Experiment set5IT055 for Methanococcus maripaludis S2

Compare to:

Formate with trimethoprim

200 most important genes:

  gene name fitness t score description  
MMP_RS01175 -3.7 -7.7 triphosphoribosyl-dephospho-CoA synthase compare
MMP_RS03315 -3.1 -2.9 ferrous iron transport protein A compare
MMP_RS06700 -2.9 -18.7 hypothetical protein compare
MMP_RS01005 -2.8 -3.4 riboflavin synthase compare
MMP_RS06680 -2.8 -19.6 Coenzyme F420 hydrogenase/dehydrogenase beta subunit C-terminal domain compare
MMP_RS02280 -2.7 -2.3 DUF211 domain-containing protein compare
MMP_RS06685 -2.7 -15.1 formate dehydrogenase H subunit alpha selenocysteine-containing compare
MMP_RS08720 -2.6 -3.5 4Fe-4S binding protein compare
MMP_RS08210 -2.5 -5.3 phosphatidylglycerophosphatase A compare
MMP_RS02195 -2.4 -6.7 tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase compare
MMP_RS08820 -2.4 -7.8 hypothetical protein compare
MMP_RS07635 -2.4 -8.6 MogA/MoaB family molybdenum cofactor biosynthesis protein compare
MMP_RS08300 -2.4 -2.7 metal-sulfur cluster assembly factor compare
MMP_RS01020 -2.4 -2.6 3 4-dihydroxy-2-butanone-4-phosphate synthase compare
MMP_RS06345 -2.3 -15.6 formate dehydrogenase accessory sulfurtransferase FdhD compare
MMP_RS00115 -2.3 -16.9 radical SAM protein compare
MMP_RS07575 -2.3 -7.2 RNA ligase partner protein compare
MMP_RS06355 -2.3 -3.8 molybdenum cofactor biosynthesis protein MoaE compare
MMP_RS07845 -2.3 -3.9 LL-diaminopimelate aminotransferase compare
MMP_RS01265 -2.2 -3.9 hypothetical protein compare
MMP_RS05920 -2.2 -1.6 50S ribosomal protein L37e compare
MMP_RS04775 -2.1 -5.3 adenosylhomocysteinase compare
MMP_RS05515 -2.1 -14.2 cyclic pyranopterin monophosphate synthase MoaC compare
MMP_RS02010 -2.0 -9.7 PHP domain-containing protein compare
MMP_RS00895 -2.0 -5.8 hypothetical protein compare
MMP_RS08635 -2.0 -3.8 UbiA family prenyltransferase compare
MMP_RS06295 -2.0 -8.3 methanogenesis marker 14 protein compare
MMP_RS06720 -1.9 -10.3 response regulator transcription factor compare
MMP_RS08460 -1.9 -4.2 proteasome-activating nucleotidase compare
MMP_RS06350 -1.9 -7.3 HesA/MoeB/ThiF family protein compare
MMP_RS03015 -1.9 -13.7 GTP 3' 8-cyclase MoaA compare
MMP_RS01500 -1.9 -3.0 CBS domain-containing protein compare
MMP_RS08745 -1.9 -7.6 CDP-2 3-bis-(O-geranylgeranyl)-sn-glycerol synthase compare
MMP_RS05875 -1.8 -4.4 hydroxyethylthiazole kinase compare
MMP_RS06715 -1.8 -14.0 cache domain-containing protein compare
MMP_RS04685 -1.7 -5.3 DUF126 domain-containing protein compare
MMP_RS01220 -1.7 -9.0 hypothetical protein compare
MMP_RS06340 -1.7 -8.6 phosphoadenosine phosphosulfate reductase family protein compare
MMP_RS00295 -1.7 -4.9 gamma carbonic anhydrase family protein compare
MMP_RS07445 -1.7 -7.2 helix-turn-helix domain-containing protein compare
MMP_RS07005 -1.7 -1.1 4Fe-4S binding protein compare
MMP_RS07730 -1.6 -3.3 pyruvate synthase subunit beta compare
MMP_RS06400 -1.6 -2.8 4Fe-4S binding protein compare
MMP_RS07755 -1.6 -1.7 DUF555 domain-containing protein compare
MMP_RS06020 -1.5 -5.2 archaeoflavoprotein AfpA compare
MMP_RS04585 -1.5 -8.2 AIR synthase related protein compare
MMP_RS04780 -1.5 -2.9 ribonuclease P compare
MMP_RS06705 -1.5 -5.8 formate/nitrite transporter family protein compare
MMP_RS01325 -1.5 -3.1 dihydroneopterin aldolase family protein compare
MMP_RS03025 -1.5 -6.1 molybdenum cofactor guanylyltransferase compare
MMP_RS01755 -1.5 -2.4 DUF2097 domain-containing protein compare
MMP_RS03600 -1.4 -2.7 triose-phosphate isomerase compare
MMP_RS07545 -1.4 -2.0 HTH domain-containing protein compare
MMP_RS06270 -1.4 -6.3 TIGR00300 family protein compare
MMP_RS06895 -1.4 -2.7 selenocysteine-specific translation elongation factor compare
MMP_RS03445 -1.4 -1.9 methanogenesis marker 17 protein compare
MMP_RS01800 -1.4 -5.0 TIGR00303 family protein compare
MMP_RS02355 -1.4 -3.1 30S ribosomal protein S27ae compare
MMP_RS03035 -1.4 -4.1 4-hydroxy-tetrahydrodipicolinate synthase compare
MMP_RS03435 -1.4 -2.7 ketol-acid reductoisomerase compare
MMP_RS05550 -1.3 -1.3 cation:proton antiporter compare
MMP_RS07735 -1.3 -1.5 2-ketoisovalerate ferredoxin oxidoreductase subunit alpha compare
MMP_RS02240 -1.3 -4.8 methanogenesis marker 7 protein compare
MMP_RS04710 -1.3 -1.9 hypothetical protein compare
MMP_RS07380 -1.3 -2.4 transcription elongation factor Spt5 compare
MMP_RS07630 -1.3 -2.3 ATP-binding cassette domain-containing protein compare
MMP_RS02800 -1.3 -7.1 nucleotidyltransferase domain-containing protein compare
MMP_RS06475 -1.3 -5.9 FAD-dependent oxidoreductase compare
MMP_RS03475 -1.3 -1.0 hypothetical protein compare
MMP_RS00685 -1.3 -4.1 2-phospho-L-lactate guanylyltransferase compare
MMP_RS05245 -1.3 -8.6 archaeosine biosynthesis radical SAM protein RaSEA compare
MMP_RS07525 -1.3 -8.3 4Fe-4S binding protein compare
MMP_RS07765 -1.2 -7.8 sodium:alanine symporter family protein compare
MMP_RS00305 -1.2 -2.9 phosphoribosyl-ATP diphosphatase compare
MMP_RS00300 -1.2 -1.1 6 7-dimethyl-8-ribityllumazine synthase compare
MMP_RS01795 -1.2 -2.0 methanogenesis marker 6 protein compare
MMP_RS07200 -1.2 -5.6 [5-(aminomethyl)furan-3-yl]methyl phosphate kinase compare
MMP_RS01610 -1.2 -4.1 hypothetical protein compare
MMP_RS08435 -1.2 -3.4 Era-like GTP-binding protein compare
MMP_RS02135 -1.2 -3.6 DUF5612 domain-containing protein compare
MMP_RS01180 -1.2 -1.8 XTP/dITP diphosphatase compare
MMP_RS08200 -1.2 -10.0 archaeosine synthase subunit alpha compare
MMP_RS08715 -1.1 -2.7 formylmethanofuran dehydrogenase subunit B compare
MMP_RS00110 -1.1 -3.7 hypothetical protein compare
MMP_RS07600 -1.1 -3.1 Ni-sirohydrochlorin a c-diamide synthase compare
MMP_RS06630 -1.1 -1.5 UPF0058 family protein compare
MMP_RS02235 -1.1 -8.9 CBS domain-containing protein compare
MMP_RS04890 -1.1 -0.9 adenylyltransferase/cytidyltransferase family protein compare
MMP_RS00810 -1.1 -6.2 topoisomerase DNA-binding C4 zinc finger domain-containing protein compare
MMP_RS06625 -1.1 -2.6 DNA primase compare
MMP_RS02345 -1.1 -3.3 GTP-dependent dephospho-CoA kinase family protein compare
MMP_RS01365 -1.1 -2.8 archaeal proteasome endopeptidase complex subunit alpha compare
MMP_RS06120 -1.1 -2.4 UPF0147 family protein compare
MMP_RS05540 -1.1 -4.5 hypothetical protein compare
MMP_RS03400 -1.1 -4.0 archease compare
MMP_RS00695 -1.1 -1.4 biotin--[acetyl-CoA-carboxylase] ligase compare
MMP_RS06315 -1.0 -1.4 cobalt-precorrin-7 (C(5))-methyltransferase compare
MMP_RS06730 -1.0 -1.7 phosphopantothenate/pantothenate synthetase compare
MMP_RS08645 -1.0 -5.9 UPF0179 family protein compare
MMP_RS07750 -1.0 -3.5 DUF357 domain-containing protein compare
MMP_RS01980 -1.0 -8.2 trimeric intracellular cation channel family protein compare
MMP_RS08790 -1.0 -2.5 translation initiation factor IF-2 subunit alpha compare
MMP_RS05510 -1.0 -5.6 Rrf2 family transcriptional regulator compare
MMP_RS00290 -1.0 -4.8 hypothetical protein compare
MMP_RS01700 -1.0 -1.3 dihydroxy-acid dehydratase compare
MMP_RS02190 -1.0 -2.5 sulfopyruvate decarboxylase subunit alpha compare
MMP_RS07580 -1.0 -3.3 DUF356 domain-containing protein compare
MMP_RS09020 -0.9 -2.0 hypothetical protein compare
MMP_RS03640 -0.9 -3.9 archaeal proteasome endopeptidase complex subunit beta compare
MMP_RS01385 -0.9 -0.9 imidazole glycerol phosphate synthase subunit HisH compare
MMP_RS00515 -0.9 -1.5 DUF655 domain-containing protein compare
MMP_RS02165 -0.9 -5.8 tRNA-dihydrouridine synthase compare
MMP_RS00315 -0.9 -4.7 Nif3-like dinuclear metal center hexameric protein compare
MMP_RS06865 -0.9 -2.0 HypC/HybG/HupF family hydrogenase formation chaperone compare
MMP_RS05555 -0.9 -1.9 DUF4040 domain-containing protein compare
MMP_RS07365 -0.9 -7.3 2-phosphoglycerate kinase compare
MMP_RS06285 -0.9 -2.5 precorrin-6Y C5 15-methyltransferase (decarboxylating) subunit CbiT compare
MMP_RS01225 -0.9 -4.6 DUF5379 domain-containing protein compare
MMP_RS03095 -0.8 -6.0 diphthine synthase compare
MMP_RS04605 -0.8 -4.7 cobalt ECF transporter T component CbiQ compare
MMP_RS08320 -0.8 -4.8 molybdopterin molybdotransferase MoeA compare
MMP_RS08165 -0.8 -2.1 phosphoglycerate dehydrogenase compare
MMP_RS06105 -0.8 -5.6 hydrogenase maturation peptidase HycI compare
MMP_RS03470 -0.8 -5.5 phosphoadenosine phosphosulfate reductase family protein compare
MMP_RS01830 -0.8 -1.4 tRNA-Val compare
MMP_RS05445 -0.8 -5.9 CoB--CoM heterodisulfide reductase subunit B compare
MMP_RS07700 -0.8 -5.8 DUF1188 domain-containing protein compare
MMP_RS05430 -0.8 -3.5 TIGR00288 family NYN domain-containing protein compare
MMP_RS01250 -0.8 -3.5 tRNA (guanine(26)-N(2))-dimethyltransferase compare
MMP_RS05815 -0.8 -1.6 NOL1/NOP2/sun family putative RNA methylase compare
MMP_RS08915 -0.8 -1.8 2 5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase compare
MMP_RS01240 -0.8 -0.9 7-cyano-7-deazaguanine synthase QueC compare
MMP_RS00985 -0.8 -3.1 CDC48 family AAA ATPase compare
MMP_RS05250 -0.8 -1.6 NFYB/HAP3 family transcription factor subunit compare
MMP_RS07390 -0.8 -2.1 cell division protein FtsZ compare
MMP_RS06925 -0.7 -1.9 ribonuclease VapC4 compare
MMP_RS02875 -0.7 -5.3 chorismate pyruvate-lyase family protein compare
MMP_RS05425 -0.7 -3.9 monovalent cation/H+ antiporter complex subunit F compare
MMP_RS07605 -0.7 -2.1 diadenylate cyclase compare
MMP_RS03580 -0.7 -2.4 signal recognition particle-docking protein FtsY compare
MMP_RS00620 -0.7 -5.7 4Fe-4S binding protein compare
MMP_RS03385 -0.7 -1.2 cation diffusion facilitator family transporter compare
MMP_RS01720 -0.7 -1.1 replication factor C large subunit compare
MMP_RS04850 -0.7 -6.2 UPF0254 family protein compare
MMP_RS00735 -0.7 -3.6 5 10-methenyltetrahydromethanopterin hydrogenase compare
MMP_RS03960 -0.7 -0.8 hypothetical protein compare
MMP_RS02885 -0.7 -5.7 molybdopterin biosynthesis protein compare
MMP_RS02340 -0.7 -0.7 DNA-directed RNA polymerase subunit E'' compare
MMP_RS05345 -0.7 -3.1 hypothetical protein compare
MMP_RS05265 -0.7 -2.0 2-isopropylmalate synthase compare
MMP_RS05765 -0.7 -2.7 M42 family metallopeptidase compare
MMP_RS00320 -0.7 -2.1 class I SAM-dependent methyltransferase compare
MMP_RS05845 -0.7 -1.4 tRNA-intron lyase compare
MMP_RS06230 -0.7 -1.5 helix-turn-helix domain-containing protein compare
MMP_RS03555 -0.7 -4.3 transcriptional regulator compare
MMP_RS08330 -0.7 -3.7 NADH-quinone oxidoreductase subunit H compare
MMP_RS07425 -0.7 -3.2 GTP-binding protein compare
MMP_RS02900 -0.7 -0.5 imidazoleglycerol-phosphate dehydratase HisB compare
MMP_RS01890 -0.6 -3.6 nucleotide sugar dehydrogenase compare
MMP_RS03155 -0.6 -4.2 precorrin-6A reductase compare
MMP_RS00730 -0.6 -3.1 5 10-methenyltetrahydromethanopterin hydrogenase cofactor biosynthesis protein HmdB compare
MMP_RS04955 -0.6 -3.1 DNA topoisomerase I compare
MMP_RS08240 -0.6 -4.0 methanogenesis marker 16 metalloprotein compare
MMP_RS07625 -0.6 -2.3 cobalt ECF transporter T component CbiQ compare
MMP_RS05060 -0.6 -4.8 AAA family ATPase compare
MMP_RS07695 -0.6 -3.3 DUF3236 domain-containing protein compare
MMP_RS08675 -0.6 -2.7 class III signal peptide-containing protein compare
MMP_RS00725 -0.6 -3.8 5 10-methenyltetrahydromethanopterin hydrogenase cofactor biosynthesis protein HmdC compare
MMP_RS00060 -0.6 -0.8 3-dehydroquinate synthase II compare
MMP_RS01380 -0.6 -1.7 PHP domain-containing protein compare
MMP_RS06885 -0.6 -1.7 50S ribosome-binding GTPase compare
MMP_RS00040 -0.6 -3.5 TIGR03576 family pyridoxal phosphate-dependent enzyme compare
MMP_RS01665 -0.6 -2.6 DUF2111 domain-containing protein compare
MMP_RS08070 -0.6 -4.1 DUF2096 domain-containing protein compare
MMP_RS01985 -0.6 -2.1 F420-dependent methylenetetrahydromethanopterin dehydrogenase compare
MMP_RS07190 -0.5 -3.3 chromosome segregation protein SMC compare
MMP_RS00345 -0.5 -3.7 DUF2666 domain-containing protein compare
MMP_RS08725 -0.5 -1.8 Ni/Fe hydrogenase subunit alpha compare
MMP_RS02470 -0.5 -0.7 helix-turn-helix transcriptional regulator compare
MMP_RS08290 -0.5 -3.2 DNA-binding protein Alba compare
MMP_RS02245 -0.5 -1.8 hypothetical protein compare
MMP_RS01780 -0.5 -2.8 TrmJ/YjtD family RNA methyltransferase compare
MMP_RS05090 -0.5 -3.7 CO dehydrogenase/CO-methylating acetyl-CoA synthase complex subunit beta compare
MMP_RS07685 -0.5 -3.5 TIGR01212 family radical SAM protein compare
MMP_RS05545 -0.5 -2.0 pyridoxal phosphate-dependent aminotransferase compare
MMP_RS00915 -0.5 -3.2 DUF116 domain-containing protein compare
MMP_RS04615 -0.5 -2.7 PDGLE domain-containing protein compare
MMP_RS01030 -0.5 -2.3 MTAP family purine nucleoside phosphorylase compare
MMP_RS03210 -0.5 -4.2 tRNA guanosine(15) transglycosylase TgtA compare
MMP_RS00520 -0.5 -1.2 RNA polymerase Rpb4 family protein compare
MMP_RS00675 -0.5 -1.0 nitroreductase family protein compare
MMP_RS01965 -0.5 -2.1 DUF1616 domain-containing protein compare
MMP_RS07535 -0.5 -3.3 4Fe-4S binding protein compare
MMP_RS01100 -0.5 -1.4 ABC transporter ATP-binding protein compare
MMP_RS02605 -0.5 -0.8 MotA/TolQ/ExbB proton channel family protein compare
MMP_RS05075 -0.5 -3.8 acetyl-CoA decarbonylase/synthase complex subunit gamma compare
MMP_RS00720 -0.5 -3.1 metal-dependent hydrolase compare
MMP_RS06395 -0.5 -1.5 ThiF family adenylyltransferase compare
MMP_RS06855 -0.5 -3.3 hypothetical protein compare
MMP_RS06940 -0.5 -1.7 polyprenyl diphosphate synthase compare


Specific Phenotypes

None in this experiment

For Methanococcus maripaludis S2 in stress experiments

For stress Trimethoprim across organisms