Experiment set4S293 for Mycobacterium tuberculosis H37Rv

Compare to:

7H9 with Clarithromycin 0.967 ug/mL

200 most detrimental genes:

  gene name fitness t score description  
Rv2583c +1.8 3.1 Probable GTP pyrophosphokinase RelA (ATP:GTP 3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase) compare
Rv1072 +1.6 2.9 Probable conserved transmembrane protein compare
Rv1986 +1.5 2.7 Probable conserved integral membrane protein compare
Rv0563 +1.5 3.2 Probable protease transmembrane protein heat shock protein HtpX compare
Rv2072c +1.4 2.2 Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL compare
Rv0738 +1.3 2.6 Conserved protein compare
Rv0964c +1.2 1.2 Hypothetical protein compare
Rv1422 +1.2 1.6 Conserved hypothetical protein compare
Rv3331 +1.2 5.0 Probable sugar-transport integral membrane protein SugI compare
Rv0056 +1.1 2.5 50S ribosomal protein L9 RplI compare
Rv3230c +1.1 4.3 Hypothetical oxidoreductase compare
Rv3726 +1.1 2.8 Possible dehydrogenase compare
Rv2752c +1.1 2.9 Conserved hypothetical protein compare
Rv0544c +1.0 2.2 Possible conserved transmembrane protein compare
Rv3658c +1.0 0.9 Probable conserved transmembrane protein compare
Rv2898c +1.0 1.4 Conserved hypothetical protein compare
Rv3193c +0.9 2.0 Probable conserved transmembrane protein compare
Rv3716c +0.9 0.9 Conserved protein compare
Rv2563 +0.9 4.9 Probable glutamine-transport transmembrane protein ABC transporter compare
Rv1231c +0.9 2.7 Probable membrane protein compare
Rv0674 +0.9 1.0 Conserved hypothetical protein compare
Rv2065 +0.9 2.1 Precorrin-8X methylmutase CobH (aka precorrin isomerase) compare
Rv3198c +0.8 1.4 Probable ATP-dependent DNA helicase II UvrD2 compare
Rv3295 +0.8 6.7 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv1046c +0.8 1.1 Hypothetical protein compare
Rv2681 +0.8 4.6 Conserved hypothetical alanine rich protein compare
Rv0545c +0.8 3.2 Probable low-affinity inorganic phosphate transporter integral membrane protein PitA compare
Rv0911 +0.8 2.6 Conserved protein compare
Rv3236c +0.8 1.2 Probable conserved integral membrane transport protein compare
Rv1137c +0.8 1.6 Hypothetical protein compare
Rv0313 +0.8 1.4 Conserved protein compare
Rv0328 +0.7 1.4 Possible transcriptional regulatory protein (possibly TetR/AcrR-family) compare
Rv1259 +0.7 0.5 Probable uracil DNA glycosylase, UdgB compare
Rv1626 +0.7 2.8 Probable two-component system transcriptional regulator compare
Rv2348c +0.7 0.7 Hypothetical protein compare
Rv3897c +0.7 1.0 Conserved hypothetical protein compare
Rv0734 +0.7 1.8 Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) compare
Rv2721c +0.7 5.5 Possible conserved transmembrane alanine and glycine rich protein compare
Rv2923c +0.7 1.4 Conserved protein compare
Rv2619c +0.7 1.6 Conserved protein compare
Rv1140 +0.7 1.9 Probable integral membrane protein compare
Rv2049c +0.7 1.2 Conserved hypothetical protein compare
Rv1963c +0.7 1.3 Probable transcriptional repressor (probably TetR-family) Mce3R compare
Rv3397c +0.7 3.7 Probable phytoene synthase PhyA compare
Rv1286 +0.6 2.1 Probable bifunctional enzyme CysN/CysC: sulfate adenyltransferase (subunit 1) + adenylylsulfate kinase compare
Rv0933 +0.6 1.2 Phosphate-transport ATP-binding protein ABC transporter PstB compare
Rv0173 +0.6 3.7 Possible Mce-family lipoprotein LprK (Mce-family lipoprotein Mce1E) compare
Rv2774c +0.6 1.0 Hypothetical protein compare
Rv1010 +0.6 0.8 Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase) compare
Rv0561c +0.6 0.9 Possible oxidoreductase compare
Rv0171 +0.6 4.3 Mce-family protein Mce1C compare
Rv1239c +0.6 3.7 Possible magnesium and cobalt transport transmembrane protein CorA compare
Rv1190 +0.6 2.9 Conserved hypothetical protein compare
Rv1517 +0.6 2.8 Conserved hypothetical transmembrane protein compare
Rv1444c +0.6 1.8 Unknown protein compare
Rv2432c +0.6 1.4 Hypothetical protein compare
Rv0887c +0.6 0.9 Conserved hypothetical protein compare
Rv3338 +0.6 0.8 Conserved hypothetical protein compare
Rv0643c +0.6 3.9 Methoxy mycolic acid synthase 3 MmaA3 (methyl mycolic acid synthase 3) (MMA3) (hydroxy mycolic acid synthase) compare
Rv2850c +0.6 1.0 Possible magnesium chelatase compare
Rv0867c +0.6 0.4 Possible resuscitation-promoting factor RpfA compare
Rv3259 +0.6 1.5 Conserved hypothetical protein compare
Rv3375 +0.6 1.6 Probable amidase AmiD (acylamidase) (acylase) compare
Rv3856c +0.6 1.0 Conserved hypothetical protein compare
Rv1584c +0.6 1.6 Possible PhiRv1 phage protein compare
Rv3123 +0.6 1.0 Hypothetical protein compare
Rv3229c +0.6 1.7 Possible linoleoyl-CoA desaturase (delta(6)-desaturase) compare
Rv0678 +0.6 3.6 Conserved protein compare
Rv3277 +0.6 0.5 Probable conserved transmembrane protein compare
Rv2536 +0.6 3.2 Probable conserved transmembrane protein compare
Rv3481c +0.6 0.9 Probable integral membrane protein compare
Rv2586c +0.6 1.1 Probable protein-export membrane protein SecF compare
Rv0169 +0.6 3.7 Mce-family protein Mce1A compare
Rv2433c +0.6 2.0 Hypothetical protein compare
Rv0177 +0.6 1.3 Probable conserved Mce associated protein compare
Rv0088 +0.6 0.8 Possible polyketide cyclase/dehydrase compare
Rv1158c +0.5 1.2 Conserved hypothetical ala-, pro-rich protein compare
Rv1766 +0.5 0.7 Conserved protein compare
Rv0944 +0.5 1.3 Possible formamidopyrimidine-DNA glycosylase (FAPY-DNA glycosylase) compare
Rv0356c +0.5 2.9 Conserved protein compare
Rv3647c +0.5 0.7 Conserved hypothetical protein compare
Rv2450c +0.5 2.9 Probable resuscitation-promoting factor RpfE compare
Rv2644c +0.5 1.3 Hypothetical protein compare
Rv2206 +0.5 1.5 Probable conserved transmembrane protein compare
Rv0174 +0.5 2.9 Mce-family protein Mce1F compare
Rv2003c +0.5 0.7 Conserved hypothetical protein compare
Rv0316 +0.5 0.9 Possible muconolactone isomerase compare
Rv2902c +0.5 1.9 Probable ribonuclease HII protein RnhB (RNase HII) compare
Rv2722 +0.5 2.4 Conserved hypothetical protein compare
Rv2683 +0.5 1.0 Conserved protein compare
Rv3156 +0.5 2.6 Probable NADH dehydrogenase I (chain L) NuoL (NADH-ubiquinone oxidoreductase chain L) compare
Rv2261c +0.5 1.0 Conserved hypothetical protein compare
Rv0344c +0.5 1.4 Probable lipoprotein LpqJ compare
Rv1238 +0.5 1.7 Probable sugar-transport ATP-binding protein ABC transporter SugC compare
Rv2251 +0.5 2.2 Possible flavoprotein compare
Rv0080 +0.5 1.3 Conserved hypothetical protein compare
Rv2564 +0.5 2.4 Probable glutamine-transport ATP-binding protein ABC transporter GlnQ compare
Rv2702 +0.5 0.5 Polyphosphate glucokinase PpgK (polyphosphate-glucose phosphotransferase) compare
Rv1957 +0.5 0.6 Hypothetical protein compare
Rv1192 +0.5 1.9 Unknown protein compare
Rv1840c +0.5 1.2 PE-PGRS family protein PE_PGRS34 compare
Rv0057 +0.5 1.2 Hypothetical protein compare
Rv2558 +0.5 0.8 Conserved protein compare
Rv3720 +0.5 3.3 Possible fatty acid synthase compare
Rv2684 +0.5 3.0 Probable arsenic-transport integral membrane protein ArsA compare
Rv3431c +0.5 2.7 Possible transposase (fragment) compare
Rv1579c +0.5 1.5 Probable PhiRv1 phage protein compare
Rv0877 +0.5 3.0 Conserved hypothetical protein compare
Rv2039c +0.5 1.3 Probable sugar-transport integral membrane protein ABC transporter compare
Rv2901c +0.5 1.6 Conserved protein compare
Rv3263 +0.5 3.2 Probable DNA methylase (modification methylase) (methyltransferase) compare
Rv3549c +0.5 1.5 Probable short-chain type dehydrogenase/reductase compare
Rv3007c +0.5 1.3 Possible oxidoreductase compare
Rv1234 +0.5 1.5 Probable transmembrane protein compare
Rv2331A +0.5 0.8 Hypothetical protein compare
Rv2826c +0.5 2.3 Hypothetical protein compare
Rv1884c +0.5 1.1 Probable resuscitation-promoting factor RpfC compare
Rv2208 +0.5 2.7 Probable cobalamin 5'-phosphate synthase CobS compare
Rv3484 +0.5 3.6 Possible conserved protein CpsA compare
Rv2275 +0.5 1.2 Conserved hypothetical protein compare
Rv1798 +0.5 0.6 ESX conserved component EccA5. ESX-5 type VII secretion system protein. compare
Rv3664c +0.5 0.7 Probable dipeptide-transport integral membrane protein ABC transporter DppC compare
Rv2758c +0.5 0.8 Possible antitoxin VapB21 compare
Rv0889c +0.5 1.5 Probable citrate synthase II CitA compare
Rv1773c +0.5 1.3 Probable transcriptional regulatory protein compare
Rv2792c +0.5 1.3 Possible resolvase compare
Rv0608 +0.5 0.9 Possible antitoxin VapB28 compare
Rv2043c +0.5 1.4 Pyrazinamidase/nicotinamidase PncA (PZase) compare
Rv0374c +0.5 1.0 Probable carbon monoxyde dehydrogenase (small chain) compare
Rv0302 +0.5 2.0 Probable transcriptional regulatory protein (probably TetR/AcrR-family) compare
Rv0975c +0.4 2.1 Probable acyl-CoA dehydrogenase FadE13 compare
Rv0343 +0.4 2.3 Isoniazid inductible gene protein IniC compare
Rv2809 +0.4 1.2 Hypothetical protein compare
Rv3103c +0.4 2.5 Hypothetical proline-rich protein compare
Rv0323c +0.4 1.1 Conserved hypothetical protein compare
Rv1528c +0.4 1.1 Probable conserved polyketide synthase associated protein PapA4 compare
Rv3591c +0.4 0.8 Possible hydrolase compare
Rv0696 +0.4 2.0 Probable membrane sugar transferase compare
Rv0170 +0.4 1.8 Mce-family protein Mce1B compare
Rv1707 +0.4 1.8 Probable conserved transmembrane protein compare
Rv0587 +0.4 1.1 Conserved hypothetical integral membrane protein YrbE2A compare
Rv0176 +0.4 2.6 Probable conserved Mce associated transmembrane protein compare
Rv2305 +0.4 2.1 Unknown protein compare
Rv3631 +0.4 0.5 Possible transferase (possibly glycosyltransferase) compare
Rv3198A +0.4 1.5 Possible glutaredoxin protein compare
Rv2910c +0.4 2.1 Conserved hypothetical protein compare
Rv0692 +0.4 1.7 Conserved hypothetical protein compare
Rv2250c +0.4 1.2 Possible transcriptional regulatory protein compare
Rv0673 +0.4 1.3 Possible enoyl-CoA hydratase EchA4 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv0610c +0.4 0.4 Hypothetical protein compare
Rv0908 +0.4 2.0 Probable metal cation transporter ATPase P-type CtpE compare
Rv3666c +0.4 1.4 Probable periplasmic dipeptide-binding lipoprotein DppA compare
Rv1537 +0.4 1.5 Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) compare
Rv3004 +0.4 0.9 Low molecular weight protein antigen 6 (CFP-6) compare
Rv3719 +0.4 2.6 Conserved protein compare
Rv0857 +0.4 1.0 Conserved hypothetical protein compare
Rv1928c +0.4 1.6 Probable short-chain type dehydrogenase/reductase compare
Rv0655 +0.4 1.5 Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl compare
Rv0617 +0.4 0.9 Possible toxin VapC29. Contains PIN domain. compare
Rv1519 +0.4 1.0 Conserved hypothetical protein compare
Rv2044c +0.4 0.5 Conserved hypothetical protein compare
Rv1049 +0.4 0.5 Probable transcriptional repressor protein compare
Rv1912c +0.4 1.7 Possible oxidoreductase FadB5 compare
Rv2501c +0.4 2.0 Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA1: biotin carboxylase + biotin carboxyl carrier protein (BCCP) compare
Rv1448c +0.4 1.2 Probable transaldolase Tal compare
Rv1334 +0.4 2.3 Possible hydrolase compare
Rv0870c +0.4 0.6 Possible conserved integral membrane protein compare
Rv0724 +0.4 2.2 Possible protease IV SppA (endopeptidase IV) (signal peptide peptidase) compare
Rv1938 +0.4 1.6 Probable epoxide hydrolase EphB (epoxide hydratase) compare
Rv1153c +0.4 2.2 Probable O-methyltransferase Omt compare
Rv0679c +0.4 0.9 Conserved threonine rich protein compare
Rv2551c +0.4 1.0 Conserved hypothetical protein compare
Rv2041c +0.4 1.3 Probable sugar-binding lipoprotein compare
Rv0974c +0.4 1.2 Probable acetyl-/propionyl-CoA carboxylase (beta subunit) AccD2 compare
Rv2331 +0.4 1.4 Hypothetical protein compare
Rv2462c +0.4 2.0 Probable trigger factor (TF) protein Tig compare
Rv0456c +0.4 2.2 enoyl-CoA hydratase EchA2 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv3469c +0.4 1.9 Probable 4-hydroxy-2-oxovalerate aldolase MhpE (HOA) compare
Rv2621c +0.4 0.8 Possible transcriptional regulatory protein compare
Rv1171 +0.4 1.1 Conserved hypothetical protein compare
Rv1142c +0.4 2.4 Probable enoyl-CoA hydratase EchA10 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv3760 +0.4 1.0 Possible conserved membrane protein compare
Rv2277c +0.4 0.9 Possible glycerolphosphodiesterase compare
Rv2126c +0.4 1.9 PE-PGRS family protein PE_PGRS37 compare
Rv3174 +0.4 0.5 Probable short-chain dehydrogenase/reductase compare
Rv1768 +0.4 2.1 PE-PGRS family protein PE_PGRS31 compare
Rv3614c +0.4 1.1 ESX-1 secretion-associated protein EspD compare
Rv0656c +0.4 1.9 Possible toxin VapC6 compare
Rv1777 +0.4 2.4 Probable cytochrome P450 144 Cyp144 compare
Rv0571c +0.4 1.2 Conserved protein compare
Rv2042c +0.4 0.8 Conserved protein compare
Rv0927c +0.4 0.7 Probable short-chain type dehydrogenase/reductase compare
Rv0237 +0.4 1.3 Probable conserved lipoprotein LpqI compare
Rv0039c +0.4 1.7 Possible conserved transmembrane protein compare
Rv0172 +0.4 2.1 Mce-family protein Mce1D compare
Rv0554 +0.4 2.7 Possible peroxidase BpoC (non-haem peroxidase) compare
Rv3146 +0.4 1.8 Probable NADH dehydrogenase I (chain B) NuoB (NADH-ubiquinone oxidoreductase chain B) compare
Rv1591 +0.4 2.7 Probable transmembrane protein compare
Rv0345 +0.4 1.4 Conserved hypothetical protein compare
Rv1791 +0.4 0.9 PE family protein PE19 compare


Specific Phenotypes

For 5 genes in this experiment

For stress Clarithromycin in Mycobacterium tuberculosis H37Rv

For stress Clarithromycin across organisms