Experiment set3S269 for Mycobacterium tuberculosis H37Rv

200 most important genes:

gene	name	fitness	t score	description
Rv0949		-4.0	-1.3	Probable ATP-dependent DNA helicase II UvrD1
Rv2044c		-3.9	-1.2	Conserved hypothetical protein
Rv0007		-3.7	-1.2	Possible conserved membrane protein
Rv0929		-3.7	-2.5	Phosphate-transport integral membrane ABC transporter PstC2
Rv0437c		-3.1	-1.3	Possible phosphatidylserine decarboxylase Psd (PS decarboxylase)
Rv3202c		-2.7	-7.3	Possible ATP-dependent DNA helicase
Rv0930		-2.7	-7.5	Probable phosphate-transport integral membrane ABC transporter PstA1
Rv0275c		-2.7	-2.2	Possible transcriptional regulatory protein (possibly TetR-family)
Rv3201c		-2.6	-9.0	Probable ATP-dependent DNA helicase
Rv1010		-2.5	-1.3	Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase)
Rv0146		-2.4	-9.6	Possible S-adenosylmethionine-dependent methyltransferase
Rv2869c		-2.3	-1.8	Membrane bound metalloprotease
Rv2737c		-2.2	-5.1	RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)].
Rv2095c		-2.2	-8.0	Proteasome accessory factor C PafC
Rv3277		-2.1	-0.9	Probable conserved transmembrane protein
Rv3364c		-2.0	-1.5	Conserved protein
Rv3810		-2.0	-1.9	Exported repetitive protein precursor PirG (cell surface protein) (EXP53)
Rv2096c		-2.0	-3.7	Proteasome accessory factor B PafB
Rv1107c		-1.9	-1.5	Probable exodeoxyribonuclease VII (small subunit) XseB (exonuclease VII small subunit)
Rv0819		-1.9	-3.2	GCN5-related N-acetyltransferase, MshD
Rv0642c		-1.9	-1.8	Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase)
Rv3198c		-1.8	-1.1	Probable ATP-dependent DNA helicase II UvrD2
Rv1372		-1.8	-1.7	Conserved hypothetical protein
Rv1411c		-1.8	-3.3	Conserved lipoprotein LprG
Rv3850		-1.8	-1.6	Conserved protein
Rv1930c		-1.8	-1.1	Conserved hypothetical protein
Rv1450c		-1.8	-2.2	PE-PGRS family protein PE_PGRS27
Rv0367c		-1.8	-0.9	Hypothetical protein
Rv0991c		-1.8	-1.1	Conserved serine rich protein
Rv1941		-1.7	-1.4	Probable short-chain type dehydrogenase/reductase
Rv0928		-1.7	-2.9	Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1)
Rv1410c		-1.7	-6.4	Aminoglycosides/tetracycline-transport integral membrane protein
Rv0003		-1.6	-3.0	DNA replication and repair protein RecF (single-strand DNA binding protein)
Rv2224c		-1.6	-9.8	Probable carboxylesterase CaeA
Rv1825		-1.6	-3.6	Conserved protein
Rv3171c		-1.6	-0.9	Possible non-heme haloperoxidase Hpx
Rv0531		-1.6	-1.2	Possible conserved membrane protein
Rv0994		-1.6	-6.8	Probable molybdopterin biosynthesis protein MoeA1
Rv0959		-1.6	-1.1	Conserved hypothetical protein
Rv1823		-1.5	-3.0	Conserved protein
Rv0375c		-1.5	-2.0	Probable carbon monoxyde dehydrogenase (medium chain)
Rv1278		-1.5	-2.5	Hypothetical protein
Rv2624c		-1.4	-1.0	Universal stress protein family protein
Rv0805		-1.4	-0.9	Class III cyclic nucleotide phosphodiesterase (cNMP PDE)
Rv0549c		-1.4	-1.3	Possible toxin VapC3
Rv1860		-1.4	-3.7	Alanine and proline rich secreted protein Apa (fibronectin attachment protein) (immunogenic protein MPT32) (antigen MPT-32) (45-kDa glycoprotein) (45/47 kDa antigen)
Rv1824		-1.4	-1.3	Conserved hypothetical membrane protein
Rv2230c		-1.4	-1.1	Conserved protein
Rv1277		-1.3	-4.2	Conserved hypothetical protein
Rv3717		-1.3	-3.6	Conserved hypothetical protein
Rv3267		-1.3	-1.9	Conserved protein (CPSA-related protein)
Rv3214		-1.3	-1.0	Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM)
Rv3102c		-1.3	-2.6	Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter)
Rv3101c		-1.3	-1.6	Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter)
Rv0247c		-1.3	-0.7	Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase)
Rv2581c		-1.3	-0.9	Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II)
Rv2647		-1.3	-1.1	Hypothetical protein
Rv3760		-1.3	-1.9	Possible conserved membrane protein
Rv2586c		-1.2	-1.0	Probable protein-export membrane protein SecF
Rv2474c		-1.2	-1.1	Conserved hypothetical protein
Rv3843c		-1.2	-1.4	Probable conserved transmembrane protein
Rv2099c		-1.2	-1.3	PE family protein PE21
Rv2733c		-1.2	-1.5	Conserved hypothetical alanine, arginine-rich protein
Rv2331A		-1.2	-1.0	Hypothetical protein
Rv0580c		-1.2	-0.7	Conserved protein
Rv2694c		-1.2	-3.5	Conserved protein
Rv3287c		-1.2	-0.9	Anti-sigma factor RsbW (sigma negative effector)
Rv2923c		-1.2	-1.1	Conserved protein
Rv0383c		-1.2	-0.7	Possible conserved secreted protein
Rv0876c		-1.1	-1.8	Possible conserved transmembrane protein
Rv2750		-1.1	-1.7	Probable dehydrogenase
Rv0012		-1.1	-4.5	Probable conserved membrane protein
Rv3005c		-1.1	-5.8	Conserved hypothetical protein
Rv2938		-1.1	-6.1	Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC
Rv2272		-1.1	-0.6	Probable conserved transmembrane protein
Rv3897c		-1.1	-0.8	Conserved hypothetical protein
Rv1020		-1.1	-7.0	Probable transcription-repair coupling factor Mfd (TRCF)	conserved
Rv2942		-1.1	-7.2	Conserved transmembrane transport protein MmpL7
Rv1715		-1.1	-1.3	Probable 3-hydroxybutyryl-CoA dehydrogenase FadB3 (beta-hydroxybutyryl-CoA dehydrogenase) (BHBD)
Rv2503c		-1.1	-1.9	Probable succinyl-CoA:3-ketoacid-coenzyme A transferase (beta subunit) ScoB (3-oxo-acid:CoA transferase) (OXCT B) (succinyl CoA:3-oxoacid CoA-transferase)
Rv3131		-1.1	-1.0	Conserved protein
Rv3114		-1.1	-0.8	Conserved hypothetical protein
Rv1004c		-1.0	-1.2	Probable membrane protein
Rv3405c		-1.0	-0.9	Possible transcriptional regulatory protein
Rv0085		-1.0	-1.5	Possible hydrogenase HycP
Rv0609		-1.0	-0.6	Possible toxin VapC28. Contains PIN domain.
Rv0870c		-1.0	-1.4	Possible conserved integral membrane protein
Rv0612		-1.0	-1.2	Conserved hypothetical protein
Rv2635		-1.0	-0.4	Hypothetical protein
Rv2234		-1.0	-2.2	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)
Rv0615		-1.0	-1.1	Probable integral membrane protein
Rv0056		-1.0	-1.1	50S ribosomal protein L9 RplI
Rv0426c		-1.0	-1.4	Possible transmembrane protein
Rv3357		-1.0	-2.0	Antitoxin RelJ
Rv2171		-1.0	-1.5	Probable conserved lipoprotein LppM
Rv1109c		-0.9	-2.4	Conserved protein
Rv3273		-0.9	-4.6	Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase)
Rv1366A		-0.9	-0.6	Conserved protein
Rv2315c		-0.9	-3.4	Conserved protein
Rv2432c		-0.9	-0.9	Hypothetical protein
Rv0154c		-0.9	-2.8	Probable acyl-CoA dehydrogenase FadE2
Rv0649		-0.9	-2.0	Possible malonyl CoA-acyl carrier protein transacylase FabD2 (MCT)
Rv0820		-0.9	-2.0	Probable phosphate-transport ATP-binding protein ABC transporter PhoT
Rv1962A		-0.9	-0.8	Possible antitoxin VapB35
Rv2001		-0.9	-0.5	Conserved hypothetical protein
Rv1836c		-0.9	-1.6	Conserved protein
Rv1283c		-0.9	-1.3	Probable oligopeptide-transport integral membrane protein ABC transporter OppB
Rv1116A		-0.9	-0.8	Conserved hypothetical protein (fragment)
Rv2691		-0.9	-3.2	TRK system potassium uptake protein CeoB
Rv1531		-0.9	-1.0	Conserved protein
Rv0472c		-0.9	-2.2	Probable transcriptional regulatory protein (possibly TetR-family)
Rv1260		-0.9	-1.8	Probable oxidoreductase
Rv2922c		-0.9	-2.7	Probable chromosome partition protein Smc
Rv1944c		-0.9	-2.1	Conserved protein
Rv2937		-0.9	-5.7	Daunorubicin-dim-transport integral membrane protein ABC transporter DrrB
Rv1570		-0.9	-0.9	Dethiobiotin synthetase BioD
Rv2680		-0.9	-0.9	Conserved protein
Rv0504c		-0.9	-1.3	Conserved protein
Rv1035c		-0.9	-0.8	Probable transposase (fragment)
Rv1232c		-0.9	-2.0	Conserved protein
Rv2672		-0.9	-4.2	Possible secreted protease
Rv0955		-0.9	-0.8	Probable conserved integral membrane protein
Rv1180		-0.9	-1.9	Probable polyketide beta-ketoacyl synthase Pks3
Rv2936		-0.9	-5.7	Daunorubicin-dim-transport ATP-binding protein ABC transporter DrrA
Rv1194c		-0.9	-3.1	Conserved protein
Rv2231c		-0.8	-1.1	Possible aminotransferase CobC
Rv2417c		-0.8	-1.6	Conserved protein
Rv1102c		-0.8	-0.9	Toxin MazF3
Rv1280c		-0.8	-3.5	Probable periplasmic oligopeptide-binding lipoprotein OppA
Rv3204		-0.8	-0.6	Possible DNA-methyltransferase (modification methylase)
Rv0212c		-0.8	-1.4	Possible transcriptional regulatory protein NadR (probably AsnC-family)
Rv1108c		-0.8	-3.1	Probable exodeoxyribonuclease VII (large subunit) XseA (exonuclease VII large subunit)
Rv0674		-0.8	-0.4	Conserved hypothetical protein
Rv3073c		-0.8	-1.1	Conserved hypothetical protein
Rv0694		-0.8	-2.1	Possible L-lactate dehydrogenase (cytochrome) LldD1
Rv3647c		-0.8	-0.5	Conserved hypothetical protein
Rv0089		-0.8	-1.8	Possible methyltransferase/methylase
Rv2525c		-0.8	-4.3	Conserved hypothetical protein. Secreted; predicted to be a substrate of the twin arginine translocation (tat) export system.
Rv0563		-0.8	-1.6	Probable protease transmembrane protein heat shock protein HtpX
Rv2310		-0.8	-2.5	Possible excisionase
Rv2932		-0.8	-5.0	Phenolpthiocerol synthesis type-I polyketide synthase PpsB
Rv0680c		-0.8	-1.1	Probable conserved transmembrane protein
Rv0989c		-0.8	-3.9	Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase)
Rv1435c		-0.8	-1.9	Probable conserved proline, glycine, valine-rich secreted protein
Rv3414c		-0.8	-2.5	Probable alternative RNA polymerase sigma-D factor SigD
Rv0397		-0.8	-2.0	Conserved 13E12 repeat family protein
Rv3445c		-0.8	-1.4	ESAT-6 like protein EsxU
Rv2035		-0.8	-1.6	Conserved hypothetical protein
Rv1421		-0.8	-1.8	Conserved protein
Rv1256c		-0.8	-2.4	Probable cytochrome P450 130 Cyp130
Rv2551c		-0.8	-1.0	Conserved hypothetical protein
Rv0818		-0.8	-3.1	Transcriptional regulatory protein
Rv1139c		-0.8	-1.5	Conserved hypothetical membrane protein
Rv0892		-0.8	-0.9	Probable monooxygenase
Rv3335c		-0.8	-1.8	Probable conserved integral membrane protein
Rv2374c		-0.8	-0.9	Probable heat shock protein transcriptional repressor HrcA
Rv2408		-0.7	-0.9	Possible PE family-related protein PE24
Rv3748		-0.7	-1.0	Conserved hypothetical protein
Rv3270		-0.7	-0.6	Probable metal cation-transporting P-type ATPase C CtpC
Rv1890c		-0.7	-0.6	Hypothetical protein
Rv2686c		-0.7	-1.4	Antibiotic-transport integral membrane leucine and alanine and valine rich protein ABC transporter
Rv0079		-0.7	-1.8	Unknown protein
Rv1272c		-0.7	-2.4	Probable drugs-transport transmembrane ATP-binding protein ABC transporter
Rv3777		-0.7	-3.2	Probable oxidoreductase
Rv0690c		-0.7	-0.9	Conserved hypothetical protein
Rv2377c		-0.7	-0.9	Putative conserved protein MbtH
Rv0990c		-0.7	-0.5	Hypothetical protein
Rv2251		-0.7	-1.6	Possible flavoprotein
Rv3313c		-0.7	-2.7	Probable adenosine deaminase Add (adenosine aminohydrolase)
Rv1006		-0.7	-2.6	Unknown protein
Rv2625c		-0.7	-3.6	Probable conserved transmembrane alanine and leucine rich protein
Rv2365c		-0.7	-0.4	Conserved hypothetical protein
Rv2307A		-0.7	-1.6	Hypothetical glycine rich protein
Rv3672c		-0.7	-0.8	Conserved hypothetical protein
Rv3132c		-0.7	-2.0	Two component sensor histidine kinase DevS
Rv0319		-0.7	-2.1	Probable pyrrolidone-carboxylate peptidase Pcp (5-oxoprolyl-peptidase) (pyroglutamyl-peptidase I) (PGP-I) (pyrase)
Rv2018		-0.7	-2.0	Conserved protein
Rv1072		-0.7	-0.7	Probable conserved transmembrane protein
Rv1834		-0.7	-1.5	Probable hydrolase
Rv0560c		-0.7	-1.5	Possible benzoquinone methyltransferase (methylase)
Rv0207c		-0.7	-1.7	Conserved hypothetical protein
Rv2410c		-0.7	-1.3	Conserved protein
Rv3687c		-0.7	-0.6	Anti-anti-sigma factor RsfB (anti-sigma factor antagonist) (regulator of sigma F B)
Rv3365c		-0.7	-2.6	Conserved protein
Rv3182		-0.7	-0.4	Conserved hypothetical protein
Rv0040c		-0.7	-3.2	Secreted proline rich protein Mtc28 (proline rich 28 kDa antigen)
Rv1671		-0.6	-1.8	Probable membrane protein
Rv1361c		-0.6	-1.1	PPE family protein PPE19
Rv3278c		-0.6	-2.4	Probable conserved transmembrane protein
Rv0459		-0.6	-2.2	Conserved hypothetical protein
Rv3427c		-0.6	-1.0	Possible transposase
Rv2812		-0.6	-1.0	Probable transposase
Rv2941		-0.6	-4.6	Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)
Rv3626c		-0.6	-3.3	Conserved hypothetical protein
Rv2931		-0.6	-5.3	Phenolpthiocerol synthesis type-I polyketide synthase PpsA
Rv3651		-0.6	-1.9	Conserved hypothetical protein
Rv2960c		-0.6	-2.1	Hypothetical protein
Rv2939		-0.6	-4.6	Possible conserved polyketide synthase associated protein PapA5
Rv0392c		-0.6	-0.4	Probable membrane NADH dehydrogenase NdhA
Rv2444c		-0.6	-1.4	Possible ribonuclease E Rne

Specific Phenotypes

For 3 genes in this experiment

For stress Moxifloxacin in Mycobacterium tuberculosis H37Rv

For stress Moxifloxacin across organisms