Experiment set5S582 for Mycobacterium tuberculosis H37Rv

Compare to:

no stress control

200 most important genes:

  gene name fitness t score description  
Rv1072 -3.2 -2.1 Probable conserved transmembrane protein compare
Rv3249c -3.1 -1.8 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv3850 -2.5 -2.1 Conserved protein compare
Rv0561c -2.5 -2.3 Possible oxidoreductase compare
Rv0955 -2.5 -2.1 Probable conserved integral membrane protein compare
Rv0819 -2.5 -3.3 GCN5-related N-acetyltransferase, MshD compare
Rv0497 -2.4 -2.0 Probable conserved transmembrane protein compare
Rv3819 -2.3 -0.9 Unknown protein compare
Rv2630 -2.2 -1.6 Hypothetical protein compare
Rv1303 -2.1 -1.1 Conserved hypothetical transmembrane protein compare
Rv1420 -2.1 -2.9 Probable excinuclease ABC (subunit C-nuclease) UvrC compare
Rv0437c -2.0 -1.4 Possible phosphatidylserine decarboxylase Psd (PS decarboxylase) compare
Rv2374c -1.9 -2.7 Probable heat shock protein transcriptional repressor HrcA compare
Rv3314c -1.8 -1.7 Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) compare
Rv1621c -1.8 -3.3 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD compare
Rv1620c -1.7 -2.9 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC compare
Rv1010 -1.6 -1.3 Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase) compare
Rv1821 -1.5 -3.6 Possible preprotein translocase ATPase SecA2 compare
Rv2581c -1.5 -1.3 Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II) compare
Rv3033 -1.5 -0.7 Unknown protein compare
Rv2277c -1.4 -2.1 Possible glycerolphosphodiesterase compare
Rv0309 -1.4 -3.8 Possible conserved exported protein compare
Rv2206 -1.4 -3.9 Probable conserved transmembrane protein compare
Rv2335 -1.3 -1.4 Probable serine acetyltransferase CysE (sat) compare
Rv2709 -1.3 -4.6 Probable conserved transmembrane protein compare
Rv1159 -1.3 -2.8 Mannosyltransferase PimE compare
Rv0328 -1.3 -1.5 Possible transcriptional regulatory protein (possibly TetR/AcrR-family) compare
Rv0930 -1.2 -4.4 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv2317 -1.2 -0.8 Probable sugar-transport integral membrane protein ABC transporter UspB compare
Rv3693 -1.2 -1.8 Possible conserved membrane protein compare
Rv1013 -1.2 -7.2 Putative polyketide synthase Pks16 compare
Rv3338 -1.2 -1.0 Conserved hypothetical protein compare
Rv0043c -1.2 -1.4 Probable transcriptional regulatory protein (probably GntR-family) compare
Rv0674 -1.2 -0.7 Conserved hypothetical protein compare
Rv2272 -1.2 -0.7 Probable conserved transmembrane protein compare
Rv3438 -1.2 -2.5 Conserved protein compare
Rv1798 -1.2 -1.0 ESX conserved component EccA5. ESX-5 type VII secretion system protein. compare
Rv2691 -1.2 -5.0 TRK system potassium uptake protein CeoB compare
Rv0504c -1.1 -1.6 Conserved protein compare
Rv0825c -1.1 -1.5 Conserved protein compare
Rv0928 -1.1 -2.5 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv0999 -1.1 -2.2 Unknown protein compare
Rv0949 -1.1 -0.7 Probable ATP-dependent DNA helicase II UvrD1 compare
Rv3715c -1.1 -1.8 Probable recombination protein RecR compare
Rv0093c -1.0 -1.1 Probable conserved membrane protein compare
Rv0241c -1.0 -2.1 Probable 3-hydroxyacyl-thioester dehydratase HtdX compare
Rv0367c -1.0 -0.7 Hypothetical protein compare
Rv0749 -1.0 -2.0 Possible toxin VapC31. Contains PIN domain. compare
Rv2070c -1.0 -1.2 Precorrin-6X reductase CobK compare
Rv3140 -1.0 -3.0 Probable acyl-CoA dehydrogenase FadE23 compare
Rv2707 -1.0 -7.1 Probable conserved transmembrane alanine and leucine rich protein compare
Rv0989c -1.0 -6.3 Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) compare
Rv2173 -1.0 -2.3 Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) compare
Rv1531 -0.9 -1.5 Conserved protein compare
Rv3277 -0.9 -0.9 Probable conserved transmembrane protein compare
Rv0520 -0.9 -2.1 Possible methyltransferase/methylase (fragment) compare
Rv0019c -0.9 -3.0 Conserved protein with FHA domain, FhaB compare
Rv1112 -0.9 -0.9 Probable GTP binding protein compare
Rv0016c -0.9 -3.4 Probable penicillin-binding protein PbpA compare
Rv0452 -0.9 -2.6 Possible transcriptional regulatory protein compare
Rv1411c -0.9 -2.3 Conserved lipoprotein LprG compare
Rv2793c -0.9 -0.9 Probable tRNA pseudouridine synthase B TruB (tRNA pseudouridine 55 synthase) (PSI55 synthase) (pseudouridylate synthase) (uracil hydrolyase) compare
Rv3920c -0.9 -0.6 Conserved protein similar to jag protein compare
Rv0918 -0.9 -1.4 Conserved protein compare
Rv3565 -0.9 -1.2 Possible aspartate aminotransferase AspB (transaminase A) (ASPAT) (glutamic--oxaloacetic transaminase) (glutamic--aspartic transaminase) compare
Rv1741 -0.9 -2.0 Possible toxin VapC34. Contains PIN domain. compare
Rv0038 -0.9 -3.0 Conserved protein compare
Rv0655 -0.9 -2.3 Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl compare
Rv1400c -0.9 -0.7 Probable lipase LipH compare
Rv2039c -0.9 -1.9 Probable sugar-transport integral membrane protein ABC transporter compare
Rv3193c -0.8 -1.0 Probable conserved transmembrane protein compare
Rv3200c -0.8 -1.8 Possible transmembrane cation transporter compare
Rv0954 -0.8 -2.4 Probable conserved transmembrane protein compare
Rv3536c -0.8 -3.6 Probable hydratase compare
Rv2498c -0.8 -4.1 Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) compare
Rv1009 -0.8 -2.5 Probable resuscitation-promoting factor RpfB compare
Rv2733c -0.8 -1.2 Conserved hypothetical alanine, arginine-rich protein compare
Rv1908c -0.8 -1.8 Catalase-peroxidase-peroxynitritase T KatG compare
Rv0610c -0.8 -0.5 Hypothetical protein compare
Rv1148c -0.8 -1.1 Conserved hypothetical protein compare
Rv2732c -0.8 -2.0 Probable conserved transmembrane protein compare
Rv3375 -0.8 -2.1 Probable amidase AmiD (acylamidase) (acylase) compare
Rv3177 -0.8 -1.0 Possible peroxidase (non-haem peroxidase) compare
Rv1745c -0.8 -2.7 Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase) compare
Rv2222c -0.8 -1.9 Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) compare
Rv1496 -0.8 -2.6 Possible transport system kinase compare
Rv0523c -0.8 -1.0 Conserved protein compare
Rv3540c -0.8 -1.7 Probable lipid transfer protein or keto acyl-CoA thiolase Ltp2 compare
Rv2468A -0.8 -3.2 Conserved protein compare
Rv3584 -0.8 -1.5 Possible conserved lipoprotein LpqE compare
Rv3770B -0.8 -1.1 Probable remnant of a transposase compare
Rv0885 -0.8 -2.0 Conserved hypothetical protein compare
Rv3897c -0.8 -0.5 Conserved hypothetical protein compare
Rv3493c -0.7 -1.7 Conserved hypothetical Mce associated alanine and valine rich protein compare
Rv3843c -0.7 -0.8 Probable conserved transmembrane protein compare
Rv2696c -0.7 -0.9 Conserved alanine and glycine and valine rich protein compare
Rv2553c -0.7 -0.5 Probable conserved membrane protein compare
Rv1690 -0.7 -0.8 Probable lipoprotein LprJ compare
Rv3311 -0.7 -3.0 Conserved protein compare
Rv0820 -0.7 -2.3 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv0161 -0.7 -1.9 Possible oxidoreductase compare
Rv0658c -0.7 -1.2 Probable conserved integral membrane protein compare
Rv0679c -0.7 -1.2 Conserved threonine rich protein compare
Rv3050c -0.7 -2.4 Probable transcriptional regulatory protein (probably AsnC-family) compare
Rv2252 -0.7 -0.7 Diacylglycerol kinase compare
Rv3855 -0.7 -1.7 Transcriptional regulatory repressor protein (TetR-family) EthR compare
Rv1095 -0.7 -1.4 Probable PHOH-like protein PhoH2 (phosphate starvation-inducible protein PSIH) compare
Rv0950c -0.7 -2.3 Conserved hypothetical protein compare
Rv2342 -0.7 -1.9 Conserved hypothetical protein compare
Rv2216 -0.7 -1.6 Conserved protein compare
Rv2047c -0.7 -3.4 Conserved hypothetical protein compare
Rv3501c -0.7 -2.7 Conserved integral membrane protein YrbE4A. Possible ABC transporter. compare
Rv0675 -0.7 -0.6 Probable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv2344c -0.7 -2.6 Probable deoxyguanosine triphosphate triphosphohydrolase Dgt (dGTPase) (dGTP triphosphohydrolase) compare
Rv1410c -0.7 -3.0 Aminoglycosides/tetracycline-transport integral membrane protein compare
Rv3237c -0.7 -3.5 Conserved protein compare
Rv0204c -0.7 -2.9 Probable conserved transmembrane protein compare
Rv3862c -0.7 -3.2 Possible transcriptional regulatory protein WhiB-like WhiB6 compare
Rv2989 -0.7 -0.4 Probable transcriptional regulatory protein compare
Rv3494c -0.7 -3.3 Mce-family protein Mce4F compare
Rv0121c -0.7 -1.4 Conserved protein compare
Rv1836c -0.7 -1.5 Conserved protein compare
Rv3723 -0.7 -2.1 Probable conserved transmembrane protein compare
Rv3134c -0.7 -2.2 Universal stress protein family protein compare
Rv1324 -0.7 -0.6 Possible thioredoxin compare
Rv2799 -0.7 -3.7 Probable membrane protein compare
Rv2369c -0.7 -0.7 Hypothetical protein compare
Rv3672c -0.7 -0.8 Conserved hypothetical protein compare
Rv3500c -0.7 -3.6 Conserved integral membrane protein YrbE4B. Possible ABC transporter. compare
Rv2500c -0.7 -0.6 Possible acyl-CoA dehydrogenase FadE19 (MMGC) compare
Rv1448c -0.6 -2.3 Probable transaldolase Tal compare
Rv1514c -0.6 -1.1 Conserved hypothetical protein compare
Rv1850 -0.6 -1.1 Urease alpha subunit UreC (urea amidohydrolase) compare
Rv0924c -0.6 -2.5 Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP) compare
Rv3306c -0.6 -0.8 Probable amidohydrolase AmiB1 (aminohydrolase) compare
Rv1062 -0.6 -0.4 Conserved hypothetical protein compare
Rv0557 -0.6 -1.1 Mannosyltransferase MgtA compare
Rv3291c -0.6 -2.7 Probable transcriptional regulatory protein LrpA (Lrp/AsnC-family) compare
Rv1679 -0.6 -0.6 Possible acyl-CoA dehydrogenase FadE16 compare
Rv2694c -0.6 -1.6 Conserved protein compare
Rv0566c -0.6 -1.0 Conserved protein compare
Rv0170 -0.6 -1.8 Mce-family protein Mce1B compare
Rv0065 -0.6 -1.6 Possible toxin VapC1 compare
Rv3270 -0.6 -1.0 Probable metal cation-transporting P-type ATPase C CtpC compare
Rv2635 -0.6 -0.4 Hypothetical protein compare
Rv2714 -0.6 -1.6 Conserved alanine and leucine rich protein compare
Rv1090 -0.6 -3.9 Probable cellulase CelA2b (endo-1,4-beta-glucanase) (endoglucanase) (carboxymethyl cellulase) compare
Rv3559c -0.6 -0.4 Probable oxidoreductase compare
Rv3591c -0.6 -0.8 Possible hydrolase compare
Rv3020c -0.6 -1.8 ESAT-6 like protein EsxS compare
Rv0740 -0.6 -1.7 Conserved hypothetical protein compare
Rv0383c -0.6 -0.6 Possible conserved secreted protein compare
Rv1244 -0.6 -2.3 Probable lipoprotein LpqZ compare
Rv1565c -0.6 -2.8 Conserved hypothetical membrane protein compare
Rv1579c -0.6 -1.7 Probable PhiRv1 phage protein compare
Rv3376 -0.6 -2.4 Conserved hypothetical protein compare
Rv3922c -0.6 -1.7 Possible hemolysin compare
Rv0929 -0.6 -0.8 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv1792 -0.6 -0.6 ESAT-6 like protein EsxM compare
Rv1284 -0.6 -0.2 Beta-carbonic anhydrase compare
Rv3817 -0.6 -1.1 Possible phosphotransferase compare
Rv3499c -0.6 -3.5 Mce-family protein Mce4A compare
Rv0968 -0.6 -1.5 Conserved protein compare
Rv1336 -0.6 -3.1 Cysteine synthase B CysM (CSASE B) (O-phosphoserine sulfhydrylase B) (O-phosphoserine (thiol)-lyase B) compare
Rv3498c -0.6 -2.5 Mce-family protein Mce4B compare
Rv0756c -0.6 -2.6 Unknown protein compare
Rv2642 -0.6 -3.0 Possible transcriptional regulatory protein (probably ArsR-family) compare
Rv1127c -0.6 -0.7 Probable pyruvate, phosphate dikinase PpdK compare
Rv1766 -0.6 -1.3 Conserved protein compare
Rv2774c -0.6 -0.4 Hypothetical protein compare
Rv3557c -0.6 -2.0 Transcriptional regulatory protein (probably TetR-family) compare
Rv0472c -0.6 -1.7 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv0743c -0.6 -3.0 Hypothetical protein compare
Rv0184 -0.6 -1.6 Conserved hypothetical protein compare
Rv0017c -0.6 -2.1 Probable cell division protein RodA compare
Rv2569c -0.6 -2.4 Conserved hypothetical protein compare
Rv3527 -0.6 -0.8 Hypothetical protein compare
Rv2922c -0.6 -1.4 Probable chromosome partition protein Smc compare
Rv1022 -0.6 -2.5 Probable conserved lipoprotein LpqU compare
Rv0145 -0.6 -2.7 Possible S-adenosylmethionine-dependent methyltransferase compare
Rv3256c -0.6 -0.7 Conserved protein compare
Rv2446c -0.6 -1.8 Probable conserved integral membrane protein compare
Rv3553 -0.6 -1.0 Possible oxidoreductase compare
Rv1331 -0.6 -1.1 Conserved hypothetical protein compare
Rv1892 -0.6 -2.3 Probable membrane protein compare
Rv0588 -0.6 -1.2 Conserved hypothetical integral membrane protein YrbE2B compare
Rv1049 -0.6 -0.8 Probable transcriptional repressor protein compare
Rv1421 -0.6 -1.0 Conserved protein compare
Rv1071c -0.5 -2.1 Possible enoyl-CoA hydratase EchA9 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv0672 -0.5 -2.5 Probable acyl-CoA dehydrogenase FadE8 compare
Rv3818 -0.5 -2.3 Unknown protein compare
Rv0818 -0.5 -1.8 Transcriptional regulatory protein compare
Rv0080 -0.5 -1.8 Conserved hypothetical protein compare
Rv3119 -0.5 -1.7 Probable molybdenum cofactor biosynthesis protein E MoaE1 (molybdopterin converting factor large subunit) (molybdopterin [MPT] converting factor, subunit 2) compare
Rv1701 -0.5 -1.8 Probable integrase/recombinase compare
Rv0406c -0.5 -2.5 Beta lactamase like protein compare
Rv0953c -0.5 -2.6 Possible oxidoreductase compare
Rv1091 -0.5 -2.9 PE-PGRS family protein PE_PGRS22 compare
Rv2616 -0.5 -3.1 Conserved protein compare
Rv1088 -0.5 -2.5 PE family protein PE9 compare


Specific Phenotypes

None in this experiment

For Mycobacterium tuberculosis H37Rv in no stress control experiments