Experiment set5S587 for Mycobacterium tuberculosis H37Rv

Compare to:

7H9 with Cumene hydroperoxide 0.05 mM

200 most detrimental genes:

  gene name fitness t score description  
Rv2044c +3.0 1.5 Conserved hypothetical protein compare
Rv3874 +2.0 1.4 10 kDa culture filtrate antigen EsxB (LHP) (CFP10) compare
Rv2774c +1.5 1.9 Hypothetical protein compare
Rv3230c +1.5 6.9 Hypothetical oxidoreductase compare
Rv0742 +1.4 1.9 PE-PGRS family protein PE_PGRS8 compare
Rv3065 +1.3 3.3 Multidrugs-transport integral membrane protein Mmr compare
Rv1284 +1.3 0.7 Beta-carbonic anhydrase compare
Rv1577c +1.3 1.4 Probable PhiRv1 phage protein compare
Rv1290A +1.3 1.6 Hypothetical protein compare
Rv3229c +1.2 3.0 Possible linoleoyl-CoA desaturase (delta(6)-desaturase) compare
Rv3848 +1.2 2.1 Probable conserved transmembrane protein compare
Rv3104c +1.2 3.1 Possible conserved transmembrane protein compare
Rv2975c +1.2 1.4 Conserved hypothetical protein compare
Rv2949c +1.1 1.9 Chorismate pyruvate lyase compare
Rv3481c +1.1 2.6 Probable integral membrane protein compare
Rv2099c +1.1 1.6 PE family protein PE21 compare
Rv0113 +1.1 1.3 Probable sedoheptulose-7-phosphate isomerase GmhA (phosphoheptose isomerase) compare
Rv0610c +1.1 1.1 Hypothetical protein compare
Rv0871 +1.1 2.2 Probable cold shock-like protein B CspB compare
Rv1890c +1.1 1.7 Hypothetical protein compare
Rv2260 +1.0 2.0 Conserved hypothetical protein compare
Rv1062 +1.0 0.8 Conserved hypothetical protein compare
Rv1495 +1.0 2.0 Possible toxin MazF4 compare
Rv2935 +1.0 7.9 Phenolpthiocerol synthesis type-I polyketide synthase PpsE compare
Rv2702 +1.0 0.8 Polyphosphate glucokinase PpgK (polyphosphate-glucose phosphotransferase) compare
Rv3687c +1.0 0.7 Anti-anti-sigma factor RsfB (anti-sigma factor antagonist) (regulator of sigma F B) compare
Rv2929 +1.0 6.1 Hypothetical protein compare
Rv0545c +1.0 2.4 Probable low-affinity inorganic phosphate transporter integral membrane protein PitA compare
Rv3287c +1.0 1.4 Anti-sigma factor RsbW (sigma negative effector) compare
Rv0587 +1.0 1.4 Conserved hypothetical integral membrane protein YrbE2A compare
Rv3331 +1.0 3.6 Probable sugar-transport integral membrane protein SugI compare
Rv2993c +1.0 2.5 Possible 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) compare
Rv2934 +1.0 8.1 Phenolpthiocerol synthesis type-I polyketide synthase PpsD compare
Rv2932 +0.9 6.8 Phenolpthiocerol synthesis type-I polyketide synthase PpsB compare
Rv0841 +0.9 2.9 Probable conserved transmembrane protein compare
Rv3559c +0.9 0.9 Probable oxidoreductase compare
Rv2506 +0.9 2.0 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv2939 +0.9 6.6 Possible conserved polyketide synthase associated protein PapA5 compare
Rv0877 +0.9 6.9 Conserved hypothetical protein compare
Rv2930 +0.9 7.6 Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) compare
Rv2933 +0.9 7.2 Phenolpthiocerol synthesis type-I polyketide synthase PpsC compare
Rv2931 +0.9 7.7 Phenolpthiocerol synthesis type-I polyketide synthase PpsA compare
Rv2940c +0.9 7.9 Probable multifunctional mycocerosic acid synthase membrane-associated Mas compare
Rv2276 +0.9 1.3 Cytochrome P450 121 Cyp121 compare
Rv1986 +0.9 1.2 Probable conserved integral membrane protein compare
Rv2408 +0.9 1.0 Possible PE family-related protein PE24 compare
Rv3828c +0.9 2.5 Possible resolvase compare
Rv3058c +0.9 3.9 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv0897c +0.9 2.0 Probable oxidoreductase compare
Rv1614 +0.8 2.5 Possible prolipoprotein diacylglyceryl transferases Lgt compare
Rv3748 +0.8 1.5 Conserved hypothetical protein compare
Rv2758c +0.8 1.1 Possible antitoxin VapB21 compare
Rv0862c +0.8 1.9 Conserved protein compare
Rv0782 +0.8 2.0 Probable protease II PtrBb [second part] (oligopeptidase B) compare
Rv0868c +0.8 2.1 Probable molybdenum cofactor biosynthesis protein D 2 MoaD2 (molybdopterin converting factor small subunit) (molybdopterin [MPT] converting factor, subunit 1) compare
Rv2650c +0.8 0.9 Possible PhiRv2 prophage protein compare
Rv2821c +0.8 2.2 Conserved hypothetical protein compare
Rv1055 +0.8 1.1 Possible integrase (fragment) compare
Rv2928 +0.8 3.5 Probable thioesterase TesA compare
Rv0356c +0.8 3.1 Conserved protein compare
Rv1707 +0.8 3.5 Probable conserved transmembrane protein compare
Rv1332 +0.8 1.0 Probable transcriptional regulatory protein compare
Rv2042c +0.7 2.3 Conserved protein compare
Rv2331 +0.7 1.9 Hypothetical protein compare
Rv3417c +0.7 1.7 60 kDa chaperonin 1 GroEL1 (protein CPN60-1) (GroEL protein 1) compare
Rv1178 +0.7 1.7 Probable aminotransferase compare
Rv2745c +0.7 1.5 Transcriptional regulatory protein ClgR compare
Rv0250c +0.7 1.8 Conserved protein compare
Rv1372 +0.7 1.4 Conserved hypothetical protein compare
Rv1170 +0.7 2.2 N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) compare
Rv3314c +0.7 1.0 Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) compare
Rv2941 +0.7 5.7 Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) compare
Rv3162c +0.7 1.0 Possible integral membrane protein compare
Rv3816c +0.7 0.7 Possible acyltransferase compare
Rv0396 +0.7 1.0 Hypothetical protein compare
Rv0081 +0.7 1.6 Probable transcriptional regulatory protein compare
Rv3700c +0.7 2.1 Conserved hypothetical protein compare
Rv0617 +0.7 2.1 Possible toxin VapC29. Contains PIN domain. compare
Rv2836c +0.7 1.3 Possible DNA-damage-inducible protein F DinF compare
Rv3419c +0.7 1.2 Probable O-sialoglycoprotein endopeptidase Gcp (glycoprotease) compare
Rv2967c +0.7 3.1 Probable pyruvate carboxylase Pca (pyruvic carboxylase) compare
Rv3397c +0.7 1.6 Probable phytoene synthase PhyA compare
Rv0207c +0.7 1.6 Conserved hypothetical protein compare
Rv0554 +0.7 3.8 Possible peroxidase BpoC (non-haem peroxidase) compare
Rv3377c +0.7 1.5 Halimadienyl diphosphate synthase compare
Rv2292c +0.7 0.9 Hypothetical protein compare
Rv0047c +0.6 2.5 Conserved protein compare
Rv1239c +0.6 4.0 Possible magnesium and cobalt transport transmembrane protein CorA compare
Rv2736c +0.6 1.0 Regulatory protein RecX compare
Rv2416c +0.6 1.7 Enhanced intracellular survival protein Eis,GCN5-related N-acetyltransferase compare
Rv2923c +0.6 0.8 Conserved protein compare
Rv2529 +0.6 2.1 Hypothetical protein compare
Rv3198c +0.6 0.8 Probable ATP-dependent DNA helicase II UvrD2 compare
Rv1025 +0.6 0.5 Conserved protein compare
Rv0130 +0.6 1.0 Probable 3-hydroxyl-thioester dehydratase compare
Rv3512 +0.6 1.7 PE-PGRS family protein PE_PGRS56 compare
Rv3751 +0.6 0.7 Probable integrase (fragment) compare
Rv3295 +0.6 4.6 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv2377c +0.6 1.3 Putative conserved protein MbtH compare
Rv0986 +0.6 1.9 Probable adhesion component transport ATP-binding protein ABC transporter compare
Rv3046c +0.6 0.6 Conserved protein compare
Rv1742 +0.6 1.7 Unknown protein compare
Rv1116A +0.6 0.8 Conserved hypothetical protein (fragment) compare
Rv3395c +0.6 1.5 Conserved hypothetical protein compare
Rv0496 +0.6 1.8 Conserved hypothetical protein compare
Rv1929c +0.6 1.9 Conserved hypothetical protein compare
Rv1791 +0.6 0.9 PE family protein PE19 compare
Rv0959 +0.6 0.7 Conserved hypothetical protein compare
Rv3705A +0.6 1.2 Conserved hypothetical proline rich protein compare
Rv1203c +0.6 1.2 Hypothetical protein compare
Rv3549c +0.6 1.4 Probable short-chain type dehydrogenase/reductase compare
Rv0311 +0.6 1.0 Unknown protein compare
Rv1962A +0.6 0.8 Possible antitoxin VapB35 compare
Rv3856c +0.6 0.9 Conserved hypothetical protein compare
Rv2086 +0.6 1.4 Conserved hypothetical protein compare
Rv2432c +0.6 0.9 Hypothetical protein compare
Rv1468c +0.6 1.4 PE-PGRS family protein PE_PGRS29 compare
Rv1350 +0.6 0.7 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) compare
Rv2719c +0.6 2.0 Possible conserved membrane protein compare
Rv3236c +0.6 0.8 Probable conserved integral membrane transport protein compare
Rv0563 +0.6 1.6 Probable protease transmembrane protein heat shock protein HtpX compare
Rv2436 +0.6 1.5 Ribokinase RbsK compare
Rv2319c +0.6 1.2 Universal stress protein family protein compare
Rv1509 +0.6 2.9 Hypothetical protein compare
Rv3827c +0.6 2.6 Possible transposase compare
Rv1054 +0.6 1.1 Probable integrase (fragment) compare
Rv0219 +0.6 1.6 Probable conserved transmembrane protein compare
Rv3174 +0.6 0.8 Probable short-chain dehydrogenase/reductase compare
Rv1137c +0.6 1.5 Hypothetical protein compare
Rv1677 +0.6 1.2 Probable conserved lipoprotein DsbF compare
Rv1187 +0.6 1.7 Probable pyrroline-5-carboxylate dehydrogenase RocA compare
Rv1687c +0.5 2.1 Probable conserved ATP-binding protein ABC transporter compare
Rv3842c +0.5 2.9 Probable glycerophosphoryl diester phosphodiesterase GlpQ1 (glycerophosphodiester phosphodiesterase) compare
Rv1792 +0.5 0.7 ESAT-6 like protein EsxM compare
Rv0030 +0.5 2.0 Conserved hypothetical protein compare
Rv3133c +0.5 1.6 Two component transcriptional regulatory protein DevR (probably LuxR/UhpA-family) compare
Rv2429 +0.5 0.7 Alkyl hydroperoxide reductase D protein AhpD (alkyl hydroperoxidase D) compare
Rv1608c +0.5 1.2 Probable peroxidoxin BcpB compare
Rv2513 +0.5 1.8 Hypothetical protein compare
Rv3651 +0.5 1.7 Conserved hypothetical protein compare
Rv1205 +0.5 2.6 Conserved hypothetical protein compare
Rv3759c +0.5 1.5 Possible osmoprotectant (glycine betaine/carnitine/choline/L-proline) binding lipoprotein ProX compare
Rv3610c +0.5 1.3 Membrane-bound protease FtsH (cell division protein) compare
Rv0764c +0.5 1.2 Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) compare
Rv2010 +0.5 0.8 Toxin VapC15 compare
Rv2621c +0.5 0.6 Possible transcriptional regulatory protein compare
Rv0480c +0.5 2.3 Possible amidohydrolase compare
Rv1963c +0.5 1.0 Probable transcriptional repressor (probably TetR-family) Mce3R compare
Rv3124 +0.5 0.9 Transcriptional regulatory protein MoaR1 compare
Rv0629c +0.5 0.8 Probable exonuclease V (alpha chain) RecD (exodeoxyribonuclease V alpha chain) (exodeoxyribonuclease V polypeptide) compare
Rv2249c +0.5 1.6 Probable glycerol-3-phosphate dehydrogenase GlpD1 compare
Rv0117 +0.5 2.2 Oxidative stress response regulatory protein OxyS compare
Rv1558 +0.5 1.3 Conserved protein compare
Rv3196A +0.5 1.3 Unknown protein compare
Rv0275c +0.5 1.3 Possible transcriptional regulatory protein (possibly TetR-family) compare
Rv3263 +0.5 4.0 Probable DNA methylase (modification methylase) (methyltransferase) compare
Rv0354c +0.5 1.5 PPE family protein PPE7 compare
Rv2061c +0.5 1.2 Conserved protein compare
Rv3477 +0.5 0.6 PE family protein PE31 compare
Rv1286 +0.5 2.3 Probable bifunctional enzyme CysN/CysC: sulfate adenyltransferase (subunit 1) + adenylylsulfate kinase compare
Rv1329c +0.5 1.5 Probable ATP-dependent helicase DinG compare
Rv2087 +0.5 1.3 Conserved hypothetical protein compare
Rv0613c +0.5 2.0 Unknown protein compare
Rv2772c +0.5 0.6 Probable conserved transmembrane protein compare
Rv2887 +0.5 0.8 Probable transcriptional regulatory protein compare
Rv0591 +0.5 1.2 Mce-family protein Mce2C compare
Rv0615 +0.5 0.7 Probable integral membrane protein compare
Rv2899c +0.5 0.6 Possible FdhD protein homolog compare
Rv2706c +0.5 0.5 Hypothetical protein compare
Rv3888c +0.5 1.0 Probable conserved membrane protein compare
Rv0853c +0.5 1.9 Probable pyruvate or indole-3-pyruvate decarboxylase Pdc compare
Rv2132 +0.5 1.0 Conserved hypothetical protein compare
Rv3787c +0.5 1.2 Conserved hypothetical protein compare
Rv1860 +0.5 1.8 Alanine and proline rich secreted protein Apa (fibronectin attachment protein) (immunogenic protein MPT32) (antigen MPT-32) (45-kDa glycoprotein) (45/47 kDa antigen) compare
Rv2813 +0.5 0.9 Conserved hypothetical protein compare
Rv2749 +0.5 1.4 Conserved protein compare
Rv2077A +0.5 1.4 Conserved hypothetical protein compare
Rv1538c +0.5 2.2 Probable L-aparaginase AnsA compare
Rv0378 +0.5 0.9 Conserved hypothetical glycine rich protein compare
Rv3565 +0.5 0.9 Possible aspartate aminotransferase AspB (transaminase A) (ASPAT) (glutamic--oxaloacetic transaminase) (glutamic--aspartic transaminase) compare
Rv2734 +0.5 2.1 Conserved hypothetical protein compare
Rv3824c +0.5 2.2 Conserved polyketide synthase associated protein PapA1 compare
Rv2551c +0.5 0.6 Conserved hypothetical protein compare
Rv0649 +0.5 1.0 Possible malonyl CoA-acyl carrier protein transacylase FabD2 (MCT) compare
Rv0327c +0.5 2.7 Possible cytochrome P450 135A1 Cyp135A1 compare
Rv3478 +0.5 0.8 PE family protein PPE60 compare
Rv3150 +0.5 2.2 Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) compare
Rv1751 +0.5 0.6 Probable oxidoreductase compare
Rv1523 +0.5 1.4 Probable methyltransferase compare
Rv3061c +0.5 1.6 Probable acyl-CoA dehydrogenase FadE22 compare
Rv0082 +0.5 1.5 Probable oxidoreductase compare
Rv2035 +0.5 2.2 Conserved hypothetical protein compare
Rv2107 +0.5 0.7 PE family protein PE22 compare
Rv2484c +0.5 2.5 Possible triacylglycerol synthase (diacylglycerol acyltransferase) compare
Rv2360c +0.5 1.4 Unknown protein compare
Rv2046 +0.5 1.5 Probable lipoprotein LppI compare
Rv1107c +0.5 0.7 Probable exodeoxyribonuclease VII (small subunit) XseB (exonuclease VII small subunit) compare
Rv0907 +0.4 1.9 Conserved protein compare
Rv3147 +0.4 1.3 Probable NADH dehydrogenase I (chain C) NuoC (NADH-ubiquinone oxidoreductase chain C) compare
Rv1775 +0.4 1.6 Conserved hypothetical protein compare


Specific Phenotypes

For 1 genes in this experiment

For stress Cumene hydroperoxide in Mycobacterium tuberculosis H37Rv

For stress Cumene hydroperoxide across organisms