Experiment set3S288 for Mycobacterium tuberculosis H37Rv

Compare to:

7H9 with Streptomycin sulfate salt 0.178 ug/mL

200 most detrimental genes:

  gene name fitness t score description  
Rv3171c +2.7 3.9 Possible non-heme haloperoxidase Hpx compare
Rv3919c +2.2 6.5 Probable glucose-inhibited division protein B Gid compare
Rv1290A +2.1 2.4 Hypothetical protein compare
Rv1819c +2.0 17.5 Probable drug-transport transmembrane ATP-binding protein ABC transporter BacA compare
Rv3513c +1.9 1.5 Probable fatty-acid-CoA ligase FadD18 (fragment) (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv1259 +1.6 1.5 Probable uracil DNA glycosylase, UdgB compare
Rv3816c +1.5 1.0 Possible acyltransferase compare
Rv1414 +1.3 1.2 Conserved hypothetical protein compare
Rv0675 +1.2 1.3 Probable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv2260 +1.1 2.4 Conserved hypothetical protein compare
Rv1096 +1.0 1.5 Possible glycosyl hydrolase compare
Rv0088 +1.0 1.3 Possible polyketide cyclase/dehydrase compare
Rv1372 +1.0 1.5 Conserved hypothetical protein compare
Rv2879c +1.0 1.1 Conserved hypothetical protein compare
Rv2657c +1.0 1.0 Probable PhiRv2 prophage protein compare
Rv3058c +1.0 4.6 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv2901c +1.0 2.6 Conserved protein compare
Rv2758c +1.0 1.8 Possible antitoxin VapB21 compare
Rv3405c +1.0 1.7 Possible transcriptional regulatory protein compare
Rv1473A +1.0 0.7 Possible transcriptional regulatory protein compare
Rv0544c +0.9 1.9 Possible conserved transmembrane protein compare
Rv0113 +0.9 1.3 Probable sedoheptulose-7-phosphate isomerase GmhA (phosphoheptose isomerase) compare
Rv2049c +0.9 1.6 Conserved hypothetical protein compare
Rv2930 +0.9 7.8 Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) compare
Rv1691 +0.9 2.6 Conserved hypothetical protein compare
Rv2292c +0.9 0.9 Hypothetical protein compare
Rv1761c +0.9 1.7 Possible exported protein compare
Rv2940c +0.9 8.1 Probable multifunctional mycocerosic acid synthase membrane-associated Mas compare
Rv2621c +0.9 1.6 Possible transcriptional regulatory protein compare
Rv1448c +0.9 2.4 Probable transaldolase Tal compare
Rv1459c +0.9 1.0 Possible conserved integral membrane protein compare
Rv2007c +0.9 1.5 Ferredoxin FdxA compare
Rv1824 +0.8 2.2 Conserved hypothetical membrane protein compare
Rv1581c +0.8 1.7 Probable PhiRv1 phage protein compare
Rv2939 +0.8 6.6 Possible conserved polyketide synthase associated protein PapA5 compare
Rv2935 +0.8 7.3 Phenolpthiocerol synthesis type-I polyketide synthase PpsE compare
Rv0554 +0.8 4.0 Possible peroxidase BpoC (non-haem peroxidase) compare
Rv2929 +0.8 4.5 Hypothetical protein compare
Rv0999 +0.8 1.4 Unknown protein compare
Rv2931 +0.8 7.1 Phenolpthiocerol synthesis type-I polyketide synthase PpsA compare
Rv2762c +0.8 1.0 Conserved hypothetical protein compare
Rv2933 +0.8 6.5 Phenolpthiocerol synthesis type-I polyketide synthase PpsC compare
Rv0319 +0.8 1.5 Probable pyrrolidone-carboxylate peptidase Pcp (5-oxoprolyl-peptidase) (pyroglutamyl-peptidase I) (PGP-I) (pyrase) compare
Rv2369c +0.8 1.0 Hypothetical protein compare
Rv0737 +0.8 1.5 Possible transcriptional regulatory protein compare
Rv2932 +0.8 6.1 Phenolpthiocerol synthesis type-I polyketide synthase PpsB compare
Rv0893c +0.7 2.0 Possible S-adenosylmethionine-dependent methyltransferase compare
Rv3143 +0.7 0.8 Probable response regulator compare
Rv1823 +0.7 3.6 Conserved protein compare
Rv2934 +0.7 6.2 Phenolpthiocerol synthesis type-I polyketide synthase PpsD compare
Rv2376c +0.7 0.9 Low molecular weight antigen CFP2 (low molecular weight protein antigen 2) (CFP-2) compare
Rv1447c +0.7 2.3 Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) compare
Rv3229c +0.7 1.9 Possible linoleoyl-CoA desaturase (delta(6)-desaturase) compare
Rv2941 +0.7 6.4 Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) compare
Rv2739c +0.7 1.6 Possible alanine rich transferase compare
Rv3848 +0.7 1.7 Probable conserved transmembrane protein compare
Rv0832 +0.7 2.1 PE-PGRS family protein PE_PGRS12 compare
Rv0561c +0.7 1.4 Possible oxidoreductase compare
Rv2598 +0.7 1.3 Conserved hypothetical protein compare
Rv3259 +0.7 2.8 Conserved hypothetical protein compare
Rv0632c +0.7 1.5 Probable enoyl-CoA hydratase EchA3 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv3377c +0.7 3.8 Halimadienyl diphosphate synthase compare
Rv3516 +0.7 1.9 Possible enoyl-CoA hydratase EchA19 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv3182 +0.7 0.7 Conserved hypothetical protein compare
Rv2563 +0.7 3.5 Probable glutamine-transport transmembrane protein ABC transporter compare
Rv3591c +0.7 1.2 Possible hydrolase compare
Rv0764c +0.7 2.0 Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) compare
Rv1064c +0.7 2.3 Possible lipoprotein LpqV compare
Rv1538c +0.7 3.2 Probable L-aparaginase AnsA compare
Rv3481c +0.7 1.0 Probable integral membrane protein compare
Rv3198c +0.7 1.0 Probable ATP-dependent DNA helicase II UvrD2 compare
Rv1841c +0.7 2.0 Conserved hypothetical membrane protein compare
Rv1116A +0.7 1.2 Conserved hypothetical protein (fragment) compare
Rv3559c +0.7 0.9 Probable oxidoreductase compare
Rv1694 +0.7 1.0 2'-O-methyltransferase TlyA compare
Rv1159A +0.6 1.4 Unknown protein compare
Rv3514 +0.6 1.5 PE-PGRS family protein PE_PGRS57 compare
Rv2586c +0.6 1.2 Probable protein-export membrane protein SecF compare
Rv1957 +0.6 1.1 Hypothetical protein compare
Rv0617 +0.6 1.2 Possible toxin VapC29. Contains PIN domain. compare
Rv1055 +0.6 0.8 Possible integrase (fragment) compare
Rv0356c +0.6 2.4 Conserved protein compare
Rv1068c +0.6 1.3 PE-PGRS family protein PE_PGRS20 compare
Rv0959 +0.6 1.1 Conserved hypothetical protein compare
Rv0251c +0.6 1.3 Heat shock protein Hsp (heat-stress-induced ribosome-binding protein A) compare
Rv2722 +0.6 2.7 Conserved hypothetical protein compare
Rv2821c +0.6 1.4 Conserved hypothetical protein compare
Rv3157 +0.6 2.8 Probable NADH dehydrogenase I (chain M) NUOK (NADH-ubiquinone oxidoreductase chain M) compare
Rv1158c +0.6 1.3 Conserved hypothetical ala-, pro-rich protein compare
Rv0821c +0.6 2.4 Probable phosphate-transport system transcriptional regulatory protein PhoY2 compare
Rv2548 +0.6 1.4 Possible toxin VapC19 compare
Rv3363c +0.6 2.2 Conserved hypothetical protein compare
Rv2902c +0.6 2.0 Probable ribonuclease HII protein RnhB (RNase HII) compare
Rv1825 +0.6 2.0 Conserved protein compare
Rv1128c +0.6 1.3 Conserved hypothetical protein compare
Rv2042c +0.6 1.8 Conserved protein compare
Rv0741 +0.6 1.6 Probable transposase (fragment) compare
Rv0084 +0.6 1.3 Possible formate hydrogenlyase HycD (FHL) compare
Rv0735 +0.6 2.4 Probable alternative RNA polymerase sigma factor SigL compare
Rv0012 +0.6 3.3 Probable conserved membrane protein compare
Rv3366 +0.6 0.8 Probable tRNA/rRNA methylase SpoU (tRNA/rRNA methyltransferase) compare
Rv2405 +0.6 3.2 Conserved protein compare
Rv2796c +0.6 1.7 Probable conserved lipoprotein LppV compare
Rv3633 +0.6 1.6 Conserved protein compare
Rv2452c +0.6 1.0 Hypothetical protein compare
Rv2159c +0.6 2.9 Conserved protein compare
Rv1103c +0.6 1.4 Possible antitoxin MazE3 compare
Rv1046c +0.6 1.2 Hypothetical protein compare
Rv2619c +0.6 1.3 Conserved protein compare
Rv2662 +0.6 2.4 Hypothetical protein compare
Rv2782c +0.5 1.7 Probable zinc protease PepR compare
Rv3426 +0.5 1.1 PPE family protein PPE58 compare
Rv1871c +0.5 2.3 Conserved protein compare
Rv2321c +0.5 1.1 Probable ornithine aminotransferase (C-terminus part) RocD2 (ornithine--oxo-acid aminotransferase) compare
Rv2404c +0.5 2.9 Probable GTP-binding protein LepA (GTP-binding elongation factor) compare
Rv3824c +0.5 2.7 Conserved polyketide synthase associated protein PapA1 compare
Rv0841 +0.5 0.7 Probable conserved transmembrane protein compare
Rv1679 +0.5 0.9 Possible acyl-CoA dehydrogenase FadE16 compare
Rv3207c +0.5 1.9 Conserved protein compare
Rv2985 +0.5 0.9 Possible hydrolase MutT1 compare
Rv3236c +0.5 1.2 Probable conserved integral membrane transport protein compare
Rv2296 +0.5 1.8 Probable haloalkane dehalogenase compare
Rv2564 +0.5 1.8 Probable glutamine-transport ATP-binding protein ABC transporter GlnQ compare
Rv0117 +0.5 2.3 Oxidative stress response regulatory protein OxyS compare
Rv2967c +0.5 2.9 Probable pyruvate carboxylase Pca (pyruvic carboxylase) compare
Rv2039c +0.5 1.1 Probable sugar-transport integral membrane protein ABC transporter compare
Rv1982c +0.5 1.0 Possible toxin VapC36. Contains PIN domain. compare
Rv3563 +0.5 1.0 Probable acyl-CoA dehydrogenase FadE32 compare
Rv0630c +0.5 1.6 Probable exonuclease V (beta chain) RecB (exodeoxyribonuclease V beta chain)(exodeoxyribonuclease V polypeptide) (chi-specific endonuclease) compare
Rv3128c +0.5 2.6 Conserved hypothetical protein compare
Rv2232 +0.5 1.1 Protein tyrosine kinase transcriptional regulatory protein PtkA compare
Rv1593c +0.5 2.4 Conserved protein compare
Rv3510c +0.5 2.0 Conserved protein compare
Rv2743c +0.5 2.4 Possible conserved transmembrane alanine rich protein compare
Rv3346c +0.5 1.0 Conserved transmembrane protein compare
Rv2444c +0.5 1.6 Possible ribonuclease E Rne compare
Rv0545c +0.5 1.9 Probable low-affinity inorganic phosphate transporter integral membrane protein PitA compare
Rv1820 +0.5 3.9 Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) compare
Rv1911c +0.5 1.9 Probable lipoprotein LppC compare
Rv0876c +0.5 1.4 Possible conserved transmembrane protein compare
Rv2249c +0.5 1.9 Probable glycerol-3-phosphate dehydrogenase GlpD1 compare
Rv1074c +0.5 3.5 Probable beta-ketoacyl CoA thiolase FadA3 compare
Rv0047c +0.5 1.2 Conserved protein compare
Rv2647 +0.5 0.7 Hypothetical protein compare
Rv3386 +0.5 0.8 Possible transposase compare
Rv2132 +0.5 1.6 Conserved hypothetical protein compare
Rv3509c +0.5 3.1 Probable acetohydroxyacid synthase IlvX (acetolactate synthase) compare
Rv3145 +0.5 2.2 Probable NADH dehydrogenase I (chain A) NuoA (NADH-ubiquinone oxidoreductase chain A) compare
Rv2661c +0.5 0.9 Hypothetical protein compare
Rv0354c +0.5 1.1 PPE family protein PPE7 compare
Rv1271c +0.5 1.4 Conserved hypothetical secreted protein compare
Rv3616c +0.5 3.1 ESX-1 secretion-associated protein A, EspA compare
Rv2790c +0.5 1.9 Probable lipid-transfer protein Ltp1 compare
Rv3338 +0.5 0.7 Conserved hypothetical protein compare
Rv0278c +0.5 3.0 PE-PGRS family protein PE_PGRS3 compare
Rv1818c +0.5 2.3 PE-PGRS family protein PE_PGRS33 compare
Rv1087 +0.5 3.3 PE-PGRS family protein PE_PGRS21 compare
Rv2850c +0.5 0.7 Possible magnesium chelatase compare
Rv3565 +0.5 0.9 Possible aspartate aminotransferase AspB (transaminase A) (ASPAT) (glutamic--oxaloacetic transaminase) (glutamic--aspartic transaminase) compare
Rv0395 +0.5 1.6 Hypothetical protein compare
Rv1943c +0.5 1.2 Possible antitoxin MazE5 compare
Rv3059 +0.5 2.3 Probable cytochrome P450 136 Cyp136 compare
Rv2055c +0.5 0.5 30S ribosomal protein S18 RpsR2 compare
Rv3316 +0.5 0.8 Probable succinate dehydrogenase (cytochrome B-556 subunit) SdhC (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase) compare
Rv1792 +0.5 0.7 ESAT-6 like protein EsxM compare
Rv2276 +0.5 0.7 Cytochrome P450 121 Cyp121 compare
Rv0918 +0.5 1.7 Conserved protein compare
Rv2573 +0.5 1.6 Conserved hypothetical protein compare
Rv1238 +0.5 2.1 Probable sugar-transport ATP-binding protein ABC transporter SugC compare
Rv2382c +0.5 0.6 Polyketide synthetase MbtC (polyketide synthase) compare
Rv3345c +0.5 3.3 PE-PGRS family protein PE_PGRS50 compare
Rv3684 +0.5 2.0 Probable lyase compare
Rv1598c +0.4 1.6 Conserved protein compare
Rv2741 +0.4 3.2 PE-PGRS family protein PE_PGRS47 compare
Rv0468 +0.4 0.9 3-hydroxybutyryl-CoA dehydrogenase FadB2 (beta-hydroxybutyryl-CoA dehydrogenase) (BHBD) compare
Rv0828c +0.4 2.8 Possible deaminase compare
Rv0187 +0.4 1.9 Probable O-methyltransferase compare
Rv1095 +0.4 1.6 Probable PHOH-like protein PhoH2 (phosphate starvation-inducible protein PSIH) compare
Rv3420c +0.4 1.4 Ribosomal-protein-alanine acetyltransferase RimI (acetylating enzyme for N-terminal of ribosomal protein S18) compare
Rv1730c +0.4 1.4 Possible penicillin-binding protein compare
Rv1632c +0.4 1.6 Hypothetical protein compare
Rv1325c +0.4 1.3 PE-PGRS family protein PE_PGRS24 compare
Rv0277A +0.4 1.4 Possible antitoxin VapB25 compare
Rv0643c +0.4 2.6 Methoxy mycolic acid synthase 3 MmaA3 (methyl mycolic acid synthase 3) (MMA3) (hydroxy mycolic acid synthase) compare
Rv0919 +0.4 1.4 GCN5-related N-acetyltransferase compare
Rv3658c +0.4 0.4 Probable conserved transmembrane protein compare
Rv0990c +0.4 0.6 Hypothetical protein compare
Rv3517 +0.4 1.8 Conserved hypothetical protein compare
Rv2318 +0.4 1.2 Probable periplasmic sugar-binding lipoprotein UspC compare
Rv0121c +0.4 1.2 Conserved protein compare
Rv3295 +0.4 3.5 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv1851 +0.4 0.7 Urease accessory protein UreF compare
Rv0428c +0.4 2.6 GCN5-related N-acetyltransferase compare
Rv3842c +0.4 1.9 Probable glycerophosphoryl diester phosphodiesterase GlpQ1 (glycerophosphodiester phosphodiesterase) compare
Rv3768 +0.4 1.4 Unknown protein compare
Rv0404 +0.4 2.2 Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) compare
Rv0536 +0.4 1.8 Probable UDP-glucose 4-epimerase GalE3 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridine diphospho-galactose 4-epimerase) compare
Rv3511 +0.4 2.2 PE-PGRS family protein PE_PGRS55 compare
Rv0751c +0.4 1.9 Probable 3-hydroxyisobutyrate dehydrogenase MmsB (hibadh) compare
Rv0514 +0.4 1.0 Possible transmembrane protein compare


Specific Phenotypes

For 3 genes in this experiment

For stress Streptomycin sulfate salt in Mycobacterium tuberculosis H37Rv

For stress Streptomycin sulfate salt across organisms