Experiment set4S292 for Mycobacterium tuberculosis H37Rv

200 most detrimental genes:

gene	name	fitness	t score	description
Rv3547		+2.3	14.6	Deazaflavin-dependent nitroreductase Ddn
Rv0407		+2.1	12.1	F420-dependent glucose-6-phosphate dehydrogenase Fgd1
Rv3262		+2.0	5.0	Probable F420 biosynthesis protein FbiB
Rv3261		+1.8	6.5	Probable F420 biosynthesis protein FbiA
Rv1173		+1.6	6.5	Probable F420 biosynthesis protein FbiC
Rv0078		+1.5	3.9	Probable transcriptional regulatory protein
Rv1271c		+1.4	1.2	Conserved hypothetical secreted protein
Rv0328		+1.1	2.9	Possible transcriptional regulatory protein (possibly TetR/AcrR-family)
Rv2661c		+1.1	1.9	Hypothetical protein
Rv3716c		+1.0	1.1	Conserved protein
Rv2065		+1.0	1.9	Precorrin-8X methylmutase CobH (aka precorrin isomerase)
Rv0939		+1.0	1.0	Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase
Rv1422		+0.9	1.3	Conserved hypothetical protein
Rv2072c		+0.9	1.2	Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL
Rv1628c		+0.9	2.2	Conserved protein
Rv3230c		+0.9	3.3	Hypothetical oxidoreductase
Rv0311		+0.9	2.1	Unknown protein
Rv0927c		+0.8	1.8	Probable short-chain type dehydrogenase/reductase
Rv3428c		+0.8	1.5	Possible transposase
Rv3559c		+0.8	1.3	Probable oxidoreductase
Rv1974		+0.8	2.4	Probable conserved membrane protein
Rv1171		+0.8	3.0	Conserved hypothetical protein
Rv0766c		+0.8	1.3	Probable cytochrome P450 123 Cyp123
Rv0990c		+0.8	0.9	Hypothetical protein
Rv3658c		+0.8	0.9	Probable conserved transmembrane protein
Rv1234		+0.7	2.6	Probable transmembrane protein
Rv3198c		+0.7	1.3	Probable ATP-dependent DNA helicase II UvrD2
Rv3726		+0.7	0.7	Possible dehydrogenase
Rv0887c		+0.7	1.2	Conserved hypothetical protein
Rv1450c		+0.7	1.8	PE-PGRS family protein PE_PGRS27
Rv0877		+0.7	4.8	Conserved hypothetical protein
Rv0941c		+0.7	1.2	Conserved hypothetical protein
Rv3819		+0.7	0.6	Unknown protein
Rv3651		+0.7	2.1	Conserved hypothetical protein
Rv2208		+0.6	2.1	Probable cobalamin 5'-phosphate synthase CobS
Rv0544c		+0.6	1.5	Possible conserved transmembrane protein
Rv2433c		+0.6	1.8	Hypothetical protein
Rv3386		+0.6	1.2	Possible transposase
Rv0589		+0.6	3.2	Mce-family protein Mce2A
Rv2232		+0.6	1.7	Protein tyrosine kinase transcriptional regulatory protein PtkA
Rv0610c		+0.6	0.6	Hypothetical protein
Rv2662		+0.6	1.2	Hypothetical protein
Rv1889c		+0.6	1.7	Conserved hypothetical protein
Rv2365c		+0.6	0.5	Conserved hypothetical protein
Rv3295		+0.6	4.7	Probable transcriptional regulatory protein (probably TetR-family)
Rv2381c		+0.6	1.4	Polyketide synthetase MbtD (polyketide synthase)
Rv0554		+0.6	4.1	Possible peroxidase BpoC (non-haem peroxidase)
Rv1025		+0.6	0.7	Conserved protein
Rv3171c		+0.6	0.9	Possible non-heme haloperoxidase Hpx
Rv2891		+0.6	2.5	Conserved hypothetical protein
Rv0933		+0.6	1.4	Phosphate-transport ATP-binding protein ABC transporter PstB
Rv3058c		+0.6	2.5	Possible transcriptional regulatory protein (probably TetR-family)
Rv2836c		+0.6	1.2	Possible DNA-damage-inducible protein F DinF
Rv3866		+0.6	1.1	ESX-1 secretion-associated protein EspG1
Rv0157A		+0.6	1.0	Conserved protein
Rv0278c		+0.6	2.8	PE-PGRS family protein PE_PGRS3
Rv2185c		+0.6	1.5	Conserved protein TB16.3
Rv3891c		+0.5	2.1	Possible ESAT-6 like protein EsxD
Rv0272c		+0.5	1.8	Unknown protein
Rv0588		+0.5	1.3	Conserved hypothetical integral membrane protein YrbE2B
Rv1530		+0.5	1.3	Probable alcohol dehydrogenase Adh
Rv2929		+0.5	2.4	Hypothetical protein
Rv2632c		+0.5	0.5	Conserved protein
Rv2898c		+0.5	0.7	Conserved hypothetical protein
Rv2376c		+0.5	0.8	Low molecular weight antigen CFP2 (low molecular weight protein antigen 2) (CFP-2)
Rv0545c		+0.5	2.4	Probable low-affinity inorganic phosphate transporter integral membrane protein PitA
Rv3700c		+0.5	1.9	Conserved hypothetical protein
Rv0064A		+0.5	2.1	Possible antitoxin VapB1
Rv1840c		+0.5	1.3	PE-PGRS family protein PE_PGRS34
Rv1284		+0.5	0.6	Beta-carbonic anhydrase
Rv1934c		+0.5	1.5	Probable acyl-CoA dehydrogenase FadE17
Rv2317		+0.5	0.6	Probable sugar-transport integral membrane protein ABC transporter UspB
Rv2745c		+0.5	0.9	Transcriptional regulatory protein ClgR
Rv2367c		+0.5	1.6	Conserved hypothetical protein
Rv1579c		+0.5	1.3	Probable PhiRv1 phage protein
Rv3040c		+0.5	1.0	Conserved protein
Rv2619c		+0.5	1.0	Conserved protein
Rv1773c		+0.5	0.9	Probable transcriptional regulatory protein
Rv0912		+0.5	0.8	Probable conserved transmembrane protein
Rv1957		+0.5	0.7	Hypothetical protein
Rv2982c		+0.5	1.7	Probable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA2 (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase)
Rv1986		+0.5	1.0	Probable conserved integral membrane protein
Rv3657c		+0.5	1.7	Possible conserved alanine rich membrane protein
Rv1955		+0.5	2.2	Possible toxin HigB
Rv3642c		+0.5	0.7	Hypothetical protein
Rv2637		+0.5	1.0	Possible transmembrane protein DedA
Rv0409		+0.4	1.6	Probable acetate kinase AckA (acetokinase)
Rv3491		+0.4	1.6	Unknown protein
Rv2551c		+0.4	0.9	Conserved hypothetical protein
Rv3309c		+0.4	1.1	Probable uracil phosphoribosyltransferase Upp (UMP pyrophosphorylase) (uprtase) (UMP diphosphorylase)
Rv1729c		+0.4	1.4	Possible S-adenosylmethionine-dependent methyltransferase
Rv1938		+0.4	2.4	Probable epoxide hydrolase EphB (epoxide hydratase)
Rv3229c		+0.4	1.8	Possible linoleoyl-CoA desaturase (delta(6)-desaturase)
Rv1851		+0.4	0.7	Urease accessory protein UreF
Rv3298c		+0.4	2.3	Possible esterase lipoprotein LpqC
Rv1968		+0.4	1.4	Mce-family protein Mce3C
Rv2474c		+0.4	0.9	Conserved hypothetical protein
Rv1538c		+0.4	1.6	Probable L-aparaginase AnsA
Rv0615		+0.4	0.5	Probable integral membrane protein
Rv2813		+0.4	1.4	Conserved hypothetical protein
Rv1524		+0.4	1.2	Probable glycosyltransferase
Rv2829c		+0.4	0.9	Possible toxin VapC22
Rv3431c		+0.4	2.3	Possible transposase (fragment)
Rv3565		+0.4	1.0	Possible aspartate aminotransferase AspB (transaminase A) (ASPAT) (glutamic--oxaloacetic transaminase) (glutamic--aspartic transaminase)
Rv0275c		+0.4	1.1	Possible transcriptional regulatory protein (possibly TetR-family)
Rv2647		+0.4	0.3	Hypothetical protein
Rv3400		+0.4	2.3	Probable hydrolase
Rv2267c		+0.4	2.2	Conserved hypothetical protein
Rv2933		+0.4	3.4	Phenolpthiocerol synthesis type-I polyketide synthase PpsC
Rv0741		+0.4	1.1	Probable transposase (fragment)
Rv1140		+0.4	1.2	Probable integral membrane protein
Rv1003		+0.4	0.6	Conserved protein
Rv3150		+0.4	2.5	Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F)
Rv0162c		+0.4	1.2	Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1
Rv2821c		+0.4	0.8	Conserved hypothetical protein
Rv1176c		+0.4	1.5	Conserved hypothetical protein
Rv0540		+0.4	1.2	Conserved hypothetical protein
Rv3084		+0.4	1.3	Probable acetyl-hydrolase/esterase LipR
Rv0029		+0.4	1.3	Conserved hypothetical protein
Rv2382c		+0.4	0.6	Polyketide synthetase MbtC (polyketide synthase)
Rv2123		+0.4	2.2	PPE family protein PPE37
Rv0117		+0.4	1.8	Oxidative stress response regulatory protein OxyS
Rv2237A		+0.4	0.6	Conserved protein
Rv0563		+0.4	0.9	Probable protease transmembrane protein heat shock protein HtpX
Rv2527		+0.4	1.4	Possible toxin VapC17
Rv2901c		+0.4	1.5	Conserved protein
Rv0789c		+0.4	1.7	Hypothetical protein
Rv2137c		+0.4	0.8	Conserved hypothetical protein
Rv3284		+0.4	0.7	Conserved hypothetical protein
Rv0297		+0.4	2.1	PE-PGRS family protein PE_PGRS5
Rv1777		+0.4	1.6	Probable cytochrome P450 144 Cyp144
Rv2563		+0.4	1.4	Probable glutamine-transport transmembrane protein ABC transporter
Rv0161		+0.4	1.2	Possible oxidoreductase
Rv0052		+0.4	1.5	Conserved protein
Rv3283		+0.4	1.3	Probable thiosulfate sulfurtransferase SseA (rhodanese) (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase)
Rv0863		+0.4	1.2	Conserved hypothetical protein
Rv3725		+0.4	1.2	Possible oxidoreductase
Rv1129c		+0.4	1.0	Probable transcriptional regulator protein
Rv2570		+0.4	2.0	Conserved hypothetical protein
Rv2758c		+0.4	0.7	Possible antitoxin VapB21
Rv0881		+0.4	1.2	Possible rRNA methyltransferase (rRNA methylase)
Rv3563		+0.4	0.6	Probable acyl-CoA dehydrogenase FadE32
Rv2344c		+0.4	1.5	Probable deoxyguanosine triphosphate triphosphohydrolase Dgt (dGTPase) (dGTP triphosphohydrolase)
Rv3812		+0.4	2.1	PE-PGRS family protein PE_PGRS62
Rv1672c		+0.4	1.6	Probable conserved integral membrane transport protein
Rv0968		+0.4	1.6	Conserved protein
Rv0974c		+0.4	1.0	Probable acetyl-/propionyl-CoA carboxylase (beta subunit) AccD2
Rv2006		+0.4	2.5	Probable trehalose-6-phosphate phosphatase OtsB1 (trehalose-phosphatase) (TPP)
Rv0571c		+0.4	1.0	Conserved protein
Rv0942		+0.4	0.9	Hypothetical protein
Rv2055c		+0.4	0.5	30S ribosomal protein S18 RpsR2
Rv0893c		+0.4	0.7	Possible S-adenosylmethionine-dependent methyltransferase
Rv2708c		+0.4	1.4	Conserved hypothetical protein
Rv3020c		+0.4	1.1	ESAT-6 like protein EsxS
Rv3041c		+0.3	1.5	Probable conserved ATP-binding protein ABC transporter
Rv2430c		+0.3	1.6	PPE family protein PPE41
Rv2022c		+0.3	1.6	Conserved protein
Rv1243c		+0.3	1.5	PE-PGRS family protein PE_PGRS23
Rv0679c		+0.3	0.8	Conserved threonine rich protein
Rv0919		+0.3	1.3	GCN5-related N-acetyltransferase
Rv0480c		+0.3	1.2	Possible amidohydrolase
Rv2940c		+0.3	3.2	Probable multifunctional mycocerosic acid synthase membrane-associated Mas
Rv0039c		+0.3	1.1	Possible conserved transmembrane protein
Rv2819c		+0.3	1.1	Hypothetical protein
Rv2931		+0.3	3.1	Phenolpthiocerol synthesis type-I polyketide synthase PpsA
Rv2759c		+0.3	1.3	Possible toxin VapC42. Contains PIN domain.
Rv1194c		+0.3	1.7	Conserved protein
Rv1286		+0.3	1.4	Probable bifunctional enzyme CysN/CysC: sulfate adenyltransferase (subunit 1) + adenylylsulfate kinase
Rv0316		+0.3	0.9	Possible muconolactone isomerase
Rv3397c		+0.3	1.2	Probable phytoene synthase PhyA
Rv0634c		+0.3	1.6	Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II)
Rv2586c		+0.3	0.6	Probable protein-export membrane protein SecF
Rv1616		+0.3	1.3	Conserved membrane protein
Rv1269c		+0.3	0.6	Conserved probable secreted protein
Rv2571c		+0.3	1.0	Probable transmembrane alanine and valine and leucine rich protein
Rv3329		+0.3	1.6	Probable aminotransferase
Rv3331		+0.3	1.4	Probable sugar-transport integral membrane protein SugI
Rv3647c		+0.3	0.5	Conserved hypothetical protein
Rv1788		+0.3	1.3	PE family protein PE18
Rv1182		+0.3	1.9	Probable conserved polyketide synthase associated protein PapA3
Rv1833c		+0.3	1.1	Possible haloalkane dehalogenase
Rv2548		+0.3	0.9	Possible toxin VapC19
Rv1444c		+0.3	1.0	Unknown protein
Rv3516		+0.3	1.4	Possible enoyl-CoA hydratase EchA19 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv2645		+0.3	0.7	Hypothetical protein
Rv2506		+0.3	1.1	Probable transcriptional regulatory protein (probably TetR-family)
Rv2702		+0.3	0.3	Polyphosphate glucokinase PpgK (polyphosphate-glucose phosphotransferase)
Rv1473A		+0.3	0.3	Possible transcriptional regulatory protein
Rv0649		+0.3	1.4	Possible malonyl CoA-acyl carrier protein transacylase FabD2 (MCT)
Rv3829c		+0.3	2.0	Probable dehydrogenase
Rv3536c		+0.3	1.7	Probable hydratase
Rv3055		+0.3	0.9	Possible transcriptional regulatory protein (probably TetR-family)
Rv2043c		+0.3	1.2	Pyrazinamidase/nicotinamidase PncA (PZase)
Rv3452		+0.3	1.7	Probable cutinase precursor Cut4
Rv0313		+0.3	0.9	Conserved protein
Rv2184c		+0.3	2.0	Conserved hypothetical protein
Rv2038c		+0.3	1.1	Probable sugar-transport ATP-binding protein ABC transporter
Rv3514		+0.3	1.4	PE-PGRS family protein PE_PGRS57
Rv2899c		+0.3	0.6	Possible FdhD protein homolog
Rv1528c		+0.3	1.3	Probable conserved polyketide synthase associated protein PapA4

Specific Phenotypes

For 2 genes in this experiment

For stress Delamanid in Mycobacterium tuberculosis H37Rv

For stress Delamanid across organisms