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Experiment set4IT048 for
Methanococcus maripaludis S2
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H2 deepwell autotrophic conditions
200 most important genes:
gene
name
fitness
t score
description
MMP
_RS01455
-9.3
-8.1
nickel pincer cofactor biosynthesis protein LarC
compare
MMP
_RS05500
-8.4
-10.1
2-isopropylmalate synthase
compare
MMP
_RS06975
-8.0
-2.9
sulfide-dependent adenosine diphosphate thiazole synthase
compare
MMP
_RS06270
-7.1
-8.1
TIGR00300 family protein
compare
MMP
_RS05930
-7.0
-3.2
3-isopropylmalate dehydratase large subunit
compare
MMP
_RS06730
-6.9
-2.8
phosphopantothenate/pantothenate synthetase
compare
MMP
_RS03035
-6.7
-3.9
4-hydroxy-tetrahydrodipicolinate synthase
compare
MMP
_RS07845
-6.4
-3.1
LL-diaminopimelate aminotransferase
compare
MMP
_RS07345
-6.4
-8.3
glycine synthesis protein GlyXL
(from data)
compare
MMP
_RS04605
-6.4
-4.6
cobalt ECF transporter T component CbiQ
compare
MMP
_RS01175
-6.3
-5.0
triphosphoribosyl-dephospho-CoA synthase
compare
MMP
_RS04215
-6.2
-7.2
nickel pincer cofactor biosynthesis protein LarB
compare
MMP
_RS07380
-6.0
-2.7
transcription elongation factor Spt5
compare
MMP
_RS04620
-5.9
-15.3
cobalt transporter CbiM
compare
MMP
_RS01020
-5.9
-1.2
3 4-dihydroxy-2-butanone-4-phosphate synthase
compare
MMP
_RS06895
-5.9
-2.8
selenocysteine-specific translation elongation factor
compare
MMP
_RS04615
-5.9
-4.3
PDGLE domain-containing protein
compare
MMP
_RS03450
-5.9
-3.3
glycine synthesis protein GlyXS
(from data)
compare
MMP
_RS07630
-5.8
-2.0
ATP-binding cassette domain-containing protein
compare
MMP
_RS07390
-5.7
-2.9
cell division protein FtsZ
compare
MMP
_RS05095
-5.7
-9.8
CO dehydrogenase/acetyl-CoA synthase complex subunit epsilon
compare
MMP
_RS05090
-5.7
-12.3
CO dehydrogenase/CO-methylating acetyl-CoA synthase complex subunit beta
compare
MMP
_RS03315
-5.6
-2.0
ferrous iron transport protein A
compare
MMP
_RS07185
-5.6
-15.6
pyridoxal phosphate-dependent aminotransferase
compare
MMP
_RS02280
-5.6
-1.2
DUF211 domain-containing protein
compare
MMP
_RS03960
-5.6
-1.2
hypothetical protein
compare
MMP
_RS08790
-5.5
-3.1
translation initiation factor IF-2 subunit alpha
compare
MMP
_RS05265
-5.5
-2.7
2-isopropylmalate synthase
compare
MMP
_RS08650
-5.4
-4.7
glutamine--fructose-6-phosphate transaminase (isomerizing)
compare
MMP
_RS09020
-5.4
-2.4
hypothetical protein
compare
MMP
_RS08745
-5.4
-9.7
CDP-2 3-bis-(O-geranylgeranyl)-sn-glycerol synthase
compare
MMP
_RS06230
-5.4
-2.9
helix-turn-helix domain-containing protein
compare
MMP
_RS06120
-5.4
-2.9
UPF0147 family protein
compare
MMP
_RS05060
-5.3
-14.0
AAA family ATPase
compare
MMP
_RS03435
-5.2
-2.9
ketol-acid reductoisomerase
compare
MMP
_RS05080
-5.1
-17.0
acetyl-CoA decarbonylase/synthase complex subunit delta
compare
MMP
_RS01005
-5.1
-1.5
riboflavin synthase
compare
MMP
_RS05085
-5.0
-12.3
AAA family ATPase
compare
MMP
_RS01545
-5.0
-1.5
CBS domain-containing protein
compare
MMP
_RS06375
-5.0
-6.6
ATP-dependent sacrificial sulfur transferase LarE
compare
MMP
_RS05100
-4.9
-24.9
CO dehydrogenase/acetyl-CoA synthase complex subunit alpha
compare
MMP
_RS02135
-4.9
-5.4
DUF5612 domain-containing protein
compare
MMP
_RS05075
-4.8
-20.0
acetyl-CoA decarbonylase/synthase complex subunit gamma
compare
MMP
_RS04500
-4.8
-17.2
adenosylmethionine--8-amino-7-oxononanoate transaminase
compare
MMP
_RS00300
-4.7
-1.0
6 7-dimethyl-8-ribityllumazine synthase
compare
MMP
_RS06285
-4.7
-3.5
precorrin-6Y C5 15-methyltransferase (decarboxylating) subunit CbiT
compare
MMP
_RS02195
-4.7
-4.2
tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase
compare
MMP
_RS05550
-4.7
-1.0
cation:proton antiporter
compare
MMP
_RS05070
-4.6
-11.6
4Fe-4S dicluster domain-containing protein
compare
MMP
_RS03475
-4.6
-0.9
hypothetical protein
compare
MMP
_RS05920
-4.6
-0.9
50S ribosomal protein L37e
compare
MMP
_RS03700
-4.6
-10.6
sodium:proton antiporter
compare
MMP
_RS04685
-4.6
-4.7
DUF126 domain-containing protein
compare
MMP
_RS01800
-4.5
-6.1
TIGR00303 family protein
compare
MMP
_RS00750
-4.5
-3.3
fumarate hydratase
compare
MMP
_RS08460
-4.4
-3.4
proteasome-activating nucleotidase
compare
MMP
_RS06630
-4.4
-1.3
UPF0058 family protein
compare
MMP
_RS08095
-4.4
-7.4
dethiobiotin synthase
compare
MMP
_RS05515
-4.4
-9.7
cyclic pyranopterin monophosphate synthase MoaC
compare
MMP
_RS07635
-4.3
-8.9
MogA/MoaB family molybdenum cofactor biosynthesis protein
compare
MMP
_RS07545
-4.3
-1.3
HTH domain-containing protein
compare
MMP
_RS03015
-4.3
-11.5
GTP 3' 8-cyclase MoaA
compare
MMP
_RS08100
-4.3
-9.5
8-amino-7-oxononanoate synthase
compare
MMP
_RS01380
-4.3
-5.3
PHP domain-containing protein
compare
MMP
_RS07600
-4.3
-3.7
Ni-sirohydrochlorin a c-diamide synthase
compare
MMP
_RS06370
-4.3
-3.9
biotin synthase BioB
compare
MMP
_RS08300
-4.3
-1.5
metal-sulfur cluster assembly factor
compare
MMP
_RS05425
-4.3
-5.4
monovalent cation/H+ antiporter complex subunit F
compare
MMP
_RS03640
-4.2
-5.7
archaeal proteasome endopeptidase complex subunit beta
compare
MMP
_RS02240
-4.2
-5.2
methanogenesis marker 7 protein
compare
MMP
_RS08720
-4.2
-2.2
4Fe-4S binding protein
compare
MMP
_RS07580
-4.2
-4.3
DUF356 domain-containing protein
compare
MMP
_RS01500
-4.2
-3.3
CBS domain-containing protein
compare
MMP
_RS05055
-4.2
-14.6
DUF166 domain-containing protein
compare
MMP
_RS01830
-4.2
-2.4
tRNA-Val
compare
MMP
_RS05065
-4.2
-5.7
CooT family nickel-binding protein
compare
MMP
_RS00305
-4.1
-2.9
phosphoribosyl-ATP diphosphatase
compare
MMP
_RS03400
-4.1
-3.4
archease
compare
MMP
_RS08210
-4.1
-2.7
phosphatidylglycerophosphatase A
compare
MMP
_RS01755
-4.0
-1.6
DUF2097 domain-containing protein
compare
MMP
_RS06625
-4.0
-2.9
DNA primase
compare
MMP
_RS04780
-4.0
-4.9
ribonuclease P
compare
MMP
_RS03445
-4.0
-1.4
methanogenesis marker 17 protein
compare
MMP
_RS08715
-4.0
-2.7
formylmethanofuran dehydrogenase subunit B
compare
MMP
_RS00515
-3.9
-1.1
DUF655 domain-containing protein
compare
MMP
_RS07750
-3.9
-6.0
DUF357 domain-containing protein
compare
MMP
_RS06400
-3.9
-2.4
4Fe-4S binding protein
compare
MMP
_RS06350
-3.9
-9.3
HesA/MoeB/ThiF family protein
compare
MMP
_RS04890
-3.9
-1.1
adenylyltransferase/cytidyltransferase family protein
compare
MMP
_RS04710
-3.8
-2.2
hypothetical protein
compare
MMP
_RS01905
-3.8
-16.3
glycosyltransferase
compare
MMP
_RS03580
-3.8
-5.4
signal recognition particle-docking protein FtsY
compare
MMP
_RS01265
-3.7
-3.0
hypothetical protein
compare
MMP
_RS01325
-3.7
-3.1
dihydroneopterin aldolase family protein
compare
MMP
_RS06475
-3.7
-7.3
FAD-dependent oxidoreductase
compare
MMP
_RS07755
-3.6
-1.5
DUF555 domain-containing protein
compare
MMP
_RS05555
-3.6
-1.8
DUF4040 domain-containing protein
compare
MMP
_RS07645
-3.6
-8.9
aldehyde dehydrogenase family protein
compare
MMP
_RS07735
-3.6
-1.0
2-ketoisovalerate ferredoxin oxidoreductase subunit alpha
compare
MMP
_RS04790
-3.6
-14.6
4-hydroxy-tetrahydrodipicolinate reductase
compare
MMP
_RS01700
-3.5
-1.4
dihydroxy-acid dehydratase
compare
MMP
_RS02145
-3.5
-7.5
winged helix-turn-helix transcriptional regulator
compare
MMP
_RS07875
-3.5
-5.1
hypothetical protein
compare
MMP
_RS07625
-3.5
-5.9
cobalt ECF transporter T component CbiQ
compare
MMP
_RS01925
-3.5
-9.9
DUF1616 domain-containing protein
compare
MMP
_RS02010
-3.4
-11.1
PHP domain-containing protein
compare
MMP
_RS07005
-3.4
-1.0
4Fe-4S binding protein
compare
MMP
_RS08635
-3.4
-2.9
UbiA family prenyltransferase
compare
MMP
_RS04720
-3.4
-4.3
DedA family protein
compare
MMP
_RS07955
-3.3
-5.1
FumA C-terminus/TtdB family hydratase beta subunit
compare
MMP
_RS08105
-3.3
-10.3
6-carboxyhexanoate--CoA ligase
compare
MMP
_RS08240
-3.3
-8.1
methanogenesis marker 16 metalloprotein
compare
MMP
_RS01900
-3.3
-16.1
hypothetical protein
compare
MMP
_RS06340
-3.3
-9.0
phosphoadenosine phosphosulfate reductase family protein
compare
MMP
_RS07195
-3.3
-9.2
M20 family metallo-hydrolase
compare
MMP
_RS07615
-3.3
-11.0
energy-coupling factor ABC transporter permease
compare
MMP
_RS05640
-3.2
-6.6
UTP--glucose-1-phosphate uridylyltransferase GalU
compare
MMP
_RS02345
-3.2
-5.5
GTP-dependent dephospho-CoA kinase family protein
compare
MMP
_RS07355
-3.2
-1.5
transcription factor S
compare
MMP
_RS00110
-3.2
-3.1
hypothetical protein
compare
MMP
_RS03390
-3.1
-8.2
malate dehydrogenase
compare
MMP
_RS07365
-3.1
-10.5
2-phosphoglycerate kinase
compare
MMP
_RS06315
-3.1
-1.5
cobalt-precorrin-7 (C(5))-methyltransferase
compare
MMP
_RS04775
-3.1
-4.4
adenosylhomocysteinase
compare
MMP
_RS07200
-3.1
-6.2
[5-(aminomethyl)furan-3-yl]methyl phosphate kinase
compare
MMP
_RS06295
-3.1
-7.2
methanogenesis marker 14 protein
compare
MMP
_RS06930
-3.1
-13.5
MBL fold metallo-hydrolase
compare
MMP
_RS01795
-3.0
-2.5
methanogenesis marker 6 protein
compare
MMP
_RS06670
-3.0
-7.4
glucose-6-phosphate isomerase
compare
MMP
_RS05925
-3.0
-5.4
small nuclear ribonucleoprotein
compare
MMP
_RS08820
-3.0
-6.4
hypothetical protein
compare
MMP
_RS03140
-3.0
-13.5
hypothetical protein
compare
MMP
_RS02900
-3.0
-1.0
imidazoleglycerol-phosphate dehydratase HisB
compare
MMP
_RS00685
-2.9
-5.3
2-phospho-L-lactate guanylyltransferase
compare
MMP
_RS08440
-2.9
-3.5
cell division protein SepF
compare
MMP
_RS07730
-2.9
-2.9
pyruvate synthase subunit beta
compare
MMP
_RS08330
-2.9
-3.8
NADH-quinone oxidoreductase subunit H
compare
MMP
_RS07575
-2.9
-2.8
RNA ligase partner protein
compare
MMP
_RS08435
-2.8
-2.5
Era-like GTP-binding protein
compare
MMP
_RS01955
-2.8
-3.5
hypothetical protein
compare
MMP
_RS06355
-2.8
-3.0
molybdenum cofactor biosynthesis protein MoaE
compare
MMP
_RS03025
-2.8
-5.7
molybdenum cofactor guanylyltransferase
compare
MMP
_RS02875
-2.8
-10.5
chorismate pyruvate-lyase family protein
compare
MMP
_RS03145
-2.8
-7.1
fibrillarin-like rRNA/tRNA 2'-O-methyltransferase
compare
MMP
_RS08165
-2.7
-3.3
phosphoglycerate dehydrogenase
compare
MMP
_RS08785
-2.7
-1.6
RNA-protein complex protein Nop10
compare
MMP
_RS00895
-2.7
-6.2
hypothetical protein
compare
MMP
_RS01910
-2.7
-10.6
UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)
compare
MMP
_RS07075
-2.7
-5.2
phosphomannomutase/phosphoglucomutase
compare
MMP
_RS03600
-2.7
-2.6
triose-phosphate isomerase
compare
MMP
_RS07620
-2.6
-6.1
energy-coupling factor ABC transporter substrate-binding protein
compare
MMP
_RS06020
-2.6
-5.1
archaeoflavoprotein AfpA
compare
MMP
_RS07445
-2.6
-4.9
helix-turn-helix domain-containing protein
compare
MMP
_RS07555
-2.5
-1.0
monovalent cation/H+ antiporter subunit E
compare
MMP
_RS03420
-2.5
-5.1
acetolactate synthase small subunit
compare
MMP
_RS06925
-2.5
-2.2
ribonuclease VapC4
compare
MMP
_RS07710
-2.5
-8.7
cell division protein FtsZ
compare
MMP
_RS01220
-2.5
-7.5
hypothetical protein
compare
MMP
_RS05815
-2.5
-3.1
NOL1/NOP2/sun family putative RNA methylase
compare
MMP
_RS01875
-2.4
-8.6
N-acetyltransferase
compare
MMP
_RS07525
-2.4
-8.0
4Fe-4S binding protein
compare
MMP
_RS06105
-2.4
-7.9
hydrogenase maturation peptidase HycI
compare
MMP
_RS02800
-2.4
-6.9
nucleotidyltransferase domain-containing protein
compare
MMP
_RS01610
-2.4
-3.7
hypothetical protein
compare
MMP
_RS06940
-2.4
-3.2
polyprenyl diphosphate synthase
compare
MMP
_RS00810
-2.4
-8.5
topoisomerase DNA-binding C4 zinc finger domain-containing protein
compare
MMP
_RS01975
-2.3
-13.9
hypothetical protein
compare
MMP
_RS01960
-2.3
-0.9
hypothetical protein
compare
MMP
_RS08645
-2.3
-7.8
UPF0179 family protein
compare
MMP
_RS05950
-2.2
-11.2
nickel-dependent hydrogenase large subunit
compare
MMP
_RS08340
-2.2
-6.3
4Fe-4S binding protein
compare
MMP
_RS06215
-2.2
-3.3
30S ribosomal protein S6e
compare
MMP
_RS06395
-2.2
-4.4
ThiF family adenylyltransferase
compare
MMP
_RS02355
-2.2
-3.0
30S ribosomal protein S27ae
compare
MMP
_RS01970
-2.2
-11.8
TIGR04279 domain-containing protein
compare
MMP
_RS06980
-2.1
-7.7
tRNA 2-thiocytidine biosynthesis TtcA family protein
compare
MMP
_RS07425
-2.1
-7.0
GTP-binding protein
compare
MMP
_RS06885
-2.1
-4.1
50S ribosome-binding GTPase
compare
MMP
_RS06130
-2.1
-3.6
peptidylprolyl isomerase
compare
MMP
_RS01915
-2.1
-12.0
DUF354 domain-containing protein
compare
MMP
_RS01225
-2.1
-4.3
DUF5379 domain-containing protein
compare
MMP
_RS04585
-2.1
-8.7
AIR synthase related protein
compare
MMP
_RS03095
-2.1
-5.5
diphthine synthase
compare
MMP
_RS00735
-2.1
-5.0
5 10-methenyltetrahydromethanopterin hydrogenase
compare
MMP
_RS07720
-2.1
-11.7
4Fe-4S binding protein
compare
MMP
_RS00985
-2.0
-4.8
CDC48 family AAA ATPase
compare
MMP
_RS01890
-2.0
-4.2
nucleotide sugar dehydrogenase
compare
MMP
_RS01725
-2.0
-4.0
class I SAM-dependent methyltransferase family protein
compare
MMP
_RS02885
-2.0
-14.5
molybdopterin biosynthesis protein
compare
MMP
_RS00695
-2.0
-1.0
biotin--[acetyl-CoA-carboxylase] ligase
compare
MMP
_RS00315
-2.0
-5.0
Nif3-like dinuclear metal center hexameric protein
compare
MMP
_RS08445
-2.0
-4.8
DUF2099 family protein
compare
MMP
_RS08760
-1.9
-1.3
hypothetical protein
compare
MMP
_RS06725
-1.9
-8.2
hypothetical protein
compare
MMP
_RS00130
-1.9
-1.6
nickel-responsive transcriptional regulator NikR
compare
MMP
_RS05250
-1.9
-1.6
NFYB/HAP3 family transcription factor subunit
compare
MMP
_RS01885
-1.9
-7.0
Gfo/Idh/MocA family oxidoreductase
compare
MMP
_RS04850
-1.9
-13.5
UPF0254 family protein
compare
MMP
_RS02245
-1.9
-4.1
hypothetical protein
compare
MMP
_RS01385
-1.9
-0.8
imidazole glycerol phosphate synthase subunit HisH
compare
Specific Phenotypes
None in this experiment
For Methanococcus maripaludis S2 in nutrient t2 experiments