Experiment set3S271 for Mycobacterium tuberculosis H37Rv

Compare to:

7H9 with Levofloxacin 0.3 ug/mL

200 most important genes:

  gene name fitness t score description  
Rv0949 -3.7 -1.4 Probable ATP-dependent DNA helicase II UvrD1 compare
Rv2762c -3.5 -1.3 Conserved hypothetical protein compare
Rv0247c -3.4 -1.2 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) compare
Rv1824 -3.2 -1.6 Conserved hypothetical membrane protein compare
Rv1284 -3.2 -1.2 Beta-carbonic anhydrase compare
Rv2230c -3.0 -1.6 Conserved protein compare
Rv3405c -2.9 -1.5 Possible transcriptional regulatory protein compare
Rv0375c -2.8 -2.8 Probable carbon monoxyde dehydrogenase (medium chain) compare
Rv3202c -2.8 -6.1 Possible ATP-dependent DNA helicase compare
Rv2444c -2.7 -3.1 Possible ribonuclease E Rne compare
Rv0929 -2.7 -2.6 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv2095c -2.7 -8.7 Proteasome accessory factor C PafC compare
Rv2503c -2.6 -3.0 Probable succinyl-CoA:3-ketoacid-coenzyme A transferase (beta subunit) ScoB (3-oxo-acid:CoA transferase) (OXCT B) (succinyl CoA:3-oxoacid CoA-transferase) compare
Rv1278 -2.2 -3.7 Hypothetical protein compare
Rv3364c -2.2 -1.0 Conserved protein compare
Rv2737c -2.1 -4.2 RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. compare
Rv2772c -2.0 -2.0 Probable conserved transmembrane protein compare
Rv2096c -2.0 -2.9 Proteasome accessory factor B PafB compare
Rv3843c -1.8 -1.7 Probable conserved transmembrane protein compare
Rv0392c -1.8 -1.1 Probable membrane NADH dehydrogenase NdhA compare
Rv0531 -1.7 -1.3 Possible conserved membrane protein compare
Rv2234 -1.7 -3.0 Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) compare
Rv0540 -1.7 -1.9 Conserved hypothetical protein compare
Rv0928 -1.7 -2.7 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv3201c -1.7 -4.4 Probable ATP-dependent DNA helicase compare
Rv1277 -1.7 -5.0 Conserved hypothetical protein compare
Rv2949c -1.7 -1.5 Chorismate pyruvate lyase compare
Rv0007 -1.6 -0.8 Possible conserved membrane protein compare
Rv0680c -1.6 -1.7 Probable conserved transmembrane protein compare
Rv1962A -1.6 -1.2 Possible antitoxin VapB35 compare
Rv3643 -1.6 -1.7 Hypothetical protein compare
Rv0003 -1.6 -3.4 DNA replication and repair protein RecF (single-strand DNA binding protein) compare
Rv3102c -1.6 -2.6 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv0742 -1.6 -1.9 PE-PGRS family protein PE_PGRS8 compare
Rv2302 -1.5 -0.8 Conserved protein compare
Rv0820 -1.5 -3.3 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv1109c -1.5 -3.5 Conserved protein compare
Rv3428c -1.4 -1.1 Possible transposase compare
Rv2374c -1.4 -1.9 Probable heat shock protein transcriptional repressor HrcA compare
Rv2222c -1.4 -1.8 Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) compare
Rv0085 -1.4 -1.1 Possible hydrogenase HycP compare
Rv1025 -1.4 -0.7 Conserved protein compare
Rv3282 -1.4 -1.2 Conserved hypothetical protein compare
Rv0437c -1.4 -1.2 Possible phosphatidylserine decarboxylase Psd (PS decarboxylase) compare
Rv1825 -1.4 -2.7 Conserved protein compare
Rv3174 -1.4 -1.0 Probable short-chain dehydrogenase/reductase compare
Rv3200c -1.4 -2.4 Possible transmembrane cation transporter compare
Rv0937c -1.3 -2.5 DNA end-binding protein, Mku compare
Rv1890c -1.3 -1.0 Hypothetical protein compare
Rv2553c -1.3 -0.7 Probable conserved membrane protein compare
Rv2496c -1.3 -2.5 Probable branched-chain keto acid dehydrogenase E1 component, beta subunit BkdB compare
Rv0990c -1.3 -0.8 Hypothetical protein compare
Rv2252 -1.3 -0.8 Diacylglycerol kinase compare
Rv0426c -1.3 -1.8 Possible transmembrane protein compare
Rv1116A -1.2 -1.0 Conserved hypothetical protein (fragment) compare
Rv1108c -1.2 -3.6 Probable exodeoxyribonuclease VII (large subunit) XseA (exonuclease VII large subunit) conserved
Rv0615 -1.2 -1.0 Probable integral membrane protein compare
Rv0539 -1.2 -1.8 Probable dolichyl-phosphate sugar synthase (dolichol-phosphate sugar synthetase) (dolichol-phosphate sugar transferase) (sugar phosphoryldolichol synthase) compare
Rv3273 -1.2 -5.7 Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) compare
Rv1035c -1.2 -0.9 Probable transposase (fragment) compare
Rv0396 -1.2 -2.3 Hypothetical protein compare
Rv0563 -1.2 -1.8 Probable protease transmembrane protein heat shock protein HtpX compare
Rv0871 -1.2 -1.5 Probable cold shock-like protein B CspB compare
Rv3647c -1.2 -0.7 Conserved hypothetical protein compare
Rv2277c -1.2 -1.7 Possible glycerolphosphodiesterase compare
Rv0674 -1.1 -0.6 Conserved hypothetical protein compare
Rv0361 -1.1 -1.0 Probable conserved membrane protein compare
Rv1010 -1.1 -0.9 Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase) compare
Rv2694c -1.1 -3.4 Conserved protein compare
Rv2378c -1.1 -1.8 Lysine-N-oxygenase MbtG (L-lysine 6-monooxygenase) (lysine N6-hydroxylase) compare
Rv3559c -1.1 -0.8 Probable oxidoreductase compare
Rv0612 -1.1 -1.5 Conserved hypothetical protein compare
Rv1446c -1.1 -2.4 Putative OXPP cycle protein OpcA compare
Rv3672c -1.1 -1.4 Conserved hypothetical protein compare
Rv0472c -1.1 -2.2 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv0504c -1.0 -1.3 Conserved protein compare
Rv2430c -1.0 -2.1 PPE family protein PPE41 compare
Rv0428c -1.0 -3.0 GCN5-related N-acetyltransferase compare
Rv1072 -1.0 -0.9 Probable conserved transmembrane protein compare
Rv0034 -1.0 -1.7 Conserved hypothetical protein compare
Rv3855 -1.0 -2.6 Transcriptional regulatory repressor protein (TetR-family) EthR compare
Rv0841 -1.0 -0.6 Probable conserved transmembrane protein compare
Rv2624c -1.0 -0.8 Universal stress protein family protein compare
Rv0608 -1.0 -1.3 Possible antitoxin VapB28 compare
Rv3477 -1.0 -1.0 PE family protein PE31 compare
Rv0690c -1.0 -1.6 Conserved hypothetical protein compare
Rv3033 -1.0 -0.5 Unknown protein compare
Rv0819 -1.0 -1.9 GCN5-related N-acetyltransferase, MshD compare
Rv1020 -1.0 -6.2 Probable transcription-repair coupling factor Mfd (TRCF) compare
Rv3748 -1.0 -1.2 Conserved hypothetical protein compare
Rv2044c -0.9 -0.6 Conserved hypothetical protein compare
Rv2269c -0.9 -3.8 Hypothetical protein compare
Rv3885c -0.9 -1.5 ESX conserved component EccE2. ESX-2 type VII secretion system protein. Possible membrane protein. compare
Rv2626c -0.9 -0.9 Hypoxic response protein 1 Hrp1 compare
Rv0818 -0.9 -3.2 Transcriptional regulatory protein compare
Rv1194c -0.9 -2.9 Conserved protein compare
Rv1468c -0.9 -1.7 PE-PGRS family protein PE_PGRS29 compare
Rv2513 -0.9 -2.0 Hypothetical protein compare
Rv0609 -0.9 -0.7 Possible toxin VapC28. Contains PIN domain. compare
Rv1823 -0.9 -3.2 Conserved protein compare
Rv1677 -0.9 -1.8 Probable conserved lipoprotein DsbF compare
Rv0930 -0.9 -3.1 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv2623 -0.9 -2.0 Universal stress protein family protein TB31.7 compare
Rv1127c -0.9 -0.8 Probable pyruvate, phosphate dikinase PpdK compare
Rv0989c -0.9 -4.0 Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) compare
Rv1692 -0.9 -1.6 Probable phosphatase compare
Rv3283 -0.9 -2.0 Probable thiosulfate sulfurtransferase SseA (rhodanese) (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase) compare
Rv2429 -0.9 -0.9 Alkyl hydroperoxide reductase D protein AhpD (alkyl hydroperoxidase D) compare
Rv3165c -0.9 -0.7 Unknown protein compare
Rv3395A -0.9 -3.4 Probable membrane protein compare
Rv3675 -0.9 -1.5 Possible membrane protein compare
Rv2976c -0.8 -0.6 Probable uracil-DNA glycosylase Ung (UDG) compare
Rv0452 -0.8 -2.7 Possible transcriptional regulatory protein compare
Rv3267 -0.8 -2.2 Conserved protein (CPSA-related protein) compare
Rv0899 -0.8 -1.8 Outer membrane protein A OmpA compare
Rv2691 -0.8 -3.4 TRK system potassium uptake protein CeoB compare
Rv1160 -0.8 -0.8 Probable mutator protein MutT2 (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase) compare
Rv3277 -0.8 -0.5 Probable conserved transmembrane protein compare
Rv1232c -0.8 -2.0 Conserved protein compare
Rv3270 -0.8 -1.1 Probable metal cation-transporting P-type ATPase C CtpC compare
Rv3237c -0.8 -2.5 Conserved protein compare
Rv2254c -0.8 -1.7 Probable integral membrane protein compare
Rv0569 -0.8 -1.0 Conserved protein compare
Rv0947c -0.8 -2.2 Probable mycolyl transferase, pseudogene compare
Rv2322c -0.8 -0.6 Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) compare
Rv3101c -0.8 -0.9 Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter) compare
Rv2099c -0.8 -1.2 PE family protein PE21 compare
Rv3045 -0.8 -1.3 Probable NADP-dependent alcohol dehydrogenase AdhC compare
Rv3114 -0.8 -0.6 Conserved hypothetical protein compare
Rv2301 -0.8 -3.0 Probable cutinase Cut2 compare
Rv1831 -0.8 -2.1 Hypothetical protein compare
Rv0089 -0.8 -1.3 Possible methyltransferase/methylase compare
Rv3527 -0.8 -1.0 Hypothetical protein compare
Rv0892 -0.8 -1.2 Probable monooxygenase compare
Rv0939 -0.8 -0.4 Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase compare
Rv1121 -0.8 -0.9 Probable glucose-6-phosphate 1-dehydrogenase Zwf1 (G6PD) compare
Rv2310 -0.8 -2.9 Possible excisionase compare
Rv3180c -0.8 -1.8 Hypothetical alanine rich protein compare
Rv0241c -0.8 -1.5 Probable 3-hydroxyacyl-thioester dehydratase HtdX compare
Rv3717 -0.7 -1.4 Conserved hypothetical protein compare
Rv3365c -0.7 -2.4 Conserved protein compare
Rv1328 -0.7 -2.6 Probable glycogen phosphorylase GlgP compare
Rv2567 -0.7 -2.3 Conserved hypothetical alanine and leucine rich protein compare
Rv1598c -0.7 -1.9 Conserved protein compare
Rv3787c -0.7 -1.7 Conserved hypothetical protein compare
Rv0378 -0.7 -0.9 Conserved hypothetical glycine rich protein compare
Rv3300c -0.7 -2.3 Conserved hypothetical protein compare
Rv3564 -0.7 -1.1 Probable acyl-CoA dehydrogenase FadE33 compare
Rv3019c -0.7 -2.0 Secreted ESAT-6 like protein EsxR (TB10.3) (ESAT-6 like protein 9) compare
Rv3357 -0.7 -2.5 Antitoxin RelJ compare
Rv1506c -0.7 -1.2 Hypothetical protein compare
Rv2231c -0.7 -0.9 Possible aminotransferase CobC compare
Rv3810 -0.7 -1.3 Exported repetitive protein precursor PirG (cell surface protein) (EXP53) compare
Rv1715 -0.7 -1.1 Probable 3-hydroxybutyryl-CoA dehydrogenase FadB3 (beta-hydroxybutyryl-CoA dehydrogenase) (BHBD) compare
Rv3272 -0.7 -3.3 Conserved hypothetical protein compare
Rv2836c -0.7 -1.2 Possible DNA-damage-inducible protein F DinF compare
Rv3262 -0.7 -0.6 Probable F420 biosynthesis protein FbiB compare
Rv0474 -0.7 -1.7 Probable transcriptional regulatory protein compare
Rv3563 -0.7 -1.0 Probable acyl-CoA dehydrogenase FadE32 compare
Rv3922c -0.7 -1.4 Possible hemolysin compare
Rv3301c -0.7 -1.9 Probable phosphate-transport system transcriptional regulatory protein PhoU homolog 1 PhoY1 compare
Rv3000 -0.7 -1.4 Possible conserved transmembrane protein compare
Rv2548 -0.7 -0.9 Possible toxin VapC19 compare
Rv3661 -0.7 -2.9 Conserved hypothetical protein compare
Rv3075c -0.7 -1.7 Conserved protein compare
Rv1991c -0.7 -1.8 Toxin MazF6 compare
Rv1939 -0.7 -1.2 Probable oxidoreductase compare
Rv1671 -0.7 -2.2 Probable membrane protein compare
Rv1168c -0.7 -2.6 PPE family protein PPE17 compare
Rv3278c -0.7 -2.7 Probable conserved transmembrane protein compare
Rv1371 -0.7 -3.1 Probable conserved membrane protein compare
Rv1180 -0.7 -1.0 Probable polyketide beta-ketoacyl synthase Pks3 compare
Rv1139c -0.7 -1.8 Conserved hypothetical membrane protein compare
Rv3642c -0.7 -0.9 Hypothetical protein compare
Rv2922c -0.7 -1.7 Probable chromosome partition protein Smc compare
Rv1350 -0.7 -0.4 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) compare
Rv1210 -0.7 -2.5 Probable DNA-3-methyladenine glycosylase I TagA (tag I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine glycosidase I) compare
Rv3164c -0.7 -1.8 Probable methanol dehydrogenase transcriptional regulatory protein MoxR3 compare
Rv0056 -0.7 -1.3 50S ribosomal protein L9 RplI compare
Rv0184 -0.7 -1.5 Conserved hypothetical protein compare
Rv3305c -0.7 -0.7 Possible N-acyl-L-amino acid amidohydrolase AmiA1 (N-acyl-L-amino acid aminohydrolase) compare
Rv2816c -0.7 -1.4 Conserved hypothetical protein compare
Rv3585 -0.7 -2.3 DNA repair protein RadA (DNA repair protein SMS) conserved
Rv1255c -0.7 -1.3 Probable transcriptional regulatory protein compare
Rv1064c -0.7 -1.2 Possible lipoprotein LpqV compare
Rv2818c -0.6 -1.6 Hypothetical protein compare
Rv0223c -0.6 -1.7 Probable aldehyde dehydrogenase compare
Rv0403c -0.6 -1.6 Probable conserved membrane protein MmpS1 compare
Rv2956 -0.6 -1.1 Conserved protein compare
Rv3313c -0.6 -2.5 Probable adenosine deaminase Add (adenosine aminohydrolase) compare
Rv1963c -0.6 -0.7 Probable transcriptional repressor (probably TetR-family) Mce3R compare
Rv2120c -0.6 -2.3 Probable conserved integral membrane protein compare
Rv1634 -0.6 -3.6 Possible drug efflux membrane protein compare
Rv0012 -0.6 -2.8 Probable conserved membrane protein compare
Rv1566c -0.6 -1.3 Possible Inv protein compare
Rv3480c -0.6 -2.3 Possible triacylglycerol synthase (diacylglycerol acyltransferase) compare
Rv3050c -0.6 -0.8 Probable transcriptional regulatory protein (probably AsnC-family) compare
Rv2140c -0.6 -0.8 Conserved protein TB18.6 compare
Rv2293c -0.6 -1.5 Conserved hypothetical protein compare
Rv0916c -0.6 -1.4 PE family protein PE7 compare


Specific Phenotypes

For 4 genes in this experiment

For stress Levofloxacin in Mycobacterium tuberculosis H37Rv

For stress Levofloxacin across organisms