Experiment set3S274 for Mycobacterium tuberculosis H37Rv

200 most important genes:

gene	name	fitness	t score	description
Rv1930c		-4.5	-1.5	Conserved hypothetical protein
Rv1003		-3.8	-1.3	Conserved protein
Rv3631		-3.4	-1.2	Possible transferase (possibly glycosyltransferase)
Rv0328		-3.4	-2.2	Possible transcriptional regulatory protein (possibly TetR/AcrR-family)
Rv0361		-3.0	-1.7	Probable conserved membrane protein
Rv0928		-3.0	-4.9	Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1)
Rv0871		-2.9	-1.9	Probable cold shock-like protein B CspB
Rv2348c		-2.9	-1.0	Hypothetical protein
Rv3046c		-2.8	-0.9	Conserved protein
Rv3101c		-2.8	-1.9	Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter)
Rv2680		-2.5	-2.1	Conserved protein
Rv0497		-2.5	-1.7	Probable conserved transmembrane protein
Rv0991c		-2.4	-1.2	Conserved serine rich protein
Rv2635		-2.4	-0.8	Hypothetical protein
Rv0929		-2.3	-2.3	Phosphate-transport integral membrane ABC transporter PstC2
Rv0930		-2.3	-5.5	Probable phosphate-transport integral membrane ABC transporter PstA1
Rv3114		-2.3	-1.1	Conserved hypothetical protein
Rv1531		-2.2	-1.7	Conserved protein
Rv1941		-2.2	-1.5	Probable short-chain type dehydrogenase/reductase
Rv0892		-2.2	-2.0	Probable monooxygenase
Rv2733c		-2.2	-2.1	Conserved hypothetical alanine, arginine-rich protein
Rv0190		-2.1	-3.4	Conserved protein
Rv1072		-2.1	-1.6	Probable conserved transmembrane protein
Rv0742		-2.1	-2.2	PE-PGRS family protein PE_PGRS8
Rv1010		-2.1	-1.2	Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase)
Rv1332		-2.0	-0.9	Probable transcriptional regulatory protein
Rv3897c		-2.0	-0.9	Conserved hypothetical protein
Rv0200		-2.0	-2.2	Possible conserved transmembrane protein
Rv2270		-2.0	-1.7	Probable lipoprotein LppN
Rv0642c		-2.0	-1.4	Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase)
Rv3171c		-2.0	-0.8	Possible non-heme haloperoxidase Hpx
Rv1691		-1.9	-1.6	Conserved hypothetical protein
Rv2444c		-1.9	-2.6	Possible ribonuclease E Rne
Rv2099c		-1.9	-2.0	PE family protein PE21
Rv0949		-1.8	-0.9	Probable ATP-dependent DNA helicase II UvrD1
Rv1962A		-1.8	-1.2	Possible antitoxin VapB35
Rv1679		-1.8	-1.2	Possible acyl-CoA dehydrogenase FadE16
Rv0580c		-1.7	-0.8	Conserved protein
Rv0201c		-1.7	-1.7	Conserved protein
Rv3428c		-1.7	-1.0	Possible transposase
Rv0452		-1.7	-2.6	Possible transcriptional regulatory protein
Rv3687c		-1.7	-1.0	Anti-anti-sigma factor RsfB (anti-sigma factor antagonist) (regulator of sigma F B)
Rv1116A		-1.6	-1.1	Conserved hypothetical protein (fragment)
Rv2949c		-1.6	-1.3	Chorismate pyruvate lyase
Rv2026c		-1.6	-1.2	Universal stress protein family protein
Rv3748		-1.6	-1.3	Conserved hypothetical protein
Rv1890c		-1.6	-1.1	Hypothetical protein
Rv0549c		-1.6	-1.4	Possible toxin VapC3
Rv0921		-1.5	-2.1	Possible resolvase
Rv0955		-1.5	-1.0	Probable conserved integral membrane protein
Rv1897c		-1.5	-1.2	Conserved hypothetical protein
Rv0250c		-1.5	-2.6	Conserved protein
Rv2707		-1.5	-8.0	Probable conserved transmembrane alanine and leucine rich protein
Rv1205		-1.5	-6.7	Conserved hypothetical protein
Rv3249c		-1.5	-1.0	Possible transcriptional regulatory protein (probably TetR-family)
Rv1450c		-1.4	-1.6	PE-PGRS family protein PE_PGRS27
Rv3170		-1.4	-1.7	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)
Rv3405c		-1.4	-0.9	Possible transcriptional regulatory protein
Rv0093c		-1.4	-1.1	Probable conserved membrane protein
Rv1127c		-1.4	-1.1	Probable pyruvate, phosphate dikinase PpdK
Rv1901		-1.4	-5.1	Probable CinA-like protein CinA
Rv2140c		-1.4	-1.3	Conserved protein TB18.6
Rv0989c		-1.3	-6.0	Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase)
Rv1137c		-1.3	-1.8	Hypothetical protein
Rv3193c		-1.3	-1.2	Probable conserved transmembrane protein
Rv0324		-1.3	-1.7	Possible transcriptional regulatory protein (possibly ArsR-family)
Rv2206		-1.3	-3.5	Probable conserved transmembrane protein
Rv0181c		-1.3	-3.7	Conserved hypothetical protein
Rv2553c		-1.3	-0.6	Probable conserved membrane protein
Rv0078		-1.3	-2.0	Probable transcriptional regulatory protein
Rv1051c		-1.3	-1.7	Conserved hypothetical protein
Rv0504c		-1.3	-1.5	Conserved protein
Rv0563		-1.3	-2.0	Probable protease transmembrane protein heat shock protein HtpX
Rv0007		-1.3	-0.6	Possible conserved membrane protein
Rv3377c		-1.3	-4.4	Halimadienyl diphosphate synthase
Rv1620c		-1.2	-1.9	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC
Rv3664c		-1.2	-1.6	Probable dipeptide-transport integral membrane protein ABC transporter DppC
Rv2922c		-1.2	-3.6	Probable chromosome partition protein Smc
Rv0786c		-1.2	-2.9	Conserved protein
Rv1062		-1.2	-0.8	Conserved hypothetical protein
Rv1366A		-1.2	-0.8	Conserved protein
Rv0070c		-1.2	-1.2	Serine hydroxymethyltransferase GlyA2 (serine methylase 2) (SHMT 2)
Rv1013		-1.2	-4.9	Putative polyketide synthase Pks16
Rv3182		-1.2	-0.6	Conserved hypothetical protein
Rv1247c		-1.2	-1.6	Antitoxin RelB
Rv0655		-1.2	-3.4	Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl
Rv0680c		-1.2	-1.2	Probable conserved transmembrane protein
Rv1209		-1.2	-3.0	Conserved protein
Rv2732c		-1.2	-1.7	Probable conserved transmembrane protein
Rv2500c		-1.2	-0.9	Possible acyl-CoA dehydrogenase FadE19 (MMGC)
Rv0135c		-1.2	-3.7	Possible transcriptional regulatory protein
Rv0426c		-1.2	-2.7	Possible transmembrane protein
Rv2086		-1.1	-1.7	Conserved hypothetical protein
Rv1260		-1.1	-2.2	Probable oxidoreductase
Rv2708c		-1.1	-2.0	Conserved hypothetical protein
Rv2028c		-1.1	-0.8	Universal stress protein family protein
Rv3697c		-1.1	-2.4	Possible toxin VapC48. Contains PIN domain.
Rv2422		-1.1	-2.0	Hypothetical protein
Rv2047c		-1.1	-4.2	Conserved hypothetical protein
Rv1244		-1.1	-3.4	Probable lipoprotein LpqZ
Rv1210		-1.1	-3.1	Probable DNA-3-methyladenine glycosylase I TagA (tag I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine glycosidase I)
Rv0353		-1.1	-2.7	Probable heat shock protein transcriptional repressor HspR (MerR family)
Rv3102c		-1.1	-2.1	Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter)
Rv2408		-1.1	-1.1	Possible PE family-related protein PE24
Rv2702		-1.1	-0.5	Polyphosphate glucokinase PpgK (polyphosphate-glucose phosphotransferase)
Rv2137c		-1.1	-2.4	Conserved hypothetical protein
Rv2376c		-1.1	-0.7	Low molecular weight antigen CFP2 (low molecular weight protein antigen 2) (CFP-2)
Rv1773c		-1.1	-1.5	Probable transcriptional regulatory protein
Rv0346c		-1.1	-5.2	Possible L-asparagine permease AnsP2 (L-asparagine transport protein)
Rv3852		-1.1	-4.5	Possible histone-like protein Hns
Rv1926c		-1.0	-2.2	Immunogenic protein Mpt63 (antigen Mpt63/MPB63) (16 kDa immunoprotective extracellular protein)
Rv2696c		-1.0	-1.1	Conserved alanine and glycine and valine rich protein
Rv0499		-1.0	-1.0	Conserved hypothetical protein
Rv3173c		-1.0	-2.0	Probable transcriptional regulatory protein (probably TetR/AcrR-family)
Rv2657c		-1.0	-0.7	Probable PhiRv2 prophage protein
Rv0472c		-1.0	-2.1	Probable transcriptional regulatory protein (possibly TetR-family)
Rv1621c		-1.0	-2.0	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD
Rv2342		-1.0	-2.7	Conserved hypothetical protein
Rv0019c		-1.0	-3.3	Conserved protein with FHA domain, FhaB
Rv2365c		-1.0	-0.5	Conserved hypothetical protein
Rv3760		-1.0	-1.5	Possible conserved membrane protein
Rv3321c		-1.0	-3.0	Possible antitoxin VapB44
Rv2624c		-1.0	-0.8	Universal stress protein family protein
Rv0820		-1.0	-1.9	Probable phosphate-transport ATP-binding protein ABC transporter PhoT
Rv0367c		-1.0	-0.6	Hypothetical protein
Rv3287c		-1.0	-0.8	Anti-sigma factor RsbW (sigma negative effector)
Rv0692		-1.0	-3.7	Conserved hypothetical protein
Rv0621		-1.0	-1.3	Possible membrane protein
Rv0100		-1.0	-1.1	Conserved hypothetical protein
Rv3771c		-1.0	-1.1	Conserved hypothetical protein
Rv1100		-1.0	-2.0	Conserved protein
Rv1278		-1.0	-1.9	Hypothetical protein
Rv3286c		-1.0	-1.3	Alternative RNA polymerase sigma factor SigF
Rv1565c		-1.0	-2.9	Conserved hypothetical membrane protein
Rv3663c		-1.0	-0.9	Probable dipeptide-transport ATP-binding protein ABC transporter DppD
Rv3386		-1.0	-0.7	Possible transposase
Rv1160		-1.0	-1.1	Probable mutator protein MutT2 (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase)
Rv0470c		-1.0	-1.3	Mycolic acid synthase PcaA (cyclopropane synthase)
Rv2567		-1.0	-3.6	Conserved hypothetical alanine and leucine rich protein
Rv2912c		-1.0	-1.6	Probable transcriptional regulatory protein (probably TetR-family)
Rv0413		-1.0	-2.9	Possible mutator protein MutT3 (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase) (dGTP pyrophosphohydrolase)
Rv3164c		-0.9	-1.6	Probable methanol dehydrogenase transcriptional regulatory protein MoxR3
Rv3217c		-0.9	-1.2	Probable conserved integral membrane protein
Rv1745c		-0.9	-2.6	Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase)
Rv3691		-0.9	-0.9	Conserved protein
Rv0758		-0.9	-1.4	Possible two component system response sensor kinase membrane associated PhoR
Rv0158		-0.9	-4.8	Probable transcriptional regulatory protein (possibly TetR-family)
Rv0649		-0.9	-1.7	Possible malonyl CoA-acyl carrier protein transacylase FabD2 (MCT)
Rv3338		-0.9	-0.6	Conserved hypothetical protein
Rv3813c		-0.9	-1.6	Conserved protein
Rv1372		-0.9	-1.2	Conserved hypothetical protein
Rv2548		-0.9	-1.1	Possible toxin VapC19
Rv1593c		-0.9	-2.6	Conserved protein
Rv3167c		-0.9	-1.4	Probable transcriptional regulatory protein (probably TetR-family)
Rv0765c		-0.9	-1.1	Probable oxidoreductase
Rv0959		-0.9	-0.7	Conserved hypothetical protein
Rv3763		-0.9	-1.1	19 kDa lipoprotein antigen precursor LpqH
Rv2812		-0.9	-1.2	Probable transposase
Rv2429		-0.9	-0.9	Alkyl hydroperoxide reductase D protein AhpD (alkyl hydroperoxidase D)
Rv1591		-0.9	-2.6	Probable transmembrane protein
Rv1974		-0.9	-1.1	Probable conserved membrane protein
Rv0323c		-0.9	-0.8	Conserved hypothetical protein
Rv0954		-0.9	-2.6	Probable conserved transmembrane protein
Rv3576		-0.9	-2.2	Possible conserved lipoprotein LppH
Rv2051c		-0.9	-1.6	Polyprenol-monophosphomannose synthase Ppm1
Rv3538		-0.9	-0.7	Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase.
Rv2427c		-0.9	-2.2	Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialdehyde dehydrogenase)
Rv2989		-0.9	-0.4	Probable transcriptional regulatory protein
Rv3655c		-0.9	-1.1	Conserved hypothetical protein
Rv2048c		-0.9	-2.9	Polyketide synthase Pks12
Rv0936		-0.9	-1.8	Phosphate-transport integral membrane ABC transporter PstA2
Rv0089		-0.9	-1.4	Possible methyltransferase/methylase
Rv3569c		-0.9	-0.9	4,9-DHSA hydrolase
Rv2709		-0.8	-2.3	Probable conserved transmembrane protein
Rv3214		-0.8	-0.7	Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM)
Rv3045		-0.8	-1.6	Probable NADP-dependent alcohol dehydrogenase AdhC
Rv3427c		-0.8	-1.1	Possible transposase
Rv3419c		-0.8	-0.9	Probable O-sialoglycoprotein endopeptidase Gcp (glycoprotease)
Rv3313c		-0.8	-2.8	Probable adenosine deaminase Add (adenosine aminohydrolase)
Rv1234		-0.8	-0.9	Probable transmembrane protein
Rv0625c		-0.8	-2.3	Probable conserved transmembrane protein
Rv0370c		-0.8	-1.7	Possible oxidoreductase
Rv1213		-0.8	-3.2	Glucose-1-phosphate adenylyltransferase GlgC (ADP-glucose synthase) (ADP-glucose pyrophosphorylase)
Rv2506		-0.8	-1.5	Probable transcriptional regulatory protein (probably TetR-family)
Rv3690		-0.8	-1.6	Probable conserved membrane protein
Rv1333		-0.8	-2.4	Probable hydrolase
Rv3557c		-0.8	-2.3	Transcriptional regulatory protein (probably TetR-family)
Rv0610c		-0.8	-0.5	Hypothetical protein
Rv0612		-0.8	-1.9	Conserved hypothetical protein
Rv3278c		-0.8	-1.9	Probable conserved transmembrane protein
Rv3651		-0.8	-1.3	Conserved hypothetical protein
Rv3484		-0.8	-3.4	Possible conserved protein CpsA
Rv1938		-0.8	-2.5	Probable epoxide hydrolase EphB (epoxide hydratase)
Rv1920		-0.8	-3.1	Probable membrane protein
Rv2293c		-0.8	-1.8	Conserved hypothetical protein
Rv2035		-0.8	-1.9	Conserved hypothetical protein
Rv3059		-0.8	-3.4	Probable cytochrome P450 136 Cyp136
Rv0876c		-0.8	-1.1	Possible conserved transmembrane protein
Rv3111		-0.8	-2.5	Probable molybdenum cofactor biosynthesis protein C MoaC1
Rv1693		-0.8	-0.7	Conserved hypothetical protein

Specific Phenotypes

For 9 genes in this experiment

For stress Isoniazid in Mycobacterium tuberculosis H37Rv

For stress Isoniazid across organisms