Experiment set2S638 for Mycobacterium tuberculosis H37Rv

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L-Glutamic acid monopotassium salt monohydrate 10 mM nitrogen source

200 most important genes:

  gene name fitness t score description  
Rv1127c -3.7 -1.6 Probable pyruvate, phosphate dikinase PpdK compare
Rv0991c -2.9 -1.2 Conserved serine rich protein compare
Rv0436c -2.8 -2.6 Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase) compare
Rv3338 -2.5 -1.1 Conserved hypothetical protein compare
Rv0549c -2.5 -2.5 Possible toxin VapC3 compare
Rv0825c -2.2 -1.6 Conserved protein compare
Rv2272 -2.1 -1.1 Probable conserved transmembrane protein compare
Rv0642c -2.1 -2.0 Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase) compare
Rv2879c -2.0 -0.8 Conserved hypothetical protein compare
Rv2553c -2.0 -1.2 Probable conserved membrane protein compare
Rv0819 -1.9 -3.8 GCN5-related N-acetyltransferase, MshD compare
Rv1693 -1.9 -1.6 Conserved hypothetical protein compare
Rv2869c -1.9 -2.5 Membrane bound metalloprotease compare
Rv2170 -1.9 -1.5 GCN5-related N-acetyltransferase compare
Rv0930 -1.8 -5.6 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv0675 -1.7 -0.9 Probable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv3314c -1.7 -1.2 Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) compare
Rv3650 -1.6 -1.3 PE family protein PE33 compare
Rv3309c -1.6 -2.6 Probable uracil phosphoribosyltransferase Upp (UMP pyrophosphorylase) (uprtase) (UMP diphosphorylase) compare
Rv2745c -1.5 -1.7 Transcriptional regulatory protein ClgR compare
Rv3249c -1.5 -0.8 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv1577c -1.4 -1.2 Probable PhiRv1 phage protein compare
Rv0531 -1.4 -1.1 Possible conserved membrane protein compare
Rv2230c -1.4 -1.2 Conserved protein compare
Rv3033 -1.4 -0.8 Unknown protein compare
Rv0677c -1.4 -1.6 Possible conserved membrane protein MmpS5 compare
Rv3843c -1.3 -1.5 Probable conserved transmembrane protein compare
Rv2276 -1.3 -1.0 Cytochrome P450 121 Cyp121 compare
Rv1400c -1.3 -0.9 Probable lipase LipH compare
Rv0202c -1.2 -6.2 Probable conserved transmembrane transport protein MmpL11 compare
Rv2047c -1.2 -6.3 Conserved hypothetical protein compare
Rv2630 -1.2 -1.3 Hypothetical protein compare
Rv2621c -1.2 -1.3 Possible transcriptional regulatory protein compare
Rv0676c -1.2 -8.9 Probable conserved transmembrane transport protein MmpL5 compare
Rv2171 -1.2 -1.6 Probable conserved lipoprotein LppM compare
Rv2887 -1.2 -1.3 Probable transcriptional regulatory protein compare
Rv2003c -1.2 -0.9 Conserved hypothetical protein compare
Rv3102c -1.1 -1.9 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv0472c -1.1 -2.7 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv3874 -1.1 -0.8 10 kDa culture filtrate antigen EsxB (LHP) (CFP10) compare
Rv3081 -1.1 -1.3 Conserved hypothetical protein compare
Rv0927c -1.1 -1.4 Probable short-chain type dehydrogenase/reductase compare
Rv2048c -1.1 -4.1 Polyketide synthase Pks12 compare
Rv1159 -1.1 -1.9 Mannosyltransferase PimE compare
Rv2632c -1.1 -1.3 Conserved protein compare
Rv0820 -1.0 -3.5 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv3819 -1.0 -1.0 Unknown protein compare
Rv0200 -1.0 -2.4 Possible conserved transmembrane protein compare
Rv0383c -1.0 -0.8 Possible conserved secreted protein compare
Rv3174 -1.0 -1.4 Probable short-chain dehydrogenase/reductase compare
Rv2624c -1.0 -0.9 Universal stress protein family protein compare
Rv1411c -1.0 -2.4 Conserved lipoprotein LprG compare
Rv0018c -0.9 -2.8 Phosphoserine/threonine phosphatase PstP compare
Rv3005c -0.9 -5.5 Conserved hypothetical protein compare
Rv3133c -0.9 -3.0 Two component transcriptional regulatory protein DevR (probably LuxR/UhpA-family) compare
Rv2626c -0.9 -2.2 Hypoxic response protein 1 Hrp1 compare
Rv1332 -0.9 -0.8 Probable transcriptional regulatory protein compare
Rv0821c -0.9 -1.8 Probable phosphate-transport system transcriptional regulatory protein PhoY2 compare
Rv2055c -0.9 -1.1 30S ribosomal protein S18 RpsR2 compare
Rv3101c -0.9 -0.7 Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter) compare
Rv0563 -0.9 -1.5 Probable protease transmembrane protein heat shock protein HtpX compare
Rv0955 -0.9 -1.0 Probable conserved integral membrane protein compare
Rv1450c -0.9 -0.7 PE-PGRS family protein PE_PGRS27 compare
Rv2224c -0.8 -5.7 Probable carboxylesterase CaeA compare
Rv2500c -0.8 -0.8 Possible acyl-CoA dehydrogenase FadE19 (MMGC) compare
Rv1824 -0.8 -1.4 Conserved hypothetical membrane protein compare
Rv3204 -0.8 -0.6 Possible DNA-methyltransferase (modification methylase) compare
Rv1272c -0.8 -2.6 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv1570 -0.8 -1.5 Dethiobiotin synthetase BioD compare
Rv3328c -0.8 -2.2 Probable alternative RNA polymerase sigma factor (fragment) SigJ compare
Rv1421 -0.8 -1.9 Conserved protein compare
Rv1614 -0.8 -1.3 Possible prolipoprotein diacylglyceryl transferases Lgt compare
Rv1621c -0.8 -2.0 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD compare
Rv3140 -0.8 -2.9 Probable acyl-CoA dehydrogenase FadE23 compare
Rv3723 -0.8 -2.4 Probable conserved transmembrane protein compare
Rv2733c -0.8 -1.2 Conserved hypothetical alanine, arginine-rich protein compare
Rv3165c -0.8 -0.8 Unknown protein compare
Rv1013 -0.8 -3.8 Putative polyketide synthase Pks16 compare
Rv0928 -0.8 -2.2 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv0539 -0.8 -1.3 Probable dolichyl-phosphate sugar synthase (dolichol-phosphate sugar synthetase) (dolichol-phosphate sugar transferase) (sugar phosphoryldolichol synthase) compare
Rv1490 -0.8 -2.1 Probable membrane protein compare
Rv2275 -0.8 -1.2 Conserved hypothetical protein compare
Rv3193c -0.7 -1.0 Probable conserved transmembrane protein compare
Rv3492c -0.7 -1.6 Conserved hypothetical Mce associated protein compare
Rv0556 -0.7 -0.9 Probable conserved transmembrane protein compare
Rv0929 -0.7 -1.1 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv3922c -0.7 -1.6 Possible hemolysin compare
Rv1010 -0.7 -0.9 Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase) compare
Rv2222c -0.7 -1.7 Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) compare
Rv2376c -0.7 -0.6 Low molecular weight antigen CFP2 (low molecular weight protein antigen 2) (CFP-2) compare
Rv3893c -0.7 -1.5 PE family protein PE36 compare
Rv0818 -0.7 -3.2 Transcriptional regulatory protein compare
Rv0610c -0.7 -0.6 Hypothetical protein compare
Rv1589 -0.7 -3.7 Probable biotin synthetase BioB compare
Rv0242c -0.7 -1.8 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase) compare
Rv1568 -0.7 -4.4 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA compare
Rv3371 -0.7 -1.8 Possible triacylglycerol synthase (diacylglycerol acyltransferase) compare
Rv3321c -0.7 -1.9 Possible antitoxin VapB44 compare
Rv1701 -0.7 -2.1 Probable integrase/recombinase compare
Rv1410c -0.7 -3.8 Aminoglycosides/tetracycline-transport integral membrane protein compare
Rv3208A -0.7 -0.7 Conserved protein TB9.4 compare
Rv3289c -0.7 -2.0 Possible transmembrane protein compare
Rv0661c -0.7 -1.2 Possible toxin VapC7 compare
Rv3726 -0.7 -1.2 Possible dehydrogenase compare
Rv0605 -0.7 -2.2 Possible resolvase compare
Rv3643 -0.7 -0.8 Hypothetical protein compare
Rv3277 -0.7 -0.4 Probable conserved transmembrane protein compare
Rv3066 -0.7 -2.9 Probable transcriptional regulatory protein (probably DeoR-family) compare
Rv1566c -0.7 -1.8 Possible Inv protein compare
Rv1281c -0.7 -2.9 Probable oligopeptide-transport ATP-binding protein ABC transporter OppD compare
Rv3897c -0.7 -0.4 Conserved hypothetical protein compare
Rv0857 -0.7 -1.1 Conserved hypothetical protein compare
Rv3358 -0.7 -2.0 Toxin RelK compare
Rv2922c -0.7 -1.6 Probable chromosome partition protein Smc compare
Rv1273c -0.7 -2.4 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv0204c -0.7 -2.5 Probable conserved transmembrane protein compare
Rv1160 -0.6 -1.0 Probable mutator protein MutT2 (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase) compare
Rv1148c -0.6 -0.9 Conserved hypothetical protein compare
Rv2647 -0.6 -0.6 Hypothetical protein compare
Rv2923c -0.6 -1.0 Conserved protein compare
Rv3131 -0.6 -0.9 Conserved protein compare
Rv0348 -0.6 -1.6 Possible transcriptional regulatory protein compare
Rv1495 -0.6 -0.6 Possible toxin MazF4 compare
Rv0012 -0.6 -3.3 Probable conserved membrane protein compare
Rv0040c -0.6 -2.9 Secreted proline rich protein Mtc28 (proline rich 28 kDa antigen) compare
Rv1072 -0.6 -0.9 Probable conserved transmembrane protein compare
Rv3311 -0.6 -2.1 Conserved protein compare
Rv3493c -0.6 -2.4 Conserved hypothetical Mce associated alanine and valine rich protein compare
Rv1446c -0.6 -2.0 Putative OXPP cycle protein OpcA compare
Rv3412 -0.6 -2.6 Conserved hypothetical protein compare
Rv3170 -0.6 -1.4 Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) compare
Rv0557 -0.6 -1.0 Mannosyltransferase MgtA compare
Rv1730c -0.6 -1.6 Possible penicillin-binding protein compare
Rv2551c -0.6 -0.9 Conserved hypothetical protein compare
Rv1459c -0.6 -0.8 Possible conserved integral membrane protein compare
Rv0367c -0.6 -0.5 Hypothetical protein compare
Rv3717 -0.6 -2.3 Conserved hypothetical protein compare
Rv1335 -0.6 -2.9 Sulfur carrier protein CysO compare
Rv3538 -0.6 -0.8 Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase. compare
Rv2668 -0.6 -2.5 Possible exported alanine and valine rich protein compare
Rv2206 -0.6 -2.3 Probable conserved transmembrane protein compare
Rv3550 -0.6 -1.4 Probable enoyl-CoA hydratase EchA20 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv2429 -0.6 -0.9 Alkyl hydroperoxide reductase D protein AhpD (alkyl hydroperoxidase D) compare
Rv1203c -0.6 -1.8 Hypothetical protein compare
Rv2378c -0.6 -1.4 Lysine-N-oxygenase MbtG (L-lysine 6-monooxygenase) (lysine N6-hydroxylase) compare
Rv0653c -0.6 -2.0 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv2801c -0.6 -0.6 Toxin MazF9 compare
Rv2691 -0.6 -2.5 TRK system potassium uptake protein CeoB compare
Rv2862A -0.6 -1.2 Possible antitoxin VapB23 compare
Rv0009 -0.6 -0.4 Probable iron-regulated peptidyl-prolyl cis-trans isomerase A PpiA (PPIase A) (rotamase A) compare
Rv2985 -0.6 -0.9 Possible hydrolase MutT1 compare
Rv3209 -0.6 -2.1 Conserved hypothetical threonine and proline rich protein compare
Rv2635 -0.6 -0.4 Hypothetical protein compare
Rv3500c -0.6 -3.5 Conserved integral membrane protein YrbE4B. Possible ABC transporter. compare
Rv0007 -0.6 -0.3 Possible conserved membrane protein compare
Rv2173 -0.6 -1.8 Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) compare
Rv2216 -0.6 -1.8 Conserved protein compare
Rv3267 -0.6 -1.5 Conserved protein (CPSA-related protein) compare
Rv1890c -0.6 -0.5 Hypothetical protein compare
Rv1474c -0.6 -1.2 Probable transcriptional regulatory protein compare
Rv3760 -0.6 -1.4 Possible conserved membrane protein compare
Rv2979c -0.6 -1.6 Probable resolvase compare
Rv1019 -0.6 -2.8 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv3399 -0.6 -1.9 Possible S-adenosylmethionine-dependent methyltransferase compare
Rv0298 -0.5 -2.1 Hypothetical protein compare
Rv3222c -0.5 -0.6 Conserved hypothetical protein compare
Rv2804c -0.5 -2.5 Hypothetical protein compare
Rv0426c -0.5 -1.5 Possible transmembrane protein compare
Rv1660 -0.5 -2.5 Chalcone synthase Pks10 compare
Rv3414c -0.5 -1.0 Probable alternative RNA polymerase sigma-D factor SigD compare
Rv3046c -0.5 -0.5 Conserved protein compare
Rv0672 -0.5 -2.6 Probable acyl-CoA dehydrogenase FadE8 compare
Rv1111c -0.5 -1.9 Conserved hypothetical protein compare
Rv3771c -0.5 -0.9 Conserved hypothetical protein compare
Rv2586c -0.5 -0.5 Probable protein-export membrane protein SecF compare
Rv1941 -0.5 -0.7 Probable short-chain type dehydrogenase/reductase compare
Rv1058 -0.5 -1.9 Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv3823c -0.5 -3.5 Conserved integral membrane transport protein MmpL8 compare
Rv3229c -0.5 -1.2 Possible linoleoyl-CoA desaturase (delta(6)-desaturase) compare
Rv3633 -0.5 -2.0 Conserved protein compare
Rv3521 -0.5 -1.9 Conserved hypothetical protein compare
Rv1884c -0.5 -0.8 Probable resuscitation-promoting factor RpfC compare
Rv3067 -0.5 -1.0 Conserved hypothetical protein compare
Rv0113 -0.5 -0.6 Probable sedoheptulose-7-phosphate isomerase GmhA (phosphoheptose isomerase) compare
Rv0756c -0.5 -1.7 Unknown protein compare
Rv3803c -0.5 -3.3 Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) (85C) compare
Rv0257 -0.5 -1.8 Conserved hypothetical protein compare
Rv3282 -0.5 -0.7 Conserved hypothetical protein compare
Rv3050c -0.5 -1.7 Probable transcriptional regulatory protein (probably AsnC-family) compare
Rv2873 -0.5 -1.5 Cell surface lipoprotein Mpt83 (lipoprotein P23) compare
Rv3878 -0.5 -1.7 ESX-1 secretion-associated protein EspJ. Conserved alanine rich protein. compare
Rv1194c -0.5 -3.3 Conserved protein compare
Rv0655 -0.5 -2.7 Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl compare
Rv3386 -0.5 -0.6 Possible transposase compare
Rv0084 -0.5 -0.7 Possible formate hydrogenlyase HycD (FHL) compare
Rv1287 -0.5 -1.8 Conserved hypothetical protein compare
Rv2964 -0.5 -2.6 Probable formyltetrahydrofolate deformylase PurU (formyl-FH(4) hydrolase) compare
Rv3501c -0.5 -1.8 Conserved integral membrane protein YrbE4A. Possible ABC transporter. compare
Rv3192 -0.5 -1.9 Conserved hypothetical alanine and proline-rich protein compare
Rv1009 -0.5 -1.9 Probable resuscitation-promoting factor RpfB compare


Specific Phenotypes

None in this experiment

For Mycobacterium tuberculosis H37Rv in nitrogen source experiments

For nitrogen source L-Glutamic acid monopotassium salt monohydrate across organisms