Experiment set3S286 for Mycobacterium tuberculosis H37Rv

200 most detrimental genes:

gene	name	fitness	t score	description
Rv3332		+1.7	4.4	Probable N-acetylglucosamine-6-phosphate deacetylase NagA (GlcNAc 6-P deacetylase)
Rv2876		+1.5	2.3	Possible conserved transmembrane protein
Rv1259		+1.4	1.4	Probable uracil DNA glycosylase, UdgB
Rv3193c		+1.4	3.0	Probable conserved transmembrane protein
Rv1159A		+1.3	3.6	Unknown protein
Rv3481c		+1.3	1.5	Probable integral membrane protein
Rv3065		+1.2	3.3	Multidrugs-transport integral membrane protein Mmr
Rv3819		+1.2	1.2	Unknown protein
Rv1290A		+1.2	1.3	Hypothetical protein
Rv1577c		+1.2	1.4	Probable PhiRv1 phage protein
Rv2975c		+1.1	1.7	Conserved hypothetical protein
Rv2671		+1.1	4.6	Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reductase (HTP reductase)
Rv0328		+1.1	2.0	Possible transcriptional regulatory protein (possibly TetR/AcrR-family)
Rv1096		+1.0	1.4	Possible glycosyl hydrolase
Rv1766		+1.0	1.9	Conserved protein
Rv1414		+1.0	0.9	Conserved hypothetical protein
Rv0544c		+1.0	2.5	Possible conserved transmembrane protein
Rv3174		+1.0	2.2	Probable short-chain dehydrogenase/reductase
Rv0451c		+1.0	1.9	Probable conserved membrane protein MmpS4
Rv2237A		+0.9	1.1	Conserved protein
Rv3514		+0.9	3.3	PE-PGRS family protein PE_PGRS57
Rv2039c		+0.9	1.7	Probable sugar-transport integral membrane protein ABC transporter
Rv3309c		+0.9	1.7	Probable uracil phosphoribosyltransferase Upp (UMP pyrophosphorylase) (uprtase) (UMP diphosphorylase)
Rv1046c		+0.9	1.9	Hypothetical protein
Rv0632c		+0.9	1.6	Probable enoyl-CoA hydratase EchA3 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv2007c		+0.9	2.1	Ferredoxin FdxA
Rv1825		+0.8	3.3	Conserved protein
Rv0088		+0.8	1.1	Possible polyketide cyclase/dehydrase
Rv0460		+0.8	1.6	Conserved hydrophobic protein
Rv1068c		+0.8	1.5	PE-PGRS family protein PE_PGRS20
Rv2788		+0.8	1.7	Probable transcriptional repressor SirR
Rv0897c		+0.8	1.9	Probable oxidoreductase
Rv1473A		+0.8	0.7	Possible transcriptional regulatory protein
Rv2275		+0.8	1.6	Conserved hypothetical protein
Rv3726		+0.8	1.1	Possible dehydrogenase
Rv2318		+0.7	2.5	Probable periplasmic sugar-binding lipoprotein UspC
Rv1823		+0.7	3.2	Conserved protein
Rv0245		+0.7	1.2	Possible oxidoreductase
Rv1690		+0.7	1.6	Probable lipoprotein LprJ
Rv3828c		+0.7	2.5	Possible resolvase
Rv3085		+0.7	1.1	Probable short-chain type dehydrogenase/reductase
Rv3874		+0.7	0.6	10 kDa culture filtrate antigen EsxB (LHP) (CFP10)
Rv2252		+0.7	1.1	Diacylglycerol kinase
Rv0674		+0.7	0.7	Conserved hypothetical protein
Rv0893c		+0.7	1.6	Possible S-adenosylmethionine-dependent methyltransferase
Rv3419c		+0.7	1.6	Probable O-sialoglycoprotein endopeptidase Gcp (glycoprotease)
Rv3176c		+0.7	1.1	Probable epoxide hydrolase MesT (epoxide hydratase) (arene-oxide hydratase)
Rv3346c		+0.7	1.7	Conserved transmembrane protein
Rv2647		+0.7	0.8	Hypothetical protein
Rv3368c		+0.7	1.8	Possible oxidoreductase
Rv2621c		+0.7	0.9	Possible transcriptional regulatory protein
Rv1824		+0.7	1.4	Conserved hypothetical membrane protein
Rv0135c		+0.7	1.2	Possible transcriptional regulatory protein
Rv0056		+0.7	1.5	50S ribosomal protein L9 RplI
Rv3204		+0.7	1.0	Possible DNA-methyltransferase (modification methylase)
Rv1615		+0.6	3.1	Probable membrane protein
Rv3366		+0.6	1.3	Probable tRNA/rRNA methylase SpoU (tRNA/rRNA methyltransferase)
Rv2055c		+0.6	0.6	30S ribosomal protein S18 RpsR2
Rv1791		+0.6	1.4	PE family protein PE19
Rv3229c		+0.6	2.4	Possible linoleoyl-CoA desaturase (delta(6)-desaturase)
Rv2372c		+0.6	1.6	Conserved hypothetical protein
Rv3632		+0.6	2.3	Possible conserved membrane protein
Rv0588		+0.6	1.3	Conserved hypothetical integral membrane protein YrbE2B
Rv1944c		+0.6	1.3	Conserved protein
Rv0742		+0.6	0.9	PE-PGRS family protein PE_PGRS8
Rv2404c		+0.6	3.5	Probable GTP-binding protein LepA (GTP-binding elongation factor)
Rv1361c		+0.6	2.1	PPE family protein PPE19
Rv2276		+0.6	0.8	Cytochrome P450 121 Cyp121
Rv0113		+0.6	0.8	Probable sedoheptulose-7-phosphate isomerase GmhA (phosphoheptose isomerase)
Rv1871c		+0.6	1.9	Conserved protein
Rv1444c		+0.6	1.4	Unknown protein
Rv0680c		+0.6	1.4	Probable conserved transmembrane protein
Rv0561c		+0.6	1.2	Possible oxidoreductase
Rv1262c		+0.6	0.6	Hypothetical hit-like protein
Rv3666c		+0.6	2.0	Probable periplasmic dipeptide-binding lipoprotein DppA
Rv3586		+0.6	3.0	Conserved hypothetical protein
Rv0109		+0.6	2.8	PE-PGRS family protein PE_PGRS1
Rv2403c		+0.6	1.4	Probable conserved lipoprotein LppR
Rv2236c		+0.6	1.4	Probable cobalamin biosynthesis transmembrane protein CobD
Rv1889c		+0.6	1.9	Conserved hypothetical protein
Rv1400c		+0.6	0.7	Probable lipase LipH
Rv1792		+0.6	0.9	ESAT-6 like protein EsxM
Rv1222		+0.5	1.9	Anti-sigma factor RseA
Rv1798		+0.5	0.6	ESX conserved component EccA5. ESX-5 type VII secretion system protein.
Rv2728c		+0.5	2.4	Conserved alanine rich protein
Rv0203		+0.5	2.1	Possible exported protein
Rv0556		+0.5	0.9	Probable conserved transmembrane protein
Rv1578c		+0.5	0.5	Probable PhiRv1 phage protein
Rv2292c		+0.5	0.5	Hypothetical protein
Rv1239c		+0.5	2.9	Possible magnesium and cobalt transport transmembrane protein CorA
Rv3081		+0.5	0.8	Conserved hypothetical protein
Rv2635		+0.5	0.4	Hypothetical protein
Rv0741		+0.5	1.2	Probable transposase (fragment)
Rv2044c		+0.5	0.7	Conserved hypothetical protein
Rv0535		+0.5	1.0	Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase)
Rv3207c		+0.5	1.7	Conserved protein
Rv0572c		+0.5	2.4	Hypothetical protein
Rv0356c		+0.5	2.5	Conserved protein
Rv3519		+0.5	1.4	Unknown protein
Rv1049		+0.5	0.8	Probable transcriptional repressor protein
Rv3371		+0.5	1.3	Possible triacylglycerol synthase (diacylglycerol acyltransferase)
Rv3236c		+0.5	0.7	Probable conserved integral membrane transport protein
Rv3631		+0.5	0.6	Possible transferase (possibly glycosyltransferase)
Rv1087		+0.5	3.3	PE-PGRS family protein PE_PGRS21
Rv2042c		+0.5	1.3	Conserved protein
Rv1452c		+0.5	1.7	PE-PGRS family protein PE_PGRS28
Rv3230c		+0.5	2.1	Hypothetical oxidoreductase
Rv2322c		+0.5	0.7	Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase)
Rv0375c		+0.5	0.5	Probable carbon monoxyde dehydrogenase (medium chain)
Rv2717c		+0.5	1.3	Conserved protein
Rv1422		+0.5	0.7	Conserved hypothetical protein
Rv0277c		+0.5	2.1	Possible toxin VapC25. Contains PIN domain.
Rv0084		+0.5	1.1	Possible formate hydrogenlyase HycD (FHL)
Rv0012		+0.5	2.0	Probable conserved membrane protein
Rv3468c		+0.5	1.3	Possible dTDP-glucose 4,6-dehydratase
Rv3157		+0.5	2.5	Probable NADH dehydrogenase I (chain M) NUOK (NADH-ubiquinone oxidoreductase chain M)
Rv2993c		+0.5	1.2	Possible 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase)
Rv0221		+0.5	2.6	Possible triacylglycerol synthase (diacylglycerol acyltransferase)
Rv3369		+0.5	2.1	Conserved protein
Rv2619c		+0.5	1.6	Conserved protein
Rv0354c		+0.5	1.4	PPE family protein PPE7
Rv0665		+0.5	1.1	Possible toxin VapC8
Rv3099c		+0.5	1.1	Conserved protein
Rv1490		+0.5	2.0	Probable membrane protein
Rv2321c		+0.5	0.9	Probable ornithine aminotransferase (C-terminus part) RocD2 (ornithine--oxo-acid aminotransferase)
Rv0927c		+0.5	1.0	Probable short-chain type dehydrogenase/reductase
Rv3331		+0.4	1.5	Probable sugar-transport integral membrane protein SugI
Rv2790c		+0.4	1.6	Probable lipid-transfer protein Ltp1
Rv2033c		+0.4	2.9	Conserved hypothetical protein
Rv0545c		+0.4	1.7	Probable low-affinity inorganic phosphate transporter integral membrane protein PitA
Rv1861		+0.4	2.0	Probable conserved transmembrane protein
Rv1608c		+0.4	1.9	Probable peroxidoxin BcpB
Rv0273c		+0.4	1.4	Possible transcriptional regulatory protein
Rv3779		+0.4	3.3	Probable conserved transmembrane protein alanine and leucine rich
Rv1242		+0.4	0.9	Possible toxin VapC33. Contains PIN domain.
Rv0836c		+0.4	1.3	Hypothetical protein
Rv1271c		+0.4	1.5	Conserved hypothetical secreted protein
Rv1207		+0.4	2.4	Dihydropteroate synthase 2 FolP2 (DHPS 2) (dihydropteroate pyrophosphorylase 2)
Rv1878		+0.4	2.1	Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I)
Rv3277		+0.4	0.5	Probable conserved transmembrane protein
Rv3295		+0.4	3.5	Probable transcriptional regulatory protein (probably TetR-family)
Rv0726c		+0.4	2.2	Possible S-adenosylmethionine-dependent methyltransferase
Rv2331A		+0.4	0.8	Hypothetical protein
Rv2005c		+0.4	1.7	Universal stress protein family protein
Rv2026c		+0.4	0.9	Universal stress protein family protein
Rv1509		+0.4	1.2	Hypothetical protein
Rv2897c		+0.4	1.0	Conserved hypothetical protein
Rv2886c		+0.4	2.4	Probable resolvase
Rv0832		+0.4	1.5	PE-PGRS family protein PE_PGRS12
Rv2381c		+0.4	0.8	Polyketide synthetase MbtD (polyketide synthase)
Rv2025c		+0.4	1.8	Conserved membrane protein
Rv1255c		+0.4	1.8	Probable transcriptional regulatory protein
Rv0746		+0.4	2.1	PE-PGRS family protein PE_PGRS9
Rv1581c		+0.4	1.1	Probable PhiRv1 phage protein
Rv2506		+0.4	1.5	Probable transcriptional regulatory protein (probably TetR-family)
Rv1447c		+0.4	1.9	Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD)
Rv2782c		+0.4	0.9	Probable zinc protease PepR
Rv0360c		+0.4	1.5	Conserved protein
Rv1546		+0.4	1.6	Conserved protein
Rv0737		+0.4	0.9	Possible transcriptional regulatory protein
Rv3777		+0.4	2.0	Probable oxidoreductase
Rv1090		+0.4	2.8	Probable cellulase CelA2b (endo-1,4-beta-glucanase) (endoglucanase) (carboxymethyl cellulase)
Rv2314c		+0.4	1.4	Conserved protein
Rv3415c		+0.4	1.7	Conserved hypothetical protein
Rv1322		+0.4	0.7	Conserved hypothetical protein
Rv2781c		+0.4	2.2	Possible alanine rich oxidoreductase
Rv1322A		+0.4	1.9	Conserved protein
Rv3136		+0.4	1.8	PPE family protein PPE51
Rv2558		+0.4	0.9	Conserved protein
Rv2955c		+0.4	2.0	Conserved protein
Rv3865		+0.4	1.7	ESX-1 secretion-associated protein EspF
Rv3377c		+0.4	1.6	Halimadienyl diphosphate synthase
Rv2316		+0.4	1.8	Probable sugar-transport integral membrane protein ABC transporter UspA
Rv3920c		+0.4	0.4	Conserved protein similar to jag protein
Rv2564		+0.4	1.6	Probable glutamine-transport ATP-binding protein ABC transporter GlnQ
Rv2367c		+0.4	1.2	Conserved hypothetical protein
Rv1455		+0.4	2.8	Conserved protein
Rv0118c		+0.4	2.1	Probable oxalyl-CoA decarboxylase OxcA
Rv1170		+0.4	1.0	N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase)
Rv3766		+0.4	1.3	Hypothetical protein
Rv3067		+0.4	1.2	Conserved hypothetical protein
Rv2775		+0.4	1.1	GCN5-related N-acetyltransferase
Rv3911		+0.4	1.7	Possible alternative RNA polymerase sigma factor SigM
Rv2743c		+0.4	2.7	Possible conserved transmembrane alanine rich protein
Rv0986		+0.4	1.3	Probable adhesion component transport ATP-binding protein ABC transporter
Rv1140		+0.4	1.1	Probable integral membrane protein
Rv1112		+0.4	0.6	Probable GTP binding protein
Rv3677c		+0.4	2.4	Possible hydrolase
Rv1538c		+0.4	1.9	Probable L-aparaginase AnsA
Rv1499		+0.4	2.0	Hypothetical protein
Rv1282c		+0.4	1.3	Probable oligopeptide-transport integral membrane protein ABC transporter OppC
Rv0276		+0.4	1.9	Conserved hypothetical protein
Rv0868c		+0.4	0.8	Probable molybdenum cofactor biosynthesis protein D 2 MoaD2 (molybdopterin converting factor small subunit) (molybdopterin [MPT] converting factor, subunit 1)
Rv1735c		+0.4	1.5	Hypothetical membrane protein
Rv3256c		+0.4	0.4	Conserved protein
Rv3180c		+0.4	1.9	Hypothetical alanine rich protein
Rv0173		+0.4	2.2	Possible Mce-family lipoprotein LprK (Mce-family lipoprotein Mce1E)
Rv3312A		+0.4	2.2	Secreted protein antigen
Rv2749		+0.4	1.2	Conserved protein
Rv0574c		+0.4	1.5	Conserved hypothetical protein

Specific Phenotypes

None in this experiment

For Mycobacterium tuberculosis H37Rv in stress experiments

For stress para-aminosalicylic acid across organisms