Experiment set5IT089 for Methanococcus maripaludis S2

Compare to:

Formate with Nalidixic acid 12.5 mM

200 most important genes:

  gene name fitness t score description  
MMP_RS03315 -3.4 -2.7 ferrous iron transport protein A compare
MMP_RS01175 -3.2 -6.4 triphosphoribosyl-dephospho-CoA synthase compare
MMP_RS06700 -3.2 -18.5 hypothetical protein compare
MMP_RS08635 -3.1 -4.2 UbiA family prenyltransferase compare
MMP_RS06685 -3.1 -18.4 formate dehydrogenase H subunit alpha selenocysteine-containing compare
MMP_RS06680 -3.1 -19.3 Coenzyme F420 hydrogenase/dehydrogenase beta subunit C-terminal domain compare
MMP_RS02010 -3.1 -16.6 PHP domain-containing protein compare
MMP_RS01020 -2.8 -2.6 3 4-dihydroxy-2-butanone-4-phosphate synthase compare
MMP_RS06345 -2.7 -13.7 formate dehydrogenase accessory sulfurtransferase FdhD compare
MMP_RS07845 -2.7 -4.6 LL-diaminopimelate aminotransferase compare
MMP_RS07635 -2.7 -12.8 MogA/MoaB family molybdenum cofactor biosynthesis protein compare
MMP_RS03015 -2.6 -15.7 GTP 3' 8-cyclase MoaA compare
MMP_RS05515 -2.6 -10.4 cyclic pyranopterin monophosphate synthase MoaC compare
MMP_RS06350 -2.6 -15.8 HesA/MoeB/ThiF family protein compare
MMP_RS08300 -2.6 -2.3 metal-sulfur cluster assembly factor compare
MMP_RS06355 -2.5 -4.5 molybdenum cofactor biosynthesis protein MoaE compare
MMP_RS07735 -2.5 -2.2 2-ketoisovalerate ferredoxin oxidoreductase subunit alpha compare
MMP_RS05920 -2.3 -1.6 50S ribosomal protein L37e compare
MMP_RS07545 -2.3 -2.7 HTH domain-containing protein compare
MMP_RS01795 -2.3 -3.6 methanogenesis marker 6 protein compare
MMP_RS08820 -2.2 -7.2 hypothetical protein compare
MMP_RS08210 -2.2 -3.6 phosphatidylglycerophosphatase A compare
MMP_RS06400 -2.2 -3.5 4Fe-4S binding protein compare
MMP_RS06285 -2.1 -5.0 precorrin-6Y C5 15-methyltransferase (decarboxylating) subunit CbiT compare
MMP_RS03435 -2.1 -3.8 ketol-acid reductoisomerase compare
MMP_RS02280 -2.1 -2.1 DUF211 domain-containing protein compare
MMP_RS08460 -2.0 -4.4 proteasome-activating nucleotidase compare
MMP_RS07445 -2.0 -7.8 helix-turn-helix domain-containing protein compare
MMP_RS06705 -2.0 -9.5 formate/nitrite transporter family protein compare
MMP_RS06715 -2.0 -14.5 cache domain-containing protein compare
MMP_RS06295 -1.9 -8.8 methanogenesis marker 14 protein compare
MMP_RS01265 -1.9 -4.0 hypothetical protein compare
MMP_RS00115 -1.9 -13.0 radical SAM protein compare
MMP_RS08745 -1.9 -8.2 CDP-2 3-bis-(O-geranylgeranyl)-sn-glycerol synthase compare
MMP_RS05550 -1.9 -1.6 cation:proton antiporter compare
MMP_RS07575 -1.9 -6.9 RNA ligase partner protein compare
MMP_RS00895 -1.9 -5.4 hypothetical protein compare
MMP_RS06720 -1.8 -9.3 response regulator transcription factor compare
MMP_RS06110 -1.8 -5.8 ATP-dependent protease LonB compare
MMP_RS06625 -1.8 -3.6 DNA primase compare
MMP_RS07730 -1.8 -3.9 pyruvate synthase subunit beta compare
MMP_RS04585 -1.8 -9.5 AIR synthase related protein compare
MMP_RS01005 -1.8 -2.7 riboflavin synthase compare
MMP_RS01220 -1.8 -8.3 hypothetical protein compare
MMP_RS03600 -1.7 -3.6 triose-phosphate isomerase compare
MMP_RS00300 -1.7 -1.3 6 7-dimethyl-8-ribityllumazine synthase compare
MMP_RS00305 -1.7 -2.5 phosphoribosyl-ATP diphosphatase compare
MMP_RS02195 -1.7 -5.4 tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase compare
MMP_RS06730 -1.6 -2.6 phosphopantothenate/pantothenate synthetase compare
MMP_RS00685 -1.6 -6.0 2-phospho-L-lactate guanylyltransferase compare
MMP_RS07380 -1.6 -3.6 transcription elongation factor Spt5 compare
MMP_RS00695 -1.6 -1.4 biotin--[acetyl-CoA-carboxylase] ligase compare
MMP_RS07005 -1.6 -1.0 4Fe-4S binding protein compare
MMP_RS01610 -1.5 -5.6 hypothetical protein compare
MMP_RS04685 -1.5 -3.4 DUF126 domain-containing protein compare
MMP_RS02800 -1.5 -5.6 nucleotidyltransferase domain-containing protein compare
MMP_RS03640 -1.5 -5.8 archaeal proteasome endopeptidase complex subunit beta compare
MMP_RS03400 -1.5 -3.7 archease compare
MMP_RS01225 -1.4 -6.1 DUF5379 domain-containing protein compare
MMP_RS07600 -1.4 -3.8 Ni-sirohydrochlorin a c-diamide synthase compare
MMP_RS07525 -1.4 -8.5 4Fe-4S binding protein compare
MMP_RS06340 -1.4 -8.5 phosphoadenosine phosphosulfate reductase family protein compare
MMP_RS08715 -1.4 -2.2 formylmethanofuran dehydrogenase subunit B compare
MMP_RS01385 -1.4 -1.2 imidazole glycerol phosphate synthase subunit HisH compare
MMP_RS01500 -1.4 -3.1 CBS domain-containing protein compare
MMP_RS02355 -1.4 -4.7 30S ribosomal protein S27ae compare
MMP_RS03035 -1.4 -3.5 4-hydroxy-tetrahydrodipicolinate synthase compare
MMP_RS01755 -1.4 -2.4 DUF2097 domain-containing protein compare
MMP_RS00110 -1.4 -3.4 hypothetical protein compare
MMP_RS04955 -1.4 -4.2 DNA topoisomerase I compare
MMP_RS01325 -1.4 -3.8 dihydroneopterin aldolase family protein compare
MMP_RS05875 -1.3 -3.5 hydroxyethylthiazole kinase compare
MMP_RS06885 -1.3 -4.0 50S ribosome-binding GTPase compare
MMP_RS03025 -1.3 -6.1 molybdenum cofactor guanylyltransferase compare
MMP_RS02240 -1.3 -4.5 methanogenesis marker 7 protein compare
MMP_RS06895 -1.3 -2.0 selenocysteine-specific translation elongation factor compare
MMP_RS04605 -1.3 -4.7 cobalt ECF transporter T component CbiQ compare
MMP_RS06230 -1.3 -2.3 helix-turn-helix domain-containing protein compare
MMP_RS05540 -1.3 -3.6 hypothetical protein compare
MMP_RS00295 -1.2 -3.1 gamma carbonic anhydrase family protein compare
MMP_RS08720 -1.2 -1.9 4Fe-4S binding protein compare
MMP_RS06630 -1.2 -1.6 UPF0058 family protein compare
MMP_RS06020 -1.2 -5.4 archaeoflavoprotein AfpA compare
MMP_RS03580 -1.2 -3.3 signal recognition particle-docking protein FtsY compare
MMP_RS02235 -1.2 -7.9 CBS domain-containing protein compare
MMP_RS01800 -1.2 -3.9 TIGR00303 family protein compare
MMP_RS00720 -1.2 -6.9 metal-dependent hydrolase compare
MMP_RS09020 -1.2 -2.2 hypothetical protein compare
MMP_RS06270 -1.2 -4.6 TIGR00300 family protein compare
MMP_RS02135 -1.2 -4.6 DUF5612 domain-containing protein compare
MMP_RS03205 -1.1 -1.0 peptidyl-tRNA hydrolase Pth2 compare
MMP_RS08790 -1.1 -2.3 translation initiation factor IF-2 subunit alpha compare
MMP_RS04780 -1.1 -2.8 ribonuclease P compare
MMP_RS06840 -1.1 -1.6 DNA-directed RNA polymerase subunit N compare
MMP_RS01250 -1.1 -5.2 tRNA (guanine(26)-N(2))-dimethyltransferase compare
MMP_RS04775 -1.1 -3.4 adenosylhomocysteinase compare
MMP_RS06105 -1.1 -5.6 hydrogenase maturation peptidase HycI compare
MMP_RS05245 -1.0 -7.8 archaeosine biosynthesis radical SAM protein RaSEA compare
MMP_RS07420 -1.0 -3.7 metalloregulator ArsR/SmtB family transcription factor compare
MMP_RS00515 -1.0 -1.2 DUF655 domain-containing protein compare
MMP_RS07390 -1.0 -2.3 cell division protein FtsZ compare
MMP_RS06315 -1.0 -1.2 cobalt-precorrin-7 (C(5))-methyltransferase compare
MMP_RS06925 -1.0 -2.1 ribonuclease VapC4 compare
MMP_RS05845 -1.0 -1.4 tRNA-intron lyase compare
MMP_RS02875 -1.0 -5.2 chorismate pyruvate-lyase family protein compare
MMP_RS07755 -0.9 -1.7 DUF555 domain-containing protein compare
MMP_RS07200 -0.9 -4.3 [5-(aminomethyl)furan-3-yl]methyl phosphate kinase compare
MMP_RS00520 -0.9 -1.5 RNA polymerase Rpb4 family protein compare
MMP_RS06865 -0.9 -1.9 HypC/HybG/HupF family hydrogenase formation chaperone compare
MMP_RS00915 -0.9 -5.3 DUF116 domain-containing protein compare
MMP_RS03095 -0.9 -5.7 diphthine synthase compare
MMP_RS07750 -0.9 -3.0 DUF357 domain-containing protein compare
MMP_RS08725 -0.9 -1.3 Ni/Fe hydrogenase subunit alpha compare
MMP_RS04500 -0.8 -6.7 adenosylmethionine--8-amino-7-oxononanoate transaminase compare
MMP_RS05265 -0.8 -1.9 2-isopropylmalate synthase compare
MMP_RS07190 -0.8 -5.7 chromosome segregation protein SMC compare
MMP_RS07790 -0.8 -5.6 segregation/condensation protein A compare
MMP_RS03155 -0.8 -4.8 precorrin-6A reductase compare
MMP_RS04875 -0.8 -3.0 energy-converting hydrogenase B subunit P compare
MMP_RS00900 -0.8 -1.9 50S ribosomal protein L39e compare
MMP_RS08435 -0.8 -1.5 Era-like GTP-binding protein compare
MMP_RS01700 -0.8 -0.9 dihydroxy-acid dehydratase compare
MMP_RS02165 -0.8 -4.5 tRNA-dihydrouridine synthase compare
MMP_RS06370 -0.8 -3.4 biotin synthase BioB compare
MMP_RS01180 -0.8 -0.8 XTP/dITP diphosphatase compare
MMP_RS01365 -0.8 -3.7 archaeal proteasome endopeptidase complex subunit alpha compare
MMP_RS05430 -0.8 -4.1 TIGR00288 family NYN domain-containing protein compare
MMP_RS07385 -0.8 -1.9 protein translocase SEC61 complex subunit gamma compare
MMP_RS02145 -0.8 -4.2 winged helix-turn-helix transcriptional regulator compare
MMP_RS01725 -0.8 -3.6 class I SAM-dependent methyltransferase family protein compare
MMP_RS01840 -0.8 -4.7 TIGR00289 family protein compare
MMP_RS08200 -0.7 -6.5 archaeosine synthase subunit alpha compare
MMP_RS00620 -0.7 -5.3 4Fe-4S binding protein compare
MMP_RS05315 -0.7 -2.0 hypothetical protein compare
MMP_RS06175 -0.7 -4.1 winged helix-turn-helix transcriptional regulator compare
MMP_RS06130 -0.7 -2.6 peptidylprolyl isomerase compare
MMP_RS00290 -0.7 -4.1 hypothetical protein compare
MMP_RS05555 -0.7 -1.8 DUF4040 domain-containing protein compare
MMP_RS05445 -0.7 -5.1 CoB--CoM heterodisulfide reductase subunit B compare
MMP_RS00120 -0.7 -4.4 LysR family transcriptional regulator compare
MMP_RS04870 -0.7 -2.7 TIGR02253 family HAD-type hydrolase compare
MMP_RS07350 -0.7 -2.4 preprotein translocase subunit Sec61beta compare
MMP_RS00060 -0.7 -1.0 3-dehydroquinate synthase II compare
MMP_RS02190 -0.7 -2.3 sulfopyruvate decarboxylase subunit alpha compare
MMP_RS03555 -0.7 -4.8 transcriptional regulator compare
MMP_RS02245 -0.7 -2.6 hypothetical protein compare
MMP_RS04615 -0.7 -2.2 PDGLE domain-containing protein compare
MMP_RS08330 -0.7 -4.0 NADH-quinone oxidoreductase subunit H compare
MMP_RS07365 -0.7 -5.3 2-phosphoglycerate kinase compare
MMP_RS07955 -0.7 -3.1 FumA C-terminus/TtdB family hydratase beta subunit compare
MMP_RS03960 -0.7 -0.8 hypothetical protein compare
MMP_RS07765 -0.7 -4.2 sodium:alanine symporter family protein compare
MMP_RS02885 -0.6 -5.5 molybdopterin biosynthesis protein compare
MMP_RS01720 -0.6 -1.5 replication factor C large subunit compare
MMP_RS06120 -0.6 -0.9 UPF0147 family protein compare
MMP_RS01985 -0.6 -4.1 F420-dependent methylenetetrahydromethanopterin dehydrogenase compare
MMP_RS08100 -0.6 -4.9 8-amino-7-oxononanoate synthase compare
MMP_RS07195 -0.6 -3.8 M20 family metallo-hydrolase compare
MMP_RS01600 -0.6 -0.9 50S ribosomal protein L15e compare
MMP_RS06200 -0.6 -5.3 M24 family metallopeptidase compare
MMP_RS08095 -0.6 -3.5 dethiobiotin synthase compare
MMP_RS07535 -0.6 -3.8 4Fe-4S binding protein compare
MMP_RS08165 -0.6 -1.8 phosphoglycerate dehydrogenase compare
MMP_RS08645 -0.6 -2.4 UPF0179 family protein compare
MMP_RS01195 -0.6 -1.3 metalloregulator ArsR/SmtB family transcription factor compare
MMP_RS06475 -0.6 -2.0 FAD-dependent oxidoreductase compare
MMP_RS08105 -0.6 -3.8 6-carboxyhexanoate--CoA ligase compare
MMP_RS03475 -0.6 -0.5 hypothetical protein compare
MMP_RS00320 -0.6 -1.2 class I SAM-dependent methyltransferase compare
MMP_RS02130 -0.6 -2.2 zinc metalloprotease HtpX compare
MMP_RS04620 -0.5 -3.9 cobalt transporter CbiM compare
MMP_RS03250 -0.5 -2.5 MJ1244 family protein compare
MMP_RS00750 -0.5 -1.9 fumarate hydratase compare
MMP_RS05815 -0.5 -1.6 NOL1/NOP2/sun family putative RNA methylase compare
MMP_RS08915 -0.5 -1.3 2 5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase compare
MMP_RS05510 -0.5 -3.4 Rrf2 family transcriptional regulator compare
MMP_RS07580 -0.5 -1.8 DUF356 domain-containing protein compare
MMP_RS06215 -0.5 -2.3 30S ribosomal protein S6e compare
MMP_RS08650 -0.5 -2.0 glutamine--fructose-6-phosphate transaminase (isomerizing) compare
MMP_RS02340 -0.5 -0.6 DNA-directed RNA polymerase subunit E'' compare
MMP_RS07605 -0.5 -1.6 diadenylate cyclase compare
MMP_RS08320 -0.5 -3.0 molybdopterin molybdotransferase MoeA compare
MMP_RS04890 -0.5 -0.6 adenylyltransferase/cytidyltransferase family protein compare
MMP_RS07625 -0.5 -1.6 cobalt ECF transporter T component CbiQ compare
MMP_RS07645 -0.5 -3.0 aldehyde dehydrogenase family protein compare
MMP_RS01545 -0.5 -0.6 CBS domain-containing protein compare
MMP_RS03110 -0.5 -2.4 glycosyltransferase family 2 protein compare
MMP_RS03445 -0.5 -0.8 methanogenesis marker 17 protein compare
MMP_RS05930 -0.5 -1.2 3-isopropylmalate dehydratase large subunit compare
MMP_RS07090 -0.4 -2.7 tRNA (adenine-N1)-methyltransferase compare
MMP_RS05765 -0.4 -2.9 M42 family metallopeptidase compare
MMP_RS03305 -0.4 -3.2 winged helix-turn-helix domain-containing protein compare
MMP_RS01495 -0.4 -3.1 TraB/GumN family protein compare
MMP_RS07425 -0.4 -2.2 GTP-binding protein compare
MMP_RS01045 -0.4 -2.5 diphthamide biosynthesis enzyme Dph2 compare
MMP_RS05295 -0.4 -3.5 minichromosome maintenance protein MCM compare
MMP_RS00810 -0.4 -2.6 topoisomerase DNA-binding C4 zinc finger domain-containing protein compare
MMP_RS08445 -0.4 -1.8 DUF2099 family protein compare
MMP_RS05065 -0.4 -2.6 CooT family nickel-binding protein compare
MMP_RS00735 -0.4 -2.3 5 10-methenyltetrahydromethanopterin hydrogenase compare


Specific Phenotypes

None in this experiment

For Methanococcus maripaludis S2 in stress experiments

For stress Nalidixic acid sodium salt across organisms