Experiment set2S634 for Mycobacterium tuberculosis H37Rv

Compare to:

L-Aspartic Acid 10 mM nitrogen source

200 most important genes:

  gene name fitness t score description  
Rv2553c -2.5 -1.7 Probable conserved membrane protein compare
Rv0949 -2.2 -1.3 Probable ATP-dependent DNA helicase II UvrD1 compare
Rv0007 -2.2 -1.0 Possible conserved membrane protein compare
Rv2047c -2.1 -10.5 Conserved hypothetical protein compare
Rv3101c -1.9 -2.5 Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter) compare
Rv2048c -1.9 -7.5 Polyketide synthase Pks12 compare
Rv0930 -1.9 -7.9 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv0313 -1.9 -2.7 Conserved protein compare
Rv0504c -1.8 -2.8 Conserved protein compare
Rv0820 -1.8 -5.1 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv0928 -1.8 -3.5 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv2869c -1.8 -2.8 Membrane bound metalloprotease compare
Rv1272c -1.8 -7.8 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv0955 -1.8 -2.2 Probable conserved integral membrane protein compare
Rv3306c -1.8 -1.6 Probable amidohydrolase AmiB1 (aminohydrolase) compare
Rv3102c -1.7 -3.8 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv0676c -1.7 -11.1 Probable conserved transmembrane transport protein MmpL5 compare
Rv1127c -1.7 -2.1 Probable pyruvate, phosphate dikinase PpdK compare
Rv2989 -1.7 -0.9 Probable transcriptional regulatory protein compare
Rv3920c -1.6 -1.6 Conserved protein similar to jag protein compare
Rv0084 -1.6 -2.2 Possible formate hydrogenlyase HycD (FHL) compare
Rv0202c -1.6 -8.2 Probable conserved transmembrane transport protein MmpL11 compare
Rv0819 -1.6 -3.8 GCN5-related N-acetyltransferase, MshD compare
Rv1411c -1.6 -3.8 Conserved lipoprotein LprG compare
Rv3843c -1.5 -2.2 Probable conserved transmembrane protein compare
Rv2923c -1.4 -1.9 Conserved protein compare
Rv0436c -1.4 -2.1 Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase) compare
Rv3287c -1.4 -1.2 Anti-sigma factor RsbW (sigma negative effector) compare
Rv0929 -1.4 -1.9 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv2879c -1.3 -1.1 Conserved hypothetical protein compare
Rv1421 -1.3 -3.5 Conserved protein compare
Rv1072 -1.3 -1.9 Probable conserved transmembrane protein compare
Rv3309c -1.3 -3.2 Probable uracil phosphoribosyltransferase Upp (UMP pyrophosphorylase) (uprtase) (UMP diphosphorylase) compare
Rv1821 -1.3 -4.0 Possible preprotein translocase ATPase SecA2 compare
Rv0242c -1.3 -4.0 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase) compare
Rv3143 -1.3 -1.0 Probable response regulator compare
Rv1035c -1.3 -1.2 Probable transposase (fragment) compare
Rv1410c -1.2 -6.1 Aminoglycosides/tetracycline-transport integral membrane protein compare
Rv1836c -1.2 -2.4 Conserved protein compare
Rv0677c -1.2 -1.6 Possible conserved membrane protein MmpS5 compare
Rv2240c -1.2 -1.8 Unknown protein compare
Rv1049 -1.2 -1.6 Probable transcriptional repressor protein compare
Rv0241c -1.1 -1.9 Probable 3-hydroxyacyl-thioester dehydratase HtdX compare
Rv3283 -1.1 -2.6 Probable thiosulfate sulfurtransferase SseA (rhodanese) (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase) compare
Rv3267 -1.1 -3.7 Conserved protein (CPSA-related protein) compare
Rv0249c -1.1 -3.2 Probable succinate dehydrogenase [membrane anchor subunit] (succinic dehydrogenase) compare
Rv1010 -1.1 -1.3 Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase) compare
Rv3066 -1.0 -3.9 Probable transcriptional regulatory protein (probably DeoR-family) compare
Rv3912 -1.0 -3.0 Hypothetical alanine rich protein compare
Rv0018c -1.0 -2.1 Phosphoserine/threonine phosphatase PstP compare
Rv0887c -1.0 -1.3 Conserved hypothetical protein compare
Rv3819 -1.0 -1.2 Unknown protein compare
Rv3565 -1.0 -1.5 Possible aspartate aminotransferase AspB (transaminase A) (ASPAT) (glutamic--oxaloacetic transaminase) (glutamic--aspartic transaminase) compare
Rv3810 -1.0 -2.4 Exported repetitive protein precursor PirG (cell surface protein) (EXP53) compare
Rv1273c -1.0 -2.7 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv0995 -1.0 -1.5 Ribosomal-protein-alanine acetyltransferase RimJ (acetylating enzyme for N-terminal of ribosomal protein S5) compare
Rv2444c -1.0 -1.7 Possible ribonuclease E Rne compare
Rv1159 -1.0 -2.0 Mannosyltransferase PimE compare
Rv2985 -0.9 -1.9 Possible hydrolase MutT1 compare
Rv1930c -0.9 -0.7 Conserved hypothetical protein compare
Rv0088 -0.9 -1.0 Possible polyketide cyclase/dehydrase compare
Rv3200c -0.9 -3.1 Possible transmembrane cation transporter compare
Rv1570 -0.9 -1.8 Dethiobiotin synthetase BioD compare
Rv3569c -0.9 -1.3 4,9-DHSA hydrolase compare
Rv3658c -0.9 -1.1 Probable conserved transmembrane protein compare
Rv2275 -0.9 -1.8 Conserved hypothetical protein compare
Rv1577c -0.9 -0.8 Probable PhiRv1 phage protein compare
Rv3193c -0.9 -1.6 Probable conserved transmembrane protein compare
Rv0472c -0.9 -3.2 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv1291c -0.9 -1.4 Conserved hypothetical secreted protein compare
Rv1589 -0.9 -4.4 Probable biotin synthetase BioB compare
Rv3803c -0.9 -4.0 Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) (85C) compare
Rv0040c -0.9 -3.8 Secreted proline rich protein Mtc28 (proline rich 28 kDa antigen) compare
Rv3229c -0.9 -1.7 Possible linoleoyl-CoA desaturase (delta(6)-desaturase) compare
Rv1459c -0.9 -1.3 Possible conserved integral membrane protein compare
Rv1259 -0.8 -0.9 Probable uracil DNA glycosylase, UdgB compare
Rv0653c -0.8 -4.4 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv2372c -0.8 -1.4 Conserved hypothetical protein compare
Rv1013 -0.8 -4.3 Putative polyketide synthase Pks16 compare
Rv1400c -0.8 -0.8 Probable lipase LipH compare
Rv3005c -0.8 -5.3 Conserved hypothetical protein compare
Rv0391 -0.8 -4.3 Probable O-succinylhomoserine sulfhydrylase MetZ (OSH sulfhydrylase) compare
Rv0452 -0.8 -2.2 Possible transcriptional regulatory protein compare
Rv0821c -0.8 -1.8 Probable phosphate-transport system transcriptional regulatory protein PhoY2 compare
Rv0749 -0.8 -0.8 Possible toxin VapC31. Contains PIN domain. compare
Rv2691 -0.8 -3.8 TRK system potassium uptake protein CeoB compare
Rv2072c -0.8 -0.9 Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL compare
Rv2849c -0.8 -1.5 Probable cob(I)alamin adenosyltransferase CobO (corrinoid adenosyltransferase) (corrinoid adotransferase activity) compare
Rv0994 -0.7 -3.7 Probable molybdopterin biosynthesis protein MoeA1 compare
Rv2693c -0.7 -3.4 Probable conserved integral membrane alanine and leucine rich protein compare
Rv0321 -0.7 -1.6 Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase) compare
Rv3204 -0.7 -0.6 Possible DNA-methyltransferase (modification methylase) compare
Rv0201c -0.7 -1.4 Conserved protein compare
Rv0444c -0.7 -2.8 Anti-sigma factor RskA (regulator of sigma K) compare
Rv0971c -0.7 -1.8 Probable enoyl-CoA hydratase EchA7 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv0361 -0.7 -1.3 Probable conserved membrane protein compare
Rv3249c -0.7 -1.0 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv1590 -0.7 -1.8 Conserved hypothetical protein compare
Rv1281c -0.7 -2.0 Probable oligopeptide-transport ATP-binding protein ABC transporter OppD compare
Rv3399 -0.7 -2.3 Possible S-adenosylmethionine-dependent methyltransferase compare
Rv1568 -0.7 -4.1 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA compare
Rv2091c -0.7 -3.0 Probable membrane protein compare
Rv0497 -0.7 -1.1 Probable conserved transmembrane protein compare
Rv0367c -0.7 -0.7 Hypothetical protein compare
Rv3140 -0.7 -1.5 Probable acyl-CoA dehydrogenase FadE23 compare
Rv2224c -0.7 -4.8 Probable carboxylesterase CaeA compare
Rv2366c -0.7 -1.5 Probable conserved transmembrane protein compare
Rv3497c -0.7 -2.9 Mce-family protein Mce4C compare
Rv0563 -0.7 -2.3 Probable protease transmembrane protein heat shock protein HtpX compare
Rv0113 -0.6 -0.9 Probable sedoheptulose-7-phosphate isomerase GmhA (phosphoheptose isomerase) compare
Rv1895 -0.6 -2.5 Possible dehydrogenase compare
Rv2707 -0.6 -3.7 Probable conserved transmembrane alanine and leucine rich protein compare
Rv2171 -0.6 -1.5 Probable conserved lipoprotein LppM compare
Rv0437c -0.6 -0.7 Possible phosphatidylserine decarboxylase Psd (PS decarboxylase) compare
Rv1620c -0.6 -1.9 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC compare
Rv3091 -0.6 -2.3 Conserved protein compare
Rv1247c -0.6 -1.9 Antitoxin RelB compare
Rv2365c -0.6 -0.7 Conserved hypothetical protein compare
Rv0586 -0.6 -1.6 Probable transcriptional regulatory protein Mce2R (GntR-family) compare
Rv1745c -0.6 -3.5 Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase) compare
Rv1569 -0.6 -2.1 Probable 8-amino-7-oxononanoate synthase BioF1 (AONS) (8-amino-7-ketopelargonate synthase) (7-keto-8-amino-pelargonic acid synthetase) (7-KAP synthetase) (L-alanine--pimelyl CoA ligase) compare
Rv0470c -0.6 -1.3 Mycolic acid synthase PcaA (cyclopropane synthase) compare
Rv2762c -0.6 -0.9 Conserved hypothetical protein compare
Rv3085 -0.6 -1.0 Probable short-chain type dehydrogenase/reductase compare
Rv2912c -0.6 -2.5 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv2232 -0.6 -1.4 Protein tyrosine kinase transcriptional regulatory protein PtkA compare
Rv1717 -0.6 -1.8 Conserved hypothetical protein compare
Rv3284 -0.6 -1.7 Conserved hypothetical protein compare
Rv1262c -0.6 -1.1 Hypothetical hit-like protein compare
Rv1665 -0.6 -2.7 Chalcone synthase Pks11 compare
Rv1824 -0.6 -1.2 Conserved hypothetical membrane protein compare
Rv2606c -0.6 -1.9 Possible pyridoxine biosynthesis protein SnzP compare
Rv0550c -0.6 -1.1 Possible antitoxin VapB3 compare
Rv2887 -0.6 -0.8 Probable transcriptional regulatory protein compare
Rv3610c -0.6 -1.7 Membrane-bound protease FtsH (cell division protein) compare
Rv1009 -0.6 -2.5 Probable resuscitation-promoting factor RpfB compare
Rv1740 -0.6 -1.1 Possible antitoxin VapB34 compare
Rv1280c -0.6 -3.2 Probable periplasmic oligopeptide-binding lipoprotein OppA compare
Rv2799 -0.6 -3.5 Probable membrane protein compare
Rv3495c -0.6 -3.9 Possible Mce-family lipoprotein LprN (Mce-family lipoprotein Mce4E) compare
Rv2331A -0.6 -0.7 Hypothetical protein compare
Rv3717 -0.6 -1.6 Conserved hypothetical protein compare
Rv3321c -0.6 -1.7 Possible antitoxin VapB44 compare
Rv2190c -0.6 -2.2 Conserved hypothetical protein compare
Rv1693 -0.6 -1.0 Conserved hypothetical protein compare
Rv0243 -0.6 -3.3 Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase) compare
Rv0203 -0.6 -1.3 Possible exported protein compare
Rv3310 -0.6 -1.9 Acid phosphatase (acid phosphomonoesterase) (phosphomonoesterase) (glycerophosphatase) compare
Rv1025 -0.6 -0.6 Conserved protein compare
Rv3414c -0.6 -2.5 Probable alternative RNA polymerase sigma-D factor SigD compare
Rv0960 -0.6 -1.0 Possible toxin VapC9 compare
Rv0012 -0.6 -2.8 Probable conserved membrane protein compare
Rv0769 -0.5 -2.3 Probable dehydrogenase/reductase compare
Rv0851c -0.5 -1.2 Probable short-chain type dehydrogenase/reductase compare
Rv1946c -0.5 -1.3 Possible lipoprotein compare
Rv2621c -0.5 -1.0 Possible transcriptional regulatory protein compare
Rv0200 -0.5 -1.3 Possible conserved transmembrane protein compare
Rv1657 -0.5 -1.0 Probable arginine repressor ArgR (AHRC) compare
Rv3135 -0.5 -1.8 PPE family protein PPE50 compare
Rv0954 -0.5 -1.6 Probable conserved transmembrane protein compare
Rv1986 -0.5 -1.1 Probable conserved integral membrane protein compare
Rv2127 -0.5 -3.4 L-asparagine permease AnsP1 compare
Rv1701 -0.5 -1.6 Probable integrase/recombinase compare
Rv2330c -0.5 -2.6 Probable lipoprotein LppP compare
Rv1366A -0.5 -0.3 Conserved protein compare
Rv2993c -0.5 -1.1 Possible 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) compare
Rv1414 -0.5 -0.5 Conserved hypothetical protein compare
Rv3716c -0.5 -0.6 Conserved protein compare
Rv3328c -0.5 -1.5 Probable alternative RNA polymerase sigma factor (fragment) SigJ compare
Rv3527 -0.5 -0.7 Hypothetical protein compare
Rv1741 -0.5 -2.0 Possible toxin VapC34. Contains PIN domain. compare
Rv0643c -0.5 -2.1 Methoxy mycolic acid synthase 3 MmaA3 (methyl mycolic acid synthase 3) (MMA3) (hydroxy mycolic acid synthase) compare
Rv3660c -0.5 -2.6 Conserved hypothetical protein compare
Rv1962A -0.5 -0.8 Possible antitoxin VapB35 compare
Rv0802c -0.5 -2.0 Possible succinyltransferase in the GCN5-related N-acetyltransferase family compare
Rv2249c -0.5 -1.3 Probable glycerol-3-phosphate dehydrogenase GlpD1 compare
Rv2497c -0.5 -3.0 Probable branched-chain keto acid dehydrogenase E1 component, alpha subunit BkdA compare
Rv0248c -0.5 -2.1 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) compare
Rv3344c -0.5 -2.0 PE-PGRS family protein PE_PGRS49 compare
Rv0456c -0.5 -2.4 enoyl-CoA hydratase EchA2 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv0460 -0.5 -1.2 Conserved hydrophobic protein compare
Rv0825c -0.5 -0.8 Conserved protein compare
Rv3316 -0.5 -0.8 Probable succinate dehydrogenase (cytochrome B-556 subunit) SdhC (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase) compare
Rv1420 -0.5 -1.1 Probable excinuclease ABC (subunit C-nuclease) UvrC compare
Rv0033 -0.5 -1.4 Probable acyl carrier protein AcpA (ACP) compare
Rv2475c -0.5 -1.5 Conserved protein compare
Rv1242 -0.5 -1.2 Possible toxin VapC33. Contains PIN domain. compare
Rv1058 -0.5 -2.0 Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv2474c -0.5 -0.7 Conserved hypothetical protein compare
Rv1325c -0.5 -1.8 PE-PGRS family protein PE_PGRS24 compare
Rv3139 -0.5 -2.2 Probable acyl-CoA dehydrogenase FadE24 compare
Rv3017c -0.5 -2.9 ESAT-6 like protein EsxQ (TB12.9) (ESAT-6 like protein 8) compare
Rv2860c -0.5 -2.5 Probable glutamine synthetase GlnA4 (glutamine synthase) (GS-II) compare
Rv3445c -0.5 -0.6 ESAT-6 like protein EsxU compare
Rv0818 -0.5 -2.0 Transcriptional regulatory protein compare
Rv1255c -0.5 -1.5 Probable transcriptional regulatory protein compare
Rv1934c -0.5 -1.3 Probable acyl-CoA dehydrogenase FadE17 compare
Rv2791c -0.5 -1.6 Probable transposase compare
Rv0680c -0.5 -0.7 Probable conserved transmembrane protein compare
Rv0841 -0.5 -1.1 Probable conserved transmembrane protein compare


Specific Phenotypes

None in this experiment

For Mycobacterium tuberculosis H37Rv in nitrogen source experiments

For nitrogen source L-Aspartic Acid across organisms