Experiment set2S643 for Mycobacterium tuberculosis H37Rv

Compare to:

L-Valine 10 mM nitrogen source

200 most important genes:

  gene name fitness t score description  
Rv2967c -2.3 -8.6 Probable pyruvate carboxylase Pca (pyruvic carboxylase) compare
Rv2382c -2.2 -1.4 Polyketide synthetase MbtC (polyketide synthase) compare
Rv0007 -2.2 -1.0 Possible conserved membrane protein compare
Rv1626 -2.0 -4.0 Probable two-component system transcriptional regulator compare
Rv3897c -1.9 -0.8 Conserved hypothetical protein compare
Rv1273c -1.8 -5.0 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv2869c -1.7 -2.2 Membrane bound metalloprotease compare
Rv3046c -1.5 -1.3 Conserved protein compare
Rv0545c -1.5 -4.3 Probable low-affinity inorganic phosphate transporter integral membrane protein PitA compare
Rv3102c -1.5 -2.5 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv3283 -1.5 -1.8 Probable thiosulfate sulfurtransferase SseA (rhodanese) (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase) compare
Rv3220c -1.4 -3.8 Probable two component sensor kinase compare
Rv0472c -1.4 -3.2 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv3287c -1.4 -1.2 Anti-sigma factor RsbW (sigma negative effector) compare
Rv0242c -1.4 -4.4 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase) compare
Rv1791 -1.4 -1.3 PE family protein PE19 compare
Rv2801c -1.4 -1.1 Toxin MazF9 compare
Rv1272c -1.3 -4.4 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv0544c -1.3 -2.4 Possible conserved transmembrane protein compare
Rv0675 -1.3 -0.9 Probable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv0392c -1.3 -1.4 Probable membrane NADH dehydrogenase NdhA compare
Rv2989 -1.3 -0.8 Probable transcriptional regulatory protein compare
Rv1178 -1.2 -3.6 Probable aminotransferase compare
Rv3810 -1.2 -1.5 Exported repetitive protein precursor PirG (cell surface protein) (EXP53) compare
Rv2680 -1.2 -1.8 Conserved protein compare
Rv1071c -1.2 -4.1 Possible enoyl-CoA hydratase EchA9 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv0876c -1.2 -1.8 Possible conserved transmembrane protein compare
Rv3114 -1.2 -1.1 Conserved hypothetical protein compare
Rv1577c -1.2 -1.2 Probable PhiRv1 phage protein compare
Rv3850 -1.2 -1.3 Conserved protein compare
Rv3314c -1.1 -1.3 Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) compare
Rv1421 -1.1 -2.4 Conserved protein compare
Rv3085 -1.1 -1.1 Probable short-chain type dehydrogenase/reductase compare
Rv3716c -1.1 -1.0 Conserved protein compare
Rv1570 -1.1 -2.2 Dethiobiotin synthetase BioD compare
Rv2049c -1.1 -1.1 Conserved hypothetical protein compare
Rv1010 -1.1 -1.3 Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase) compare
Rv1411c -1.1 -2.2 Conserved lipoprotein LprG compare
Rv0655 -1.1 -4.1 Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl compare
Rv1908c -1.1 -1.9 Catalase-peroxidase-peroxynitritase T KatG compare
Rv0200 -1.1 -2.2 Possible conserved transmembrane protein compare
Rv0248c -1.0 -5.2 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) compare
Rv1085c -1.0 -4.1 Possible hemolysin-like protein compare
Rv2774c -1.0 -0.8 Hypothetical protein compare
Rv2581c -1.0 -1.1 Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II) compare
Rv3136 -1.0 -2.7 PPE family protein PPE51 compare
Rv3310 -1.0 -2.2 Acid phosphatase (acid phosphomonoesterase) (phosphomonoesterase) (glycerophosphatase) compare
Rv0561c -1.0 -1.5 Possible oxidoreductase compare
Rv3204 -1.0 -0.7 Possible DNA-methyltransferase (modification methylase) compare
Rv1444c -1.0 -1.9 Unknown protein compare
Rv0819 -1.0 -2.0 GCN5-related N-acetyltransferase, MshD compare
Rv0018c -0.9 -2.6 Phosphoserine/threonine phosphatase PstP compare
Rv2046 -0.9 -1.9 Probable lipoprotein LppI compare
Rv2003c -0.9 -0.8 Conserved hypothetical protein compare
Rv0825c -0.9 -1.3 Conserved protein compare
Rv0642c -0.9 -1.0 Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase) compare
Rv1159 -0.9 -1.4 Mannosyltransferase PimE compare
Rv2277c -0.9 -1.6 Possible glycerolphosphodiesterase compare
Rv0168 -0.9 -3.1 Conserved integral membrane protein YrbE1B compare
Rv3726 -0.9 -0.8 Possible dehydrogenase compare
Rv1332 -0.9 -0.9 Probable transcriptional regulatory protein compare
Rv0928 -0.9 -2.4 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv3135 -0.9 -2.3 PPE family protein PPE50 compare
Rv1986 -0.9 -1.6 Probable conserved integral membrane protein compare
Rv0056 -0.9 -1.2 50S ribosomal protein L9 RplI compare
Rv3513c -0.9 -1.1 Probable fatty-acid-CoA ligase FadD18 (fragment) (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv2621c -0.9 -1.3 Possible transcriptional regulatory protein compare
Rv3165c -0.9 -1.0 Unknown protein compare
Rv1620c -0.9 -2.3 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC compare
Rv1169c -0.9 -2.7 PE family protein. Possible lipase LipX. compare
Rv2009 -0.9 -1.3 Antitoxin VapB15 compare
Rv3005c -0.9 -5.6 Conserved hypothetical protein compare
Rv0820 -0.9 -3.2 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv2091c -0.8 -3.0 Probable membrane protein compare
Rv2635 -0.8 -0.7 Hypothetical protein compare
Rv2240c -0.8 -1.4 Unknown protein compare
Rv3282 -0.8 -1.2 Conserved hypothetical protein compare
Rv0078 -0.8 -1.0 Probable transcriptional regulatory protein compare
Rv1410c -0.8 -4.6 Aminoglycosides/tetracycline-transport integral membrane protein compare
Rv2872 -0.8 -2.5 Possible toxin VapC43. Contains PIN domain. compare
Rv3723 -0.8 -2.4 Probable conserved transmembrane protein compare
Rv2222c -0.8 -1.9 Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) compare
Rv3484 -0.8 -5.3 Possible conserved protein CpsA compare
Rv1824 -0.8 -1.7 Conserved hypothetical membrane protein compare
Rv3311 -0.7 -3.5 Conserved protein compare
Rv1621c -0.7 -2.4 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD compare
Rv2171 -0.7 -1.5 Probable conserved lipoprotein LppM compare
Rv3697c -0.7 -1.6 Possible toxin VapC48. Contains PIN domain. compare
Rv0994 -0.7 -3.5 Probable molybdopterin biosynthesis protein MoeA1 compare
Rv3316 -0.7 -1.7 Probable succinate dehydrogenase (cytochrome B-556 subunit) SdhC (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase) compare
Rv0494 -0.7 -1.7 Probable transcriptional regulatory protein (probably GntR-family) compare
Rv1333 -0.7 -2.6 Probable hydrolase compare
Rv0178 -0.7 -2.0 Probable conserved Mce associated membrane protein compare
Rv0531 -0.7 -0.8 Possible conserved membrane protein compare
Rv2887 -0.7 -1.1 Probable transcriptional regulatory protein compare
Rv3193c -0.7 -1.0 Probable conserved transmembrane protein compare
Rv2997 -0.7 -2.8 Possible alanine rich dehydrogenase compare
Rv0093c -0.7 -0.9 Probable conserved membrane protein compare
Rv0580c -0.7 -0.8 Conserved protein compare
Rv0452 -0.7 -2.0 Possible transcriptional regulatory protein compare
Rv1120c -0.7 -2.0 Conserved hypothetical protein compare
Rv3101c -0.7 -1.3 Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter) compare
Rv3306c -0.7 -0.7 Probable amidohydrolase AmiB1 (aminohydrolase) compare
Rv0696 -0.7 -2.5 Probable membrane sugar transferase compare
Rv0857 -0.7 -1.3 Conserved hypothetical protein compare
Rv3040c -0.7 -2.3 Conserved protein compare
Rv2170 -0.7 -0.9 GCN5-related N-acetyltransferase compare
Rv3803c -0.6 -4.1 Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) (85C) compare
Rv0161 -0.6 -1.3 Possible oxidoreductase compare
Rv3771c -0.6 -1.5 Conserved hypothetical protein compare
Rv0394c -0.6 -2.5 Possible secreted protein compare
Rv0436c -0.6 -1.1 Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase) compare
Rv3338 -0.6 -0.6 Conserved hypothetical protein compare
Rv0375c -0.6 -1.5 Probable carbon monoxyde dehydrogenase (medium chain) compare
Rv0746 -0.6 -2.3 PE-PGRS family protein PE_PGRS9 compare
Rv2736c -0.6 -0.9 Regulatory protein RecX compare
Rv2745c -0.6 -1.4 Transcriptional regulatory protein ClgR compare
Rv0971c -0.6 -1.8 Probable enoyl-CoA hydratase EchA7 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv2707 -0.6 -4.6 Probable conserved transmembrane alanine and leucine rich protein compare
Rv2436 -0.6 -1.4 Ribokinase RbsK compare
Rv3346c -0.6 -2.0 Conserved transmembrane protein compare
Rv2378c -0.6 -1.8 Lysine-N-oxygenase MbtG (L-lysine 6-monooxygenase) (lysine N6-hydroxylase) compare
Rv0130 -0.6 -0.9 Probable 3-hydroxyl-thioester dehydratase compare
Rv1364c -0.6 -2.8 Possible sigma factor regulatory protein compare
Rv3363c -0.6 -1.2 Conserved hypothetical protein compare
Rv2762c -0.6 -0.8 Conserved hypothetical protein compare
Rv1112 -0.6 -0.9 Probable GTP binding protein compare
Rv2023A -0.6 -1.8 Hypothetical protein, pseudogene compare
Rv2647 -0.6 -0.7 Hypothetical protein compare
Rv2821c -0.6 -1.4 Conserved hypothetical protein compare
Rv1823 -0.6 -2.1 Conserved protein compare
Rv0249c -0.6 -1.8 Probable succinate dehydrogenase [membrane anchor subunit] (succinic dehydrogenase) compare
Rv1331 -0.6 -1.4 Conserved hypothetical protein compare
Rv3477 -0.6 -0.8 PE family protein PE31 compare
Rv2250c -0.6 -1.0 Possible transcriptional regulatory protein compare
Rv1468c -0.6 -1.0 PE-PGRS family protein PE_PGRS29 compare
Rv1049 -0.6 -1.0 Probable transcriptional repressor protein compare
Rv1821 -0.6 -1.8 Possible preprotein translocase ATPase SecA2 compare
Rv0870c -0.6 -1.0 Possible conserved integral membrane protein compare
Rv2004c -0.6 -1.0 Conserved protein compare
Rv3091 -0.6 -2.0 Conserved protein compare
Rv0057 -0.6 -1.3 Hypothetical protein compare
Rv2275 -0.6 -1.1 Conserved hypothetical protein compare
Rv0753c -0.6 -2.6 Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH) compare
Rv1962A -0.5 -0.9 Possible antitoxin VapB35 compare
Rv3576 -0.5 -2.1 Possible conserved lipoprotein LppH compare
Rv0929 -0.5 -1.0 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv1798 -0.5 -0.4 ESX conserved component EccA5. ESX-5 type VII secretion system protein. compare
Rv0258c -0.5 -1.5 Conserved hypothetical protein compare
Rv3678A -0.5 -1.0 Conserved hypothetical protein compare
Rv3321c -0.5 -1.0 Possible antitoxin VapB44 compare
Rv1420 -0.5 -2.0 Probable excinuclease ABC (subunit C-nuclease) UvrC compare
Rv1131 -0.5 -1.2 Probable methylcitrate synthase PrpC compare
Rv0959 -0.5 -0.8 Conserved hypothetical protein compare
Rv2148c -0.5 -2.3 Conserved protein compare
Rv1259 -0.5 -0.5 Probable uracil DNA glycosylase, UdgB compare
Rv2504c -0.5 -2.1 Probable succinyl-CoA:3-ketoacid-coenzyme A transferase (alpha subunit) ScoA (3-oxo acid:CoA transferase) (OXCT A) (succinyl-CoA:3-oxoacid-coenzyme A transferase) compare
Rv0499 -0.5 -0.9 Conserved hypothetical protein compare
Rv3062 -0.5 -1.2 Probable ATP-dependent DNA ligase LigB (polydeoxyribonucleotide synthase [ATP]) (polynucleotide ligase [ATP]) (sealase) (DNA repair protein) (DNA joinase) compare
Rv3893c -0.5 -1.7 PE family protein PE36 compare
Rv0612 -0.5 -1.6 Conserved hypothetical protein compare
Rv1187 -0.5 -1.7 Probable pyrroline-5-carboxylate dehydrogenase RocA compare
Rv2369c -0.5 -0.7 Hypothetical protein compare
Rv0451c -0.5 -0.7 Probable conserved membrane protein MmpS4 compare
Rv0141c -0.5 -1.8 Unknown protein compare
Rv0016c -0.5 -1.5 Probable penicillin-binding protein PbpA compare
Rv0975c -0.5 -2.4 Probable acyl-CoA dehydrogenase FadE13 compare
Rv2784c -0.5 -2.5 Probable lipoprotein LppU compare
Rv0250c -0.5 -1.4 Conserved protein compare
Rv0003 -0.5 -1.1 DNA replication and repair protein RecF (single-strand DNA binding protein) compare
Rv0949 -0.5 -0.4 Probable ATP-dependent DNA helicase II UvrD1 compare
Rv1255c -0.5 -1.7 Probable transcriptional regulatory protein compare
Rv0081 -0.5 -1.2 Probable transcriptional regulatory protein compare
Rv3119 -0.5 -1.7 Probable molybdenum cofactor biosynthesis protein E MoaE1 (molybdopterin converting factor large subunit) (molybdopterin [MPT] converting factor, subunit 2) compare
Rv3267 -0.5 -1.1 Conserved protein (CPSA-related protein) compare
Rv1111c -0.5 -2.1 Conserved hypothetical protein compare
Rv0399c -0.5 -1.6 Possible conserved lipoprotein LpqK compare
Rv0069c -0.5 -0.8 Probable L-serine dehydratase SdaA (L-serine deaminase) (SDH) (L-SD) compare
Rv2236c -0.5 -1.1 Probable cobalamin biosynthesis transmembrane protein CobD compare
Rv1943c -0.5 -1.0 Possible antitoxin MazE5 compare
Rv3919c -0.5 -1.5 Probable glucose-inhibited division protein B Gid compare
Rv2991 -0.5 -1.4 Conserved protein compare
Rv0867c -0.5 -0.5 Possible resuscitation-promoting factor RpfA compare
Rv2693c -0.5 -2.0 Probable conserved integral membrane alanine and leucine rich protein compare
Rv2923c -0.5 -0.5 Conserved protein compare
Rv0944 -0.5 -1.6 Possible formamidopyrimidine-DNA glycosylase (FAPY-DNA glycosylase) compare
Rv0068 -0.5 -2.3 Probable oxidoreductase compare
Rv0201c -0.5 -1.0 Conserved protein compare
Rv1095 -0.5 -1.4 Probable PHOH-like protein PhoH2 (phosphate starvation-inducible protein PSIH) compare
Rv2176 -0.5 -2.6 Probable transmembrane serine/threonine-protein kinase L PknL (protein kinase L) (STPK L) compare
Rv2216 -0.5 -2.3 Conserved protein compare
Rv1569 -0.5 -1.5 Probable 8-amino-7-oxononanoate synthase BioF1 (AONS) (8-amino-7-ketopelargonate synthase) (7-keto-8-amino-pelargonic acid synthetase) (7-KAP synthetase) (L-alanine--pimelyl CoA ligase) compare
Rv3650 -0.5 -0.6 PE family protein PE33 compare
Rv2280 -0.5 -1.3 Probable dehydrogenase compare
Rv1938 -0.5 -1.3 Probable epoxide hydrolase EphB (epoxide hydratase) compare
Rv2107 -0.5 -0.9 PE family protein PE22 compare
Rv3414c -0.5 -1.1 Probable alternative RNA polymerase sigma-D factor SigD compare
Rv1829 -0.5 -1.8 Conserved protein compare
Rv1779c -0.4 -1.5 Possible integral membrane protein compare
Rv2602 -0.4 -2.6 Possible toxin VapC41. Contains PIN domain. compare


Specific Phenotypes

None in this experiment

For Mycobacterium tuberculosis H37Rv in nitrogen source experiments

For nitrogen source L-Valine across organisms