Experiment set3S288 for Mycobacterium tuberculosis H37Rv

Compare to:

7H9 with Streptomycin sulfate salt 0.178 ug/mL

200 most important genes:

  gene name fitness t score description  
Rv3610c -3.8 -6.1 Membrane-bound protease FtsH (cell division protein) compare
Rv0928 -3.3 -6.3 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv0929 -2.9 -3.5 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv1258c -2.6 -13.5 Probable conserved integral membrane transport protein compare
Rv0930 -2.5 -10.0 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv0437c -2.4 -1.9 Possible phosphatidylserine decarboxylase Psd (PS decarboxylase) compare
Rv0007 -2.0 -1.1 Possible conserved membrane protein compare
Rv1640c -1.8 -9.2 Lysyl-tRNA synthetase 2 LysX compare
Rv1072 -1.8 -2.2 Probable conserved transmembrane protein compare
Rv0989c -1.8 -8.5 Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) compare
Rv2348c -1.7 -1.0 Hypothetical protein compare
Rv3249c -1.7 -1.4 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv1280c -1.6 -6.2 Probable periplasmic oligopeptide-binding lipoprotein OppA compare
Rv1283c -1.6 -2.8 Probable oligopeptide-transport integral membrane protein ABC transporter OppB compare
Rv0819 -1.6 -3.5 GCN5-related N-acetyltransferase, MshD compare
Rv1745c -1.6 -6.8 Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase) compare
Rv0056 -1.6 -3.1 50S ribosomal protein L9 RplI compare
Rv2989 -1.5 -0.9 Probable transcriptional regulatory protein compare
Rv2691 -1.5 -6.3 TRK system potassium uptake protein CeoB compare
Rv0820 -1.4 -4.6 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv2694c -1.4 -4.4 Conserved protein compare
Rv1422 -1.4 -1.0 Conserved hypothetical protein compare
Rv2680 -1.4 -1.8 Conserved protein compare
Rv2869c -1.4 -1.8 Membrane bound metalloprotease compare
Rv0452 -1.4 -4.3 Possible transcriptional regulatory protein compare
Rv3010c -1.4 -4.1 Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) compare
Rv3273 -1.3 -6.9 Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) compare
Rv3277 -1.3 -0.9 Probable conserved transmembrane protein compare
Rv0472c -1.3 -3.5 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv3102c -1.3 -3.9 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv2088 -1.3 -1.5 Transmembrane serine/threonine-protein kinase J PknJ (protein kinase J) (STPK J) compare
Rv0009 -1.3 -0.9 Probable iron-regulated peptidyl-prolyl cis-trans isomerase A PpiA (PPIase A) (rotamase A) compare
Rv3631 -1.3 -1.0 Possible transferase (possibly glycosyltransferase) compare
Rv1620c -1.2 -3.0 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC compare
Rv2173 -1.2 -2.8 Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) compare
Rv3855 -1.2 -5.0 Transcriptional regulatory repressor protein (TetR-family) EthR compare
Rv3193c -1.2 -1.5 Probable conserved transmembrane protein compare
Rv0353 -1.2 -4.3 Probable heat shock protein transcriptional repressor HspR (MerR family) compare
Rv1411c -1.2 -3.3 Conserved lipoprotein LprG compare
Rv3433c -1.2 -2.2 Conserved protein compare
Rv3720 -1.1 -6.6 Possible fatty acid synthase compare
Rv3140 -1.1 -4.1 Probable acyl-CoA dehydrogenase FadE23 compare
Rv3716c -1.1 -0.9 Conserved protein compare
Rv0245 -1.1 -1.9 Possible oxidoreductase compare
Rv2567 -1.1 -5.7 Conserved hypothetical alanine and leucine rich protein compare
Rv0497 -1.1 -1.6 Probable conserved transmembrane protein compare
Rv0436c -1.0 -1.4 Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase) compare
Rv0016c -1.0 -4.8 Probable penicillin-binding protein PbpA compare
Rv1350 -1.0 -1.1 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) compare
Rv2707 -1.0 -7.3 Probable conserved transmembrane alanine and leucine rich protein compare
Rv1107c -1.0 -1.4 Probable exodeoxyribonuclease VII (small subunit) XseB (exonuclease VII small subunit) compare
Rv0738 -1.0 -1.2 Conserved protein compare
Rv1281c -1.0 -4.0 Probable oligopeptide-transport ATP-binding protein ABC transporter OppD compare
Rv0680c -1.0 -1.6 Probable conserved transmembrane protein compare
Rv2272 -1.0 -0.7 Probable conserved transmembrane protein compare
Rv3272 -1.0 -5.3 Conserved hypothetical protein compare
Rv3874 -1.0 -0.9 10 kDa culture filtrate antigen EsxB (LHP) (CFP10) compare
Rv3200c -1.0 -2.3 Possible transmembrane cation transporter compare
Rv0887c -1.0 -1.2 Conserved hypothetical protein compare
Rv1621c -1.0 -2.1 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD compare
Rv3428c -1.0 -1.2 Possible transposase compare
Rv2224c -0.9 -7.3 Probable carboxylesterase CaeA compare
Rv0018c -0.9 -2.0 Phosphoserine/threonine phosphatase PstP compare
Rv2335 -0.9 -2.1 Probable serine acetyltransferase CysE (sat) compare
Rv0502 -0.9 -5.0 Conserved protein compare
Rv0991c -0.9 -1.0 Conserved serine rich protein compare
Rv3687c -0.9 -1.1 Anti-anti-sigma factor RsfB (anti-sigma factor antagonist) (regulator of sigma F B) compare
Rv1102c -0.9 -1.4 Toxin MazF3 compare
Rv2709 -0.9 -3.8 Probable conserved transmembrane protein compare
Rv2975c -0.9 -0.9 Conserved hypothetical protein compare
Rv0093c -0.9 -1.4 Probable conserved membrane protein compare
Rv0955 -0.9 -1.0 Probable conserved integral membrane protein compare
Rv2044c -0.9 -0.8 Conserved hypothetical protein compare
Rv0426c -0.9 -2.3 Possible transmembrane protein compare
Rv1821 -0.9 -2.1 Possible preprotein translocase ATPase SecA2 compare
Rv0241c -0.9 -3.1 Probable 3-hydroxyacyl-thioester dehydratase HtdX compare
Rv2706c -0.9 -0.9 Hypothetical protein compare
Rv2408 -0.9 -1.1 Possible PE family-related protein PE24 compare
Rv0050 -0.8 -1.9 Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase) compare
Rv1836c -0.8 -1.9 Conserved protein compare
Rv1683 -0.8 -3.4 Possible bifunctional enzyme; long-chain acyl-CoA synthase and lipase. compare
Rv1962A -0.8 -1.2 Possible antitoxin VapB35 compare
Rv2569c -0.8 -3.9 Conserved hypothetical protein compare
Rv2140c -0.8 -1.3 Conserved protein TB18.6 compare
Rv2588c -0.8 -1.7 Probable conserved membrane protein secretion factor YajC compare
Rv2801c -0.8 -0.9 Toxin MazF9 compare
Rv0954 -0.8 -3.6 Probable conserved transmembrane protein compare
Rv3311 -0.8 -2.6 Conserved protein compare
Rv2277c -0.8 -1.4 Possible glycerolphosphodiesterase compare
Rv1013 -0.8 -4.7 Putative polyketide synthase Pks16 compare
Rv0504c -0.8 -1.8 Conserved protein compare
Rv0569 -0.8 -1.6 Conserved protein compare
Rv3819 -0.8 -0.5 Unknown protein compare
Rv2829c -0.8 -2.0 Possible toxin VapC22 compare
Rv0242c -0.8 -1.9 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase) compare
Rv1127c -0.8 -0.9 Probable pyruvate, phosphate dikinase PpdK compare
Rv3650 -0.8 -0.8 PE family protein PE33 compare
Rv3237c -0.8 -2.0 Conserved protein compare
Rv0563 -0.8 -1.3 Probable protease transmembrane protein heat shock protein HtpX compare
Rv1420 -0.8 -1.5 Probable excinuclease ABC (subunit C-nuclease) UvrC compare
Rv2462c -0.8 -2.5 Probable trigger factor (TF) protein Tig compare
Rv2792c -0.8 -1.6 Possible resolvase compare
Rv1333 -0.8 -3.0 Probable hydrolase compare
Rv3856c -0.7 -1.4 Conserved hypothetical protein compare
Rv0531 -0.7 -1.0 Possible conserved membrane protein compare
Rv3897c -0.7 -0.8 Conserved hypothetical protein compare
Rv0924c -0.7 -4.0 Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP) compare
Rv0197 -0.7 -3.1 Possible oxidoreductase compare
Rv2206 -0.7 -1.4 Probable conserved transmembrane protein compare
Rv0392c -0.7 -0.9 Probable membrane NADH dehydrogenase NdhA compare
Rv2302 -0.7 -0.6 Conserved protein compare
Rv3287c -0.7 -0.9 Anti-sigma factor RsbW (sigma negative effector) compare
Rv1025 -0.7 -0.6 Conserved protein compare
Rv3649 -0.7 -2.6 Probable helicase compare
Rv0019c -0.7 -2.7 Conserved protein with FHA domain, FhaB compare
Rv0949 -0.7 -0.7 Probable ATP-dependent DNA helicase II UvrD1 compare
Rv3643 -0.7 -1.4 Hypothetical protein compare
Rv1908c -0.7 -1.2 Catalase-peroxidase-peroxynitritase T KatG compare
Rv0017c -0.7 -3.1 Probable cell division protein RodA compare
Rv1986 -0.7 -1.1 Probable conserved integral membrane protein compare
Rv2307A -0.7 -1.3 Hypothetical glycine rich protein compare
Rv1410c -0.7 -4.1 Aminoglycosides/tetracycline-transport integral membrane protein compare
Rv3208A -0.7 -0.9 Conserved protein TB9.4 compare
Rv2624c -0.7 -0.9 Universal stress protein family protein compare
Rv1930c -0.7 -0.8 Conserved hypothetical protein compare
Rv0003 -0.7 -1.7 DNA replication and repair protein RecF (single-strand DNA binding protein) compare
Rv0361 -0.7 -0.6 Probable conserved membrane protein compare
Rv0769 -0.6 -2.3 Probable dehydrogenase/reductase compare
Rv3283 -0.6 -1.5 Probable thiosulfate sulfurtransferase SseA (rhodanese) (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase) compare
Rv1624c -0.6 -2.9 Probable conserved membrane protein compare
Rv0742 -0.6 -1.5 PE-PGRS family protein PE_PGRS8 compare
Rv3484 -0.6 -3.8 Possible conserved protein CpsA compare
Rv1720c -0.6 -2.3 Possible toxin VapC12 compare
Rv3719 -0.6 -3.6 Conserved protein compare
Rv2922c -0.6 -2.5 Probable chromosome partition protein Smc compare
Rv1829 -0.6 -3.7 Conserved protein compare
Rv0499 -0.6 -1.6 Conserved hypothetical protein compare
Rv3139 -0.6 -2.3 Probable acyl-CoA dehydrogenase FadE24 compare
Rv0960 -0.6 -1.7 Possible toxin VapC9 compare
Rv3251c -0.6 -2.5 Probable rubredoxin RubA compare
Rv1019 -0.6 -3.6 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv0642c -0.6 -1.4 Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase) compare
Rv2551c -0.6 -1.2 Conserved hypothetical protein compare
Rv3543c -0.6 -2.0 Probable acyl-CoA dehydrogenase FadE29 compare
Rv3744 -0.6 -3.2 Metal sensor transcriptional regulator (ArsR-SmtB family) compare
Rv0655 -0.6 -2.1 Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl compare
Rv1234 -0.6 -1.1 Probable transmembrane protein compare
Rv0220 -0.6 -2.4 Probable esterase LipC compare
Rv3492c -0.6 -1.4 Conserved hypothetical Mce associated protein compare
Rv3194c -0.6 -3.8 Possible conserved secreted protein compare
Rv3005c -0.6 -4.0 Conserved hypothetical protein compare
Rv0818 -0.6 -2.3 Transcriptional regulatory protein compare
Rv0070c -0.6 -1.0 Serine hydroxymethyltransferase GlyA2 (serine methylase 2) (SHMT 2) compare
Rv2793c -0.6 -0.8 Probable tRNA pseudouridine synthase B TruB (tRNA pseudouridine 55 synthase) (PSI55 synthase) (pseudouridylate synthase) (uracil hydrolyase) compare
Rv1003 -0.6 -0.6 Conserved protein compare
Rv1890c -0.6 -0.8 Hypothetical protein compare
Rv0476 -0.6 -1.8 Possible conserved transmembrane protein compare
Rv2070c -0.6 -1.2 Precorrin-6X reductase CobK compare
Rv2330c -0.6 -1.8 Probable lipoprotein LppP compare
Rv1662 -0.6 -1.7 Probable polyketide synthase Pks8 compare
Rv2365c -0.6 -0.4 Conserved hypothetical protein compare
Rv0863 -0.6 -1.8 Conserved hypothetical protein compare
Rv0782 -0.6 -1.5 Probable protease II PtrBb [second part] (oligopeptidase B) compare
Rv1359 -0.6 -1.6 Probable transcriptional regulatory protein compare
Rv3101c -0.5 -1.1 Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter) compare
Rv1403c -0.5 -1.6 Putative methyltransferase compare
Rv2998 -0.5 -2.2 Hypothetical protein compare
Rv2912c -0.5 -1.3 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv3771c -0.5 -1.1 Conserved hypothetical protein compare
Rv0418 -0.5 -1.9 Probable lipoprotein aminopeptidase LpqL compare
Rv0444c -0.5 -1.8 Anti-sigma factor RskA (regulator of sigma K) compare
Rv0580c -0.5 -0.5 Conserved protein compare
Rv0427c -0.5 -2.2 Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) compare
Rv0939 -0.5 -0.5 Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase compare
Rv0937c -0.5 -1.8 DNA end-binding protein, Mku compare
Rv0375c -0.5 -1.4 Probable carbon monoxyde dehydrogenase (medium chain) compare
Rv2236c -0.5 -1.0 Probable cobalamin biosynthesis transmembrane protein CobD compare
Rv0379 -0.5 -0.6 Possible protein transport protein SecE2 compare
Rv3335c -0.5 -1.7 Probable conserved integral membrane protein compare
Rv3698 -0.5 -2.1 Conserved protein compare
Rv3262 -0.5 -1.1 Probable F420 biosynthesis protein FbiB compare
Rv3527 -0.5 -0.9 Hypothetical protein compare
Rv0207c -0.5 -1.5 Conserved hypothetical protein compare
Rv0748 -0.5 -1.0 Possible antitoxin VapB31 compare
Rv3495c -0.5 -3.7 Possible Mce-family lipoprotein LprN (Mce-family lipoprotein Mce4E) compare
Rv3332 -0.5 -1.3 Probable N-acetylglucosamine-6-phosphate deacetylase NagA (GlcNAc 6-P deacetylase) compare
Rv3843c -0.5 -1.1 Probable conserved transmembrane protein compare
Rv3416 -0.5 -1.6 Transcriptional regulatory protein WhiB-like WhiB3. Contains [4FE-4S] cluster. compare
Rv2047c -0.5 -2.5 Conserved hypothetical protein compare
Rv1070c -0.5 -1.5 Probable enoyl-CoA hydratase EchA8 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv2468A -0.5 -2.1 Conserved protein compare
Rv0658c -0.5 -1.0 Probable conserved integral membrane protein compare
Rv3270 -0.5 -0.9 Probable metal cation-transporting P-type ATPase C CtpC compare
Rv1940 -0.5 -1.0 Probable riboflavin biosynthesis protein RibA1 (GTP cyclohydrolase II) compare
Rv3218 -0.5 -3.0 Conserved protein compare
Rv0758 -0.5 -1.1 Possible two component system response sensor kinase membrane associated PhoR compare
Rv2618 -0.5 -2.3 Conserved hypothetical protein compare
Rv3538 -0.5 -0.8 Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase. compare
Rv3033 -0.5 -0.3 Unknown protein compare
Rv3162c -0.5 -0.5 Possible integral membrane protein compare


Specific Phenotypes

For 4 genes in this experiment

For stress Streptomycin sulfate salt in Mycobacterium tuberculosis H37Rv

For stress Streptomycin sulfate salt across organisms