Experiment set3S276 for Mycobacterium tuberculosis H37Rv

200 most detrimental genes:

gene	name	fitness	t score	description
Rv3083		+2.2	13.0	Probable monooxygenase (hydroxylase)
Rv3082c		+2.1	10.1	Virulence-regulating transcriptional regulator VirS (AraC/XylS family)
Rv0544c		+1.9	3.3	Possible conserved transmembrane protein
Rv1259		+1.6	1.3	Probable uracil DNA glycosylase, UdgB
Rv0310c		+1.6	2.4	Conserved protein
Rv2055c		+1.5	1.3	30S ribosomal protein S18 RpsR2
Rv0436c		+1.5	3.4	Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase)
Rv1170		+1.5	3.1	N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase)
Rv2887		+1.5	2.4	Probable transcriptional regulatory protein
Rv0588		+1.3	2.7	Conserved hypothetical integral membrane protein YrbE2B
Rv0545c		+1.3	2.6	Probable low-affinity inorganic phosphate transporter integral membrane protein PitA
Rv2185c		+1.3	2.6	Conserved protein TB16.3
Rv3204		+1.3	1.5	Possible DNA-methyltransferase (modification methylase)
Rv0767c		+1.2	4.2	Conserved hypothetical protein
Rv1608c		+1.2	2.7	Probable peroxidoxin BcpB
Rv2183c		+1.2	1.8	Conserved protein
Rv3236c		+1.2	2.3	Probable conserved integral membrane transport protein
Rv1414		+1.2	0.8	Conserved hypothetical protein
Rv2752c		+1.2	4.7	Conserved hypothetical protein
Rv1851		+1.1	0.9	Urease accessory protein UreF
Rv2774c		+1.1	1.4	Hypothetical protein
Rv3726		+1.1	1.9	Possible dehydrogenase
Rv3819		+1.1	0.8	Unknown protein
Rv1158c		+1.1	2.0	Conserved hypothetical ala-, pro-rich protein
Rv2758c		+1.1	1.6	Possible antitoxin VapB21
Rv2739c		+1.1	2.4	Possible alanine rich transferase
Rv1577c		+1.1	1.3	Probable PhiRv1 phage protein
Rv0472c		+1.1	3.1	Probable transcriptional regulatory protein (possibly TetR-family)
Rv2929		+1.0	5.6	Hypothetical protein
Rv3180c		+1.0	2.4	Hypothetical alanine rich protein
Rv3433c		+1.0	2.2	Conserved protein
Rv3263		+1.0	6.1	Probable DNA methylase (modification methylase) (methyltransferase)
Rv1730c		+1.0	1.9	Possible penicillin-binding protein
Rv3651		+1.0	2.0	Conserved hypothetical protein
Rv3046c		+1.0	0.8	Conserved protein
Rv3816c		+1.0	0.5	Possible acyltransferase
Rv1422		+1.0	1.3	Conserved hypothetical protein
Rv2583c		+0.9	1.6	Probable GTP pyrophosphokinase RelA (ATP:GTP 3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase)
Rv2007c		+0.9	1.0	Ferredoxin FdxA
Rv1444c		+0.9	1.3	Unknown protein
Rv0540		+0.9	2.2	Conserved hypothetical protein
Rv3854c		+0.9	4.7	Monooxygenase EthA
Rv0741		+0.9	2.6	Probable transposase (fragment)
Rv2743c		+0.9	3.9	Possible conserved transmembrane alanine rich protein
Rv2237A		+0.9	1.0	Conserved protein
Rv0679c		+0.9	1.8	Conserved threonine rich protein
Rv3104c		+0.9	2.2	Possible conserved transmembrane protein
Rv3085		+0.9	0.9	Probable short-chain type dehydrogenase/reductase
Rv0889c		+0.9	2.5	Probable citrate synthase II CitA
Rv0995		+0.9	1.4	Ribosomal-protein-alanine acetyltransferase RimJ (acetylating enzyme for N-terminal of ribosomal protein S5)
Rv3715c		+0.8	1.4	Probable recombination protein RecR
Rv3067		+0.8	2.7	Conserved hypothetical protein
Rv0841		+0.8	0.9	Probable conserved transmembrane protein
Rv3477		+0.8	1.3	PE family protein PE31
Rv2072c		+0.8	1.0	Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL
Rv2369c		+0.8	0.8	Hypothetical protein
Rv0999		+0.8	2.1	Unknown protein
Rv3338		+0.8	1.2	Conserved hypothetical protein
Rv0098		+0.8	1.4	Probable fatty acyl CoA thioesterase type III FcoT
Rv0038		+0.8	2.1	Conserved protein
Rv3772		+0.8	4.1	Probable histidinol-phosphate aminotransferase HisC2 (imidazole acetol-phosphate transaminase) (imidazolylacetolphosphate aminotransferase)
Rv3886c		+0.8	3.1	Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-2)
Rv2322c		+0.8	0.9	Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase)
Rv2383c		+0.8	1.5	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)
Rv3157		+0.8	2.3	Probable NADH dehydrogenase I (chain M) NUOK (NADH-ubiquinone oxidoreductase chain M)
Rv2496c		+0.8	2.1	Probable branched-chain keto acid dehydrogenase E1 component, beta subunit BkdB
Rv2529		+0.8	2.5	Hypothetical protein
Rv1271c		+0.8	1.6	Conserved hypothetical secreted protein
Rv3643		+0.8	0.9	Hypothetical protein
Rv2650c		+0.8	0.9	Possible PhiRv2 prophage protein
Rv0272c		+0.8	2.1	Unknown protein
Rv3511		+0.8	3.8	PE-PGRS family protein PE_PGRS55
Rv2382c		+0.8	0.7	Polyketide synthetase MbtC (polyketide synthase)
Rv3346c		+0.8	1.3	Conserved transmembrane protein
Rv1628c		+0.8	1.6	Conserved protein
Rv2681		+0.8	2.1	Conserved hypothetical alanine rich protein
Rv0043c		+0.8	1.1	Probable transcriptional regulatory protein (probably GntR-family)
Rv3633		+0.8	1.8	Conserved protein
Rv3188		+0.7	1.1	Conserved hypothetical protein
Rv2236c		+0.7	1.3	Probable cobalamin biosynthesis transmembrane protein CobD
Rv3295		+0.7	5.1	Probable transcriptional regulatory protein (probably TetR-family)
Rv0580c		+0.7	0.7	Conserved protein
Rv1273c		+0.7	2.2	Probable drugs-transport transmembrane ATP-binding protein ABC transporter
Rv3261		+0.7	1.9	Probable F420 biosynthesis protein FbiA
Rv3719		+0.7	3.9	Conserved protein
Rv3481c		+0.7	0.6	Probable integral membrane protein
Rv3678A		+0.7	1.3	Conserved hypothetical protein
Rv0897c		+0.7	2.2	Probable oxidoreductase
Rv1282c		+0.7	1.6	Probable oligopeptide-transport integral membrane protein ABC transporter OppC
Rv3174		+0.7	1.1	Probable short-chain dehydrogenase/reductase
Rv3415c		+0.7	4.0	Conserved hypothetical protein
Rv0994		+0.7	3.3	Probable molybdopterin biosynthesis protein MoeA1
Rv1626		+0.7	2.5	Probable two-component system transcriptional regulator
Rv0561c		+0.7	1.0	Possible oxidoreductase
Rv2051c		+0.7	1.9	Polyprenol-monophosphomannose synthase Ppm1
Rv3565		+0.7	0.9	Possible aspartate aminotransferase AspB (transaminase A) (ASPAT) (glutamic--oxaloacetic transaminase) (glutamic--aspartic transaminase)
Rv0093c		+0.7	1.1	Probable conserved membrane protein
Rv0234c		+0.7	1.5	Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1
Rv3054c		+0.7	1.5	Conserved hypothetical protein
Rv2662		+0.7	1.8	Hypothetical protein
Rv0451c		+0.7	1.0	Probable conserved membrane protein MmpS4
Rv3478		+0.7	2.0	PE family protein PPE60
Rv0125		+0.7	2.5	Probable serine protease PepA (serine proteinase) (MTB32A)
Rv1290A		+0.7	0.5	Hypothetical protein
Rv0080		+0.7	2.1	Conserved hypothetical protein
Rv3103c		+0.7	3.4	Hypothetical proline-rich protein
Rv3162c		+0.7	1.1	Possible integral membrane protein
Rv1454c		+0.7	2.4	Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein)
Rv1792		+0.7	0.8	ESAT-6 like protein EsxM
Rv0274		+0.7	1.4	Conserved protein
Rv2184c		+0.7	2.6	Conserved hypothetical protein
Rv0893c		+0.7	1.0	Possible S-adenosylmethionine-dependent methyltransferase
Rv0130		+0.7	0.8	Probable 3-hydroxyl-thioester dehydratase
Rv0847		+0.7	2.2	Probable lipoprotein LpqS
Rv1825		+0.7	1.8	Conserved protein
Rv3642c		+0.7	0.7	Hypothetical protein
Rv2103c		+0.7	1.8	Possible toxin VapC37. Contains PIN domain.
Rv0554		+0.7	3.9	Possible peroxidase BpoC (non-haem peroxidase)
Rv3179		+0.7	2.4	Conserved protein
Rv1079		+0.7	3.2	Cystathionine gamma-synthase MetB (CGS) (O-succinylhomoserine [thiol]-lyase)
Rv0212c		+0.7	2.0	Possible transcriptional regulatory protein NadR (probably AsnC-family)
Rv1235		+0.7	1.8	Probable sugar-binding lipoprotein LpqY
Rv2324		+0.7	1.0	Probable transcriptional regulatory protein (probably AsnC-family)
Rv2475c		+0.7	1.4	Conserved protein
Rv0518		+0.7	1.8	Possible exported protein
Rv3262		+0.7	1.1	Probable F420 biosynthesis protein FbiB
Rv0502		+0.7	3.3	Conserved protein
Rv1766		+0.7	1.1	Conserved protein
Rv0444c		+0.7	2.5	Anti-sigma factor RskA (regulator of sigma K)
Rv3510c		+0.7	2.6	Conserved protein
Rv0919		+0.7	1.6	GCN5-related N-acetyltransferase
Rv1112		+0.7	0.5	Probable GTP binding protein
Rv0966c		+0.7	1.6	Conserved protein
Rv0307c		+0.6	3.0	Unknown protein
Rv3387		+0.6	0.9	Possible transposase
Rv3591c		+0.6	1.3	Possible hydrolase
Rv2639c		+0.6	1.7	Probable conserved integral membrane protein
Rv2009		+0.6	1.1	Antitoxin VapB15
Rv1403c		+0.6	2.4	Putative methyltransferase
Rv2372c		+0.6	1.0	Conserved hypothetical protein
Rv2275		+0.6	0.9	Conserved hypothetical protein
Rv2462c		+0.6	2.2	Probable trigger factor (TF) protein Tig
Rv1049		+0.6	0.7	Probable transcriptional repressor protein
Rv0201c		+0.6	1.1	Conserved protein
Rv1169c		+0.6	1.7	PE family protein. Possible lipase LipX.
Rv0593		+0.6	1.7	Possible Mce-family lipoprotein LprL (Mce-family lipoprotein Mce2E)
Rv1972		+0.6	2.0	Probable conserved Mce associated membrane protein
Rv1140		+0.6	0.8	Probable integral membrane protein
Rv0556		+0.6	0.7	Probable conserved transmembrane protein
Rv0278c		+0.6	1.8	PE-PGRS family protein PE_PGRS3
Rv0088		+0.6	0.6	Possible polyketide cyclase/dehydrase
Rv0496		+0.6	1.5	Conserved hypothetical protein
Rv2232		+0.6	1.1	Protein tyrosine kinase transcriptional regulatory protein PtkA
Rv3371		+0.6	0.9	Possible triacylglycerol synthase (diacylglycerol acyltransferase)
Rv1912c		+0.6	1.6	Possible oxidoreductase FadB5
Rv2899c		+0.6	0.6	Possible FdhD protein homolog
Rv0912		+0.6	0.9	Probable conserved transmembrane protein
Rv0939		+0.6	0.6	Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase
Rv3666c		+0.6	1.1	Probable periplasmic dipeptide-binding lipoprotein DppA
Rv0279c		+0.6	2.7	PE-PGRS family protein PE_PGRS4
Rv2437		+0.6	1.2	Conserved transmembrane protein
Rv1694		+0.6	0.8	2'-O-methyltransferase TlyA
Rv0356c		+0.6	2.1	Conserved protein
Rv3176c		+0.6	2.1	Probable epoxide hydrolase MesT (epoxide hydratase) (arene-oxide hydratase)
Rv0583c		+0.6	2.2	Probable conserved lipoprotein LpqN
Rv3746c		+0.6	1.5	Probable PE family protein PE34 (PE family-related protein)
Rv1473A		+0.6	0.5	Possible transcriptional regulatory protein
Rv0838		+0.6	2.0	Probable conserved lipoprotein LpqR
Rv0400c		+0.6	2.2	Acyl-CoA dehydrogenase FadE7
Rv2149c		+0.6	1.4	Conserved protein YfiH
Rv3600c		+0.6	1.8	Conserved protein
Rv2951c		+0.6	2.7	Possible oxidoreductase
Rv2025c		+0.6	1.5	Conserved membrane protein
Rv2955c		+0.6	2.3	Conserved protein
Rv3358		+0.6	1.1	Toxin RelK
Rv0839		+0.6	2.6	Conserved hypothetical protein
Rv0737		+0.6	1.1	Possible transcriptional regulatory protein
Rv2274c		+0.6	1.1	Possible toxin MazF8
Rv2918c		+0.6	1.7	Probable [protein-PII] uridylyltransferase GlnD (PII uridylyl-transferase) (uridylyl removing enzyme) (UTASE)
Rv1401		+0.6	0.8	Possible membrane protein
Rv3810		+0.6	1.0	Exported repetitive protein precursor PirG (cell surface protein) (EXP53)
Rv2985		+0.5	0.6	Possible hydrolase MutT1
Rv2297		+0.5	1.4	Unknown protein
Rv0868c		+0.5	0.6	Probable molybdenum cofactor biosynthesis protein D 2 MoaD2 (molybdopterin converting factor small subunit) (molybdopterin [MPT] converting factor, subunit 1)
Rv3087		+0.5	1.4	Possible triacylglycerol synthase (diacylglycerol acyltransferase)
Rv1910c		+0.5	2.2	Probable exported protein
Rv0881		+0.5	0.9	Possible rRNA methyltransferase (rRNA methylase)
Rv3622c		+0.5	2.0	PE family protein PE32
Rv2404c		+0.5	2.5	Probable GTP-binding protein LepA (GTP-binding elongation factor)
Rv1487		+0.5	1.5	Conserved membrane protein
Rv2403c		+0.5	0.9	Probable conserved lipoprotein LppR
Rv1410c		+0.5	3.2	Aminoglycosides/tetracycline-transport integral membrane protein
Rv0265c		+0.5	2.3	Probable periplasmic iron-transport lipoprotein
Rv2796c		+0.5	1.3	Probable conserved lipoprotein LppV
Rv1861		+0.5	3.1	Probable conserved transmembrane protein
Rv2091c		+0.5	1.8	Probable membrane protein
Rv3905c		+0.5	1.1	Putative ESAT-6 like protein EsxF (hypothetical alanine and glycine rich protein) (ESAT-6 like protein 13)
Rv2381c		+0.5	0.8	Polyketide synthetase MbtD (polyketide synthase)
Rv3751		+0.5	0.9	Probable integrase (fragment)
Rv0188		+0.5	0.9	Probable conserved transmembrane protein

Specific Phenotypes

For 2 genes in this experiment

For stress Ethionamide in Mycobacterium tuberculosis H37Rv

For stress Ethionamide across organisms