Experiment set5IT033 for Klebsiella michiganensis M5al

Compare to:

L-Sorbose carbon source

200 most important genes:

  gene name fitness t score description  
BWI76_RS18930 -9.0 -5.1 histidinol-phosphate transaminase compare
BWI76_RS18950 -7.6 -5.0 imidazole glycerol phosphate synthase cyclase subunit compare
BWI76_RS24285 -7.1 -4.9 cystathionine beta-lyase compare
BWI76_RS18935 -7.0 -7.7 bifunctional imidazole glycerol-phosphate dehydratase/histidinol phosphatase compare
BWI76_RS04160 -6.8 -7.4 phosphoserine phosphatase compare
BWI76_RS18920 -6.7 -4.5 ATP phosphoribosyltransferase compare
BWI76_RS11855 -6.7 -7.9 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase compare
BWI76_RS00850 -6.7 -6.6 acetylglutamate kinase compare
BWI76_RS21475 -6.5 -6.5 bifunctional chorismate mutase/prephenate dehydrogenase compare
BWI76_RS04255 -6.3 -6.2 threonine synthase compare
BWI76_RS05015 -6.2 -4.2 transcriptional regulator compare
BWI76_RS04470 -6.2 -9.5 carbamoyl phosphate synthase large subunit compare
BWI76_RS04675 -6.2 -5.5 3-isopropylmalate dehydrogenase compare
BWI76_RS00835 -6.1 -11.7 phosphoenolpyruvate carboxylase compare
BWI76_RS20350 -6.1 -6.9 amidophosphoribosyltransferase compare
BWI76_RS05840 -6.0 -5.2 glutamate 5-kinase compare
BWI76_RS00805 -6.0 -4.0 5,10-methylenetetrahydrofolate reductase compare
BWI76_RS00855 -6.0 -7.1 argininosuccinate lyase compare
BWI76_RS04665 -5.9 -18.6 3-isopropylmalate dehydratase small subunit compare
BWI76_RS04685 -5.8 -11.2 putative leucine operon leader peptide compare
BWI76_RS08385 -5.8 -2.9 citrate (Si)-synthase compare
BWI76_RS01750 -5.8 -15.4 Cro/Cl family transcriptional regulator compare
BWI76_RS20995 -5.7 -3.8 RNA degradosome polyphosphate kinase compare
BWI76_RS23360 -5.7 -3.5 diaminopimelate decarboxylase compare
BWI76_RS21265 -5.6 -10.5 phosphoribosylformylglycinamidine synthase compare
BWI76_RS09755 -5.5 -9.5 phosphoserine transaminase compare
BWI76_RS01655 -5.5 -5.8 homoserine O-succinyltransferase compare
BWI76_RS26455 -5.5 -2.6 4-amino-4-deoxy-L-arabinose-phospho-UDP flippase compare
BWI76_RS04250 -5.5 -6.3 homoserine kinase compare
BWI76_RS17720 -5.4 -1.8 muramoyltetrapeptide carboxypeptidase compare
BWI76_RS22805 -5.4 -9.1 GTP diphosphokinase compare
BWI76_RS11840 -5.4 -2.5 tryptophan synthase subunit alpha compare
BWI76_RS26085 -5.4 -3.2 3-dehydroquinate synthase compare
BWI76_RS23220 -5.3 -8.1 amino-acid N-acetyltransferase compare
BWI76_RS01615 -5.3 -11.2 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/inosine monophosphate cyclohydrolase compare
BWI76_RS23330 -5.3 -6.3 transcriptional regulator GalR compare
BWI76_RS26190 -5.3 -6.3 glycerol-3-phosphate dehydrogenase compare
BWI76_RS18955 -5.3 -5.9 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase compare
BWI76_RS27385 -5.2 -5.1 orotate phosphoribosyltransferase compare
BWI76_RS04245 -5.2 -14.5 bifunctional aspartate kinase/homoserine dehydrogenase I compare
BWI76_RS17065 -5.2 -10.5 phosphoenolpyruvate synthase compare
BWI76_RS27390 -5.1 -5.5 ribonuclease PH compare
BWI76_RS11965 -5.1 -5.1 orotidine-5'-phosphate decarboxylase compare
BWI76_RS04645 -5.1 -5.8 3-dehydroquinase compare
BWI76_RS27510 -5.0 -6.0 aquaporin compare
BWI76_RS00785 -5.0 -6.0 cystathionine gamma-synthase compare
BWI76_RS04680 -5.0 -11.9 2-isopropylmalate synthase compare
BWI76_RS11850 -5.0 -6.8 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase compare
BWI76_RS09645 -5.0 -1.7 thioredoxin-disulfide reductase compare
BWI76_RS00240 -4.9 -3.3 FMN-binding protein MioC compare
BWI76_RS18940 -4.9 -5.6 imidazole glycerol phosphate synthase subunit HisH compare
BWI76_RS26685 -4.9 -6.7 glutathione-disulfide reductase compare
BWI76_RS20895 -4.9 -5.0 phosphoribosylaminoimidazolesuccinocarboxamide synthase compare
BWI76_RS22755 -4.9 -7.5 phosphoadenosine phosphosulfate reductase compare
BWI76_RS07065 -4.9 -7.6 5-(carboxyamino)imidazole ribonucleotide synthase compare
BWI76_RS05835 -4.8 -4.0 gamma-glutamyl-phosphate reductase compare
BWI76_RS10990 -4.7 -3.9 dihydroorotase compare
BWI76_RS04670 -4.6 -9.7 3-isopropylmalate dehydratase large subunit compare
BWI76_RS00965 -4.6 -1.6 acetolactate synthase 2 small subunit compare
BWI76_RS18925 -4.6 -6.1 histidinol dehydrogenase compare
BWI76_RS00990 -4.5 -7.5 ketol-acid reductoisomerase compare
BWI76_RS25115 -4.5 -5.6 argininosuccinate synthase compare
BWI76_RS01720 -4.5 -6.6 L-sorbose 1-phosphate reductase (EC 1.1.1.-) (from data) compare
BWI76_RS23920 -4.5 -4.6 D-3-phosphoglycerate dehydrogenase compare
BWI76_RS04465 -4.5 -5.2 carbamoyl-phosphate synthase small subunit compare
BWI76_RS00140 -4.4 -1.5 phosphate transport system regulator PhoU compare
BWI76_RS09910 -4.4 -14.3 dihydroorotate dehydrogenase (quinone) compare
BWI76_RS11860 -4.4 -8.0 anthranilate synthase component I compare
BWI76_RS00980 -4.4 -8.7 PLP-dependent threonine dehydratase compare
BWI76_RS03010 -4.3 -6.3 ornithine carbamoyltransferase compare
BWI76_RS02530 -4.3 -2.9 tRNA dimethylallyltransferase compare
BWI76_RS27515 -4.3 -13.8 glycerol kinase compare
BWI76_RS21465 -4.2 -4.5 bifunctional chorismate mutase/prephenate dehydratase compare
BWI76_RS26460 -4.2 -4.4 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE compare
BWI76_RS04240 -4.2 -1.7 thr operon leader peptide compare
BWI76_RS22765 -4.2 -13.6 sulfite reductase subunit alpha compare
BWI76_RS01730 -4.2 -13.4 PTS mannose/fructose/sorbose transporter subunit IIC compare
BWI76_RS11845 -4.2 -2.3 tryptophan synthase subunit beta compare
BWI76_RS00845 -4.1 -6.7 N-acetyl-gamma-glutamyl-phosphate reductase compare
BWI76_RS07070 -4.0 -6.4 5-(carboxyamino)imidazole ribonucleotide mutase compare
BWI76_RS23240 -3.9 -2.7 exonuclease V subunit gamma compare
BWI76_RS25065 -3.9 -4.4 polyribonucleotide nucleotidyltransferase compare
BWI76_RS01200 -3.8 -2.6 diaminopimelate epimerase compare
BWI76_RS04705 -3.8 -8.4 DNA-binding transcriptional regulator FruR compare
BWI76_RS00975 -3.8 -5.0 dihydroxy-acid dehydratase compare
BWI76_RS01350 -3.8 -1.3 NAD(P)H-flavin reductase compare
BWI76_RS02735 -3.8 -5.1 3'(2'),5'-bisphosphate nucleotidase CysQ compare
BWI76_RS01725 -3.8 -6.8 PTS mannose/fructose/sorbose family transporter subunit IID compare
BWI76_RS01610 -3.7 -4.5 phosphoribosylamine--glycine ligase compare
BWI76_RS09635 -3.7 -2.9 amino acid ABC transporter ATP-binding protein compare
BWI76_RS20435 -3.7 -1.8 chorismate synthase compare
BWI76_RS22760 -3.7 -6.1 sulfite reductase subunit beta compare
BWI76_RS02995 -3.7 -6.1 aspartate carbamoyltransferase compare
BWI76_RS24075 -3.6 -5.7 glutathione synthase compare
BWI76_RS20355 -3.6 -4.8 colicin V production protein compare
BWI76_RS05200 -3.6 -3.4 bifunctional uridylyltransferase/uridylyl-removing protein compare
BWI76_RS09760 -3.5 -2.8 3-phosphoshikimate 1-carboxyvinyltransferase compare
BWI76_RS25070 -3.5 -1.7 hypothetical protein compare
BWI76_RS03080 -3.5 -4.9 (Fe-S)-cluster assembly protein compare
BWI76_RS09615 -3.3 -3.0 ATP-dependent Clp protease ATP-binding subunit ClpA compare
BWI76_RS00985 -3.3 -6.1 transcriptional regulator IlvY compare
BWI76_RS25645 -3.3 -7.0 shikimate dehydrogenase compare
BWI76_RS04270 -3.3 -4.9 transaldolase compare
BWI76_RS00400 -3.3 -1.8 glutamine synthetase compare
BWI76_RS01745 -3.3 -12.8 Sorbitol-6-phosphate 2-dehydrogenase (EC 1.1.1.140) (from data) compare
BWI76_RS09660 -3.2 -2.9 DNA translocase FtsK compare
BWI76_RS20965 -3.2 -2.7 phosphoribosylformylglycinamidine cyclo-ligase compare
BWI76_RS01185 -3.1 -2.1 adenylate cyclase compare
BWI76_RS23885 -3.0 -2.0 2-octaprenylphenol hydroxylase compare
BWI76_RS27075 -3.0 -7.0 IclR family transcriptional regulator compare
BWI76_RS21140 -2.9 -3.2 molecular chaperone HscA compare
BWI76_RS25335 -2.9 -3.8 stringent starvation protein A compare
BWI76_RS23365 -2.9 -3.0 LysR family transcriptional regulator compare
BWI76_RS01740 -2.9 -4.1 PTS enzyme IIAB, mannose-specific compare
BWI76_RS20650 -2.8 -1.9 phosphoenolpyruvate--protein phosphotransferase compare
BWI76_RS09640 -2.8 -6.5 cysteine/glutathione ABC transporter permease/ATP-binding protein CydD compare
BWI76_RS08395 -2.8 -2.3 succinate dehydrogenase cytochrome b556 large subunit compare
BWI76_RS19730 -2.8 -3.1 1-phosphofructokinase compare
BWI76_RS26055 -2.7 -7.2 siroheme synthase compare
BWI76_RS26000 -2.7 -7.2 aspartate aminotransferase family protein compare
BWI76_RS08605 -2.6 -2.7 phosphoglyceromutase compare
BWI76_RS23230 -2.6 -3.8 exodeoxyribonuclease V subunit beta compare
BWI76_RS22690 -2.5 -2.1 adenylyl-sulfate kinase compare
BWI76_RS01735 -2.5 -13.1 PTS mannose/fructose/sorbose family transporter subunit IIB compare
BWI76_RS01800 -2.4 -3.6 glucose-6-phosphate isomerase compare
BWI76_RS16200 -2.3 -2.2 NAD(P) transhydrogenase subunit beta compare
BWI76_RS25320 -2.3 -5.9 glutamate synthase compare
BWI76_RS20640 -2.3 -4.7 cysteine synthase A compare
BWI76_RS16275 -2.2 -2.7 fumarate hydratase FumA compare
BWI76_RS08520 -2.2 -2.9 colicin transporter TolQ compare
BWI76_RS08500 -2.2 -3.7 cytochrome d ubiquinol oxidase subunit 2 compare
BWI76_RS08495 -2.1 -4.2 cytochrome bd-I ubiquinol oxidase subunit I compare
BWI76_RS08405 -2.1 -1.6 succinate dehydrogenase flavoprotein subunit compare
BWI76_RS17980 -2.1 -4.4 RNA chaperone ProQ compare
BWI76_RS22120 -2.0 -8.6 glutamate--cysteine ligase compare
BWI76_RS19025 -2.0 -8.3 phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating) compare
BWI76_RS22230 -2.0 -5.9 Sorbitol-6-phosphate 2-dehydrogenase (EC 1.1.1.140) (from data) compare
BWI76_RS23480 -1.9 -8.7 EAL domain-containing protein compare
BWI76_RS12090 -1.9 -2.2 HNH endonuclease compare
BWI76_RS17975 -1.9 -3.4 tail-specific protease compare
BWI76_RS01210 -1.9 -1.4 tyrosine recombinase XerC compare
BWI76_RS25920 -1.9 -1.6 peptidylprolyl isomerase compare
BWI76_RS04530 -1.9 -1.8 peptidylprolyl isomerase SurA compare
BWI76_RS15825 -1.9 -2.3 hypothetical protein compare
BWI76_RS02410 -1.9 -2.1 EF-P beta-lysylation protein EpmB compare
BWI76_RS27430 -1.9 -1.4 (p)ppGpp synthetase compare
BWI76_RS04100 -1.8 -4.2 peptide chain release factor 3 compare
BWI76_RS00380 -1.8 -6.9 oxygen-independent coproporphyrinogen III oxidase compare
BWI76_RS08425 -1.8 -3.7 succinyl-CoA ligase subunit beta compare
BWI76_RS09655 -1.8 -6.1 leucine-responsive regulatory protein compare
BWI76_RS04625 -1.8 -1.7 glucose uptake inhibitor SgrT compare
BWI76_RS21370 -1.8 -1.9 ATP-dependent RNA helicase SrmB compare
BWI76_RS22695 -1.8 -4.7 sulfate adenylyltransferase compare
BWI76_RS04510 -1.8 -1.4 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) compare
BWI76_RS06525 -1.7 -2.2 ATP-dependent Clp protease proteolytic subunit compare
BWI76_RS04620 -1.7 -7.3 transcriptional regulator SgrR compare
BWI76_RS07305 -1.7 -4.8 sucrose operon repressor compare
BWI76_RS04955 -1.7 -1.7 hypoxanthine phosphoribosyltransferase compare
BWI76_RS01070 -1.7 -3.1 thiol reductase thioredoxin compare
BWI76_RS16205 -1.7 -5.1 NAD(P) transhydrogenase subunit alpha compare
BWI76_RS07465 -1.7 -2.1 TetR family transcriptional regulator compare
BWI76_RS00345 -1.7 -2.3 protein disulfide oxidoreductase DsbA compare
BWI76_RS25315 -1.7 -8.7 glutamate synthase large subunit compare
BWI76_RS19690 -1.7 -2.4 LysR family transcriptional regulator compare
BWI76_RS24900 -1.7 -1.9 DeoR family transcriptional regulator compare
BWI76_RS25425 -1.6 -1.7 arginine repressor compare
BWI76_RS00960 -1.6 -4.0 acetolactate synthase 2 catalytic subunit compare
BWI76_RS01385 -1.6 -1.9 potassium transporter compare
BWI76_RS01110 -1.6 -2.6 TDP-fucosamine acetyltransferase compare
BWI76_RS19495 -1.6 -1.4 ABC transporter, quaternary amine uptake transporter (QAT) family, ATP-binding protein compare
BWI76_RS00390 -1.6 -2.9 two-component system sensor histidine kinase NtrB compare
BWI76_RS13965 -1.6 -2.9 binding-protein-dependent transport system inner membrane protein compare
BWI76_RS15955 -1.5 -8.3 transcriptional regulator compare
BWI76_RS21375 -1.5 -1.4 autonomous glycyl radical cofactor GrcA compare
BWI76_RS25960 -1.5 -3.0 NUDIX hydrolase compare
BWI76_RS21685 -1.5 -1.4 hypothetical protein compare
BWI76_RS25280 -1.5 -1.7 RNase adaptor protein RapZ compare
BWI76_RS01715 -1.5 -4.0 shikimate 5-dehydrogenase compare
BWI76_RS21480 -1.5 -3.0 phospho-2-dehydro-3-deoxyheptonate aldolase compare
BWI76_RS15060 -1.4 -3.9 MarR family transcriptional regulator compare
BWI76_RS13595 -1.4 -3.5 transcriptional regulator compare
BWI76_RS15685 -1.4 -2.2 hypothetical protein compare
BWI76_RS01080 -1.4 -6.3 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase compare
BWI76_RS12570 -1.4 -3.0 DUF1365 domain-containing protein compare
BWI76_RS17190 -1.4 -2.2 TonB system transport protein TonB compare
BWI76_RS20440 -1.4 -2.0 50S ribosomal protein L3 N(5)-glutamine methyltransferase compare
BWI76_RS19735 -1.4 -3.5 bifunctional PTS fructose transporter subunit IIA/HPr protein compare
BWI76_RS14435 -1.4 -1.2 glutamine ABC transporter ATP-binding protein compare
BWI76_RS21310 -1.4 -1.0 DNA repair protein RecO compare
BWI76_RS15715 -1.4 -2.4 putative ninG protein compare
BWI76_RS16910 -1.4 -1.2 2-keto-4-pentenoate hydratase compare
BWI76_RS08580 -1.4 -2.7 quinolinate synthetase compare
BWI76_RS15695 -1.4 -2.7 hypothetical protein compare
BWI76_RS01115 -1.3 -2.4 dTDP-4-amino-4,6-dideoxygalactose transaminase compare
BWI76_RS08430 -1.3 -4.4 succinate--CoA ligase subunit alpha compare
BWI76_RS02985 -1.3 -3.9 reactive intermediate/imine deaminase compare
BWI76_RS08535 -1.3 -1.6 translocation protein TolB compare
BWI76_RS02610 -1.3 -3.2 transcriptional regulator compare
BWI76_RS05120 -1.3 -5.3 bifunctional glycosyl transferase/transpeptidase compare
BWI76_RS03295 -1.3 -1.1 transposase compare


Specific Phenotypes

For 12 genes in this experiment

For carbon source L-(-)-sorbose in Klebsiella michiganensis M5al

For carbon source L-(-)-sorbose across organisms