Experiment set3S274 for Mycobacterium tuberculosis H37Rv

200 most detrimental genes:

gene	name	fitness	t score	description
Rv0877		+3.2	20.0	Conserved hypothetical protein
Rv2404c		+3.2	19.4	Probable GTP-binding protein LepA (GTP-binding elongation factor)
Rv2583c		+3.0	4.9	Probable GTP pyrophosphokinase RelA (ATP:GTP 3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase)
Rv1908c		+2.9	8.3	Catalase-peroxidase-peroxynitritase T KatG
Rv1170		+2.8	7.1	N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase)
Rv2621c		+2.6	2.3	Possible transcriptional regulatory protein
Rv0248c		+2.4	8.2	Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase)
Rv0056		+2.2	3.7	50S ribosomal protein L9 RplI
Rv0249c		+2.1	9.5	Probable succinate dehydrogenase [membrane anchor subunit] (succinic dehydrogenase)
Rv1626		+2.1	8.3	Probable two-component system transcriptional regulator
Rv3810		+2.0	2.5	Exported repetitive protein precursor PirG (cell surface protein) (EXP53)
Rv0782		+2.0	3.4	Probable protease II PtrBb [second part] (oligopeptidase B)
Rv2739c		+1.9	3.7	Possible alanine rich transferase
Rv3136		+1.9	7.1	PPE family protein PPE51
Rv1259		+1.9	1.6	Probable uracil DNA glycosylase, UdgB
Rv1291c		+1.8	3.0	Conserved hypothetical secreted protein
Rv2154c		+1.8	1.2	FtsW-like protein FtsW
Rv0544c		+1.8	3.2	Possible conserved transmembrane protein
Rv3514		+1.8	3.7	PE-PGRS family protein PE_PGRS57
Rv1112		+1.7	2.6	Probable GTP binding protein
Rv3768		+1.7	2.2	Unknown protein
Rv2433c		+1.7	6.8	Hypothetical protein
Rv3261		+1.7	6.3	Probable F420 biosynthesis protein FbiA
Rv1090		+1.7	6.6	Probable cellulase CelA2b (endo-1,4-beta-glucanase) (endoglucanase) (carboxymethyl cellulase)
Rv3848		+1.6	2.9	Probable conserved transmembrane protein
Rv1414		+1.6	1.2	Conserved hypothetical protein
Rv0310c		+1.6	2.3	Conserved protein
Rv2752c		+1.6	6.0	Conserved hypothetical protein
Rv3309c		+1.6	3.3	Probable uracil phosphoribosyltransferase Upp (UMP pyrophosphorylase) (uprtase) (UMP diphosphorylase)
Rv3316		+1.6	3.5	Probable succinate dehydrogenase (cytochrome B-556 subunit) SdhC (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase)
Rv2276		+1.6	2.2	Cytochrome P450 121 Cyp121
Rv1946c		+1.5	2.3	Possible lipoprotein
Rv3591c		+1.5	2.6	Possible hydrolase
Rv0279c		+1.5	6.9	PE-PGRS family protein PE_PGRS4
Rv2055c		+1.5	2.2	30S ribosomal protein S18 RpsR2
Rv2933		+1.5	9.5	Phenolpthiocerol synthesis type-I polyketide synthase PpsC
Rv1091		+1.5	7.2	PE-PGRS family protein PE_PGRS22
Rv2931		+1.4	10.4	Phenolpthiocerol synthesis type-I polyketide synthase PpsA
Rv3306c		+1.4	1.1	Probable amidohydrolase AmiB1 (aminohydrolase)
Rv3719		+1.4	6.9	Conserved protein
Rv2930		+1.4	11.6	Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)
Rv3220c		+1.4	3.4	Probable two component sensor kinase
Rv3717		+1.4	4.0	Conserved hypothetical protein
Rv0819		+1.4	3.8	GCN5-related N-acetyltransferase, MshD
Rv3658c		+1.4	1.0	Probable conserved transmembrane protein
Rv2434c		+1.4	3.9	Probable conserved transmembrane protein
Rv3085		+1.3	1.4	Probable short-chain type dehydrogenase/reductase
Rv1730c		+1.3	1.8	Possible penicillin-binding protein
Rv2009		+1.3	2.5	Antitoxin VapB15
Rv0038		+1.3	3.8	Conserved protein
Rv2850c		+1.3	1.6	Possible magnesium chelatase
Rv1262c		+1.3	1.2	Hypothetical hit-like protein
Rv2932		+1.3	9.3	Phenolpthiocerol synthesis type-I polyketide synthase PpsB
Rv3715c		+1.3	2.1	Probable recombination protein RecR
Rv1282c		+1.2	2.2	Probable oligopeptide-transport integral membrane protein ABC transporter OppC
Rv2919c		+1.2	2.1	Probable nitrogen regulatory protein P-II GlnB
Rv0561c		+1.2	1.7	Possible oxidoreductase
Rv3819		+1.2	0.8	Unknown protein
Rv3668c		+1.2	3.9	Possible protease
Rv2432c		+1.1	1.6	Hypothetical protein
Rv1957		+1.1	1.7	Hypothetical protein
Rv1444c		+1.1	2.7	Unknown protein
Rv0867c		+1.1	0.6	Possible resuscitation-promoting factor RpfA
Rv2935		+1.1	7.5	Phenolpthiocerol synthesis type-I polyketide synthase PpsE
Rv1087		+1.1	6.7	PE-PGRS family protein PE_PGRS21
Rv0994		+1.1	5.2	Probable molybdopterin biosynthesis protein MoeA1
Rv2388c		+1.1	6.0	Probable oxygen-independent coproporphyrinogen III oxidase HemN (coproporphyrinogenase) (coprogen oxidase)
Rv1791		+1.1	1.0	PE family protein PE19
Rv3816c		+1.1	0.5	Possible acyltransferase
Rv1411c		+1.1	3.5	Conserved lipoprotein LprG
Rv2940c		+1.1	8.0	Probable multifunctional mycocerosic acid synthase membrane-associated Mas
Rv2934		+1.1	7.8	Phenolpthiocerol synthesis type-I polyketide synthase PpsD
Rv0939		+1.1	1.1	Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase
Rv3010c		+1.1	4.0	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)
Rv3511		+1.1	4.0	PE-PGRS family protein PE_PGRS55
Rv0155		+1.1	4.8	Probable NAD(P) transhydrogenase (subunit alpha) PntAa [first part; catalytic part] (pyridine nucleotide transhydrogenase subunit alpha) (nicotinamide nucleotide transhydrogenase subunit alpha)
Rv2899c		+1.0	1.2	Possible FdhD protein homolog
Rv0436c		+1.0	1.8	Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase)
Rv1577c		+1.0	0.7	Probable PhiRv1 phage protein
Rv2312		+1.0	2.0	Hypothetical protein
Rv1079		+1.0	2.8	Cystathionine gamma-synthase MetB (CGS) (O-succinylhomoserine [thiol]-lyase)
Rv2939		+1.0	5.4	Possible conserved polyketide synthase associated protein PapA5
Rv0919		+1.0	2.6	GCN5-related N-acetyltransferase
Rv2292c		+1.0	0.7	Hypothetical protein
Rv1435c		+1.0	2.5	Probable conserved proline, glycine, valine-rich secreted protein
Rv0746		+1.0	4.4	PE-PGRS family protein PE_PGRS9
Rv1459c		+1.0	0.9	Possible conserved integral membrane protein
Rv2588c		+1.0	1.1	Probable conserved membrane protein secretion factor YajC
Rv1410c		+1.0	5.0	Aminoglycosides/tetracycline-transport integral membrane protein
Rv0745		+1.0	2.2	Conserved hypothetical protein
Rv1473A		+1.0	0.7	Possible transcriptional regulatory protein
Rv0674		+1.0	0.7	Conserved hypothetical protein
Rv2662		+1.0	2.0	Hypothetical protein
Rv2383c		+1.0	2.7	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)
Rv3433c		+1.0	1.9	Conserved protein
Rv3081		+1.0	0.8	Conserved hypothetical protein
Rv0247c		+1.0	0.8	Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase)
Rv0963c		+1.0	3.0	Conserved hypothetical protein
Rv0157		+0.9	2.4	Probable NAD(P) transhydrogenase (subunit beta) PntB [integral membrane protein] (pyridine nucleotide transhydrogenase subunit beta) (nicotinamide nucleotide transhydrogenase subunit beta)
Rv0737		+0.9	2.3	Possible transcriptional regulatory protein
Rv2695		+0.9	4.7	Conserved hypothetical alanine rich protein
Rv2793c		+0.9	1.3	Probable tRNA pseudouridine synthase B TruB (tRNA pseudouridine 55 synthase) (PSI55 synthase) (pseudouridylate synthase) (uracil hydrolyase)
Rv1159A		+0.9	1.8	Unknown protein
Rv2985		+0.9	1.1	Possible hydrolase MutT1
Rv1088		+0.9	3.2	PE family protein PE9
Rv0281		+0.9	3.9	Possible S-adenosylmethionine-dependent methyltransferase
Rv2431c		+0.9	3.8	PE family protein PE25
Rv1055		+0.9	0.9	Possible integrase (fragment)
Rv3518c		+0.9	1.6	Probable cytochrome P450 monooxygenase 142 Cyp142
Rv0973c		+0.9	1.6	Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrier protein (BCCP)
Rv2681		+0.9	3.4	Conserved hypothetical alanine rich protein
Rv0556		+0.9	1.0	Probable conserved transmembrane protein
Rv3067		+0.9	2.1	Conserved hypothetical protein
Rv0360c		+0.9	2.7	Conserved protein
Rv3318		+0.9	3.0	Probable succinate dehydrogenase (flavoprotein subunit) SdhA (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase)
Rv2475c		+0.9	2.2	Conserved protein
Rv0545c		+0.9	2.1	Probable low-affinity inorganic phosphate transporter integral membrane protein PitA
Rv1925		+0.9	4.9	Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase)
Rv0767c		+0.9	3.2	Conserved hypothetical protein
Rv1454c		+0.9	3.5	Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein)
Rv0741		+0.9	2.3	Probable transposase (fragment)
Rv0999		+0.8	2.1	Unknown protein
Rv0583c		+0.8	2.5	Probable conserved lipoprotein LpqN
Rv0344c		+0.8	1.2	Probable lipoprotein LpqJ
Rv3162c		+0.8	1.1	Possible integral membrane protein
Rv2743c		+0.8	2.6	Possible conserved transmembrane alanine rich protein
Rv1566c		+0.8	2.4	Possible Inv protein
Rv2941		+0.8	6.6	Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)
Rv0632c		+0.8	1.2	Probable enoyl-CoA hydratase EchA3 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv3414c		+0.8	1.0	Probable alternative RNA polymerase sigma-D factor SigD
Rv0040c		+0.8	4.0	Secreted proline rich protein Mtc28 (proline rich 28 kDa antigen)
Rv0356c		+0.8	1.3	Conserved protein
Rv1087A		+0.8	3.2	Conserved hypothetical protein
Rv2212		+0.8	2.9	Adenylyl cyclase (ATP pyrophosphate-lyase) (adenylate cyclase)
Rv0769		+0.8	1.5	Probable dehydrogenase/reductase
Rv3747		+0.8	1.4	Conserved protein
Rv1615		+0.8	1.6	Probable membrane protein
Rv1322		+0.8	1.1	Conserved hypothetical protein
Rv3751		+0.8	1.3	Probable integrase (fragment)
Rv0748		+0.8	1.7	Possible antitoxin VapB31
Rv2184c		+0.8	2.6	Conserved hypothetical protein
Rv1490		+0.8	2.1	Probable membrane protein
Rv0277c		+0.8	2.4	Possible toxin VapC25. Contains PIN domain.
Rv1761c		+0.8	1.3	Possible exported protein
Rv0178		+0.8	2.1	Probable conserved Mce associated membrane protein
Rv3559c		+0.8	0.7	Probable oxidoreductase
Rv2647		+0.8	1.1	Hypothetical protein
Rv1071c		+0.8	2.5	Possible enoyl-CoA hydratase EchA9 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv2474c		+0.8	1.1	Conserved hypothetical protein
Rv2046		+0.8	2.1	Probable lipoprotein LppI
Rv1628c		+0.8	2.0	Conserved protein
Rv3069		+0.8	1.4	Probable conserved transmembrane protein
Rv0609		+0.8	0.6	Possible toxin VapC28. Contains PIN domain.
Rv2929		+0.8	4.7	Hypothetical protein
Rv0392c		+0.8	0.9	Probable membrane NADH dehydrogenase NdhA
Rv0276		+0.8	2.6	Conserved hypothetical protein
Rv0588		+0.8	1.1	Conserved hypothetical integral membrane protein YrbE2B
Rv3725		+0.8	1.2	Possible oxidoreductase
Rv3360		+0.8	1.9	Conserved hypothetical protein
Rv2021c		+0.8	2.1	Transcriptional regulatory protein
Rv0743c		+0.7	3.2	Hypothetical protein
Rv3507		+0.7	3.1	PE-PGRS family protein PE_PGRS53
Rv2395		+0.7	4.7	Probable conserved integral membrane protein
Rv3371		+0.7	1.2	Possible triacylglycerol synthase (diacylglycerol acyltransferase)
Rv3207c		+0.7	1.8	Conserved protein
Rv1792		+0.7	0.8	ESAT-6 like protein EsxM
Rv3666c		+0.7	1.5	Probable periplasmic dipeptide-binding lipoprotein DppA
Rv0535		+0.7	0.9	Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase)
Rv1895		+0.7	1.0	Possible dehydrogenase
Rv0050		+0.7	0.9	Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase)
Rv3142c		+0.7	1.1	Hypothetical protein
Rv3509c		+0.7	5.0	Probable acetohydroxyacid synthase IlvX (acetolactate synthase)
Rv0234c		+0.7	2.1	Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1
Rv3695		+0.7	1.1	Possible conserved membrane protein
Rv0971c		+0.7	1.2	Probable enoyl-CoA hydratase EchA7 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv3417c		+0.7	1.6	60 kDa chaperonin 1 GroEL1 (protein CPN60-1) (GroEL protein 1)
Rv2740		+0.7	2.9	Epoxide hydrolase
Rv0251c		+0.7	2.5	Heat shock protein Hsp (heat-stress-induced ribosome-binding protein A)
Rv0113		+0.7	0.7	Probable sedoheptulose-7-phosphate isomerase GmhA (phosphoheptose isomerase)
Rv0161		+0.7	1.7	Possible oxidoreductase
Rv0098		+0.7	0.9	Probable fatty acyl CoA thioesterase type III FcoT
Rv1692		+0.7	1.9	Probable phosphatase
Rv0581		+0.7	2.2	Possible antitoxin VapB26
Rv2923c		+0.7	0.8	Conserved protein
Rv3515c		+0.7	2.3	Fatty-acid-CoA ligase FadD19 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Rv1065		+0.7	3.0	Conserved hypothetical protein
Rv0818		+0.7	2.5	Transcriptional regulatory protein
Rv1776c		+0.7	1.9	Possible transcriptional regulatory protein
Rv2887		+0.7	0.8	Probable transcriptional regulatory protein
Rv0080		+0.7	1.8	Conserved hypothetical protein
Rv0273c		+0.7	1.4	Possible transcriptional regulatory protein
Rv0677c		+0.7	1.4	Possible conserved membrane protein MmpS5
Rv1064c		+0.7	2.4	Possible lipoprotein LpqV
Rv2302		+0.7	0.4	Conserved protein
Rv3746c		+0.7	1.5	Probable PE family protein PE34 (PE family-related protein)
Rv1067c		+0.7	1.6	PE-PGRS family protein PE_PGRS19
Rv2072c		+0.7	0.8	Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL
Rv1441c		+0.7	1.4	PE-PGRS family protein PE_PGRS26
Rv3469c		+0.7	2.0	Probable 4-hydroxy-2-oxovalerate aldolase MhpE (HOA)
Rv3706c		+0.7	1.4	Conserved hypothetical proline rich protein

Specific Phenotypes

For 9 genes in this experiment

For stress Isoniazid in Mycobacterium tuberculosis H37Rv

For stress Isoniazid across organisms