Experiment set4S292 for Mycobacterium tuberculosis H37Rv

200 most important genes:

gene	name	fitness	t score	description
Rv1620c		-2.3	-4.7	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC
Rv1836c		-2.2	-3.6	Conserved protein
Rv0472c		-2.1	-5.1	Probable transcriptional regulatory protein (possibly TetR-family)
Rv3920c		-1.8	-2.0	Conserved protein similar to jag protein
Rv0819		-1.8	-4.6	GCN5-related N-acetyltransferase, MshD
Rv2073c		-1.7	-9.0	Probable shortchain dehydrogenase
Rv3193c		-1.7	-2.6	Probable conserved transmembrane protein
Rv2694c		-1.6	-4.9	Conserved protein
Rv0930		-1.6	-7.1	Probable phosphate-transport integral membrane ABC transporter PstA1
Rv1821		-1.6	-4.6	Possible preprotein translocase ATPase SecA2
Rv2476c		-1.6	-5.0	Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase)
Rv0820		-1.5	-4.4	Probable phosphate-transport ATP-binding protein ABC transporter PhoT
Rv0758		-1.5	-3.1	Possible two component system response sensor kinase membrane associated PhoR
Rv2581c		-1.5	-1.5	Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II)
Rv3101c		-1.5	-2.6	Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter)
Rv1565c		-1.5	-6.2	Conserved hypothetical membrane protein
Rv0632c		-1.5	-2.9	Probable enoyl-CoA hydratase EchA3 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv1908c		-1.5	-3.5	Catalase-peroxidase-peroxynitritase T KatG
Rv0504c		-1.4	-1.8	Conserved protein
Rv1013		-1.4	-7.0	Putative polyketide synthase Pks16
Rv0989c		-1.4	-8.0	Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase)
Rv1930c		-1.4	-1.5	Conserved hypothetical protein
Rv1414		-1.4	-1.2	Conserved hypothetical protein
Rv1420		-1.4	-3.5	Probable excinuclease ABC (subunit C-nuclease) UvrC
Rv3102c		-1.3	-3.8	Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter)
Rv0928		-1.3	-4.4	Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1)
Rv2272		-1.3	-1.2	Probable conserved transmembrane protein
Rv0929		-1.3	-2.7	Phosphate-transport integral membrane ABC transporter PstC2
Rv0241c		-1.3	-2.9	Probable 3-hydroxyacyl-thioester dehydratase HtdX
Rv1621c		-1.3	-2.7	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD
Rv3033		-1.2	-0.9	Unknown protein
Rv0016c		-1.2	-3.2	Probable penicillin-binding protein PbpA
Rv1909c		-1.2	-3.8	Ferric uptake regulation protein FurA (fur)
Rv0748		-1.2	-3.1	Possible antitoxin VapB31
Rv1946c		-1.2	-2.7	Possible lipoprotein
Rv3655c		-1.2	-2.7	Conserved hypothetical protein
Rv2630		-1.1	-1.3	Hypothetical protein
Rv1421		-1.1	-2.6	Conserved protein
Rv1577c		-1.1	-1.2	Probable PhiRv1 phage protein
Rv0200		-1.1	-2.4	Possible conserved transmembrane protein
Rv2691		-1.1	-4.8	TRK system potassium uptake protein CeoB
Rv1411c		-1.1	-3.7	Conserved lipoprotein LprG
Rv0971c		-1.1	-2.9	Probable enoyl-CoA hydratase EchA7 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv3287c		-1.1	-1.2	Anti-sigma factor RsbW (sigma negative effector)
Rv1127c		-1.1	-1.6	Probable pyruvate, phosphate dikinase PpdK
Rv0018c		-1.1	-2.5	Phosphoserine/threonine phosphatase PstP
Rv0093c		-1.1	-1.3	Probable conserved membrane protein
Rv1410c		-1.0	-4.9	Aminoglycosides/tetracycline-transport integral membrane protein
Rv0321		-1.0	-2.3	Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase)
Rv0451c		-1.0	-1.5	Probable conserved membrane protein MmpS4
Rv1272c		-1.0	-5.2	Probable drugs-transport transmembrane ATP-binding protein ABC transporter
Rv0270		-1.0	-4.1	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Rv1683		-1.0	-5.1	Possible bifunctional enzyme; long-chain acyl-CoA synthase and lipase.
Rv3306c		-1.0	-1.4	Probable amidohydrolase AmiB1 (aminohydrolase)
Rv3222c		-1.0	-1.1	Conserved hypothetical protein
Rv1159		-1.0	-2.1	Mannosyltransferase PimE
Rv0954		-1.0	-4.8	Probable conserved transmembrane protein
Rv0383c		-1.0	-1.0	Possible conserved secreted protein
Rv0353		-0.9	-3.9	Probable heat shock protein transcriptional repressor HspR (MerR family)
Rv0497		-0.9	-1.9	Probable conserved transmembrane protein
Rv2869c		-0.9	-1.5	Membrane bound metalloprotease
Rv2224c		-0.9	-7.5	Probable carboxylesterase CaeA
Rv2048c		-0.9	-4.3	Polyketide synthase Pks12
Rv2240c		-0.9	-1.2	Unknown protein
Rv3013		-0.9	-1.1	Conserved protein
Rv0007		-0.9	-0.6	Possible conserved membrane protein
Rv3481c		-0.9	-0.9	Probable integral membrane protein
Rv1273c		-0.9	-3.8	Probable drugs-transport transmembrane ATP-binding protein ABC transporter
Rv2049c		-0.9	-1.1	Conserved hypothetical protein
Rv0017c		-0.9	-3.5	Probable cell division protein RodA
Rv1244		-0.9	-4.0	Probable lipoprotein LpqZ
Rv0950c		-0.9	-4.3	Conserved hypothetical protein
Rv0452		-0.9	-2.2	Possible transcriptional regulatory protein
Rv2369c		-0.8	-0.9	Hypothetical protein
Rv3850		-0.8	-1.4	Conserved protein
Rv2936		-0.8	-6.8	Daunorubicin-dim-transport ATP-binding protein ABC transporter DrrA
Rv0019c		-0.8	-4.0	Conserved protein with FHA domain, FhaB
Rv2553c		-0.8	-0.6	Probable conserved membrane protein
Rv0470c		-0.8	-1.8	Mycolic acid synthase PcaA (cyclopropane synthase)
Rv1366A		-0.8	-0.9	Conserved protein
Rv2171		-0.8	-1.5	Probable conserved lipoprotein LppM
Rv1290A		-0.8	-0.8	Hypothetical protein
Rv0437c		-0.8	-0.7	Possible phosphatidylserine decarboxylase Psd (PS decarboxylase)
Rv1053c		-0.8	-0.8	Hypothetical protein
Rv1062		-0.8	-0.9	Conserved hypothetical protein
Rv1401		-0.8	-1.0	Possible membrane protein
Rv2912c		-0.8	-2.5	Probable transcriptional regulatory protein (probably TetR-family)
Rv0050		-0.8	-1.9	Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase)
Rv1447c		-0.8	-3.0	Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD)
Rv1021		-0.8	-1.2	Conserved protein
Rv2680		-0.8	-1.3	Conserved protein
Rv3182		-0.8	-0.7	Conserved hypothetical protein
Rv2733c		-0.7	-1.5	Conserved hypothetical alanine, arginine-rich protein
Rv0580c		-0.7	-0.7	Conserved protein
Rv1710		-0.7	-1.0	Possible segregation and condensation protein ScpB
Rv1901		-0.7	-4.6	Probable CinA-like protein CinA
Rv1941		-0.7	-1.3	Probable short-chain type dehydrogenase/reductase
Rv1102c		-0.7	-1.4	Toxin MazF3
Rv3237c		-0.7	-3.7	Conserved protein
Rv1745c		-0.7	-3.1	Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase)
Rv0243		-0.7	-3.8	Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase)
Rv1096		-0.7	-0.9	Possible glycosyl hydrolase
Rv1566c		-0.7	-2.5	Possible Inv protein
Rv2374c		-0.7	-2.0	Probable heat shock protein transcriptional repressor HrcA
Rv2945c		-0.7	-3.9	Probable conserved lipoprotein LppX
Rv2429		-0.7	-1.6	Alkyl hydroperoxide reductase D protein AhpD (alkyl hydroperoxidase D)
Rv0395		-0.7	-1.5	Hypothetical protein
Rv2942		-0.7	-6.1	Conserved transmembrane transport protein MmpL7
Rv3405c		-0.7	-1.1	Possible transcriptional regulatory protein
Rv3922c		-0.7	-1.7	Possible hemolysin
Rv3200c		-0.7	-2.1	Possible transmembrane cation transporter
Rv1291c		-0.7	-1.1	Conserved hypothetical secreted protein
Rv0177		-0.7	-1.3	Probable conserved Mce associated protein
Rv3872		-0.7	-1.1	PE family-related protein PE35
Rv3803c		-0.7	-3.6	Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) (85C)
Rv0113		-0.7	-0.8	Probable sedoheptulose-7-phosphate isomerase GmhA (phosphoheptose isomerase)
Rv0245		-0.7	-1.9	Possible oxidoreductase
Rv3081		-0.7	-0.9	Conserved hypothetical protein
Rv1675c		-0.7	-1.5	Probable transcriptional regulatory protein Cmr
Rv3843c		-0.7	-1.3	Probable conserved transmembrane protein
Rv3139		-0.7	-2.4	Probable acyl-CoA dehydrogenase FadE24
Rv0202c		-0.7	-4.0	Probable conserved transmembrane transport protein MmpL11
Rv0564c		-0.7	-1.4	Probable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA1 (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase) (NAD(P)H-dependent dihydroxyacetone-phosphate reductase)
Rv2706c		-0.7	-0.8	Hypothetical protein
Rv2275		-0.7	-0.9	Conserved hypothetical protein
Rv3813c		-0.7	-1.7	Conserved protein
Rv3438		-0.7	-1.7	Conserved protein
Rv3874		-0.7	-0.7	10 kDa culture filtrate antigen EsxB (LHP) (CFP10)
Rv0003		-0.7	-1.9	DNA replication and repair protein RecF (single-strand DNA binding protein)
Rv0135c		-0.7	-2.7	Possible transcriptional regulatory protein
Rv0598c		-0.7	-1.5	Possible toxin VapC27. Contains PIN domain.
Rv2709		-0.7	-2.9	Probable conserved transmembrane protein
Rv0310c		-0.6	-1.4	Conserved protein
Rv3630		-0.6	-2.8	Probable conserved integral membrane protein
Rv2437		-0.6	-1.6	Conserved transmembrane protein
Rv3140		-0.6	-1.3	Probable acyl-CoA dehydrogenase FadE23
Rv3249c		-0.6	-0.8	Possible transcriptional regulatory protein (probably TetR-family)
Rv2427A		-0.6	-1.6	'Transcriptional regulator OxyR', pseudogene' pseudogene=unknown transl_table=11
Rv2372c		-0.6	-0.9	Conserved hypothetical protein
Rv2529		-0.6	-2.0	Hypothetical protein
Rv2510c		-0.6	-2.5	Conserved protein
Rv2047c		-0.6	-3.2	Conserved hypothetical protein
Rv3311		-0.6	-2.9	Conserved protein
Rv0020c		-0.6	-4.3	Conserved protein with FHA domain, FhaA
Rv0306		-0.6	-1.8	Putative oxidoreductase
Rv2973c		-0.6	-3.2	Probable ATP-dependent DNA helicase RecG
Rv0852		-0.6	-1.3	Possible fatty-acid-CoA ligase FadD16 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Rv0569		-0.6	-1.4	Conserved protein
Rv3768		-0.6	-1.2	Unknown protein
Rv1350		-0.6	-0.8	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase)
Rv3133c		-0.6	-1.5	Two component transcriptional regulatory protein DevR (probably LuxR/UhpA-family)
Rv0740		-0.6	-2.1	Conserved hypothetical protein
Rv1287		-0.6	-1.1	Conserved hypothetical protein
Rv2922c		-0.6	-2.0	Probable chromosome partition protein Smc
Rv2975c		-0.6	-0.7	Conserved hypothetical protein
Rv1131		-0.6	-1.8	Probable methylcitrate synthase PrpC
Rv1598c		-0.6	-2.0	Conserved protein
Rv2707		-0.6	-4.3	Probable conserved transmembrane alanine and leucine rich protein
Rv2850c		-0.6	-0.8	Possible magnesium chelatase
Rv3557c		-0.6	-3.2	Transcriptional regulatory protein (probably TetR-family)
Rv2937		-0.6	-4.1	Daunorubicin-dim-transport integral membrane protein ABC transporter DrrB
Rv2569c		-0.6	-2.5	Conserved hypothetical protein
Rv2635		-0.6	-0.5	Hypothetical protein
Rv0199		-0.6	-1.6	Probable conserved membrane protein
Rv1398c		-0.6	-1.0	Possible antitoxin VapB10
Rv3513c		-0.6	-0.5	Probable fatty-acid-CoA ligase FadD18 (fragment) (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Rv1281c		-0.6	-1.3	Probable oligopeptide-transport ATP-binding protein ABC transporter OppD
Rv0655		-0.6	-1.9	Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl
Rv0738		-0.6	-0.8	Conserved protein
Rv3364c		-0.6	-1.7	Conserved protein
Rv2938		-0.6	-3.9	Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC
Rv3143		-0.6	-0.5	Probable response regulator
Rv1640c		-0.6	-3.7	Lysyl-tRNA synthetase 2 LysX
Rv0207c		-0.6	-1.4	Conserved hypothetical protein
Rv2696c		-0.6	-0.9	Conserved alanine and glycine and valine rich protein
Rv2190c		-0.6	-2.2	Conserved hypothetical protein
Rv2793c		-0.6	-0.9	Probable tRNA pseudouridine synthase B TruB (tRNA pseudouridine 55 synthase) (PSI55 synthase) (pseudouridylate synthase) (uracil hydrolyase)
Rv0675		-0.5	-0.5	Probable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv1925		-0.5	-3.6	Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase)
Rv0752c		-0.5	-1.9	Probable acyl-CoA dehydrogenase FadE9
Rv1100		-0.5	-1.7	Conserved protein
Rv1006		-0.5	-2.6	Unknown protein
Rv3855		-0.5	-2.4	Transcriptional regulatory repressor protein (TetR-family) EthR
Rv0905		-0.5	-1.5	Possible enoyl-CoA hydratase EchA6 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv0490		-0.5	-2.2	Putative two component sensor histidine kinase SenX3
Rv2867c		-0.5	-2.4	GCN5-related N-acetyltransferase
Rv3433c		-0.5	-1.1	Conserved protein
Rv0038		-0.5	-2.3	Conserved protein
Rv1303		-0.5	-0.6	Conserved hypothetical transmembrane protein
Rv1935c		-0.5	-2.3	Possible enoyl-CoA hydratase EchA13 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv2618		-0.5	-2.7	Conserved hypothetical protein
Rv0084		-0.5	-1.2	Possible formate hydrogenlyase HycD (FHL)
Rv1531		-0.5	-0.6	Conserved protein
Rv2737c		-0.5	-2.0	RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)].
Rv1514c		-0.5	-1.8	Conserved hypothetical protein
Rv1247c		-0.5	-1.2	Antitoxin RelB
Rv1128c		-0.5	-1.1	Conserved hypothetical protein
Rv3073c		-0.5	-1.0	Conserved hypothetical protein
Rv3335c		-0.5	-2.1	Probable conserved integral membrane protein
Rv0653c		-0.5	-1.9	Possible transcriptional regulatory protein (probably TetR-family)

Specific Phenotypes

For 2 genes in this experiment

For stress Delamanid in Mycobacterium tuberculosis H37Rv

For stress Delamanid across organisms