Experiment set5IT004 for Methanococcus maripaludis S2

Compare to:

Formate with Nalidixic acid 6.25 mM

200 most important genes:

  gene name fitness t score description  
MMP_RS01175 -3.7 -6.4 triphosphoribosyl-dephospho-CoA synthase compare
MMP_RS06355 -3.7 -7.0 molybdenum cofactor biosynthesis protein MoaE compare
MMP_RS06700 -3.3 -18.6 hypothetical protein compare
MMP_RS01020 -3.3 -2.6 3 4-dihydroxy-2-butanone-4-phosphate synthase compare
MMP_RS01005 -3.2 -2.9 riboflavin synthase compare
MMP_RS06685 -3.1 -12.3 formate dehydrogenase H subunit alpha selenocysteine-containing compare
MMP_RS06680 -3.1 -19.2 Coenzyme F420 hydrogenase/dehydrogenase beta subunit C-terminal domain compare
MMP_RS02010 -3.0 -12.9 PHP domain-containing protein compare
MMP_RS05515 -2.9 -12.7 cyclic pyranopterin monophosphate synthase MoaC compare
MMP_RS06345 -2.7 -18.3 formate dehydrogenase accessory sulfurtransferase FdhD compare
MMP_RS06350 -2.7 -12.0 HesA/MoeB/ThiF family protein compare
MMP_RS02900 -2.6 -1.3 imidazoleglycerol-phosphate dehydratase HisB compare
MMP_RS07635 -2.6 -10.6 MogA/MoaB family molybdenum cofactor biosynthesis protein compare
MMP_RS03015 -2.6 -16.0 GTP 3' 8-cyclase MoaA compare
MMP_RS02195 -2.6 -8.6 tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase compare
MMP_RS08820 -2.5 -10.0 hypothetical protein compare
MMP_RS07730 -2.3 -3.9 pyruvate synthase subunit beta compare
MMP_RS01265 -2.3 -3.3 hypothetical protein compare
MMP_RS08720 -2.2 -3.0 4Fe-4S binding protein compare
MMP_RS08635 -2.2 -3.4 UbiA family prenyltransferase compare
MMP_RS07845 -2.2 -5.8 LL-diaminopimelate aminotransferase compare
MMP_RS05920 -2.2 -1.6 50S ribosomal protein L37e compare
MMP_RS06730 -2.2 -3.3 phosphopantothenate/pantothenate synthetase compare
MMP_RS03025 -2.1 -7.7 molybdenum cofactor guanylyltransferase compare
MMP_RS00685 -2.1 -5.1 2-phospho-L-lactate guanylyltransferase compare
MMP_RS06715 -2.1 -15.9 cache domain-containing protein compare
MMP_RS03315 -2.1 -2.7 ferrous iron transport protein A compare
MMP_RS08745 -2.1 -7.9 CDP-2 3-bis-(O-geranylgeranyl)-sn-glycerol synthase compare
MMP_RS06630 -2.1 -2.1 UPF0058 family protein compare
MMP_RS01220 -2.1 -11.0 hypothetical protein compare
MMP_RS06705 -2.0 -12.7 formate/nitrite transporter family protein compare
MMP_RS03205 -2.0 -1.6 peptidyl-tRNA hydrolase Pth2 compare
MMP_RS06720 -2.0 -11.2 response regulator transcription factor compare
MMP_RS06400 -1.9 -3.2 4Fe-4S binding protein compare
MMP_RS06230 -1.8 -4.1 helix-turn-helix domain-containing protein compare
MMP_RS04780 -1.8 -4.8 ribonuclease P compare
MMP_RS07445 -1.8 -5.9 helix-turn-helix domain-containing protein compare
MMP_RS01610 -1.8 -6.2 hypothetical protein compare
MMP_RS06295 -1.8 -6.7 methanogenesis marker 14 protein compare
MMP_RS07735 -1.8 -1.6 2-ketoisovalerate ferredoxin oxidoreductase subunit alpha compare
MMP_RS02355 -1.8 -3.8 30S ribosomal protein S27ae compare
MMP_RS00115 -1.7 -13.3 radical SAM protein compare
MMP_RS02280 -1.7 -1.9 DUF211 domain-containing protein compare
MMP_RS05550 -1.7 -1.5 cation:proton antiporter compare
MMP_RS06315 -1.7 -1.8 cobalt-precorrin-7 (C(5))-methyltransferase compare
MMP_RS08435 -1.7 -3.4 Era-like GTP-binding protein compare
MMP_RS05555 -1.7 -2.4 DUF4040 domain-containing protein compare
MMP_RS02135 -1.7 -5.8 DUF5612 domain-containing protein compare
MMP_RS07575 -1.7 -5.5 RNA ligase partner protein compare
MMP_RS07420 -1.6 -6.1 metalloregulator ArsR/SmtB family transcription factor compare
MMP_RS06840 -1.6 -2.1 DNA-directed RNA polymerase subunit N compare
MMP_RS07005 -1.6 -1.1 4Fe-4S binding protein compare
MMP_RS02235 -1.6 -12.3 CBS domain-containing protein compare
MMP_RS02800 -1.6 -4.7 nucleotidyltransferase domain-containing protein compare
MMP_RS08460 -1.6 -3.8 proteasome-activating nucleotidase compare
MMP_RS07755 -1.6 -2.4 DUF555 domain-containing protein compare
MMP_RS03445 -1.6 -2.0 methanogenesis marker 17 protein compare
MMP_RS07545 -1.6 -2.2 HTH domain-containing protein compare
MMP_RS01755 -1.6 -2.3 DUF2097 domain-containing protein compare
MMP_RS06285 -1.6 -3.4 precorrin-6Y C5 15-methyltransferase (decarboxylating) subunit CbiT compare
MMP_RS02240 -1.6 -4.1 methanogenesis marker 7 protein compare
MMP_RS04585 -1.6 -9.3 AIR synthase related protein compare
MMP_RS03035 -1.5 -7.1 4-hydroxy-tetrahydrodipicolinate synthase compare
MMP_RS01500 -1.5 -3.8 CBS domain-containing protein compare
MMP_RS00895 -1.5 -4.1 hypothetical protein compare
MMP_RS00300 -1.5 -1.2 6 7-dimethyl-8-ribityllumazine synthase compare
MMP_RS03475 -1.5 -1.0 hypothetical protein compare
MMP_RS07380 -1.5 -3.5 transcription elongation factor Spt5 compare
MMP_RS07525 -1.4 -9.5 4Fe-4S binding protein compare
MMP_RS05430 -1.4 -6.1 TIGR00288 family NYN domain-containing protein compare
MMP_RS03960 -1.4 -1.3 hypothetical protein compare
MMP_RS07600 -1.4 -3.1 Ni-sirohydrochlorin a c-diamide synthase compare
MMP_RS06625 -1.4 -3.2 DNA primase compare
MMP_RS04775 -1.4 -4.4 adenosylhomocysteinase compare
MMP_RS07390 -1.4 -3.7 cell division protein FtsZ compare
MMP_RS00695 -1.4 -1.6 biotin--[acetyl-CoA-carboxylase] ligase compare
MMP_RS04875 -1.4 -5.3 energy-converting hydrogenase B subunit P compare
MMP_RS00305 -1.4 -1.8 phosphoribosyl-ATP diphosphatase compare
MMP_RS05845 -1.4 -2.5 tRNA-intron lyase compare
MMP_RS05540 -1.3 -3.7 hypothetical protein compare
MMP_RS06120 -1.3 -3.3 UPF0147 family protein compare
MMP_RS09020 -1.3 -2.0 hypothetical protein compare
MMP_RS02145 -1.3 -6.3 winged helix-turn-helix transcriptional regulator compare
MMP_RS03600 -1.3 -3.2 triose-phosphate isomerase compare
MMP_RS04955 -1.2 -5.3 DNA topoisomerase I compare
MMP_RS03400 -1.2 -3.2 archease compare
MMP_RS01700 -1.2 -1.1 dihydroxy-acid dehydratase compare
MMP_RS06270 -1.2 -4.8 TIGR00300 family protein compare
MMP_RS00750 -1.2 -3.4 fumarate hydratase compare
MMP_RS06865 -1.2 -2.2 HypC/HybG/HupF family hydrogenase formation chaperone compare
MMP_RS01250 -1.2 -4.6 tRNA (guanine(26)-N(2))-dimethyltransferase compare
MMP_RS06105 -1.2 -7.0 hydrogenase maturation peptidase HycI compare
MMP_RS06110 -1.2 -4.7 ATP-dependent protease LonB compare
MMP_RS06215 -1.2 -4.4 30S ribosomal protein S6e compare
MMP_RS03640 -1.1 -4.1 archaeal proteasome endopeptidase complex subunit beta compare
MMP_RS08210 -1.1 -2.8 phosphatidylglycerophosphatase A compare
MMP_RS03435 -1.1 -2.0 ketol-acid reductoisomerase compare
MMP_RS05875 -1.1 -5.5 hydroxyethylthiazole kinase compare
MMP_RS07190 -1.1 -6.8 chromosome segregation protein SMC compare
MMP_RS01325 -1.1 -2.5 dihydroneopterin aldolase family protein compare
MMP_RS04500 -1.1 -8.6 adenosylmethionine--8-amino-7-oxononanoate transaminase compare
MMP_RS06925 -1.1 -2.2 ribonuclease VapC4 compare
MMP_RS06020 -1.1 -3.8 archaeoflavoprotein AfpA compare
MMP_RS06340 -1.1 -8.2 phosphoadenosine phosphosulfate reductase family protein compare
MMP_RS00110 -1.1 -3.1 hypothetical protein compare
MMP_RS02190 -1.1 -3.2 sulfopyruvate decarboxylase subunit alpha compare
MMP_RS07435 -1.1 -1.8 GMP synthase subunit A compare
MMP_RS01225 -1.1 -5.1 DUF5379 domain-containing protein compare
MMP_RS02875 -1.1 -6.9 chorismate pyruvate-lyase family protein compare
MMP_RS04720 -1.1 -2.5 DedA family protein compare
MMP_RS08715 -1.1 -2.3 formylmethanofuran dehydrogenase subunit B compare
MMP_RS08650 -1.1 -2.9 glutamine--fructose-6-phosphate transaminase (isomerizing) compare
MMP_RS06895 -1.0 -1.7 selenocysteine-specific translation elongation factor compare
MMP_RS04685 -1.0 -3.0 DUF126 domain-containing protein compare
MMP_RS01800 -1.0 -3.9 TIGR00303 family protein compare
MMP_RS06475 -1.0 -4.3 FAD-dependent oxidoreductase compare
MMP_RS07200 -1.0 -4.6 [5-(aminomethyl)furan-3-yl]methyl phosphate kinase compare
MMP_RS02345 -1.0 -2.3 GTP-dependent dephospho-CoA kinase family protein compare
MMP_RS06885 -1.0 -2.0 50S ribosome-binding GTPase compare
MMP_RS03095 -1.0 -5.8 diphthine synthase compare
MMP_RS01385 -1.0 -0.9 imidazole glycerol phosphate synthase subunit HisH compare
MMP_RS07555 -1.0 -1.0 monovalent cation/H+ antiporter subunit E compare
MMP_RS04870 -1.0 -4.3 TIGR02253 family HAD-type hydrolase compare
MMP_RS05930 -1.0 -2.3 3-isopropylmalate dehydratase large subunit compare
MMP_RS00720 -1.0 -6.2 metal-dependent hydrolase compare
MMP_RS00900 -1.0 -2.9 50S ribosomal protein L39e compare
MMP_RS07580 -0.9 -2.8 DUF356 domain-containing protein compare
MMP_RS08300 -0.9 -1.2 metal-sulfur cluster assembly factor compare
MMP_RS01985 -0.9 -5.4 F420-dependent methylenetetrahydromethanopterin dehydrogenase compare
MMP_RS00295 -0.9 -3.1 gamma carbonic anhydrase family protein compare
MMP_RS00915 -0.9 -4.6 DUF116 domain-containing protein compare
MMP_RS08095 -0.9 -4.0 dethiobiotin synthase compare
MMP_RS00120 -0.9 -5.2 LysR family transcriptional regulator compare
MMP_RS05815 -0.9 -2.0 NOL1/NOP2/sun family putative RNA methylase compare
MMP_RS07630 -0.9 -1.9 ATP-binding cassette domain-containing protein compare
MMP_RS01180 -0.9 -1.2 XTP/dITP diphosphatase compare
MMP_RS07790 -0.9 -6.6 segregation/condensation protein A compare
MMP_RS06175 -0.9 -5.4 winged helix-turn-helix transcriptional regulator compare
MMP_RS01840 -0.8 -5.8 TIGR00289 family protein compare
MMP_RS08320 -0.8 -4.5 molybdopterin molybdotransferase MoeA compare
MMP_RS00675 -0.8 -1.4 nitroreductase family protein compare
MMP_RS04605 -0.8 -2.6 cobalt ECF transporter T component CbiQ compare
MMP_RS00620 -0.8 -5.3 4Fe-4S binding protein compare
MMP_RS08915 -0.8 -1.4 2 5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase compare
MMP_RS08100 -0.8 -5.5 8-amino-7-oxononanoate synthase compare
MMP_RS07195 -0.8 -5.5 M20 family metallo-hydrolase compare
MMP_RS06370 -0.8 -2.4 biotin synthase BioB compare
MMP_RS01195 -0.8 -1.6 metalloregulator ArsR/SmtB family transcription factor compare
MMP_RS08105 -0.7 -4.7 6-carboxyhexanoate--CoA ligase compare
MMP_RS00290 -0.7 -4.6 hypothetical protein compare
MMP_RS01905 -0.7 -5.1 glycosyltransferase compare
MMP_RS01915 -0.7 -5.7 DUF354 domain-containing protein compare
MMP_RS05245 -0.7 -5.5 archaeosine biosynthesis radical SAM protein RaSEA compare
MMP_RS00515 -0.7 -0.7 DUF655 domain-containing protein compare
MMP_RS03580 -0.7 -3.3 signal recognition particle-docking protein FtsY compare
MMP_RS01380 -0.7 -2.2 PHP domain-containing protein compare
MMP_RS06310 -0.7 -3.3 NAD(P)/FAD-dependent oxidoreductase compare
MMP_RS02130 -0.7 -3.0 zinc metalloprotease HtpX compare
MMP_RS07645 -0.7 -4.7 aldehyde dehydrogenase family protein compare
MMP_RS01910 -0.7 -4.8 UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) compare
MMP_RS02885 -0.7 -5.5 molybdopterin biosynthesis protein compare
MMP_RS06975 -0.7 -1.6 sulfide-dependent adenosine diphosphate thiazole synthase compare
MMP_RS07090 -0.7 -4.5 tRNA (adenine-N1)-methyltransferase compare
MMP_RS05445 -0.7 -4.7 CoB--CoM heterodisulfide reductase subunit B compare
MMP_RS05265 -0.7 -1.8 2-isopropylmalate synthase compare
MMP_RS03155 -0.6 -4.2 precorrin-6A reductase compare
MMP_RS03555 -0.6 -3.9 transcriptional regulator compare
MMP_RS01920 -0.6 -5.4 glycosyltransferase family 2 protein compare
MMP_RS08165 -0.6 -0.8 phosphoglycerate dehydrogenase compare
MMP_RS01365 -0.6 -3.0 archaeal proteasome endopeptidase complex subunit alpha compare
MMP_RS02165 -0.6 -3.2 tRNA-dihydrouridine synthase compare
MMP_RS01970 -0.6 -5.1 TIGR04279 domain-containing protein compare
MMP_RS01045 -0.6 -3.7 diphthamide biosynthesis enzyme Dph2 compare
MMP_RS07365 -0.6 -4.8 2-phosphoglycerate kinase compare
MMP_RS05425 -0.6 -2.6 monovalent cation/H+ antiporter complex subunit F compare
MMP_RS08200 -0.6 -5.4 archaeosine synthase subunit alpha compare
MMP_RS08790 -0.6 -1.4 translation initiation factor IF-2 subunit alpha compare
MMP_RS01900 -0.6 -4.8 hypothetical protein compare
MMP_RS07955 -0.6 -3.1 FumA C-terminus/TtdB family hydratase beta subunit compare
MMP_RS08370 -0.6 -0.6 cation:proton antiporter subunit C compare
MMP_RS00050 -0.6 -3.2 AarF/UbiB family protein compare
MMP_RS06200 -0.6 -4.7 M24 family metallopeptidase compare
MMP_RS07750 -0.6 -1.8 DUF357 domain-containing protein compare
MMP_RS05295 -0.6 -4.1 minichromosome maintenance protein MCM compare
MMP_RS04620 -0.6 -3.8 cobalt transporter CbiM compare
MMP_RS01725 -0.6 -2.2 class I SAM-dependent methyltransferase family protein compare
MMP_RS01795 -0.6 -1.3 methanogenesis marker 6 protein compare
MMP_RS06870 -0.5 -3.2 DedA family protein compare
MMP_RS05925 -0.5 -2.2 small nuclear ribonucleoprotein compare
MMP_RS08725 -0.5 -0.9 Ni/Fe hydrogenase subunit alpha compare
MMP_RS05020 -0.5 -1.4 hypothetical protein compare
MMP_RS01100 -0.5 -1.5 ABC transporter ATP-binding protein compare
MMP_RS02170 -0.5 -2.9 CBS domain-containing protein compare
MMP_RS06940 -0.5 -1.8 polyprenyl diphosphate synthase compare
MMP_RS01925 -0.5 -3.1 DUF1616 domain-containing protein compare
MMP_RS06130 -0.5 -1.9 peptidylprolyl isomerase compare
MMP_RS01830 -0.5 -1.2 tRNA-Val compare
MMP_RS08195 -0.5 -3.6 hypothetical protein compare
MMP_RS01720 -0.5 -1.5 replication factor C large subunit compare
MMP_RS06275 -0.5 -3.5 ATP-dependent DNA helicase compare


Specific Phenotypes

None in this experiment

For Methanococcus maripaludis S2 in nutrient t1 experiments

For nutrient t1 Nalidixic acid sodium salt across organisms