Experiment set2S623 for Mycobacterium tuberculosis H37Rv

Compare to:

Palmitic acid 100 uM carbon source

200 most important genes:

  gene name fitness t score description  
Rv0504c -2.4 -2.6 Conserved protein compare
Rv0247c -2.4 -1.1 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) compare
Rv3920c -2.2 -1.5 Conserved protein similar to jag protein compare
Rv2581c -2.1 -1.6 Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II) compare
Rv2055c -1.9 -1.4 30S ribosomal protein S18 RpsR2 compare
Rv1798 -1.7 -1.5 ESX conserved component EccA5. ESX-5 type VII secretion system protein. compare
Rv3419c -1.6 -2.4 Probable O-sialoglycoprotein endopeptidase Gcp (glycoprotease) compare
Rv0867c -1.6 -1.0 Possible resuscitation-promoting factor RpfA compare
Rv1127c -1.5 -1.3 Probable pyruvate, phosphate dikinase PpdK compare
Rv3481c -1.5 -1.8 Probable integral membrane protein compare
Rv0204c -1.5 -5.1 Probable conserved transmembrane protein compare
Rv1010 -1.4 -1.3 Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase) compare
Rv3306c -1.4 -1.6 Probable amidohydrolase AmiB1 (aminohydrolase) compare
Rv3249c -1.4 -1.8 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv2635 -1.4 -1.2 Hypothetical protein compare
Rv0929 -1.3 -2.9 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv3803c -1.3 -7.5 Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) (85C) compare
Rv2072c -1.3 -1.3 Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL compare
Rv3650 -1.3 -0.9 PE family protein PE33 compare
Rv3687c -1.2 -1.2 Anti-anti-sigma factor RsfB (anti-sigma factor antagonist) (regulator of sigma F B) compare
Rv1829 -1.2 -5.7 Conserved protein compare
Rv2680 -1.2 -1.8 Conserved protein compare
Rv2476c -1.2 -3.2 Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase) compare
Rv0677c -1.2 -2.2 Possible conserved membrane protein MmpS5 compare
Rv2376c -1.2 -1.4 Low molecular weight antigen CFP2 (low molecular weight protein antigen 2) (CFP-2) compare
Rv0949 -1.1 -0.8 Probable ATP-dependent DNA helicase II UvrD1 compare
Rv0694 -1.1 -4.2 Possible L-lactate dehydrogenase (cytochrome) LldD1 compare
Rv0930 -1.1 -5.6 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv3314c -1.0 -1.3 Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) compare
Rv1272c -1.0 -4.4 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv1273c -0.9 -3.4 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv0819 -0.9 -2.4 GCN5-related N-acetyltransferase, MshD compare
Rv2048c -0.9 -4.6 Polyketide synthase Pks12 compare
Rv1537 -0.9 -1.5 Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) compare
Rv2624c -0.9 -1.2 Universal stress protein family protein compare
Rv2224c -0.9 -6.7 Probable carboxylesterase CaeA compare
Rv3131 -0.9 -1.4 Conserved protein compare
Rv0674 -0.9 -0.7 Conserved hypothetical protein compare
Rv2302 -0.9 -1.5 Conserved protein compare
Rv0615 -0.8 -1.1 Probable integral membrane protein compare
Rv0520 -0.8 -2.5 Possible methyltransferase/methylase (fragment) compare
Rv3726 -0.8 -1.5 Possible dehydrogenase compare
Rv3338 -0.8 -0.9 Conserved hypothetical protein compare
Rv2028c -0.8 -0.9 Universal stress protein family protein compare
Rv1269c -0.8 -2.1 Conserved probable secreted protein compare
Rv3270 -0.8 -1.3 Probable metal cation-transporting P-type ATPase C CtpC compare
Rv3171c -0.8 -1.0 Possible non-heme haloperoxidase Hpx compare
Rv0761c -0.8 -4.3 Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB compare
Rv3143 -0.8 -0.7 Probable response regulator compare
Rv0653c -0.8 -3.3 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv0820 -0.8 -3.7 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv2702 -0.8 -0.6 Polyphosphate glucokinase PpgK (polyphosphate-glucose phosphotransferase) compare
Rv1538c -0.8 -3.1 Probable L-aparaginase AnsA compare
Rv1851 -0.8 -1.2 Urease accessory protein UreF compare
Rv1139c -0.7 -2.2 Conserved hypothetical membrane protein compare
Rv1963c -0.7 -1.0 Probable transcriptional repressor (probably TetR-family) Mce3R compare
Rv0456c -0.7 -3.0 enoyl-CoA hydratase EchA2 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv3305c -0.7 -1.0 Possible N-acyl-L-amino acid amidohydrolase AmiA1 (N-acyl-L-amino acid aminohydrolase) compare
Rv2049c -0.7 -1.1 Conserved hypothetical protein compare
Rv3193c -0.7 -1.3 Probable conserved transmembrane protein compare
Rv0408 -0.7 -3.2 Probable phosphate acetyltransferase Pta (phosphotransacetylase) compare
Rv3102c -0.7 -1.7 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv1025 -0.7 -0.6 Conserved protein compare
Rv0695 -0.7 -2.5 Conserved hypothetical protein compare
Rv3816c -0.7 -0.7 Possible acyltransferase compare
Rv0693 -0.7 -2.5 Probable coenzyme PQQ synthesis protein E PqqE (coenzyme PQQ synthesis protein III) compare
Rv1173 -0.7 -1.5 Probable F420 biosynthesis protein FbiC compare
Rv0344c -0.7 -2.0 Probable lipoprotein LpqJ compare
Rv3167c -0.7 -1.9 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv1113 -0.7 -1.7 Possible antitoxin VapB32 compare
Rv2707 -0.7 -5.2 Probable conserved transmembrane alanine and leucine rich protein compare
Rv0773c -0.7 -1.2 Probable bifunctional acylase GgtA: cephalosporin acylase (GL-7ACA acylase) + gamma-glutamyltranspeptidase (GGT) compare
Rv3768 -0.7 -1.5 Unknown protein compare
Rv3156 -0.7 -3.9 Probable NADH dehydrogenase I (chain L) NuoL (NADH-ubiquinone oxidoreductase chain L) compare
Rv2821c -0.7 -1.8 Conserved hypothetical protein compare
Rv3600c -0.7 -1.9 Conserved protein compare
Rv3693 -0.6 -1.3 Possible conserved membrane protein compare
Rv3277 -0.6 -0.5 Probable conserved transmembrane protein compare
Rv3559c -0.6 -0.6 Probable oxidoreductase compare
Rv0676c -0.6 -5.1 Probable conserved transmembrane transport protein MmpL5 compare
Rv2047c -0.6 -4.5 Conserved hypothetical protein compare
Rv3140 -0.6 -2.2 Probable acyl-CoA dehydrogenase FadE23 compare
Rv2982c -0.6 -3.3 Probable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA2 (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase) compare
Rv0590A -0.6 -2.2 Mce-family related protein compare
Rv1940 -0.6 -1.7 Probable riboflavin biosynthesis protein RibA1 (GTP cyclohydrolase II) compare
Rv3672c -0.6 -0.7 Conserved hypothetical protein compare
Rv2197c -0.6 -1.8 Probable conserved transmembrane protein compare
Rv1951c -0.6 -1.3 Conserved hypothetical protein compare
Rv1411c -0.6 -1.7 Conserved lipoprotein LprG compare
Rv0470c -0.6 -1.6 Mycolic acid synthase PcaA (cyclopropane synthase) compare
Rv3158 -0.6 -3.6 Probable NADH dehydrogenase I (chain N) NuoN (NADH-ubiquinone oxidoreductase chain N) compare
Rv1665 -0.6 -1.9 Chalcone synthase Pks11 compare
Rv1657 -0.6 -2.2 Probable arginine repressor ArgR (AHRC) compare
Rv3375 -0.6 -1.8 Probable amidase AmiD (acylamidase) (acylase) compare
Rv2790c -0.6 -1.7 Probable lipid-transfer protein Ltp1 compare
Rv1926c -0.6 -1.2 Immunogenic protein Mpt63 (antigen Mpt63/MPB63) (16 kDa immunoprotective extracellular protein) compare
Rv0049 -0.6 -1.9 Conserved hypothetical protein compare
Rv1400c -0.6 -0.5 Probable lipase LipH compare
Rv0734 -0.6 -1.8 Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) compare
Rv1051c -0.6 -1.5 Conserved hypothetical protein compare
Rv0928 -0.6 -1.3 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv2063A -0.6 -1.5 Possible toxin MazF7 compare
Rv1441c -0.6 -2.0 PE-PGRS family protein PE_PGRS26 compare
Rv1363c -0.6 -2.6 Possible membrane protein compare
Rv0516c -0.6 -2.9 Possible anti-anti-sigma factor compare
Rv1137c -0.6 -1.7 Hypothetical protein compare
Rv1516c -0.5 -1.5 Probable sugar transferase compare
Rv0202c -0.5 -3.6 Probable conserved transmembrane transport protein MmpL11 compare
Rv3331 -0.5 -2.1 Probable sugar-transport integral membrane protein SugI compare
Rv1468c -0.5 -1.4 PE-PGRS family protein PE_PGRS29 compare
Rv0184 -0.5 -1.6 Conserved hypothetical protein compare
Rv1821 -0.5 -1.6 Possible preprotein translocase ATPase SecA2 compare
Rv3026c -0.5 -3.0 Conserved hypothetical protein compare
Rv3066 -0.5 -2.6 Probable transcriptional regulatory protein (probably DeoR-family) compare
Rv0391 -0.5 -2.8 Probable O-succinylhomoserine sulfhydrylase MetZ (OSH sulfhydrylase) compare
Rv0157A -0.5 -0.8 Conserved protein compare
Rv3139 -0.5 -2.4 Probable acyl-CoA dehydrogenase FadE24 compare
Rv3530c -0.5 -1.9 Possible oxidoreductase compare
Rv2862A -0.5 -1.6 Possible antitoxin VapB23 compare
Rv0942 -0.5 -1.5 Hypothetical protein compare
Rv1506c -0.5 -1.2 Hypothetical protein compare
Rv1159 -0.5 -1.6 Mannosyltransferase PimE compare
Rv0346c -0.5 -3.8 Possible L-asparagine permease AnsP2 (L-asparagine transport protein) compare
Rv2360c -0.5 -0.9 Unknown protein compare
Rv3704c -0.5 -2.3 Glutamate--cysteine ligase GshA (gamma-glutamylcysteine synthetase) (gamma-ECS) (GCS) (gamma-glutamyl-L-cysteine synthetase) compare
Rv2007c -0.5 -0.9 Ferredoxin FdxA compare
Rv0643c -0.5 -2.4 Methoxy mycolic acid synthase 3 MmaA3 (methyl mycolic acid synthase 3) (MMA3) (hydroxy mycolic acid synthase) compare
Rv1121 -0.5 -1.2 Probable glucose-6-phosphate 1-dehydrogenase Zwf1 (G6PD) compare
Rv2606c -0.5 -2.4 Possible pyridoxine biosynthesis protein SnzP compare
Rv3301c -0.5 -1.7 Probable phosphate-transport system transcriptional regulatory protein PhoU homolog 1 PhoY1 compare
Rv3150 -0.5 -2.3 Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) compare
Rv1116A -0.5 -0.8 Conserved hypothetical protein (fragment) compare
Rv3578 -0.5 -2.3 Possible arsenical pump integral membrane protein ArsB2 compare
Rv3692 -0.5 -2.7 Probable methanol dehydrogenase transcriptional regulatory protein MoxR2 compare
Rv0821c -0.5 -1.8 Probable phosphate-transport system transcriptional regulatory protein PhoY2 compare
Rv0200 -0.5 -1.1 Possible conserved transmembrane protein compare
Rv2322c -0.5 -0.7 Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) compare
Rv2099c -0.5 -1.0 PE family protein PE21 compare
Rv3353c -0.5 -0.9 Conserved hypothetical protein compare
Rv3725 -0.5 -1.7 Possible oxidoreductase compare
Rv3162c -0.5 -0.6 Possible integral membrane protein compare
Rv2717c -0.5 -1.4 Conserved protein compare
Rv3149 -0.5 -2.8 Probable NADH dehydrogenase I (chain E) NuoE (NADH-ubiquinone oxidoreductase chain E) compare
Rv3152 -0.5 -3.6 Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H) compare
Rv0472c -0.5 -1.8 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv3229c -0.5 -1.2 Possible linoleoyl-CoA desaturase (delta(6)-desaturase) compare
Rv2003c -0.5 -0.8 Conserved hypothetical protein compare
Rv1669 -0.5 -2.2 Hypothetical protein compare
Rv1908c -0.5 -1.2 Catalase-peroxidase-peroxynitritase T KatG compare
Rv0782 -0.5 -2.0 Probable protease II PtrBb [second part] (oligopeptidase B) compare
Rv1284 -0.5 -0.4 Beta-carbonic anhydrase compare
Rv3284 -0.5 -1.3 Conserved hypothetical protein compare
Rv0069c -0.5 -0.9 Probable L-serine dehydratase SdaA (L-serine deaminase) (SDH) (L-SD) compare
Rv1028c -0.5 -2.1 Probable sensor protein KdpD compare
Rv0280 -0.5 -3.5 PPE family protein PPE3 compare
Rv0539 -0.5 -1.3 Probable dolichyl-phosphate sugar synthase (dolichol-phosphate sugar synthetase) (dolichol-phosphate sugar transferase) (sugar phosphoryldolichol synthase) compare
Rv2961 -0.5 -1.2 Probable transposase compare
Rv2252 -0.5 -0.5 Diacylglycerol kinase compare
Rv0367c -0.5 -0.5 Hypothetical protein compare
Rv1046c -0.5 -1.0 Hypothetical protein compare
Rv2021c -0.5 -1.0 Transcriptional regulatory protein compare
Rv0503c -0.5 -3.8 Cyclopropane-fatty-acyl-phospholipid synthase 2 CmaA2 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic acid synthase 2) (mycolic acid trans-cyclopropane synthetase) compare
Rv0912 -0.5 -1.1 Probable conserved transmembrane protein compare
Rv1102c -0.5 -0.8 Toxin MazF3 compare
Rv3050c -0.4 -1.4 Probable transcriptional regulatory protein (probably AsnC-family) compare
Rv2789c -0.4 -1.9 Probable acyl-CoA dehydrogenase FadE21 compare
Rv0696 -0.4 -1.5 Probable membrane sugar transferase compare
Rv0037c -0.4 -3.5 Probable conserved integral membrane protein compare
Rv1614 -0.4 -0.9 Possible prolipoprotein diacylglyceryl transferases Lgt compare
Rv1190 -0.4 -1.8 Conserved hypothetical protein compare
Rv1889c -0.4 -1.4 Conserved hypothetical protein compare
Rv1270c -0.4 -1.4 Possible lipoprotein LprA compare
Rv2029c -0.4 -1.2 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) compare
Rv0971c -0.4 -1.9 Probable enoyl-CoA hydratase EchA7 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv1729c -0.4 -1.7 Possible S-adenosylmethionine-dependent methyltransferase compare
Rv2902c -0.4 -1.8 Probable ribonuclease HII protein RnhB (RNase HII) compare
Rv0968 -0.4 -1.9 Conserved protein compare
Rv3148 -0.4 -2.5 Probable NADH dehydrogenase I (chain D) NuoD (NADH-ubiquinone oxidoreductase chain D) compare
Rv0376c -0.4 -1.6 Conserved hypothetical protein compare
Rv0617 -0.4 -1.0 Possible toxin VapC29. Contains PIN domain. compare
Rv3157 -0.4 -1.8 Probable NADH dehydrogenase I (chain M) NUOK (NADH-ubiquinone oxidoreductase chain M) compare
Rv2887 -0.4 -0.7 Probable transcriptional regulatory protein compare
Rv0969 -0.4 -2.6 Probable metal cation transporter P-type ATPase CtpV compare
Rv0374c -0.4 -1.1 Probable carbon monoxyde dehydrogenase (small chain) compare
Rv0403c -0.4 -2.6 Probable conserved membrane protein MmpS1 compare
Rv0190 -0.4 -1.7 Conserved protein compare
Rv2791c -0.4 -1.3 Probable transposase compare
Rv2856 -0.4 -2.0 Possible nickel-transport integral membrane protein NicT compare
Rv3833 -0.4 -1.6 Transcriptional regulatory protein (probably AraC-family) compare
Rv2381c -0.4 -0.8 Polyketide synthetase MbtD (polyketide synthase) compare
Rv2708c -0.4 -1.7 Conserved hypothetical protein compare
Rv2813 -0.4 -1.0 Conserved hypothetical protein compare
Rv1974 -0.4 -0.6 Probable conserved membrane protein compare
Rv2237A -0.4 -0.5 Conserved protein compare
Rv1768 -0.4 -2.2 PE-PGRS family protein PE_PGRS31 compare
Rv2011c -0.4 -0.8 Conserved hypothetical protein, probable transcription repressor. compare
Rv2468A -0.4 -1.4 Conserved protein compare
Rv0444c -0.4 -1.4 Anti-sigma factor RskA (regulator of sigma K) compare
Rv3358 -0.4 -1.4 Toxin RelK compare
Rv2039c -0.4 -0.8 Probable sugar-transport integral membrane protein ABC transporter compare


Specific Phenotypes

None in this experiment

For Mycobacterium tuberculosis H37Rv in carbon source experiments

For carbon source Palmitic acid across organisms