Experiment set2S639 for Mycobacterium tuberculosis H37Rv

Compare to:

Glycine 10 mM nitrogen source

200 most important genes:

  gene name fitness t score description  
Rv2989 -4.0 -1.3 Probable transcriptional regulatory protein compare
Rv2967c -3.8 -11.5 Probable pyruvate carboxylase Pca (pyruvic carboxylase) compare
Rv2003c -3.7 -2.1 Conserved hypothetical protein compare
Rv2553c -3.3 -1.5 Probable conserved membrane protein compare
Rv2869c -3.0 -3.7 Membrane bound metalloprotease compare
Rv0955 -2.8 -2.5 Probable conserved integral membrane protein compare
Rv3810 -2.6 -2.6 Exported repetitive protein precursor PirG (cell surface protein) (EXP53) compare
Rv3850 -2.5 -1.8 Conserved protein compare
Rv1272c -2.5 -8.1 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv3101c -2.4 -2.2 Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter) compare
Rv3102c -2.4 -4.7 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv0825c -2.3 -3.0 Conserved protein compare
Rv2047c -2.2 -7.6 Conserved hypothetical protein compare
Rv0929 -2.1 -3.2 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv3066 -2.0 -5.4 Probable transcriptional regulatory protein (probably DeoR-family) compare
Rv0676c -1.9 -12.6 Probable conserved transmembrane transport protein MmpL5 compare
Rv1836c -1.9 -2.4 Conserved protein compare
Rv2048c -1.8 -8.9 Polyketide synthase Pks12 compare
Rv0472c -1.8 -4.6 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv0202c -1.8 -7.9 Probable conserved transmembrane transport protein MmpL11 compare
Rv2647 -1.8 -1.5 Hypothetical protein compare
Rv1049 -1.7 -2.3 Probable transcriptional repressor protein compare
Rv1273c -1.7 -5.1 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv0819 -1.7 -3.9 GCN5-related N-acetyltransferase, MshD compare
Rv1821 -1.7 -5.0 Possible preprotein translocase ATPase SecA2 compare
Rv1159 -1.6 -3.2 Mannosyltransferase PimE compare
Rv1410c -1.6 -7.4 Aminoglycosides/tetracycline-transport integral membrane protein compare
Rv1421 -1.6 -4.1 Conserved protein compare
Rv0930 -1.5 -6.3 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv0820 -1.5 -3.8 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv1127c -1.5 -1.5 Probable pyruvate, phosphate dikinase PpdK compare
Rv1589 -1.5 -7.1 Probable biotin synthetase BioB compare
Rv0007 -1.5 -0.8 Possible conserved membrane protein compare
Rv1411c -1.4 -4.8 Conserved lipoprotein LprG compare
Rv0018c -1.4 -2.6 Phosphoserine/threonine phosphatase PstP compare
Rv3267 -1.4 -4.8 Conserved protein (CPSA-related protein) compare
Rv3162c -1.4 -2.1 Possible integral membrane protein compare
Rv2606c -1.4 -5.7 Possible pyridoxine biosynthesis protein SnzP compare
Rv0677c -1.4 -2.1 Possible conserved membrane protein MmpS5 compare
Rv1459c -1.4 -1.7 Possible conserved integral membrane protein compare
Rv1013 -1.3 -5.8 Putative polyketide synthase Pks16 compare
Rv3803c -1.3 -7.3 Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) (85C) compare
Rv1291c -1.3 -1.8 Conserved hypothetical secreted protein compare
Rv3193c -1.3 -2.2 Probable conserved transmembrane protein compare
Rv1908c -1.3 -2.1 Catalase-peroxidase-peroxynitritase T KatG compare
Rv3723 -1.3 -2.9 Probable conserved transmembrane protein compare
Rv1590 -1.2 -3.3 Conserved hypothetical protein compare
Rv0989c -1.2 -6.1 Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) compare
Rv0157A -1.2 -1.9 Conserved protein compare
Rv0609 -1.2 -1.3 Possible toxin VapC28. Contains PIN domain. compare
Rv0563 -1.1 -2.3 Probable protease transmembrane protein heat shock protein HtpX compare
Rv0504c -1.1 -1.7 Conserved protein compare
Rv3230c -1.1 -4.1 Hypothetical oxidoreductase compare
Rv2091c -1.1 -5.2 Probable membrane protein compare
Rv0241c -1.1 -2.9 Probable 3-hydroxyacyl-thioester dehydratase HtdX compare
Rv0200 -1.1 -2.7 Possible conserved transmembrane protein compare
Rv2691 -1.1 -5.9 TRK system potassium uptake protein CeoB compare
Rv3497c -1.1 -5.8 Mce-family protein Mce4C compare
Rv1282c -1.1 -2.7 Probable oligopeptide-transport integral membrane protein ABC transporter OppC compare
Rv0928 -1.0 -2.4 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv3513c -1.0 -1.2 Probable fatty-acid-CoA ligase FadD18 (fragment) (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv0040c -1.0 -5.0 Secreted proline rich protein Mtc28 (proline rich 28 kDa antigen) compare
Rv3717 -1.0 -3.2 Conserved hypothetical protein compare
Rv1693 -1.0 -1.5 Conserved hypothetical protein compare
Rv3085 -1.0 -1.2 Probable short-chain type dehydrogenase/reductase compare
Rv2170 -1.0 -1.3 GCN5-related N-acetyltransferase compare
Rv3493c -1.0 -4.1 Conserved hypothetical Mce associated alanine and valine rich protein compare
Rv0470c -1.0 -2.2 Mycolic acid synthase PcaA (cyclopropane synthase) compare
Rv2707 -1.0 -7.4 Probable conserved transmembrane alanine and leucine rich protein compare
Rv1657 -1.0 -2.1 Probable arginine repressor ArgR (AHRC) compare
Rv1085c -1.0 -4.8 Possible hemolysin-like protein compare
Rv0655 -1.0 -4.1 Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl compare
Rv0867c -1.0 -0.9 Possible resuscitation-promoting factor RpfA compare
Rv2224c -1.0 -6.7 Probable carboxylesterase CaeA compare
Rv3005c -0.9 -6.1 Conserved hypothetical protein compare
Rv1331 -0.9 -3.4 Conserved hypothetical protein compare
Rv0280 -0.9 -6.9 PPE family protein PPE3 compare
Rv3672c -0.9 -1.4 Conserved hypothetical protein compare
Rv0437c -0.9 -1.0 Possible phosphatidylserine decarboxylase Psd (PS decarboxylase) compare
Rv0742 -0.9 -1.6 PE-PGRS family protein PE_PGRS8 compare
Rv0994 -0.9 -4.7 Probable molybdopterin biosynthesis protein MoeA1 compare
Rv1678 -0.9 -2.7 Probable integral membrane protein compare
Rv3843c -0.9 -1.7 Probable conserved transmembrane protein compare
Rv3311 -0.9 -4.0 Conserved protein compare
Rv3139 -0.9 -3.3 Probable acyl-CoA dehydrogenase FadE24 compare
Rv1568 -0.9 -5.4 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA compare
Rv1420 -0.9 -1.9 Probable excinuclease ABC (subunit C-nuclease) UvrC compare
Rv3650 -0.9 -1.1 PE family protein PE33 compare
Rv1620c -0.9 -2.4 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC compare
Rv0361 -0.9 -1.1 Probable conserved membrane protein compare
Rv3610c -0.9 -2.1 Membrane-bound protease FtsH (cell division protein) compare
Rv3414c -0.9 -2.8 Probable alternative RNA polymerase sigma-D factor SigD compare
Rv0876c -0.9 -1.4 Possible conserved transmembrane protein compare
Rv0201c -0.9 -1.5 Conserved protein compare
Rv0436c -0.8 -0.9 Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase) compare
Rv1566c -0.8 -1.7 Possible Inv protein compare
Rv3140 -0.8 -3.4 Probable acyl-CoA dehydrogenase FadE23 compare
Rv2632c -0.8 -1.2 Conserved protein compare
Rv1565c -0.8 -4.3 Conserved hypothetical membrane protein compare
Rv3499c -0.8 -4.8 Mce-family protein Mce4A compare
Rv0242c -0.8 -2.0 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase) compare
Rv1745c -0.8 -2.6 Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase) compare
Rv2668 -0.8 -2.1 Possible exported alanine and valine rich protein compare
Rv3495c -0.8 -6.0 Possible Mce-family lipoprotein LprN (Mce-family lipoprotein Mce4E) compare
Rv3500c -0.8 -4.5 Conserved integral membrane protein YrbE4B. Possible ABC transporter. compare
Rv3358 -0.8 -1.5 Toxin RelK compare
Rv3229c -0.8 -1.8 Possible linoleoyl-CoA desaturase (delta(6)-desaturase) compare
Rv0204c -0.8 -3.0 Probable conserved transmembrane protein compare
Rv1747 -0.8 -4.9 Probable conserved transmembrane ATP-binding protein ABC transporter compare
Rv0589 -0.8 -3.3 Mce-family protein Mce2A compare
Rv3496c -0.8 -5.3 Mce-family protein Mce4D compare
Rv0452 -0.8 -2.5 Possible transcriptional regulatory protein compare
Rv3912 -0.7 -2.3 Hypothetical alanine rich protein compare
Rv2799 -0.7 -4.1 Probable membrane protein compare
Rv3492c -0.7 -1.9 Conserved hypothetical Mce associated protein compare
Rv0391 -0.7 -3.4 Probable O-succinylhomoserine sulfhydrylase MetZ (OSH sulfhydrylase) compare
Rv0497 -0.7 -1.1 Probable conserved transmembrane protein compare
Rv1450c -0.7 -1.2 PE-PGRS family protein PE_PGRS27 compare
Rv2384 -0.7 -1.9 Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase compare
Rv3494c -0.7 -4.0 Mce-family protein Mce4F compare
Rv0069c -0.7 -1.1 Probable L-serine dehydratase SdaA (L-serine deaminase) (SDH) (L-SD) compare
Rv3338 -0.7 -0.7 Conserved hypothetical protein compare
Rv2206 -0.7 -2.7 Probable conserved transmembrane protein compare
Rv0249c -0.7 -3.4 Probable succinate dehydrogenase [membrane anchor subunit] (succinic dehydrogenase) compare
Rv0520 -0.7 -1.7 Possible methyltransferase/methylase (fragment) compare
Rv2694c -0.7 -1.3 Conserved protein compare
Rv2348c -0.7 -0.6 Hypothetical protein compare
Rv1621c -0.7 -2.1 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD compare
Rv2378c -0.7 -2.3 Lysine-N-oxygenase MbtG (L-lysine 6-monooxygenase) (lysine N6-hydroxylase) compare
Rv0017c -0.7 -3.4 Probable cell division protein RodA compare
Rv0016c -0.7 -2.9 Probable penicillin-binding protein PbpA compare
Rv0590 -0.7 -1.1 Mce-family protein Mce2B compare
Rv2496c -0.7 -2.3 Probable branched-chain keto acid dehydrogenase E1 component, beta subunit BkdB compare
Rv3321c -0.7 -1.3 Possible antitoxin VapB44 compare
Rv0381c -0.7 -3.4 Hypothetical protein compare
Rv0972c -0.7 -2.2 Acyl-CoA dehydrogenase FadE12 compare
Rv3855 -0.7 -3.6 Transcriptional regulatory repressor protein (TetR-family) EthR compare
Rv0309 -0.7 -1.9 Possible conserved exported protein compare
Rv3922c -0.7 -2.1 Possible hemolysin compare
Rv3668c -0.7 -4.4 Possible protease compare
Rv2618 -0.7 -3.5 Conserved hypothetical protein compare
Rv3658c -0.7 -0.9 Probable conserved transmembrane protein compare
Rv2190c -0.7 -2.4 Conserved hypothetical protein compare
Rv2624c -0.6 -0.7 Universal stress protein family protein compare
Rv3363c -0.6 -1.8 Conserved hypothetical protein compare
Rv2474c -0.6 -0.9 Conserved hypothetical protein compare
Rv1335 -0.6 -3.4 Sulfur carrier protein CysO compare
Rv2222c -0.6 -1.2 Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) compare
Rv2369c -0.6 -1.0 Hypothetical protein compare
Rv3787c -0.6 -1.9 Conserved hypothetical protein compare
Rv3897c -0.6 -0.5 Conserved hypothetical protein compare
Rv2586c -0.6 -0.8 Probable protein-export membrane protein SecF compare
Rv2475c -0.6 -1.7 Conserved protein compare
Rv0760c -0.6 -2.2 Conserved protein compare
Rv1247c -0.6 -1.7 Antitoxin RelB compare
Rv2317 -0.6 -0.7 Probable sugar-transport integral membrane protein ABC transporter UspB compare
Rv2088 -0.6 -1.1 Transmembrane serine/threonine-protein kinase J PknJ (protein kinase J) (STPK J) compare
Rv3309c -0.6 -1.7 Probable uracil phosphoribosyltransferase Upp (UMP pyrophosphorylase) (uprtase) (UMP diphosphorylase) compare
Rv0037c -0.6 -4.4 Probable conserved integral membrane protein compare
Rv0070c -0.6 -1.1 Serine hydroxymethyltransferase GlyA2 (serine methylase 2) (SHMT 2) compare
Rv0999 -0.6 -1.5 Unknown protein compare
Rv0314c -0.6 -2.6 Possible conserved membrane protein compare
Rv0243 -0.6 -2.6 Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase) compare
Rv1072 -0.6 -1.2 Probable conserved transmembrane protein compare
Rv2679 -0.6 -1.5 Probable enoyl-CoA hydratase EchA15 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv1798 -0.6 -0.5 ESX conserved component EccA5. ESX-5 type VII secretion system protein. compare
Rv3565 -0.6 -0.9 Possible aspartate aminotransferase AspB (transaminase A) (ASPAT) (glutamic--oxaloacetic transaminase) (glutamic--aspartic transaminase) compare
Rv0376c -0.6 -1.7 Conserved hypothetical protein compare
Rv1244 -0.6 -3.2 Probable lipoprotein LpqZ compare
Rv1137c -0.6 -1.7 Hypothetical protein compare
Rv2148c -0.6 -3.0 Conserved protein compare
Rv2154c -0.6 -0.7 FtsW-like protein FtsW compare
Rv3081 -0.6 -0.8 Conserved hypothetical protein compare
Rv0870c -0.6 -0.8 Possible conserved integral membrane protein compare
Rv0821c -0.6 -2.1 Probable phosphate-transport system transcriptional regulatory protein PhoY2 compare
Rv0857 -0.6 -1.2 Conserved hypothetical protein compare
Rv2383c -0.6 -1.4 Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) compare
Rv3412 -0.5 -2.6 Conserved hypothetical protein compare
Rv3170 -0.5 -1.3 Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) compare
Rv3204 -0.5 -0.5 Possible DNA-methyltransferase (modification methylase) compare
Rv1670 -0.5 -2.2 Conserved hypothetical protein compare
Rv1570 -0.5 -1.2 Dethiobiotin synthetase BioD compare
Rv0971c -0.5 -1.8 Probable enoyl-CoA hydratase EchA7 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv3760 -0.5 -1.5 Possible conserved membrane protein compare
Rv3675 -0.5 -1.8 Possible membrane protein compare
Rv0653c -0.5 -2.0 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv3694c -0.5 -2.5 Possible conserved transmembrane protein compare
Rv2021c -0.5 -1.3 Transcriptional regulatory protein compare
Rv1941 -0.5 -0.9 Probable short-chain type dehydrogenase/reductase compare
Rv0051 -0.5 -2.7 Probable conserved transmembrane protein compare
Rv2919c -0.5 -1.3 Probable nitrogen regulatory protein P-II GlnB compare
Rv1569 -0.5 -2.4 Probable 8-amino-7-oxononanoate synthase BioF1 (AONS) (8-amino-7-ketopelargonate synthase) (7-keto-8-amino-pelargonic acid synthetase) (7-KAP synthetase) (L-alanine--pimelyl CoA ligase) compare
Rv0441c -0.5 -1.3 Hypothetical protein compare
Rv2706c -0.5 -0.8 Hypothetical protein compare
Rv0367c -0.5 -0.5 Hypothetical protein compare
Rv3828c -0.5 -1.6 Possible resolvase compare
Rv0964c -0.5 -0.7 Hypothetical protein compare
Rv3284 -0.5 -1.3 Conserved hypothetical protein compare
Rv3498c -0.5 -2.9 Mce-family protein Mce4B compare
Rv0818 -0.5 -3.0 Transcriptional regulatory protein compare


Specific Phenotypes

None in this experiment

For Mycobacterium tuberculosis H37Rv in nitrogen source experiments

For nitrogen source Glycine across organisms