothetical protein compare
Rv0247c -0.5 -0.3 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) compare
Rv2504c -0.5 -1.4 Probable succinyl-CoA:3-ketoacid-coenzyme A transferase (alpha subunit) ScoA (3-oxo acid:CoA transferase) (OXCT A) (succinyl-CoA:3-oxoacid-coenzyme A transferase) compare
Rv1414 -0.5 -0.4 Conserved hypothetical protein compare
Rv0547c -0.5 -2.9 Possible oxidoreductase compare
Rv2261c -0.5 -1.5 Conserved hypothetical protein compare
Rv3900c -0.5 -1.8 Conserved hypothetical alanine rich protein compare


Specific Phenotypes

None in this experiment

For Mycobacterium tuberculosis H37Rv in nitrogen source experiments

For nitrogen source Urea across organisms