Experiment set2S622 for Mycobacterium tuberculosis H37Rv

Compare to:

Stearic acid 100 uM carbon source

200 most important genes:

  gene name fitness t score description  
Rv0949 -2.9 -1.3 Probable ATP-dependent DNA helicase II UvrD1 compare
Rv2476c -2.9 -6.1 Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase) compare
Rv3816c -2.7 -1.5 Possible acyltransferase compare
Rv3766 -2.7 -5.1 Hypothetical protein compare
Rv1159 -2.6 -3.1 Mannosyltransferase PimE compare
Rv1273c -2.6 -6.9 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv0819 -2.3 -3.9 GCN5-related N-acetyltransferase, MshD compare
Rv1411c -2.3 -4.6 Conserved lipoprotein LprG compare
Rv2696c -2.2 -3.5 Conserved alanine and glycine and valine rich protein compare
Rv0929 -2.2 -2.8 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv0361 -2.1 -1.3 Probable conserved membrane protein compare
Rv1127c -2.1 -1.6 Probable pyruvate, phosphate dikinase PpdK compare
Rv1272c -2.1 -8.4 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv0642c -2.1 -2.3 Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase) compare
Rv0200 -2.1 -3.8 Possible conserved transmembrane protein compare
Rv0928 -2.1 -3.5 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv0674 -2.0 -1.1 Conserved hypothetical protein compare
Rv0930 -1.9 -7.2 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv3101c -1.9 -2.2 Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter) compare
Rv0655 -1.9 -4.5 Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl compare
Rv3400 -1.9 -9.0 Probable hydrolase compare
Rv0199 -1.8 -2.9 Probable conserved membrane protein compare
Rv2869c -1.8 -2.4 Membrane bound metalloprotease compare
Rv3102c -1.8 -4.3 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv0820 -1.7 -5.0 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv2047c -1.7 -8.8 Conserved hypothetical protein compare
Rv3066 -1.7 -6.6 Probable transcriptional regulatory protein (probably DeoR-family) compare
Rv2553c -1.7 -1.1 Probable conserved membrane protein compare
Rv0173 -1.7 -6.5 Possible Mce-family lipoprotein LprK (Mce-family lipoprotein Mce1E) compare
Rv2694c -1.7 -4.0 Conserved protein compare
Rv0174 -1.6 -6.9 Mce-family protein Mce1F compare
Rv1096 -1.6 -1.7 Possible glycosyl hydrolase compare
Rv3182 -1.6 -1.0 Conserved hypothetical protein compare
Rv3306c -1.6 -1.6 Probable amidohydrolase AmiB1 (aminohydrolase) compare
Rv3229c -1.6 -2.4 Possible linoleoyl-CoA desaturase (delta(6)-desaturase) compare
Rv1410c -1.6 -6.7 Aminoglycosides/tetracycline-transport integral membrane protein compare
Rv3650 -1.6 -1.0 PE family protein PE33 compare
Rv2237A -1.6 -1.4 Conserved protein compare
Rv0680c -1.6 -2.4 Probable conserved transmembrane protein compare
Rv1590 -1.6 -4.3 Conserved hypothetical protein compare
Rv3810 -1.5 -2.2 Exported repetitive protein precursor PirG (cell surface protein) (EXP53) compare
Rv1589 -1.5 -6.5 Probable biotin synthetase BioB compare
Rv1908c -1.5 -2.9 Catalase-peroxidase-peroxynitritase T KatG compare
Rv0202c -1.5 -7.2 Probable conserved transmembrane transport protein MmpL11 compare
Rv3230c -1.4 -3.2 Hypothetical oxidoreductase compare
Rv0390 -1.4 -3.9 Conserved protein compare
Rv1621c -1.4 -4.2 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD compare
Rv2879c -1.4 -1.5 Conserved hypothetical protein compare
Rv2048c -1.4 -5.4 Polyketide synthase Pks12 compare
Rv0178 -1.3 -2.9 Probable conserved Mce associated membrane protein compare
Rv3843c -1.3 -1.5 Probable conserved transmembrane protein compare
Rv0391 -1.3 -6.0 Probable O-succinylhomoserine sulfhydrylase MetZ (OSH sulfhydrylase) compare
Rv3267 -1.3 -1.3 Conserved protein (CPSA-related protein) compare
Rv0176 -1.3 -4.2 Probable conserved Mce associated transmembrane protein compare
Rv2224c -1.3 -8.9 Probable carboxylesterase CaeA compare
Rv0169 -1.3 -5.9 Mce-family protein Mce1A compare
Rv0204c -1.3 -3.6 Probable conserved transmembrane protein compare
Rv0610c -1.3 -1.2 Hypothetical protein compare
Rv1085c -1.3 -5.6 Possible hemolysin-like protein compare
Rv3311 -1.3 -3.9 Conserved protein compare
Rv0504c -1.2 -1.1 Conserved protein compare
Rv1836c -1.2 -3.0 Conserved protein compare
Rv3919c -1.2 -2.1 Probable glucose-inhibited division protein B Gid compare
Rv0170 -1.2 -2.7 Mce-family protein Mce1B compare
Rv2606c -1.2 -2.3 Possible pyridoxine biosynthesis protein SnzP compare
Rv0171 -1.2 -6.1 Mce-family protein Mce1C compare
Rv2275 -1.1 -1.6 Conserved hypothetical protein compare
Rv2982c -1.1 -5.5 Probable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA2 (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase) compare
Rv3723 -1.1 -3.7 Probable conserved transmembrane protein compare
Rv3249c -1.1 -1.2 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv0177 -1.1 -1.5 Probable conserved Mce associated protein compare
Rv3803c -1.1 -5.9 Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) (85C) compare
Rv0868c -1.1 -2.0 Probable molybdenum cofactor biosynthesis protein D 2 MoaD2 (molybdopterin converting factor small subunit) (molybdopterin [MPT] converting factor, subunit 1) compare
Rv1657 -1.1 -2.6 Probable arginine repressor ArgR (AHRC) compare
Rv1332 -1.1 -1.0 Probable transcriptional regulatory protein compare
Rv3419c -1.1 -1.6 Probable O-sialoglycoprotein endopeptidase Gcp (glycoprotease) compare
Rv1620c -1.1 -2.9 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC compare
Rv1128c -1.0 -2.4 Conserved hypothetical protein compare
Rv0452 -1.0 -2.8 Possible transcriptional regulatory protein compare
Rv0018c -1.0 -2.6 Phosphoserine/threonine phosphatase PstP compare
Rv3687c -1.0 -1.1 Anti-anti-sigma factor RsfB (anti-sigma factor antagonist) (regulator of sigma F B) compare
Rv2372c -1.0 -1.5 Conserved hypothetical protein compare
Rv1565c -1.0 -5.0 Conserved hypothetical membrane protein compare
Rv0172 -1.0 -4.9 Mce-family protein Mce1D compare
Rv1459c -1.0 -1.1 Possible conserved integral membrane protein compare
Rv0676c -1.0 -7.6 Probable conserved transmembrane transport protein MmpL5 compare
Rv2206 -1.0 -2.6 Probable conserved transmembrane protein compare
Rv3631 -1.0 -0.9 Possible transferase (possibly glycosyltransferase) compare
Rv0243 -0.9 -5.5 Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase) compare
Rv2691 -0.9 -5.0 TRK system potassium uptake protein CeoB compare
Rv3140 -0.9 -3.0 Probable acyl-CoA dehydrogenase FadE23 compare
Rv3139 -0.9 -3.5 Probable acyl-CoA dehydrogenase FadE24 compare
Rv3405c -0.9 -1.3 Possible transcriptional regulatory protein compare
Rv3162c -0.9 -1.2 Possible integral membrane protein compare
Rv0563 -0.9 -2.7 Probable protease transmembrane protein heat shock protein HtpX compare
Rv3823c -0.9 -6.2 Conserved integral membrane transport protein MmpL8 compare
Rv3498c -0.9 -4.2 Mce-family protein Mce4B compare
Rv2007c -0.8 -1.4 Ferredoxin FdxA compare
Rv1046c -0.8 -1.7 Hypothetical protein compare
Rv2799 -0.8 -4.7 Probable membrane protein compare
Rv1566c -0.8 -2.3 Possible Inv protein compare
Rv1111c -0.8 -2.1 Conserved hypothetical protein compare
Rv1013 -0.8 -5.1 Putative polyketide synthase Pks16 compare
Rv0016c -0.8 -1.8 Probable penicillin-binding protein PbpA compare
Rv3868 -0.8 -6.1 ESX conserved component EccA1. ESX-1 type VII secretion system protein. compare
Rv0017c -0.8 -2.9 Probable cell division protein RodA compare
Rv2586c -0.8 -1.0 Probable protein-export membrane protein SecF compare
Rv0168 -0.8 -1.5 Conserved integral membrane protein YrbE1B compare
Rv3867 -0.8 -4.7 ESX-1 secretion-associated protein EspH compare
Rv0954 -0.8 -3.6 Probable conserved transmembrane protein compare
Rv0444c -0.8 -2.8 Anti-sigma factor RskA (regulator of sigma K) compare
Rv2113 -0.8 -5.8 Probable integral membrane protein compare
Rv2072c -0.8 -0.9 Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL compare
Rv1336 -0.8 -3.7 Cysteine synthase B CysM (CSASE B) (O-phosphoserine sulfhydrylase B) (O-phosphoserine (thiol)-lyase B) compare
Rv0241c -0.8 -1.7 Probable 3-hydroxyacyl-thioester dehydratase HtdX compare
Rv0937c -0.8 -1.1 DNA end-binding protein, Mku compare
Rv1331 -0.8 -1.8 Conserved hypothetical protein compare
Rv3484 -0.8 -5.3 Possible conserved protein CpsA compare
Rv0924c -0.8 -3.2 Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP) compare
Rv1825 -0.8 -2.1 Conserved protein compare
Rv3513c -0.7 -0.7 Probable fatty-acid-CoA ligase FadD18 (fragment) (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv0675 -0.7 -0.6 Probable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv0190 -0.7 -2.6 Conserved protein compare
Rv0472c -0.7 -2.6 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv3575c -0.7 -4.7 Transcriptional regulatory protein (probably LacI-family) compare
Rv1821 -0.7 -2.2 Possible preprotein translocase ATPase SecA2 compare
Rv2707 -0.7 -5.4 Probable conserved transmembrane alanine and leucine rich protein compare
Rv2835c -0.7 -1.8 Probable Sn-glycerol-3-phosphate transport integral membrane protein ABC transporter UgpA compare
Rv2292c -0.7 -0.8 Hypothetical protein compare
Rv3910 -0.7 -0.9 Probable conserved transmembrane protein compare
Rv0050 -0.7 -2.0 Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase) compare
Rv2789c -0.7 -3.0 Probable acyl-CoA dehydrogenase FadE21 compare
Rv0892 -0.7 -1.5 Probable monooxygenase compare
Rv3496c -0.7 -4.7 Mce-family protein Mce4D compare
Rv1444c -0.7 -1.3 Unknown protein compare
Rv1400c -0.7 -0.6 Probable lipase LipH compare
Rv2635 -0.7 -0.7 Hypothetical protein compare
Rv0989c -0.7 -4.2 Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) compare
Rv2444c -0.7 -1.5 Possible ribonuclease E Rne compare
Rv3013 -0.7 -0.6 Conserved protein compare
Rv1009 -0.7 -2.8 Probable resuscitation-promoting factor RpfB compare
Rv1568 -0.7 -3.6 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA compare
Rv3237c -0.6 -2.6 Conserved protein compare
Rv0383c -0.6 -0.5 Possible conserved secreted protein compare
Rv0348 -0.6 -1.5 Possible transcriptional regulatory protein compare
Rv1333 -0.6 -2.3 Probable hydrolase compare
Rv3747 -0.6 -1.5 Conserved protein compare
Rv0248c -0.6 -2.6 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) compare
Rv3643 -0.6 -1.5 Hypothetical protein compare
Rv1898 -0.6 -1.4 Conserved hypothetical protein compare
Rv3200c -0.6 -1.8 Possible transmembrane cation transporter compare
Rv1640c -0.6 -4.2 Lysyl-tRNA synthetase 2 LysX compare
Rv0757 -0.6 -0.8 Possible two component system response transcriptional positive regulator PhoP compare
Rv3050c -0.6 -1.7 Probable transcriptional regulatory protein (probably AsnC-family) compare
Rv1270c -0.6 -2.3 Possible lipoprotein LprA compare
Rv1055 -0.6 -0.7 Possible integrase (fragment) compare
Rv3394c -0.6 -1.2 Conserved hypothetical protein compare
Rv3135 -0.6 -1.9 PPE family protein PPE50 compare
Rv1006 -0.6 -3.2 Unknown protein compare
Rv3503c -0.6 -2.3 Probable ferredoxin FdxD compare
Rv2302 -0.6 -0.8 Conserved protein compare
Rv1665 -0.6 -2.3 Chalcone synthase Pks11 compare
Rv1710 -0.6 -0.7 Possible segregation and condensation protein ScpB compare
Rv1745c -0.6 -1.6 Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase) compare
Rv0249c -0.6 -2.9 Probable succinate dehydrogenase [membrane anchor subunit] (succinic dehydrogenase) compare
Rv3305c -0.6 -1.3 Possible N-acyl-L-amino acid amidohydrolase AmiA1 (N-acyl-L-amino acid aminohydrolase) compare
Rv0242c -0.6 -1.7 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase) compare
Rv3500c -0.6 -3.3 Conserved integral membrane protein YrbE4B. Possible ABC transporter. compare
Rv2203 -0.6 -2.6 Possible conserved membrane protein compare
Rv0978c -0.6 -1.7 PE-PGRS family protein PE_PGRS17 compare
Rv0209 -0.6 -2.5 Hypothetical protein compare
Rv0313 -0.6 -1.1 Conserved protein compare
Rv3494c -0.6 -3.1 Mce-family protein Mce4F compare
Rv3286c -0.6 -1.6 Alternative RNA polymerase sigma factor SigF compare
Rv2087 -0.6 -1.4 Conserved hypothetical protein compare
Rv1344 -0.6 -2.0 Acyl carrier protein (ACP) MbtL compare
Rv1337 -0.6 -3.6 Probable integral membrane protein compare
Rv2049c -0.6 -0.9 Conserved hypothetical protein compare
Rv3114 -0.6 -0.8 Conserved hypothetical protein compare
Rv2862A -0.6 -1.5 Possible antitoxin VapB23 compare
Rv1851 -0.5 -0.8 Urease accessory protein UreF compare
Rv3321c -0.5 -1.4 Possible antitoxin VapB44 compare
Rv0494 -0.5 -2.0 Probable transcriptional regulatory protein (probably GntR-family) compare
Rv1955 -0.5 -0.9 Possible toxin HigB compare
Rv3499c -0.5 -3.1 Mce-family protein Mce4A compare
Rv1052 -0.5 -1.7 Hypothetical protein compare
Rv1324 -0.5 -0.8 Possible thioredoxin compare
Rv2851c -0.5 -2.6 GCN5-related N-acetyltransferase compare
Rv0069c -0.5 -0.9 Probable L-serine dehydratase SdaA (L-serine deaminase) (SDH) (L-SD) compare
Rv3426 -0.5 -0.7 PPE family protein PPE58 compare
Rv3492c -0.5 -1.2 Conserved hypothetical Mce associated protein compare
Rv0643c -0.5 -2.9 Methoxy mycolic acid synthase 3 MmaA3 (methyl mycolic acid synthase 3) (MMA3) (hydroxy mycolic acid synthase) compare
Rv0037c -0.5 -4.0 Probable conserved integral membrane protein compare
Rv0456c -0.5 -1.9 enoyl-CoA hydratase EchA2 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv0280 -0.5 -4.0 PPE family protein PPE3 compare
Rv3278c -0.5 -1.8 Probable conserved transmembrane protein compare
Rv0113 -0.5 -0.8 Probable sedoheptulose-7-phosphate isomerase GmhA (phosphoheptose isomerase) compare
Rv0503c -0.5 -4.2 Cyclopropane-fatty-acyl-phospholipid synthase 2 CmaA2 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic acid synthase 2) (mycolic acid trans-cyclopropane synthetase) compare
Rv3497c -0.5 -2.9 Mce-family protein Mce4C compare
Rv3818 -0.5 -3.0 Unknown protein compare


Specific Phenotypes

For 4 genes in this experiment

For carbon source Stearic acid in Mycobacterium tuberculosis H37Rv

For carbon source Stearic acid across organisms