Experiment set3S280 for Mycobacterium tuberculosis H37Rv

200 most important genes:

gene	name	fitness	t score	description
Rv3364c		-3.7	-2.7	Conserved protein
Rv3202c		-2.8	-8.1	Possible ATP-dependent DNA helicase
Rv1930c		-2.7	-1.3	Conserved hypothetical protein
Rv0928		-2.1	-5.4	Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1)
Rv2624c		-2.1	-1.1	Universal stress protein family protein
Rv0642c		-1.9	-2.2	Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase)
Rv0929		-1.9	-2.0	Phosphate-transport integral membrane ABC transporter PstC2
Rv2095c		-1.9	-8.3	Proteasome accessory factor C PafC
Rv3277		-1.8	-0.8	Probable conserved transmembrane protein
Rv3114		-1.8	-1.1	Conserved hypothetical protein
Rv0930		-1.7	-4.9	Probable phosphate-transport integral membrane ABC transporter PstA1
Rv1824		-1.7	-1.5	Conserved hypothetical membrane protein
Rv3201c		-1.7	-6.1	Probable ATP-dependent DNA helicase
Rv2096c		-1.7	-3.5	Proteasome accessory factor B PafB
Rv0805		-1.6	-0.9	Class III cyclic nucleotide phosphodiesterase (cNMP PDE)
Rv1107c		-1.6	-1.4	Probable exodeoxyribonuclease VII (small subunit) XseB (exonuclease VII small subunit)
Rv1962A		-1.5	-1.2	Possible antitoxin VapB35
Rv0819		-1.5	-3.1	GCN5-related N-acetyltransferase, MshD
Rv1284		-1.5	-0.7	Beta-carbonic anhydrase
Rv2099c		-1.4	-2.2	PE family protein PE21
Rv0003		-1.4	-3.6	DNA replication and repair protein RecF (single-strand DNA binding protein)
Rv1986		-1.4	-1.5	Probable conserved integral membrane protein
Rv3687c		-1.4	-1.1	Anti-anti-sigma factor RsfB (anti-sigma factor antagonist) (regulator of sigma F B)
Rv2376c		-1.3	-0.7	Low molecular weight antigen CFP2 (low molecular weight protein antigen 2) (CFP-2)
Rv0563		-1.3	-2.0	Probable protease transmembrane protein heat shock protein HtpX
Rv0820		-1.3	-2.9	Probable phosphate-transport ATP-binding protein ABC transporter PhoT
Rv0426c		-1.3	-2.0	Possible transmembrane protein
Rv2374c		-1.2	-2.0	Probable heat shock protein transcriptional repressor HrcA
Rv2694c		-1.2	-2.4	Conserved protein
Rv1715		-1.2	-1.9	Probable 3-hydroxybutyryl-CoA dehydrogenase FadB3 (beta-hydroxybutyryl-CoA dehydrogenase) (BHBD)
Rv3428c		-1.2	-1.1	Possible transposase
Rv2088		-1.2	-1.0	Transmembrane serine/threonine-protein kinase J PknJ (protein kinase J) (STPK J)
Rv0361		-1.2	-1.0	Probable conserved membrane protein
Rv2829c		-1.2	-1.7	Possible toxin VapC22
Rv1773c		-1.2	-1.6	Probable transcriptional regulatory protein
Rv3760		-1.2	-2.2	Possible conserved membrane protein
Rv0612		-1.2	-1.6	Conserved hypothetical protein
Rv3655c		-1.1	-1.5	Conserved hypothetical protein
Rv0615		-1.1	-1.3	Probable integral membrane protein
Rv1823		-1.1	-3.1	Conserved protein
Rv1072		-1.1	-1.1	Probable conserved transmembrane protein
Rv0184		-1.1	-2.5	Conserved hypothetical protein
Rv0100		-1.1	-1.4	Conserved hypothetical protein
Rv2408		-1.1	-1.3	Possible PE family-related protein PE24
Rv3209		-1.1	-2.0	Conserved hypothetical threonine and proline rich protein
Rv2140c		-1.0	-1.2	Conserved protein TB18.6
Rv3273		-1.0	-4.7	Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase)
Rv3652		-1.0	-3.4	PE-PGRS family-related protein PE_PGRS60
Rv3856c		-1.0	-0.9	Conserved hypothetical protein
Rv2044c		-1.0	-0.6	Conserved hypothetical protein
Rv0207c		-1.0	-1.6	Conserved hypothetical protein
Rv0587		-1.0	-0.9	Conserved hypothetical integral membrane protein YrbE2A
Rv2551c		-1.0	-1.2	Conserved hypothetical protein
Rv3910		-1.0	-1.0	Probable conserved transmembrane protein
Rv0375c		-1.0	-1.3	Probable carbon monoxyde dehydrogenase (medium chain)
Rv2369c		-1.0	-0.6	Hypothetical protein
Rv2737c		-1.0	-2.5	RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)].
Rv0379		-1.0	-0.7	Possible protein transport protein SecE2
Rv0531		-1.0	-0.9	Possible conserved membrane protein
Rv1940		-1.0	-1.1	Probable riboflavin biosynthesis protein RibA1 (GTP cyclohydrolase II)
Rv0437c		-1.0	-0.9	Possible phosphatidylserine decarboxylase Psd (PS decarboxylase)
Rv2331A		-0.9	-0.9	Hypothetical protein
Rv1450c		-0.9	-1.4	PE-PGRS family protein PE_PGRS27
Rv1359		-0.9	-2.4	Probable transcriptional regulatory protein
Rv1366A		-0.9	-0.6	Conserved protein
Rv2317		-0.9	-0.6	Probable sugar-transport integral membrane protein ABC transporter UspB
Rv1351		-0.9	-1.2	Hypothetical protein
Rv2922c		-0.9	-2.9	Probable chromosome partition protein Smc
Rv2251		-0.9	-1.7	Possible flavoprotein
Rv3566c		-0.9	-2.1	Arylamine N-acetyltransferase Nat (arylamine acetylase)
Rv3897c		-0.9	-0.7	Conserved hypothetical protein
Rv1400c		-0.9	-0.5	Probable lipase LipH
Rv2762c		-0.9	-0.5	Conserved hypothetical protein
Rv1775		-0.9	-1.3	Conserved hypothetical protein
Rv2417c		-0.9	-2.6	Conserved protein
Rv1035c		-0.9	-1.0	Probable transposase (fragment)
Rv3287c		-0.9	-0.8	Anti-sigma factor RsbW (sigma negative effector)
Rv0012		-0.8	-4.0	Probable conserved membrane protein
Rv2252		-0.8	-0.6	Diacylglycerol kinase
Rv1926c		-0.8	-1.6	Immunogenic protein Mpt63 (antigen Mpt63/MPB63) (16 kDa immunoprotective extracellular protein)
Rv3397c		-0.8	-1.9	Probable phytoene synthase PhyA
Rv0345		-0.8	-1.5	Conserved hypothetical protein
Rv1020		-0.8	-5.0	Probable transcription-repair coupling factor Mfd (TRCF)
Rv2630		-0.8	-0.6	Hypothetical protein
Rv1672c		-0.8	-2.2	Probable conserved integral membrane transport protein
Rv0007		-0.8	-0.5	Possible conserved membrane protein
Rv0649		-0.8	-1.9	Possible malonyl CoA-acyl carrier protein transacylase FabD2 (MCT)
Rv3000		-0.8	-1.8	Possible conserved transmembrane protein
Rv1218c		-0.8	-1.5	Probable tetronasin-transport ATP-binding protein ABC transporter
Rv1194c		-0.8	-3.5	Conserved protein
Rv0766c		-0.8	-0.6	Probable cytochrome P450 123 Cyp123
Rv0474		-0.8	-2.3	Probable transcriptional regulatory protein
Rv0499		-0.8	-1.5	Conserved hypothetical protein
Rv1109c		-0.8	-2.5	Conserved protein
Rv3748		-0.8	-1.1	Conserved hypothetical protein
Rv1780		-0.8	-2.1	Conserved protein
Rv1116A		-0.8	-0.7	Conserved hypothetical protein (fragment)
Rv2277c		-0.8	-1.0	Possible glycerolphosphodiesterase
Rv1256c		-0.8	-2.6	Probable cytochrome P450 130 Cyp130
Rv0333		-0.8	-2.4	Unknown protein
Rv1678		-0.8	-1.4	Probable integral membrane protein
Rv0986		-0.8	-1.3	Probable adhesion component transport ATP-binding protein ABC transporter
Rv1062		-0.8	-0.6	Conserved hypothetical protein
Rv2234		-0.8	-1.9	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)
Rv0549c		-0.7	-0.7	Possible toxin VapC3
Rv1350		-0.7	-0.6	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase)
Rv1108c		-0.7	-2.4	Probable exodeoxyribonuclease VII (large subunit) XseA (exonuclease VII large subunit)
Rv0629c		-0.7	-1.7	Probable exonuclease V (alpha chain) RecD (exodeoxyribonuclease V alpha chain) (exodeoxyribonuclease V polypeptide)
Rv3787c		-0.7	-1.4	Conserved hypothetical protein
Rv2586c		-0.7	-0.7	Probable protein-export membrane protein SecF
Rv3438		-0.7	-1.5	Conserved protein
Rv1283c		-0.7	-1.2	Probable oligopeptide-transport integral membrane protein ABC transporter OppB
Rv3148		-0.7	-2.3	Probable NADH dehydrogenase I (chain D) NuoD (NADH-ubiquinone oxidoreductase chain D)
Rv3237c		-0.7	-2.3	Conserved protein
Rv2818c		-0.7	-2.4	Hypothetical protein
Rv3405c		-0.7	-0.7	Possible transcriptional regulatory protein
Rv0959		-0.7	-0.7	Conserved hypothetical protein
Rv3321c		-0.7	-1.7	Possible antitoxin VapB44
Rv3182		-0.7	-0.4	Conserved hypothetical protein
Rv3278c		-0.7	-2.3	Probable conserved transmembrane protein
Rv0463		-0.7	-1.9	Probable conserved membrane protein
Rv2556c		-0.7	-1.3	Conserved hypothetical protein
Rv0367c		-0.7	-0.5	Hypothetical protein
Rv3200c		-0.7	-1.2	Possible transmembrane cation transporter
Rv2529		-0.7	-0.9	Hypothetical protein
Rv1825		-0.7	-1.6	Conserved protein
Rv2928		-0.7	-1.5	Probable thioesterase TesA
Rv0085		-0.7	-0.9	Possible hydrogenase HycP
Rv1570		-0.7	-1.3	Dethiobiotin synthetase BioD
Rv2265		-0.6	-1.8	Possible conserved integral membrane protein
Rv1566c		-0.6	-1.3	Possible Inv protein
Rv3272		-0.6	-2.5	Conserved hypothetical protein
Rv1938		-0.6	-1.9	Probable epoxide hydrolase EphB (epoxide hydratase)
Rv1291c		-0.6	-0.6	Conserved hypothetical secreted protein
Rv3843c		-0.6	-1.1	Probable conserved transmembrane protein
Rv0696		-0.6	-1.3	Probable membrane sugar transferase
Rv0609		-0.6	-0.4	Possible toxin VapC28. Contains PIN domain.
Rv1639c		-0.6	-2.0	Conserved hypothetical membrane protein
Rv1354c		-0.6	-1.4	Conserved hypothetical protein
Rv1524		-0.6	-1.4	Probable glycosyltransferase
Rv1260		-0.6	-2.3	Probable oxidoreductase
Rv0253		-0.6	-1.3	Probable nitrite reductase [NAD(P)H] small subunit NirD
Rv1361c		-0.6	-1.1	PPE family protein PPE19
Rv3546		-0.6	-1.7	Probable acetyl-CoA acetyltransferase FadA5 (acetoacetyl-CoA thiolase)
Rv0818		-0.6	-2.8	Transcriptional regulatory protein
Rv1634		-0.6	-4.1	Possible drug efflux membrane protein
Rv0680c		-0.6	-0.7	Probable conserved transmembrane protein
Rv1707		-0.6	-2.2	Probable conserved transmembrane protein
Rv2383c		-0.6	-1.5	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)
Rv3618		-0.6	-2.6	Possible monooxygenase
Rv3873		-0.6	-1.7	PPE family protein PPE68
Rv2089c		-0.6	-1.3	Dipeptidase PepE
Rv1741		-0.6	-1.2	Possible toxin VapC34. Contains PIN domain.
Rv2171		-0.6	-0.9	Probable conserved lipoprotein LppM
Rv3365c		-0.6	-2.4	Conserved protein
Rv1941		-0.6	-0.7	Probable short-chain type dehydrogenase/reductase
Rv0925c		-0.6	-2.3	Conserved protein
Rv0520		-0.6	-1.2	Possible methyltransferase/methylase (fragment)
Rv3303c		-0.6	-3.2	NAD(P)H quinone reductase LpdA
Rv2301		-0.6	-2.2	Probable cutinase Cut2
Rv3564		-0.6	-1.0	Probable acyl-CoA dehydrogenase FadE33
Rv3147		-0.5	-1.3	Probable NADH dehydrogenase I (chain C) NuoC (NADH-ubiquinone oxidoreductase chain C)
Rv2043c		-0.5	-1.6	Pyrazinamidase/nicotinamidase PncA (PZase)
Rv2575		-0.5	-1.6	Possible conserved membrane glycine rich protein
Rv1363c		-0.5	-1.7	Possible membrane protein
Rv0428c		-0.5	-1.9	GCN5-related N-acetyltransferase
Rv2028c		-0.5	-0.5	Universal stress protein family protein
Rv0383c		-0.5	-0.4	Possible conserved secreted protein
Rv1180		-0.5	-1.2	Probable polyketide beta-ketoacyl synthase Pks3
Rv0692		-0.5	-1.8	Conserved hypothetical protein
Rv2378c		-0.5	-0.6	Lysine-N-oxygenase MbtG (L-lysine 6-monooxygenase) (lysine N6-hydroxylase)
Rv0392c		-0.5	-0.4	Probable membrane NADH dehydrogenase NdhA
Rv3810		-0.5	-1.2	Exported repetitive protein precursor PirG (cell surface protein) (EXP53)
Rv1680		-0.5	-1.7	Hypothetical protein
Rv1019		-0.5	-2.9	Probable transcriptional regulatory protein (probably TetR-family)
Rv0694		-0.5	-1.6	Possible L-lactate dehydrogenase (cytochrome) LldD1
Rv0504c		-0.5	-0.9	Conserved protein
Rv0871		-0.5	-0.9	Probable cold shock-like protein B CspB
Rv3527		-0.5	-0.8	Hypothetical protein
Rv2650c		-0.5	-0.5	Possible PhiRv2 prophage protein
Rv2024c		-0.5	-2.2	Conserved hypothetical protein
Rv1003		-0.5	-0.4	Conserved protein
Rv0918		-0.5	-1.0	Conserved protein
Rv3270		-0.5	-0.5	Probable metal cation-transporting P-type ATPase C CtpC
Rv2170		-0.5	-0.6	GCN5-related N-acetyltransferase
Rv2409c		-0.5	-1.6	Conserved protein
Rv2766c		-0.5	-1.9	Probable short-chain type dehydrogenase/reductase
Rv0799c		-0.5	-2.5	Conserved protein
Rv3127		-0.5	-1.8	Conserved protein
Rv2915c		-0.5	-2.0	Conserved protein
Rv3332		-0.5	-1.0	Probable N-acetylglucosamine-6-phosphate deacetylase NagA (GlcNAc 6-P deacetylase)
Rv3720		-0.5	-2.9	Possible fatty acid synthase
Rv1929c		-0.5	-1.0	Conserved hypothetical protein
Rv0195		-0.5	-1.8	Possible two component transcriptional regulatory protein (probably LuxR-family)
Rv0569		-0.5	-1.0	Conserved protein
Rv0961		-0.5	-1.5	Probable integral membrane protein
Rv2032		-0.5	-1.7	Conserved protein Acg
Rv1192		-0.5	-0.6	Unknown protein
Rv3672c		-0.5	-0.7	Conserved hypothetical protein
Rv2935		-0.5	-3.7	Phenolpthiocerol synthesis type-I polyketide synthase PpsE

Specific Phenotypes

None in this experiment

For Mycobacterium tuberculosis H37Rv in stress experiments

For stress Ofloxacin across organisms