Experiment set3S287 for Mycobacterium tuberculosis H37Rv

Compare to:

7H9 with Streptomycin sulfate salt 0.178 ug/mL

200 most detrimental genes:

  gene name fitness t score description  
Rv3919c +2.7 7.9 Probable glucose-inhibited division protein B Gid compare
Rv3559c +2.6 2.7 Probable oxidoreductase compare
Rv2976c +2.3 2.6 Probable uracil-DNA glycosylase Ung (UDG) compare
Rv1819c +2.2 17.3 Probable drug-transport transmembrane ATP-binding protein ABC transporter BacA compare
Rv2739c +1.6 4.3 Possible alanine rich transferase compare
Rv1259 +1.3 1.1 Probable uracil DNA glycosylase, UdgB compare
Rv3514 +1.3 2.5 PE-PGRS family protein PE_PGRS57 compare
Rv1824 +1.2 3.0 Conserved hypothetical membrane protein compare
Rv0113 +1.2 1.7 Probable sedoheptulose-7-phosphate isomerase GmhA (phosphoheptose isomerase) compare
Rv2635 +1.2 1.0 Hypothetical protein compare
Rv3236c +1.1 1.3 Probable conserved integral membrane transport protein compare
Rv3512 +1.1 2.6 PE-PGRS family protein PE_PGRS56 compare
Rv1088 +1.1 5.4 PE family protein PE9 compare
Rv2899c +1.1 1.6 Possible FdhD protein homolog compare
Rv1087 +1.1 7.1 PE-PGRS family protein PE_PGRS21 compare
Rv2930 +1.1 9.3 Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) compare
Rv3631 +1.1 1.3 Possible transferase (possibly glycosyltransferase) compare
Rv1825 +1.0 4.7 Conserved protein compare
Rv3511 +1.0 4.8 PE-PGRS family protein PE_PGRS55 compare
Rv2586c +1.0 1.9 Probable protein-export membrane protein SecF compare
Rv1091 +1.0 6.3 PE-PGRS family protein PE_PGRS22 compare
Rv2553c +1.0 0.9 Probable conserved membrane protein compare
Rv2276 +1.0 1.4 Cytochrome P450 121 Cyp121 compare
Rv1090 +1.0 6.3 Probable cellulase CelA2b (endo-1,4-beta-glucanase) (endoglucanase) (carboxymethyl cellulase) compare
Rv1717 +1.0 2.6 Conserved hypothetical protein compare
Rv3058c +1.0 4.3 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv2376c +1.0 1.4 Low molecular weight antigen CFP2 (low molecular weight protein antigen 2) (CFP-2) compare
Rv1823 +1.0 4.2 Conserved protein compare
Rv2931 +1.0 8.5 Phenolpthiocerol synthesis type-I polyketide synthase PpsA compare
Rv0841 +1.0 1.9 Probable conserved transmembrane protein compare
Rv2940c +0.9 8.7 Probable multifunctional mycocerosic acid synthase membrane-associated Mas compare
Rv2939 +0.9 7.6 Possible conserved polyketide synthase associated protein PapA5 compare
Rv3222c +0.9 1.3 Conserved hypothetical protein compare
Rv2741 +0.9 6.8 PE-PGRS family protein PE_PGRS47 compare
Rv0832 +0.9 2.3 PE-PGRS family protein PE_PGRS12 compare
Rv2935 +0.9 7.9 Phenolpthiocerol synthesis type-I polyketide synthase PpsE compare
Rv0277A +0.9 3.5 Possible antitoxin VapB25 compare
Rv0745 +0.9 3.6 Conserved hypothetical protein compare
Rv2933 +0.9 7.5 Phenolpthiocerol synthesis type-I polyketide synthase PpsC compare
Rv1102c +0.9 1.6 Toxin MazF3 compare
Rv2941 +0.9 7.7 Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) compare
Rv2932 +0.9 6.4 Phenolpthiocerol synthesis type-I polyketide synthase PpsB compare
Rv0921 +0.9 2.5 Possible resolvase compare
Rv1538c +0.9 3.7 Probable L-aparaginase AnsA compare
Rv0279c +0.9 4.7 PE-PGRS family protein PE_PGRS4 compare
Rv0746 +0.9 3.1 PE-PGRS family protein PE_PGRS9 compare
Rv2934 +0.9 7.5 Phenolpthiocerol synthesis type-I polyketide synthase PpsD compare
Rv0098 +0.9 2.3 Probable fatty acyl CoA thioesterase type III FcoT compare
Rv3188 +0.9 1.4 Conserved hypothetical protein compare
Rv1087A +0.8 4.2 Conserved hypothetical protein compare
Rv3507 +0.8 6.0 PE-PGRS family protein PE_PGRS53 compare
Rv1158c +0.8 2.0 Conserved hypothetical ala-, pro-rich protein compare
Rv1691 +0.8 2.4 Conserved hypothetical protein compare
Rv2901c +0.8 2.3 Conserved protein compare
Rv1068c +0.8 1.5 PE-PGRS family protein PE_PGRS20 compare
Rv2004c +0.8 1.4 Conserved protein compare
Rv0540 +0.8 1.9 Conserved hypothetical protein compare
Rv1444c +0.8 2.4 Unknown protein compare
Rv0121c +0.8 2.3 Conserved protein compare
Rv2752c +0.8 3.2 Conserved hypothetical protein compare
Rv2758c +0.8 1.4 Possible antitoxin VapB21 compare
Rv1046c +0.8 1.5 Hypothetical protein compare
Rv3503c +0.8 2.0 Probable ferredoxin FdxD compare
Rv3259 +0.8 3.5 Conserved hypothetical protein compare
Rv2637 +0.8 1.5 Possible transmembrane protein DedA compare
Rv0554 +0.8 4.2 Possible peroxidase BpoC (non-haem peroxidase) compare
Rv3517 +0.8 3.4 Conserved hypothetical protein compare
Rv0012 +0.8 4.8 Probable conserved membrane protein compare
Rv3346c +0.8 1.1 Conserved transmembrane protein compare
Rv3314c +0.8 1.3 Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) compare
Rv0400c +0.8 3.6 Acyl-CoA dehydrogenase FadE7 compare
Rv3309c +0.8 1.8 Probable uracil phosphoribosyltransferase Upp (UMP pyrophosphorylase) (uprtase) (UMP diphosphorylase) compare
Rv2750 +0.8 2.4 Probable dehydrogenase compare
Rv2564 +0.8 3.6 Probable glutamine-transport ATP-binding protein ABC transporter GlnQ compare
Rv2007c +0.8 1.5 Ferredoxin FdxA compare
Rv2039c +0.8 2.0 Probable sugar-transport integral membrane protein ABC transporter compare
Rv1079 +0.7 3.7 Cystathionine gamma-synthase MetB (CGS) (O-succinylhomoserine [thiol]-lyase) compare
Rv2743c +0.7 4.2 Possible conserved transmembrane alanine rich protein compare
Rv2292c +0.7 0.7 Hypothetical protein compare
Rv0064A +0.7 2.5 Possible antitoxin VapB1 compare
Rv1459c +0.7 0.8 Possible conserved integral membrane protein compare
Rv1065 +0.7 2.6 Conserved hypothetical protein compare
Rv3513c +0.7 0.5 Probable fatty-acid-CoA ligase FadD18 (fragment) (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv2745c +0.7 1.6 Transcriptional regulatory protein ClgR compare
Rv1792 +0.7 1.1 ESAT-6 like protein EsxM compare
Rv0278c +0.7 2.7 PE-PGRS family protein PE_PGRS3 compare
Rv2657c +0.7 0.9 Probable PhiRv2 prophage protein compare
Rv2929 +0.7 4.9 Hypothetical protein compare
Rv0280 +0.7 5.2 PPE family protein PPE3 compare
Rv3508 +0.7 3.7 PE-PGRS family protein PE_PGRS54 compare
Rv2856 +0.7 1.7 Possible nickel-transport integral membrane protein NicT compare
Rv0900 +0.7 1.2 Possible membrane protein compare
Rv2742c +0.7 4.2 Conserved hypothetical arginine rich protein compare
Rv0310c +0.7 1.0 Conserved protein compare
Rv3405c +0.7 1.1 Possible transcriptional regulatory protein compare
Rv0588 +0.7 2.1 Conserved hypothetical integral membrane protein YrbE2B compare
Rv0675 +0.7 0.6 Probable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv0088 +0.7 0.8 Possible polyketide cyclase/dehydrase compare
Rv0460 +0.7 1.3 Conserved hydrophobic protein compare
Rv3345c +0.7 4.8 PE-PGRS family protein PE_PGRS50 compare
Rv1085c +0.7 4.0 Possible hemolysin-like protein compare
Rv3171c +0.7 1.0 Possible non-heme haloperoxidase Hpx compare
Rv2506 +0.7 1.4 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv0535 +0.7 2.2 Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase) compare
Rv0140 +0.7 3.2 Conserved protein compare
Rv2928 +0.7 2.9 Probable thioesterase TesA compare
Rv3081 +0.7 1.0 Conserved hypothetical protein compare
Rv1741 +0.7 0.9 Possible toxin VapC34. Contains PIN domain. compare
Rv3510c +0.7 4.0 Conserved protein compare
Rv1322A +0.7 2.1 Conserved protein compare
Rv2740 +0.6 4.0 Epoxide hydrolase compare
Rv1271c +0.6 2.3 Conserved hypothetical secreted protein compare
Rv3560c +0.6 1.9 Probable acyl-CoA dehydrogenase FadE30 compare
Rv0737 +0.6 1.9 Possible transcriptional regulatory protein compare
Rv3147 +0.6 2.7 Probable NADH dehydrogenase I (chain C) NuoC (NADH-ubiquinone oxidoreductase chain C) compare
Rv2427A +0.6 1.6 'Transcriptional regulator OxyR', pseudogene' pseudogene=unknown transl_table=11 compare
Rv3377c +0.6 3.4 Halimadienyl diphosphate synthase compare
Rv0665 +0.6 1.2 Possible toxin VapC8 compare
Rv3515c +0.6 3.6 Fatty-acid-CoA ligase FadD19 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv3468c +0.6 1.1 Possible dTDP-glucose 4,6-dehydratase compare
Rv2328 +0.6 1.6 PE family protein PE23 compare
Rv1131 +0.6 1.1 Probable methylcitrate synthase PrpC compare
Rv2744c +0.6 3.2 Conserved 35 kDa alanine rich protein compare
Rv1820 +0.6 5.1 Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) compare
Rv2028c +0.6 1.1 Universal stress protein family protein compare
Rv0277c +0.6 1.8 Possible toxin VapC25. Contains PIN domain. compare
Rv0586 +0.6 1.9 Probable transcriptional regulatory protein Mce2R (GntR-family) compare
Rv3363c +0.6 1.4 Conserved hypothetical protein compare
Rv1074c +0.6 4.2 Probable beta-ketoacyl CoA thiolase FadA3 compare
Rv3397c +0.6 3.3 Probable phytoene synthase PhyA compare
Rv1473A +0.6 0.4 Possible transcriptional regulatory protein compare
Rv0571c +0.6 1.9 Conserved protein compare
Rv0077c +0.6 1.6 Probable oxidoreductase compare
Rv1055 +0.6 0.7 Possible integrase (fragment) compare
Rv3428c +0.6 0.9 Possible transposase compare
Rv1064c +0.6 2.1 Possible lipoprotein LpqV compare
Rv0876c +0.6 1.5 Possible conserved transmembrane protein compare
Rv2197c +0.6 1.8 Probable conserved transmembrane protein compare
Rv2396 +0.6 3.2 PE-PGRS family protein PE_PGRS41 compare
Rv1239c +0.6 2.7 Possible magnesium and cobalt transport transmembrane protein CorA compare
Rv2796c +0.6 1.5 Probable conserved lipoprotein LppV compare
Rv3198c +0.6 0.9 Probable ATP-dependent DNA helicase II UvrD2 compare
Rv0274 +0.6 1.8 Conserved protein compare
Rv2544 +0.6 2.1 Probable conserved lipoprotein LppB compare
Rv2444c +0.6 1.9 Possible ribonuclease E Rne compare
Rv1593c +0.6 2.4 Conserved protein compare
Rv2159c +0.6 2.8 Conserved protein compare
Rv3651 +0.6 1.2 Conserved hypothetical protein compare
Rv0118c +0.6 3.3 Probable oxalyl-CoA decarboxylase OxcA compare
Rv0545c +0.6 1.4 Probable low-affinity inorganic phosphate transporter integral membrane protein PitA compare
Rv3519 +0.6 2.4 Unknown protein compare
Rv0744c +0.6 1.6 Possible transcriptional regulatory protein compare
Rv3214 +0.6 0.9 Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) compare
Rv3504 +0.6 3.5 Probable acyl-CoA dehydrogenase FadE26 compare
Rv2685 +0.5 1.0 Probable arsenic-transport integral membrane protein ArsB1 compare
Rv3157 +0.5 1.7 Probable NADH dehydrogenase I (chain M) NUOK (NADH-ubiquinone oxidoreductase chain M) compare
Rv0752c +0.5 1.2 Probable acyl-CoA dehydrogenase FadE9 compare
Rv0480c +0.5 2.3 Possible amidohydrolase compare
Rv2548 +0.5 1.4 Possible toxin VapC19 compare
Rv0271c +0.5 1.9 Probable acyl-CoA dehydrogenase FadE6 compare
Rv3374 +0.5 1.5 Probable enoyl-CoA hydratase (fragment) EchA18.1 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv3256c +0.5 0.8 Conserved protein compare
Rv0743c +0.5 2.6 Hypothetical protein compare
Rv2967c +0.5 3.0 Probable pyruvate carboxylase Pca (pyruvic carboxylase) compare
Rv0273c +0.5 1.4 Possible transcriptional regulatory protein compare
Rv0632c +0.5 0.7 Probable enoyl-CoA hydratase EchA3 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv0263c +0.5 2.2 Conserved hypothetical protein compare
Rv2722 +0.5 2.7 Conserved hypothetical protein compare
Rv0955 +0.5 0.6 Probable conserved integral membrane protein compare
Rv3509c +0.5 3.5 Probable acetohydroxyacid synthase IlvX (acetolactate synthase) compare
Rv2055c +0.5 0.6 30S ribosomal protein S18 RpsR2 compare
Rv2810c +0.5 2.0 Probable transposase compare
Rv3481c +0.5 0.7 Probable integral membrane protein compare
Rv3085 +0.5 0.7 Probable short-chain type dehydrogenase/reductase compare
Rv3364c +0.5 1.8 Conserved protein compare
Rv1469 +0.5 2.7 Probable cation transporter P-type ATPase D CtpD compare
Rv2148c +0.5 1.5 Conserved protein compare
Rv0836c +0.5 1.9 Hypothetical protein compare
Rv3388 +0.5 3.3 PE-PGRS family protein PE_PGRS52 compare
Rv0360c +0.5 1.8 Conserved protein compare
Rv0281 +0.5 2.3 Possible S-adenosylmethionine-dependent methyltransferase compare
Rv3420c +0.5 1.3 Ribosomal-protein-alanine acetyltransferase RimI (acetylating enzyme for N-terminal of ribosomal protein S18) compare
Rv0390 +0.5 2.4 Conserved protein compare
Rv2684 +0.5 2.9 Probable arsenic-transport integral membrane protein ArsA compare
Rv2231A +0.5 2.0 Possible toxin VapC16 compare
Rv0964c +0.5 1.3 Hypothetical protein compare
Rv0468 +0.5 1.2 3-hydroxybutyryl-CoA dehydrogenase FadB2 (beta-hydroxybutyryl-CoA dehydrogenase) (BHBD) compare
Rv3506 +0.5 3.2 Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) compare
Rv0741 +0.5 1.5 Probable transposase (fragment) compare
Rv0868c +0.5 1.1 Probable molybdenum cofactor biosynthesis protein D 2 MoaD2 (molybdopterin converting factor small subunit) (molybdopterin [MPT] converting factor, subunit 1) compare
Rv1598c +0.5 1.8 Conserved protein compare
Rv0275c +0.5 1.0 Possible transcriptional regulatory protein (possibly TetR-family) compare
Rv0091 +0.5 1.4 Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase) + S-adenosylhomocysteine nucleosidase (S-adenosyl-L-homocysteine homocysteinylribohydrolase) compare
Rv0356c +0.5 1.5 Conserved protein compare
Rv0276 +0.5 3.0 Conserved hypothetical protein compare
Rv2820c +0.5 2.1 Hypothetical protein compare
Rv3124 +0.5 2.3 Transcriptional regulatory protein MoaR1 compare
Rv2619c +0.5 1.7 Conserved protein compare
Rv2550c +0.5 2.3 Possible antitoxin VapB20 compare
Rv0117 +0.5 2.4 Oxidative stress response regulatory protein OxyS compare


Specific Phenotypes

For 3 genes in this experiment

For stress Streptomycin sulfate salt in Mycobacterium tuberculosis H37Rv

For stress Streptomycin sulfate salt across organisms