Experiment set3S285 for Mycobacterium tuberculosis H37Rv

200 most detrimental genes:

gene	name	fitness	t score	description
Rv2292c		+1.8	2.0	Hypothetical protein
Rv1159A		+1.7	4.6	Unknown protein
Rv1577c		+1.4	2.1	Probable PhiRv1 phage protein
Rv2762c		+1.2	1.6	Conserved hypothetical protein
Rv1259		+1.2	1.0	Probable uracil DNA glycosylase, UdgB
Rv3230c		+1.1	3.2	Hypothetical oxidoreductase
Rv0088		+1.1	1.4	Possible polyketide cyclase/dehydrase
Rv1444c		+1.1	3.1	Unknown protein
Rv0544c		+1.0	2.5	Possible conserved transmembrane protein
Rv0212c		+1.0	2.0	Possible transcriptional regulatory protein NadR (probably AsnC-family)
Rv3514		+1.0	2.7	PE-PGRS family protein PE_PGRS57
Rv2317		+1.0	1.4	Probable sugar-transport integral membrane protein ABC transporter UspB
Rv2739c		+1.0	2.5	Possible alanine rich transferase
Rv3193c		+1.0	1.9	Probable conserved transmembrane protein
Rv1414		+1.0	0.8	Conserved hypothetical protein
Rv1247c		+1.0	1.7	Antitoxin RelB
Rv0081		+0.9	2.2	Probable transcriptional regulatory protein
Rv1400c		+0.9	1.2	Probable lipase LipH
Rv1062		+0.9	1.0	Conserved hypothetical protein
Rv3413c		+0.9	1.0	Unknown alanine and proline rich protein
Rv0825c		+0.9	1.7	Conserved protein
Rv0674		+0.9	0.9	Conserved hypothetical protein
Rv0841		+0.9	1.3	Probable conserved transmembrane protein
Rv1064c		+0.9	3.0	Possible lipoprotein LpqV
Rv1096		+0.9	1.2	Possible glycosyl hydrolase
Rv0328		+0.9	1.9	Possible transcriptional regulatory protein (possibly TetR/AcrR-family)
Rv2702		+0.9	0.9	Polyphosphate glucokinase PpgK (polyphosphate-glucose phosphotransferase)
Rv1824		+0.8	2.2	Conserved hypothetical membrane protein
Rv2372c		+0.8	1.9	Conserved hypothetical protein
Rv3366		+0.8	1.7	Probable tRNA/rRNA methylase SpoU (tRNA/rRNA methyltransferase)
Rv3182		+0.8	0.9	Conserved hypothetical protein
Rv3229c		+0.8	2.6	Possible linoleoyl-CoA desaturase (delta(6)-desaturase)
Rv0677c		+0.8	1.6	Possible conserved membrane protein MmpS5
Rv3174		+0.8	1.6	Probable short-chain dehydrogenase/reductase
Rv2492		+0.8	1.4	Hypothetical protein
Rv0939		+0.8	0.9	Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase
Rv1459c		+0.8	0.9	Possible conserved integral membrane protein
Rv2671		+0.8	2.2	Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reductase (HTP reductase)
Rv2619c		+0.7	1.4	Conserved protein
Rv3328c		+0.7	1.3	Probable alternative RNA polymerase sigma factor (fragment) SigJ
Rv2568c		+0.7	1.6	Conserved hypothetical protein
Rv1287		+0.7	2.4	Conserved hypothetical protein
Rv1798		+0.7	1.1	ESX conserved component EccA5. ESX-5 type VII secretion system protein.
Rv3726		+0.7	1.4	Possible dehydrogenase
Rv0219		+0.7	2.0	Probable conserved transmembrane protein
Rv1578c		+0.7	0.7	Probable PhiRv1 phage protein
Rv3819		+0.7	0.6	Unknown protein
Rv0745		+0.7	2.5	Conserved hypothetical protein
Rv2781c		+0.7	3.8	Possible alanine rich oxidoreductase
Rv0857		+0.7	1.9	Conserved hypothetical protein
Rv0832		+0.7	2.4	PE-PGRS family protein PE_PGRS12
Rv2072c		+0.7	1.2	Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL
Rv0360c		+0.7	2.7	Conserved protein
Rv0383c		+0.7	0.8	Possible conserved secreted protein
Rv2997		+0.7	2.5	Possible alanine rich dehydrogenase
Rv0354c		+0.7	2.1	PPE family protein PPE7
Rv1447c		+0.7	3.3	Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD)
Rv2382c		+0.7	1.0	Polyketide synthetase MbtC (polyketide synthase)
Rv1238		+0.7	2.9	Probable sugar-transport ATP-binding protein ABC transporter SugC
Rv2728c		+0.6	3.3	Conserved alanine rich protein
Rv3167c		+0.6	1.8	Probable transcriptional regulatory protein (probably TetR-family)
Rv3084		+0.6	1.6	Probable acetyl-hydrolase/esterase LipR
Rv1791		+0.6	1.2	PE family protein PE19
Rv0009		+0.6	0.7	Probable iron-regulated peptidyl-prolyl cis-trans isomerase A PpiA (PPIase A) (rotamase A)
Rv2143		+0.6	4.2	Conserved hypothetical protein
Rv1825		+0.6	2.2	Conserved protein
Rv1112		+0.6	0.9	Probable GTP binding protein
Rv1085c		+0.6	3.7	Possible hemolysin-like protein
Rv2184c		+0.6	3.1	Conserved hypothetical protein
Rv2318		+0.6	2.0	Probable periplasmic sugar-binding lipoprotein UspC
Rv0940c		+0.6	1.2	Possible oxidoreductase
Rv2429		+0.6	0.9	Alkyl hydroperoxide reductase D protein AhpD (alkyl hydroperoxidase D)
Rv3910		+0.6	1.3	Probable conserved transmembrane protein
Rv1132		+0.6	2.2	Conserved membrane protein
Rv1422		+0.6	0.9	Conserved hypothetical protein
Rv3863		+0.6	1.7	Unknown alanine rich protein
Rv2149c		+0.6	1.6	Conserved protein YfiH
Rv3516		+0.6	2.3	Possible enoyl-CoA hydratase EchA19 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv1473A		+0.6	0.5	Possible transcriptional regulatory protein
Rv2879c		+0.6	0.6	Conserved hypothetical protein
Rv2813		+0.6	1.1	Conserved hypothetical protein
Rv0968		+0.6	2.1	Conserved protein
Rv0549c		+0.6	1.1	Possible toxin VapC3
Rv0665		+0.5	1.4	Possible toxin VapC8
Rv2159c		+0.5	2.9	Conserved protein
Rv3678A		+0.5	1.1	Conserved hypothetical protein
Rv0737		+0.5	1.5	Possible transcriptional regulatory protein
Rv3847		+0.5	2.1	Hypothetical protein
Rv2898c		+0.5	0.8	Conserved hypothetical protein
Rv3560c		+0.5	1.6	Probable acyl-CoA dehydrogenase FadE30
Rv3171c		+0.5	0.9	Possible non-heme haloperoxidase Hpx
Rv3857c		+0.5	1.6	Possible membrane protein
Rv1239c		+0.5	2.7	Possible magnesium and cobalt transport transmembrane protein CorA
Rv1087		+0.5	3.3	PE-PGRS family protein PE_PGRS21
Rv3445c		+0.5	0.7	ESAT-6 like protein EsxU
Rv0276		+0.5	3.4	Conserved hypothetical protein
Rv3586		+0.5	2.1	Conserved hypothetical protein
Rv3591c		+0.5	1.6	Possible hydrolase
Rv2609c		+0.5	2.1	Probable conserved membrane protein
Rv3295		+0.5	4.1	Probable transcriptional regulatory protein (probably TetR-family)
Rv0187		+0.5	2.8	Probable O-methyltransferase
Rv1046c		+0.5	1.1	Hypothetical protein
Rv0274		+0.5	1.3	Conserved protein
Rv0983		+0.5	2.3	Probable serine protease PepD (serine proteinase) (MTB32B)
Rv2510c		+0.5	1.7	Conserved protein
Rv2791c		+0.5	1.7	Probable transposase
Rv3816c		+0.5	0.3	Possible acyltransferase
Rv2404c		+0.5	3.4	Probable GTP-binding protein LepA (GTP-binding elongation factor)
Rv3143		+0.5	0.5	Probable response regulator
Rv0052		+0.5	2.1	Conserved protein
Rv2901c		+0.5	1.3	Conserved protein
Rv1284		+0.5	0.5	Beta-carbonic anhydrase
Rv0741		+0.5	1.6	Probable transposase (fragment)
Rv2788		+0.5	1.6	Probable transcriptional repressor SirR
Rv3069		+0.5	0.8	Probable conserved transmembrane protein
Rv0056		+0.5	1.6	50S ribosomal protein L9 RplI
Rv3850		+0.5	0.6	Conserved protein
Rv0121c		+0.5	1.4	Conserved protein
Rv3236c		+0.5	1.0	Probable conserved integral membrane transport protein
Rv1502		+0.5	0.6	Hypothetical protein
Rv0264c		+0.5	1.9	Conserved hypothetical protein
Rv1616		+0.5	1.3	Conserved membrane protein
Rv2624c		+0.5	0.7	Universal stress protein family protein
Rv3334		+0.5	1.3	Probable transcriptional regulatory protein (probably MerR-family)
Rv2437		+0.5	1.3	Conserved transmembrane protein
Rv0278c		+0.5	1.9	PE-PGRS family protein PE_PGRS3
Rv2650c		+0.5	0.8	Possible PhiRv2 prophage protein
Rv3553		+0.5	1.2	Possible oxidoreductase
Rv0376c		+0.5	1.3	Conserved hypothetical protein
Rv1068c		+0.5	1.3	PE-PGRS family protein PE_PGRS20
Rv0536		+0.5	2.2	Probable UDP-glucose 4-epimerase GalE3 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridine diphospho-galactose 4-epimerase)
Rv0280		+0.5	3.3	PPE family protein PPE3
Rv0012		+0.5	2.4	Probable conserved membrane protein
Rv0537c		+0.5	2.6	Probable integral membrane protein
Rv1290A		+0.5	0.4	Hypothetical protein
Rv1761c		+0.5	2.0	Possible exported protein
Rv1067c		+0.5	1.6	PE-PGRS family protein PE_PGRS19
Rv1482c		+0.5	2.2	Conserved hypothetical protein
Rv1530		+0.5	2.1	Probable alcohol dehydrogenase Adh
Rv2237A		+0.5	0.6	Conserved protein
Rv3283		+0.5	1.4	Probable thiosulfate sulfurtransferase SseA (rhodanese) (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase)
Rv0190		+0.5	1.9	Conserved protein
Rv1076		+0.5	2.7	Possible lipase LipU
Rv3114		+0.5	0.7	Conserved hypothetical protein
Rv2923c		+0.5	0.9	Conserved protein
Rv0091		+0.5	1.5	Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase) + S-adenosylhomocysteine nucleosidase (S-adenosyl-L-homocysteine homocysteinylribohydrolase)
Rv3081		+0.4	0.7	Conserved hypothetical protein
Rv2790c		+0.4	1.1	Probable lipid-transfer protein Ltp1
Rv0944		+0.4	0.8	Possible formamidopyrimidine-DNA glycosylase (FAPY-DNA glycosylase)
Rv3643		+0.4	1.1	Hypothetical protein
Rv2416c		+0.4	1.5	Enhanced intracellular survival protein Eis,GCN5-related N-acetyltransferase
Rv3157		+0.4	1.5	Probable NADH dehydrogenase I (chain M) NUOK (NADH-ubiquinone oxidoreductase chain M)
Rv2026c		+0.4	0.6	Universal stress protein family protein
Rv1730c		+0.4	1.2	Possible penicillin-binding protein
Rv2312		+0.4	1.3	Hypothetical protein
Rv3082c		+0.4	1.8	Virulence-regulating transcriptional regulator VirS (AraC/XylS family)
Rv2183c		+0.4	0.8	Conserved protein
Rv1028c		+0.4	1.7	Probable sensor protein KdpD
Rv1303		+0.4	0.5	Conserved hypothetical transmembrane protein
Rv1439c		+0.4	1.2	Unknown protein
Rv1912c		+0.4	1.8	Possible oxidoreductase FadB5
Rv1608c		+0.4	1.2	Probable peroxidoxin BcpB
Rv0577		+0.4	1.7	Conserved protein TB27.3
Rv3638		+0.4	2.6	Possible transposase
Rv0323c		+0.4	0.9	Conserved hypothetical protein
Rv1176c		+0.4	1.5	Conserved hypothetical protein
Rv0836c		+0.4	1.7	Hypothetical protein
Rv1662		+0.4	1.1	Probable polyketide synthase Pks8
Rv0726c		+0.4	2.2	Possible S-adenosylmethionine-dependent methyltransferase
Rv3075c		+0.4	1.5	Conserved protein
Rv3518c		+0.4	2.0	Probable cytochrome P450 monooxygenase 142 Cyp142
Rv3700c		+0.4	1.0	Conserved hypothetical protein
Rv3249c		+0.4	0.7	Possible transcriptional regulatory protein (probably TetR-family)
Rv0090		+0.4	1.6	Possible membrane protein
Rv1072		+0.4	0.5	Probable conserved transmembrane protein
Rv3511		+0.4	1.9	PE-PGRS family protein PE_PGRS55
Rv0580c		+0.4	0.5	Conserved protein
Rv2091c		+0.4	2.4	Probable membrane protein
Rv3733c		+0.4	2.0	Conserved hypothetical protein
Rv3519		+0.4	1.6	Unknown protein
Rv3512		+0.4	1.5	PE-PGRS family protein PE_PGRS56
Rv3282		+0.4	1.0	Conserved hypothetical protein
Rv1452c		+0.4	1.6	PE-PGRS family protein PE_PGRS28
Rv0519c		+0.4	1.5	Possible conserved membrane protein
Rv1682		+0.4	1.3	Probable coiled-coil structural protein
Rv2741		+0.4	3.1	PE-PGRS family protein PE_PGRS47
Rv2850c		+0.4	0.6	Possible magnesium chelatase
Rv0131c		+0.4	0.9	Probable acyl-CoA dehydrogenase FadE1
Rv3345c		+0.4	3.0	PE-PGRS family protein PE_PGRS50
Rv2126c		+0.4	2.3	PE-PGRS family protein PE_PGRS37
Rv1955		+0.4	1.0	Possible toxin HigB
Rv0272c		+0.4	1.5	Unknown protein
Rv2276		+0.4	0.6	Cytochrome P450 121 Cyp121
Rv2774c		+0.4	0.6	Hypothetical protein
Rv0399c		+0.4	1.2	Possible conserved lipoprotein LpqK
Rv2070c		+0.4	1.5	Precorrin-6X reductase CobK
Rv3631		+0.4	0.5	Possible transferase (possibly glycosyltransferase)
Rv0588		+0.4	1.1	Conserved hypothetical integral membrane protein YrbE2B
Rv0234c		+0.4	1.4	Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1
Rv3828c		+0.4	1.4	Possible resolvase

Specific Phenotypes

None in this experiment

For Mycobacterium tuberculosis H37Rv in stress experiments

For stress para-aminosalicylic acid across organisms