Experiment set2S620 for Mycobacterium tuberculosis H37Rv

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heptadecanoic acid 250 uM carbon source

200 most important genes:

  gene name fitness t score description  
Rv3306c -2.8 -2.7 Probable amidohydrolase AmiB1 (aminohydrolase) compare
Rv0655 -2.5 -7.7 Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl compare
Rv3766 -2.4 -5.9 Hypothetical protein compare
Rv1129c -2.4 -7.8 Probable transcriptional regulator protein compare
Rv0200 -2.4 -3.4 Possible conserved transmembrane protein compare
Rv1130 -2.2 -5.6 Possible methylcitrate dehydratase PrpD compare
Rv2476c -2.0 -4.6 Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase) compare
Rv1112 -2.0 -1.8 Probable GTP binding protein compare
Rv2606c -1.9 -6.0 Possible pyridoxine biosynthesis protein SnzP compare
Rv1131 -1.9 -2.2 Probable methylcitrate synthase PrpC compare
Rv1798 -1.8 -1.4 ESX conserved component EccA5. ESX-5 type VII secretion system protein. compare
Rv3816c -1.7 -1.3 Possible acyltransferase compare
Rv2850c -1.7 -1.1 Possible magnesium chelatase compare
Rv0199 -1.7 -3.8 Probable conserved membrane protein compare
Rv3311 -1.6 -4.3 Conserved protein compare
Rv0172 -1.6 -6.9 Mce-family protein Mce1D compare
Rv0173 -1.6 -5.5 Possible Mce-family lipoprotein LprK (Mce-family lipoprotein Mce1E) compare
Rv0176 -1.6 -6.8 Probable conserved Mce associated transmembrane protein compare
Rv0171 -1.5 -6.9 Mce-family protein Mce1C compare
Rv2224c -1.5 -10.7 Probable carboxylesterase CaeA compare
Rv1538c -1.5 -6.7 Probable L-aparaginase AnsA compare
Rv0174 -1.5 -7.5 Mce-family protein Mce1F compare
Rv0019c -1.5 -7.0 Conserved protein with FHA domain, FhaB compare
Rv3249c -1.5 -1.8 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv0177 -1.5 -2.3 Probable conserved Mce associated protein compare
Rv3033 -1.5 -1.0 Unknown protein compare
Rv3182 -1.5 -1.0 Conserved hypothetical protein compare
Rv3400 -1.4 -6.6 Probable hydrolase compare
Rv0734 -1.4 -3.4 Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) compare
Rv3723 -1.4 -3.3 Probable conserved transmembrane protein compare
Rv2635 -1.3 -1.2 Hypothetical protein compare
Rv2694c -1.3 -4.1 Conserved protein compare
Rv0676c -1.3 -9.8 Probable conserved transmembrane transport protein MmpL5 compare
Rv3277 -1.3 -0.9 Probable conserved transmembrane protein compare
Rv3484 -1.3 -7.7 Possible conserved protein CpsA compare
Rv2624c -1.3 -1.0 Universal stress protein family protein compare
Rv0563 -1.3 -2.5 Probable protease transmembrane protein heat shock protein HtpX compare
Rv1400c -1.2 -0.9 Probable lipase LipH compare
Rv3803c -1.2 -6.0 Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) (85C) compare
Rv0820 -1.2 -3.6 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv2372c -1.2 -1.0 Conserved hypothetical protein compare
Rv0677c -1.2 -1.3 Possible conserved membrane protein MmpS5 compare
Rv2709 -1.2 -4.5 Probable conserved transmembrane protein compare
Rv0169 -1.2 -4.9 Mce-family protein Mce1A compare
Rv0178 -1.2 -3.5 Probable conserved Mce associated membrane protein compare
Rv1244 -1.2 -4.6 Probable lipoprotein LpqZ compare
Rv3200c -1.2 -2.6 Possible transmembrane cation transporter compare
Rv0017c -1.2 -4.4 Probable cell division protein RodA compare
Rv1010 -1.1 -1.1 Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase) compare
Rv3046c -1.1 -1.0 Conserved protein compare
Rv0929 -1.1 -2.3 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv2048c -1.1 -4.3 Polyketide synthase Pks12 compare
Rv1908c -1.1 -2.3 Catalase-peroxidase-peroxynitritase T KatG compare
Rv3768 -1.1 -1.8 Unknown protein compare
Rv0390 -1.1 -3.3 Conserved protein compare
Rv0367c -1.1 -1.0 Hypothetical protein compare
Rv2949c -1.1 -1.9 Chorismate pyruvate lyase compare
Rv3102c -1.1 -2.5 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv0135c -1.1 -5.3 Possible transcriptional regulatory protein compare
Rv0819 -1.1 -2.7 GCN5-related N-acetyltransferase, MshD compare
Rv1192 -1.1 -2.0 Unknown protein compare
Rv0170 -1.1 -2.4 Mce-family protein Mce1B compare
Rv0204c -1.1 -3.1 Probable conserved transmembrane protein compare
Rv0930 -1.1 -4.2 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv3050c -1.1 -2.6 Probable transcriptional regulatory protein (probably AsnC-family) compare
Rv1107c -1.0 -1.4 Probable exodeoxyribonuclease VII (small subunit) XseB (exonuclease VII small subunit) compare
Rv2302 -1.0 -1.7 Conserved protein compare
Rv2047c -1.0 -4.7 Conserved hypothetical protein compare
Rv2297 -1.0 -2.2 Unknown protein compare
Rv0049 -1.0 -2.8 Conserved hypothetical protein compare
Rv3663c -1.0 -1.5 Probable dipeptide-transport ATP-binding protein ABC transporter DppD compare
Rv2691 -1.0 -6.2 TRK system potassium uptake protein CeoB compare
Rv0383c -1.0 -0.8 Possible conserved secreted protein compare
Rv3057c -1.0 -5.8 Probable short chain alcohol dehydrogenase/reductase compare
Rv2037c -1.0 -3.1 Conserved transmembrane protein compare
Rv2206 -0.9 -3.8 Probable conserved transmembrane protein compare
Rv0391 -0.9 -4.9 Probable O-succinylhomoserine sulfhydrylase MetZ (OSH sulfhydrylase) compare
Rv3140 -0.9 -2.7 Probable acyl-CoA dehydrogenase FadE23 compare
Rv3569c -0.9 -1.3 4,9-DHSA hydrolase compare
Rv1336 -0.9 -4.2 Cysteine synthase B CysM (CSASE B) (O-phosphoserine sulfhydrylase B) (O-phosphoserine (thiol)-lyase B) compare
Rv1272c -0.9 -4.8 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv1019 -0.9 -4.5 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv1121 -0.9 -1.5 Probable glucose-6-phosphate 1-dehydrogenase Zwf1 (G6PD) compare
Rv0773c -0.9 -1.7 Probable bifunctional acylase GgtA: cephalosporin acylase (GL-7ACA acylase) + gamma-glutamyltranspeptidase (GGT) compare
Rv0991c -0.9 -0.8 Conserved serine rich protein compare
Rv1640c -0.8 -4.9 Lysyl-tRNA synthetase 2 LysX compare
Rv0270 -0.8 -3.4 Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv1657 -0.8 -2.3 Probable arginine repressor ArgR (AHRC) compare
Rv3358 -0.8 -1.6 Toxin RelK compare
Rv0168 -0.8 -2.8 Conserved integral membrane protein YrbE1B compare
Rv0472c -0.8 -2.7 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv0928 -0.8 -1.6 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv3823c -0.8 -5.2 Conserved integral membrane transport protein MmpL8 compare
Rv2731 -0.8 -2.9 Conserved alanine and arginine rich protein compare
Rv3563 -0.8 -1.4 Probable acyl-CoA dehydrogenase FadE32 compare
Rv0653c -0.8 -3.6 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv0161 -0.8 -2.2 Possible oxidoreductase compare
Rv0503c -0.8 -6.3 Cyclopropane-fatty-acyl-phospholipid synthase 2 CmaA2 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic acid synthase 2) (mycolic acid trans-cyclopropane synthetase) compare
Rv1096 -0.8 -1.0 Possible glycosyl hydrolase compare
Rv2630 -0.8 -1.1 Hypothetical protein compare
Rv2237A -0.8 -0.5 Conserved protein compare
Rv2942 -0.8 -6.3 Conserved transmembrane transport protein MmpL7 compare
Rv0361 -0.8 -0.9 Probable conserved membrane protein compare
Rv1860 -0.8 -3.2 Alanine and proline rich secreted protein Apa (fibronectin attachment protein) (immunogenic protein MPT32) (antigen MPT-32) (45-kDa glycoprotein) (45/47 kDa antigen) compare
Rv1410c -0.8 -2.6 Aminoglycosides/tetracycline-transport integral membrane protein compare
Rv2335 -0.8 -1.2 Probable serine acetyltransferase CysE (sat) compare
Rv1273c -0.7 -2.9 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv0321 -0.7 -2.4 Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase) compare
Rv3664c -0.7 -2.2 Probable dipeptide-transport integral membrane protein ABC transporter DppC compare
Rv3428c -0.7 -0.7 Possible transposase compare
Rv2936 -0.7 -5.8 Daunorubicin-dim-transport ATP-binding protein ABC transporter DrrA compare
Rv3650 -0.7 -0.6 PE family protein PE33 compare
Rv0050 -0.7 -1.5 Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase) compare
Rv1303 -0.7 -0.7 Conserved hypothetical transmembrane protein compare
Rv3497c -0.7 -4.4 Mce-family protein Mce4C compare
Rv0610c -0.7 -0.8 Hypothetical protein compare
Rv0886 -0.7 -3.9 Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) compare
Rv2945c -0.7 -4.4 Probable conserved lipoprotein LppX compare
Rv3691 -0.7 -0.7 Conserved protein compare
Rv2271 -0.7 -2.3 Conserved hypothetical protein compare
Rv1170 -0.7 -1.9 N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) compare
Rv0885 -0.7 -2.4 Conserved hypothetical protein compare
Rv0399c -0.7 -1.6 Possible conserved lipoprotein LpqK compare
Rv2379c -0.7 -2.6 Peptide synthetase MbtF (peptide synthase) compare
Rv2197c -0.7 -3.0 Probable conserved transmembrane protein compare
Rv2618 -0.7 -2.1 Conserved hypothetical protein compare
Rv2468A -0.7 -3.2 Conserved protein compare
Rv2116 -0.7 -2.8 Conserved lipoprotein LppK compare
Rv2043c -0.7 -1.9 Pyrazinamidase/nicotinamidase PncA (PZase) compare
Rv2170 -0.7 -0.9 GCN5-related N-acetyltransferase compare
Rv0964c -0.7 -1.5 Hypothetical protein compare
Rv1159 -0.7 -1.5 Mannosyltransferase PimE compare
Rv2462c -0.7 -2.9 Probable trigger factor (TF) protein Tig compare
Rv0464c -0.7 -2.3 Conserved protein compare
Rv2384 -0.6 -1.2 Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase compare
Rv1193 -0.6 -2.9 Probable fatty-acid-CoA ligase FadD36 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv2365c -0.6 -0.5 Conserved hypothetical protein compare
Rv0243 -0.6 -3.7 Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase) compare
Rv1111c -0.6 -1.5 Conserved hypothetical protein compare
Rv0520 -0.6 -2.2 Possible methyltransferase/methylase (fragment) compare
Rv1046c -0.6 -1.1 Hypothetical protein compare
Rv3318 -0.6 -3.2 Probable succinate dehydrogenase (flavoprotein subunit) SdhA (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase) compare
Rv0202c -0.6 -4.0 Probable conserved transmembrane transport protein MmpL11 compare
Rv3131 -0.6 -1.1 Conserved protein compare
Rv3818 -0.6 -2.9 Unknown protein compare
Rv1957 -0.6 -1.1 Hypothetical protein compare
Rv3273 -0.6 -4.1 Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) compare
Rv2938 -0.6 -4.8 Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC compare
Rv2222c -0.6 -1.6 Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) compare
Rv0516c -0.6 -3.5 Possible anti-anti-sigma factor compare
Rv2721c -0.6 -3.9 Possible conserved transmembrane alanine and glycine rich protein compare
Rv3405c -0.6 -1.0 Possible transcriptional regulatory protein compare
Rv0680c -0.6 -1.2 Probable conserved transmembrane protein compare
Rv1009 -0.6 -1.7 Probable resuscitation-promoting factor RpfB compare
Rv0378 -0.6 -1.3 Conserved hypothetical glycine rich protein compare
Rv1222 -0.6 -1.9 Anti-sigma factor RseA compare
Rv3267 -0.6 -1.5 Conserved protein (CPSA-related protein) compare
Rv2581c -0.6 -0.5 Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II) compare
Rv1160 -0.6 -0.7 Probable mutator protein MutT2 (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase) compare
Rv3340 -0.6 -2.0 Probable O-acetylhomoserine sulfhydrylase MetC (homocysteine synthase) (O-acetylhomoserine (thiol)-lyase) (OAH sulfhydrylase) (O-acetyl-L-homoserine sulfhydrylase) compare
Rv1013 -0.6 -2.9 Putative polyketide synthase Pks16 compare
Rv3167c -0.6 -1.8 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv1745c -0.6 -1.7 Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase) compare
Rv2253 -0.6 -1.7 Possible secreted unknown protein compare
Rv0632c -0.6 -0.8 Probable enoyl-CoA hydratase EchA3 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv2277c -0.6 -1.0 Possible glycerolphosphodiesterase compare
Rv0752c -0.6 -2.1 Probable acyl-CoA dehydrogenase FadE9 compare
Rv0145 -0.6 -2.0 Possible S-adenosylmethionine-dependent methyltransferase compare
Rv0328 -0.6 -1.0 Possible transcriptional regulatory protein (possibly TetR/AcrR-family) compare
Rv1411c -0.6 -1.9 Conserved lipoprotein LprG compare
Rv0460 -0.6 -0.8 Conserved hydrophobic protein compare
Rv2322c -0.6 -0.7 Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) compare
Rv2975c -0.5 -0.4 Conserved hypothetical protein compare
Rv0247c -0.5 -0.4 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) compare
Rv0634A -0.5 -3.1 Unknown protein compare
Rv0020c -0.5 -2.2 Conserved protein with FHA domain, FhaA compare
Rv3066 -0.5 -2.8 Probable transcriptional regulatory protein (probably DeoR-family) compare
Rv0436c -0.5 -1.0 Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase) compare
Rv2873 -0.5 -1.8 Cell surface lipoprotein Mpt83 (lipoprotein P23) compare
Rv1879 -0.5 -2.6 Conserved hypothetical protein compare
Rv0821c -0.5 -1.3 Probable phosphate-transport system transcriptional regulatory protein PhoY2 compare
Rv1561 -0.5 -1.2 Possible toxin VapC11 compare
Rv3706c -0.5 -1.6 Conserved hypothetical proline rich protein compare
Rv1334 -0.5 -2.6 Possible hydrolase compare
Rv0539 -0.5 -1.0 Probable dolichyl-phosphate sugar synthase (dolichol-phosphate sugar synthetase) (dolichol-phosphate sugar transferase) (sugar phosphoryldolichol synthase) compare
Rv3642c -0.5 -0.7 Hypothetical protein compare
Rv2113 -0.5 -4.0 Probable integral membrane protein compare
Rv2793c -0.5 -0.9 Probable tRNA pseudouridine synthase B TruB (tRNA pseudouridine 55 synthase) (PSI55 synthase) (pseudouridylate synthase) (uracil hydrolyase) compare
Rv3912 -0.5 -1.6 Hypothetical alanine rich protein compare
Rv0379 -0.5 -0.5 Possible protein transport protein SecE2 compare
Rv0090 -0.5 -1.8 Possible membrane protein compare
Rv0327c -0.5 -2.4 Possible cytochrome P450 135A1 Cyp135A1 compare
Rv3394c -0.5 -1.4 Conserved hypothetical protein compare
Rv0082 -0.5 -2.2 Probable oxidoreductase compare
Rv0037c -0.5 -3.5 Probable conserved integral membrane protein compare
Rv2937 -0.5 -3.9 Daunorubicin-dim-transport integral membrane protein ABC transporter DrrB compare
Rv2055c -0.5 -0.8 30S ribosomal protein S18 RpsR2 compare
Rv0452 -0.5 -1.4 Possible transcriptional regulatory protein compare
Rv2732c -0.5 -1.5 Probable conserved transmembrane protein compare
Rv2416c -0.5 -1.4 Enhanced intracellular survival protein Eis,GCN5-related N-acetyltransferase compare


Specific Phenotypes

For 8 genes in this experiment

For carbon source heptadecanoic acid in Mycobacterium tuberculosis H37Rv

For carbon source heptadecanoic acid across organisms