Experiment set4IT068 for Pseudomonas fluorescens FW300-N1B4

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L-Histidine carbon source

200 most important genes:

  gene name fitness t score description  
Pf1N1B4_1579 -3.9 -4.6 Imidazolonepropionase (EC 3.5.2.7) (from data) compare
Pf1N1B4_6 -3.9 -3.7 Phosphoribosylanthranilate isomerase (EC 5.3.1.24) compare
Pf1N1B4_2880 -3.9 -9.9 Ketol-acid reductoisomerase (EC 1.1.1.86) compare
Pf1N1B4_5666 -3.6 -2.5 Oxidoreductase probably involved in sulfite reduction compare
Pf1N1B4_2303 -3.5 -14.0 Dihydroxy-acid dehydratase (EC 4.2.1.9) compare
Pf1N1B4_2548 -3.4 -6.0 Anthranilate phosphoribosyltransferase (EC 2.4.2.18) compare
Pf1N1B4_2545 -3.4 -11.0 Anthranilate synthase, aminase component (EC 4.1.3.27) compare
Pf1N1B4_1830 -3.3 -9.4 Tryptophan synthase alpha chain (EC 4.2.1.20) compare
Pf1N1B4_2112 -3.3 -14.6 Bona fide RidA/YjgF/TdcF/RutC subgroup compare
Pf1N1B4_1588 -3.2 -7.3 hypothetical protein compare
Pf1N1B4_1581 -3.2 -3.1 Histidine ammonia-lyase (EC 4.3.1.3) compare
Pf1N1B4_1831 -3.2 -11.6 Tryptophan synthase beta chain (EC 4.2.1.20) compare
Pf1N1B4_2384 -3.2 -11.2 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) compare
Pf1N1B4_2208 -3.2 -8.0 Polyphosphate kinase (EC 2.7.4.1) compare
Pf1N1B4_2547 -3.1 -3.0 Anthranilate synthase, amidotransferase component (EC 4.1.3.27) @ Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85) compare
Pf1N1B4_2338 -3.1 -6.3 Homoserine O-acetyltransferase (EC 2.3.1.31) compare
Pf1N1B4_5665 -3.1 -4.1 Sulfite reductase [NADPH] hemoprotein beta-component (EC 1.8.1.2) compare
Pf1N1B4_1587 -3.1 -11.3 Urocanate hydratase (EC 4.2.1.49) (from data) conserved
Pf1N1B4_1307 -3.0 -2.9 3-dehydroquinate dehydratase II (EC 4.2.1.10) compare
Pf1N1B4_2549 -3.0 -8.5 Indole-3-glycerol phosphate synthase (EC 4.1.1.48) compare
Pf1N1B4_15 -2.9 -3.4 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) compare
Pf1N1B4_1580 -2.9 -8.8 Histidine transport protein (permease) conserved
Pf1N1B4_2858 -2.9 -8.7 Two-component sensor CbrB: intrcellular carbon:nitrogen balance compare
Pf1N1B4_1578 -2.8 -7.3 N-formylglutamate deformylase (EC 3.5.1.68) (from data) conserved
Pf1N1B4_3038 -2.8 -7.4 Chemotaxis response regulator protein-glutamate methylesterase CheB (EC 3.1.1.61) compare
Pf1N1B4_2860 -2.8 -4.9 FIG00954153: hypothetical protein compare
Pf1N1B4_2878 -2.7 -8.6 Acetolactate synthase large subunit (EC 2.2.1.6) compare
Pf1N1B4_1591 -2.7 -9.0 Formiminoglutamic iminohydrolase (EC 3.5.3.13) (from data) conserved
Pf1N1B4_2491 -2.7 -4.0 Dethiobiotin synthetase (EC 6.3.3.3) compare
Pf1N1B4_742 -2.7 -6.2 Argininosuccinate synthase (EC 6.3.4.5) compare
Pf1N1B4_1585 -2.7 -9.0 Histidine ABC transporter, histidine-binding protein (TC 3.A.1) conserved
Pf1N1B4_3812 -2.7 -8.8 Phosphoadenylyl-sulfate reductase [thioredoxin] (EC 1.8.4.8) / Adenylyl-sulfate reductase [thioredoxin] (EC 1.8.4.10) compare
Pf1N1B4_2225 -2.6 -11.9 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) compare
Pf1N1B4_1617 -2.6 -8.2 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1) compare
Pf1N1B4_2284 -2.6 -5.6 FIG001592: Phosphocarrier protein kinase/phosphorylase, nitrogen regulation associated compare
Pf1N1B4_1583 -2.6 -4.1 Histidine ABC transporter, ATP-binding protein (TC 3.A.1) compare
Pf1N1B4_762 -2.6 -4.9 Ornithine carbamoyltransferase (EC 2.1.3.3) compare
Pf1N1B4_2380 -2.5 -14.7 Cytochrome B561 compare
Pf1N1B4_12 -2.5 -6.0 3-isopropylmalate dehydrogenase (EC 1.1.1.85) compare
Pf1N1B4_2526 -2.5 -14.8 Bis(5'-nucleosyl)-tetraphosphatase, symmetrical (EC 3.6.1.41) compare
Pf1N1B4_2488 -2.5 -7.4 8-amino-7-oxononanoate synthase (EC 2.3.1.47) compare
Pf1N1B4_4487 -2.4 -2.6 FIG00955631: hypothetical protein compare
Pf1N1B4_1434 -2.4 -6.9 Phosphoserine phosphatase (EC 3.1.3.3) compare
Pf1N1B4_2487 -2.4 -7.9 Biotin synthase (EC 2.8.1.6) compare
Pf1N1B4_847 -2.4 -7.9 2-isopropylmalate synthase (EC 2.3.3.13) compare
Pf1N1B4_1906 -2.4 -4.1 Shikimate 5-dehydrogenase I alpha (EC 1.1.1.25) compare
Pf1N1B4_2874 -2.4 -3.4 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) compare
Pf1N1B4_2859 -2.4 -12.3 Two-component sensor CbrA: intrcellular carbon:nitrogen balance compare
Pf1N1B4_350 -2.4 -6.5 Chorismate mutase I (EC 5.4.99.5) / Prephenate dehydratase (EC 4.2.1.51) compare
Pf1N1B4_1315 -2.4 -7.9 IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) compare
Pf1N1B4_683 -2.3 -4.7 Fumarate hydratase class I, aerobic (EC 4.2.1.2) compare
Pf1N1B4_2377 -2.3 -6.1 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62) compare
Pf1N1B4_2381 -2.3 -12.2 Protein yceI precursor compare
Pf1N1B4_2493 -2.3 -3.0 Acyl-CoA dehydrogenase (EC 1.3.8.7) compare
Pf1N1B4_1153 -2.3 -4.3 Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19) compare
Pf1N1B4_5926 -2.3 -11.1 hypothetical protein compare
Pf1N1B4_2272 -2.2 -4.0 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) compare
Pf1N1B4_2337 -2.2 -5.4 Homoserine O-acetyltransferase (EC 2.3.1.31) compare
Pf1N1B4_5925 -2.2 -9.5 hypothetical protein compare
Pf1N1B4_626 -2.2 -7.7 Quinolinate synthetase (EC 2.5.1.72) compare
Pf1N1B4_2879 -2.2 -6.2 Acetolactate synthase small subunit (EC 2.2.1.6) compare
Pf1N1B4_1545 -2.2 -9.0 NADP-dependent malic enzyme (EC 1.1.1.40) compare
Pf1N1B4_4065 -2.1 -6.7 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) compare
Pf1N1B4_1329 -2.1 -6.4 Cobalamin biosynthesis protein CobG compare
Pf1N1B4_236 -2.1 -3.2 Molybdenum cofactor biosynthesis protein MoaB compare
Pf1N1B4_5976 -2.1 -3.0 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) compare
Pf1N1B4_58 -2.1 -5.8 Transaldolase (EC 2.2.1.2) compare
Pf1N1B4_3917 -2.0 -4.0 NADPH-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.13) compare
Pf1N1B4_2009 -2.0 -5.4 LysR family transcriptional regulator PA5437 compare
Pf1N1B4_2011 -2.0 -7.9 Pyruvate carboxyl transferase subunit B (EC 6.4.1.1) compare
Pf1N1B4_2489 -2.0 -5.9 Biotin synthesis protein BioH compare
Pf1N1B4_3906 -2.0 -4.4 DNA topoisomerase I (EC 5.99.1.2) compare
Pf1N1B4_578 -2.0 -3.6 enoyl-CoA hydratase, R-specific compare
Pf1N1B4_3506 -2.0 -6.1 Cysteine synthase B (EC 2.5.1.47) compare
Pf1N1B4_2850 -1.9 -6.8 Glucose-6-phosphate isomerase (EC 5.3.1.9) compare
Pf1N1B4_1586 -1.9 -11.5 Purine-cytosine permease conserved
Pf1N1B4_5224 -1.9 -2.8 tRNA-Arg-CCT compare
Pf1N1B4_5619 -1.8 -4.2 BarA-associated response regulator UvrY (= GacA = SirA) compare
Pf1N1B4_2490 -1.8 -5.3 Biotin synthesis protein BioC compare
Pf1N1B4_1328 -1.8 -3.3 Cobalt-precorrin-8x methylmutase (EC 5.4.1.2) compare
Pf1N1B4_2010 -1.8 -5.9 Pyruvate carboxyl transferase subunit A (EC 6.4.1.1) compare
Pf1N1B4_1832 -1.8 -6.3 Glycine cleavage system transcriptional activator conserved
Pf1N1B4_3153 -1.7 -2.1 hypothetical protein compare
Pf1N1B4_2004 -1.7 -2.6 putative membrane protein compare
Pf1N1B4_3328 -1.7 -2.3 Rhodanese-like domain protein compare
Pf1N1B4_2486 -1.6 -2.0 hypothetical protein compare
Pf1N1B4_5724 -1.6 -2.8 High-affinity iron permease compare
Pf1N1B4_5927 -1.6 -12.0 Capsular polysaccharide biosynthesis protein compare
Pf1N1B4_617 -1.6 -2.4 Carbamate kinase (EC 2.7.2.2) compare
Pf1N1B4_2885 -1.5 -5.2 Paraquat-inducible protein A compare
Pf1N1B4_4123 -1.5 -2.0 Isochorismate pyruvate-lyase (EC 4.-.-.-) compare
Pf1N1B4_3152 -1.5 -4.9 LysR family transcriptional regulator PA3398 compare
Pf1N1B4_3518 -1.5 -2.0 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) compare
Pf1N1B4_1584 -1.5 -1.4 Histidine ABC transporter, permease protein (TC 3.A.1) compare
Pf1N1B4_3356 -1.5 -2.2 Cyclic nucleotide-binding protein compare
Pf1N1B4_1474 -1.5 -3.6 Glutamate-ammonia-ligase adenylyltransferase (EC 2.7.7.42) compare
Pf1N1B4_1105 -1.4 -2.1 4-carboxymuconolactone decarboxylase (EC 4.1.1.44) compare
Pf1N1B4_1234 -1.4 -3.8 Exodeoxyribonuclease V alpha chain (EC 3.1.11.5) compare
Pf1N1B4_1614 -1.4 -2.1 Protein export cytoplasm chaperone protein (SecB, maintains protein to be exported in unfolded state) compare
Pf1N1B4_3501 -1.4 -4.8 BarA sensory histidine kinase (= VarS = GacS) compare
Pf1N1B4_364 -1.4 -3.3 Rhodanese domain protein UPF0176 compare
Pf1N1B4_1317 -1.4 -2.8 Sensor histidine kinase/response regulator compare
Pf1N1B4_3168 -1.4 -2.7 AmpG permease compare
Pf1N1B4_232 -1.4 -2.4 DNA-binding response regulator, LuxR family compare
Pf1N1B4_3993 -1.4 -3.0 Isovaleryl-CoA dehydrogenase (EC 1.3.8.4) compare
Pf1N1B4_27 -1.3 -3.3 Biosynthetic Aromatic amino acid aminotransferase alpha (EC 2.6.1.57) @ Aromatic-amino-acid aminotransferase (EC 2.6.1.57) compare
Pf1N1B4_1 -1.3 -2.1 Colicin V production protein compare
Pf1N1B4_5991 -1.3 -1.9 Transcriptional regulator, AraC family compare
Pf1N1B4_4669 -1.3 -2.0 Heavy metal RND efflux outer membrane protein, CzcC family compare
Pf1N1B4_1582 -1.3 -5.9 Histidine ammonia-lyase (EC 4.3.1.3) (from data) conserved
Pf1N1B4_1113 -1.3 -4.4 Predicted D-glucarate or D-galactorate regulator, GntR family compare
Pf1N1B4_1472 -1.3 -1.8 Lipopolysaccharide heptosyltransferase I (EC 2.4.1.-) compare
Pf1N1B4_4716 -1.3 -2.5 Putrescine ABC transporter putrescine-binding protein PotF (TC 3.A.1.11.2) compare
Pf1N1B4_2173 -1.3 -2.2 Diaminopimelate epimerase (EC 5.1.1.7) compare
Pf1N1B4_4833 -1.2 -2.7 DNA-binding response regulator, LuxR family compare
Pf1N1B4_3143 -1.2 -2.4 RecA protein compare
Pf1N1B4_2283 -1.2 -1.8 Adenosine (5')-pentaphospho-(5'')-adenosine pyrophosphohydrolase (EC 3.6.1.-) compare
Pf1N1B4_3768 -1.2 -2.4 Homoserine/homoserine lactone efflux protein compare
Pf1N1B4_1673 -1.2 -5.4 Formate dehydrogenase chain D (EC 1.2.1.2) conserved
Pf1N1B4_751 -1.2 -1.5 hypothetical protein compare
Pf1N1B4_5425 -1.2 -2.0 DNA-binding protein HU-beta compare
Pf1N1B4_373 -1.2 -2.6 5-methylaminomethyl-2-thiouridine-forming enzyme mnmC compare
Pf1N1B4_2047 -1.2 -3.8 Chorismate--pyruvate lyase (EC 4.1.3.40) compare
Pf1N1B4_4212 -1.2 -2.0 Gfa-like protein compare
Pf1N1B4_2568 -1.2 -2.4 Translation elongation factor Tu compare
Pf1N1B4_3833 -1.2 -5.3 Major porin and structural outer membrane porin OprF compare
Pf1N1B4_5923 -1.2 -2.3 PhnB protein; putative DNA binding 3-demethylubiquinone-9 3-methyltransferase domain protein compare
Pf1N1B4_3006 -1.2 -4.3 tRNA-guanine transglycosylase (EC 2.4.2.29) compare
Pf1N1B4_3720 -1.2 -5.5 Long-chain fatty acid transport protein compare
Pf1N1B4_5860 -1.2 -2.0 Two-component response regulator compare
Pf1N1B4_2348 -1.2 -4.9 Uracil phosphoribosyltransferase (EC 2.4.2.9) / Pyrimidine operon regulatory protein PyrR compare
Pf1N1B4_2823 -1.1 -1.8 COG1496: Uncharacterized conserved protein compare
Pf1N1B4_3715 -1.1 -3.3 Cobalamin synthase compare
Pf1N1B4_2886 -1.1 -7.1 Paraquat-inducible protein B compare
Pf1N1B4_1615 -1.1 -3.2 Glutaredoxin 3 (Grx3) compare
Pf1N1B4_3866 -1.1 -1.8 Adenine phosphoribosyltransferase (EC 2.4.2.7) compare
Pf1N1B4_76 -1.1 -2.3 ATP binding protein compare
Pf1N1B4_1294 -1.1 -1.8 VgrG protein compare
Pf1N1B4_418 -1.1 -4.8 Molybdenum cofactor biosynthesis protein MoaA compare
Pf1N1B4_4494 -1.1 -2.5 hypothetical protein compare
Pf1N1B4_430 -1.1 -2.0 hypothetical protein compare
Pf1N1B4_3451 -1.1 -2.5 Aspartokinase (EC 2.7.2.4) compare
Pf1N1B4_5777 -1.1 -2.7 Nitrous oxide reductase maturation protein, outer-membrane lipoprotein NosL compare
Pf1N1B4_2005 -1.1 -1.8 ATP-dependent DNA helicase UvrD/PcrA compare
Pf1N1B4_412 -1.1 -1.5 L-arabinose 1-dehydrogenase / D-galactose 1-dehydrogenase (EC 1.1.1.46; EC 1.1.1.48) (from data) compare
Pf1N1B4_2105 -1.1 -2.0 ATP-dependent DNA helicase RecG (EC 3.6.1.-) compare
Pf1N1B4_2147 -1.1 -3.5 Putrescine utilization regulator compare
Pf1N1B4_3454 -1.1 -3.9 Mg/Co/Ni transporter MgtE / CBS domain compare
Pf1N1B4_4611 -1.1 -1.6 GlpG protein (membrane protein of glp regulon) compare
Pf1N1B4_2949 -1.1 -1.4 FIG00956396: hypothetical protein compare
Pf1N1B4_3350 -1.1 -2.0 FIG00954807: hypothetical protein compare
Pf1N1B4_4317 -1.1 -1.5 DNA/RNA non-specific endonuclease compare
Pf1N1B4_1057 -1.1 -1.7 Sulfate adenylyltransferase subunit 1 (EC 2.7.7.4) / Adenylylsulfate kinase (EC 2.7.1.25) compare
Pf1N1B4_235 -1.1 -4.1 Molybdopterin biosynthesis protein MoeA compare
Pf1N1B4_5924 -1.1 -4.7 hypothetical protein compare
Pf1N1B4_5838 -1.1 -1.9 FIG00956589: hypothetical protein compare
Pf1N1B4_4446 -1.1 -1.8 DNA topoisomerase III (EC 5.99.1.2) compare
Pf1N1B4_3142 -1.1 -3.1 C-terminal domain of CinA type S; Protein Implicated in DNA repair function with RecA and MutS compare
Pf1N1B4_5448 -1.1 -1.8 hypothetical protein compare
Pf1N1B4_4544 -1.1 -1.7 Uncharacterized protein ImpA compare
Pf1N1B4_3595 -1.0 -1.8 Flagellin protein FlaG compare
Pf1N1B4_1674 -1.0 -6.6 Putative formate dehydrogenase oxidoreductase protein conserved
Pf1N1B4_1570 -1.0 -2.8 Ribosomal RNA small subunit methyltransferase E (EC 2.1.1.-) compare
Pf1N1B4_4030 -1.0 -2.1 NADH-ubiquinone oxidoreductase chain L (EC 1.6.5.3) compare
Pf1N1B4_1837 -1.0 -1.8 Osmotically inducible protein C compare
Pf1N1B4_5957 -1.0 -1.9 Arsenical resistance operon repressor compare
Pf1N1B4_2483 -1.0 -2.9 DNA-binding domain of ModE / Molybdate-binding domain of ModE compare
Pf1N1B4_4872 -1.0 -1.5 Short-chain dehydrogenase/reductase SDR compare
Pf1N1B4_4481 -1.0 -2.0 Transcriptional regulator BkdR of isoleucine and valine catabolism operon compare
Pf1N1B4_5768 -1.0 -2.1 Heme d1 biosynthesis protein NirD compare
Pf1N1B4_846 -1.0 -1.3 hypothetical protein compare
Pf1N1B4_2688 -1.0 -2.9 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) compare
Pf1N1B4_2280 -1.0 -5.3 Threonine dehydratase biosynthetic (EC 4.3.1.19) compare
Pf1N1B4_3692 -1.0 -2.1 Chaperone protein HtpG compare
Pf1N1B4_3519 -1.0 -2.4 Lipase (EC 3.1.1.3) compare
Pf1N1B4_4585 -1.0 -2.2 Putative Isoquinoline 1-oxidoreductase subunit, Mll3835 protein compare
Pf1N1B4_4926 -1.0 -2.9 ATPase components of various ABC-type transport systems, contain duplicated ATPase compare
Pf1N1B4_3279 -1.0 -2.4 putative membrane protein compare
Pf1N1B4_231 -1.0 -3.2 Sensor histidine kinase compare
Pf1N1B4_3723 -1.0 -1.8 FIG00957314: hypothetical protein compare
Pf1N1B4_825 -1.0 -1.7 tRNA (uridine-5-oxyacetic acid methyl ester) 34 synthase compare
Pf1N1B4_5023 -1.0 -2.6 Alkylated DNA repair protein AlkB compare
Pf1N1B4_2939 -1.0 -3.7 Malate:quinone oxidoreductase (EC 1.1.5.4) compare
Pf1N1B4_978 -1.0 -4.8 Predicted ATPase related to phosphate starvation-inducible protein PhoH compare
Pf1N1B4_2334 -1.0 -2.3 Radical SAM family enzyme, similar to coproporphyrinogen III oxidase, oxygen-independent, clustered with nucleoside-triphosphatase RdgB compare
Pf1N1B4_237 -1.0 -2.0 Molybdopterin-guanine dinucleotide biosynthesis protein MobA compare
Pf1N1B4_5402 -1.0 -1.9 hypothetical protein compare
Pf1N1B4_32 -1.0 -2.2 Transcriptional regulator, TetR family compare
Pf1N1B4_5357 -1.0 -1.6 hypothetical protein compare
Pf1N1B4_230 -1.0 -1.6 FIG00953472: hypothetical protein compare
Pf1N1B4_5311 -1.0 -1.8 hypothetical protein compare
Pf1N1B4_419 -0.9 -1.4 Transcriptional regulator, TetR family compare
Pf1N1B4_4273 -0.9 -2.4 Predicted transcriptional regulator of the myo-inositol catabolic operon compare
Pf1N1B4_2401 -0.9 -2.1 Lipoprotein, putative compare
Pf1N1B4_202 -0.9 -2.7 ABC transporter in pyoverdin gene cluster, permease component compare
Pf1N1B4_414 -0.9 -2.5 transcriptional regulator compare
Pf1N1B4_2853 -0.9 -1.4 Pantoate--beta-alanine ligase (EC 6.3.2.1) compare
Pf1N1B4_1462 -0.9 -7.0 Oligosaccharide repeat unit polymerase Wzy; O-antigen ligase compare
Pf1N1B4_5877 -0.9 -1.7 FIG00967533: hypothetical protein compare
Pf1N1B4_5393 -0.9 -1.6 hypothetical protein compare


Specific Phenotypes

For 11 genes in this experiment

For carbon source L-Histidine in Pseudomonas fluorescens FW300-N1B4

For carbon source L-Histidine across organisms