Experiment set2S619 for Mycobacterium tuberculosis H37Rv

Compare to:

heptadecanoic acid 250 uM carbon source

200 most important genes:

  gene name fitness t score description  
Rv1130 -2.4 -9.2 Possible methylcitrate dehydratase PrpD compare
Rv3182 -2.3 -1.3 Conserved hypothetical protein compare
Rv1129c -2.3 -9.8 Probable transcriptional regulator protein compare
Rv0655 -1.9 -4.9 Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl compare
Rv2476c -1.8 -5.6 Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase) compare
Rv1131 -1.8 -3.1 Probable methylcitrate synthase PrpC compare
Rv0955 -1.8 -1.3 Probable conserved integral membrane protein compare
Rv0178 -1.8 -3.9 Probable conserved Mce associated membrane protein compare
Rv0200 -1.8 -2.4 Possible conserved transmembrane protein compare
Rv3200c -1.8 -4.7 Possible transmembrane cation transporter compare
Rv3766 -1.8 -4.1 Hypothetical protein compare
Rv0642c -1.8 -2.1 Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase) compare
Rv3400 -1.7 -7.8 Probable hydrolase compare
Rv3046c -1.7 -1.3 Conserved protein compare
Rv0176 -1.6 -7.9 Probable conserved Mce associated transmembrane protein compare
Rv1836c -1.6 -3.3 Conserved protein compare
Rv2335 -1.6 -2.6 Probable serine acetyltransferase CysE (sat) compare
Rv1538c -1.6 -5.8 Probable L-aparaginase AnsA compare
Rv2694c -1.6 -3.2 Conserved protein compare
Rv2606c -1.6 -5.6 Possible pyridoxine biosynthesis protein SnzP compare
Rv0930 -1.5 -6.4 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv0734 -1.5 -2.3 Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) compare
Rv0174 -1.5 -7.5 Mce-family protein Mce1F compare
Rv0170 -1.5 -2.9 Mce-family protein Mce1B compare
Rv1291c -1.5 -1.9 Conserved hypothetical secreted protein compare
Rv2702 -1.4 -0.9 Polyphosphate glucokinase PpgK (polyphosphate-glucose phosphotransferase) compare
Rv3484 -1.4 -6.4 Possible conserved protein CpsA compare
Rv2224c -1.4 -10.0 Probable carboxylesterase CaeA compare
Rv3311 -1.4 -5.2 Conserved protein compare
Rv1010 -1.4 -1.0 Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase) compare
Rv0367c -1.4 -1.2 Hypothetical protein compare
Rv0171 -1.3 -7.0 Mce-family protein Mce1C compare
Rv0172 -1.3 -5.8 Mce-family protein Mce1D compare
Rv0173 -1.3 -5.0 Possible Mce-family lipoprotein LprK (Mce-family lipoprotein Mce1E) compare
Rv3085 -1.3 -1.3 Probable short-chain type dehydrogenase/reductase compare
Rv3803c -1.3 -5.5 Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) (85C) compare
Rv0019c -1.3 -5.1 Conserved protein with FHA domain, FhaB compare
Rv0169 -1.3 -6.3 Mce-family protein Mce1A compare
Rv0676c -1.2 -9.2 Probable conserved transmembrane transport protein MmpL5 compare
Rv0007 -1.2 -0.9 Possible conserved membrane protein compare
Rv1072 -1.2 -1.1 Probable conserved transmembrane protein compare
Rv0928 -1.2 -3.0 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv0929 -1.2 -2.6 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv2206 -1.2 -3.4 Probable conserved transmembrane protein compare
Rv0819 -1.1 -2.5 GCN5-related N-acetyltransferase, MshD compare
Rv0677c -1.1 -2.1 Possible conserved membrane protein MmpS5 compare
Rv3249c -1.1 -1.7 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv2140c -1.1 -1.6 Conserved protein TB18.6 compare
Rv2691 -1.1 -4.7 TRK system potassium uptake protein CeoB compare
Rv1657 -1.1 -3.0 Probable arginine repressor ArgR (AHRC) compare
Rv0270 -1.1 -5.4 Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv2372c -1.1 -1.8 Conserved hypothetical protein compare
Rv1336 -1.0 -5.4 Cysteine synthase B CysM (CSASE B) (O-phosphoserine sulfhydrylase B) (O-phosphoserine (thiol)-lyase B) compare
Rv2046 -1.0 -2.8 Probable lipoprotein LppI compare
Rv1974 -1.0 -1.8 Probable conserved membrane protein compare
Rv3366 -1.0 -2.3 Probable tRNA/rRNA methylase SpoU (tRNA/rRNA methyltransferase) compare
Rv3102c -1.0 -2.1 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv0016c -1.0 -4.7 Probable penicillin-binding protein PbpA compare
Rv2154c -1.0 -1.7 FtsW-like protein FtsW compare
Rv1121 -1.0 -2.1 Probable glucose-6-phosphate 1-dehydrogenase Zwf1 (G6PD) compare
Rv2317 -1.0 -1.3 Probable sugar-transport integral membrane protein ABC transporter UspB compare
Rv3057c -1.0 -6.2 Probable short chain alcohol dehydrogenase/reductase compare
Rv2055c -0.9 -1.5 30S ribosomal protein S18 RpsR2 compare
Rv0391 -0.9 -5.5 Probable O-succinylhomoserine sulfhydrylase MetZ (OSH sulfhydrylase) compare
Rv1890c -0.9 -1.1 Hypothetical protein compare
Rv3816c -0.9 -0.9 Possible acyltransferase compare
Rv0870c -0.9 -1.8 Possible conserved integral membrane protein compare
Rv2709 -0.9 -3.6 Probable conserved transmembrane protein compare
Rv0885 -0.9 -3.1 Conserved hypothetical protein compare
Rv0168 -0.9 -2.4 Conserved integral membrane protein YrbE1B compare
Rv3723 -0.9 -3.2 Probable conserved transmembrane protein compare
Rv1116A -0.9 -1.2 Conserved hypothetical protein (fragment) compare
Rv0390 -0.9 -3.0 Conserved protein compare
Rv3358 -0.9 -1.5 Toxin RelK compare
Rv1821 -0.9 -2.9 Possible preprotein translocase ATPase SecA2 compare
Rv0199 -0.9 -1.7 Probable conserved membrane protein compare
Rv1049 -0.9 -1.1 Probable transcriptional repressor protein compare
Rv1331 -0.9 -2.6 Conserved hypothetical protein compare
Rv1513 -0.9 -1.4 Conserved protein compare
Rv1244 -0.8 -3.8 Probable lipoprotein LpqZ compare
Rv1193 -0.8 -3.4 Probable fatty-acid-CoA ligase FadD36 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv0135c -0.8 -2.7 Possible transcriptional regulatory protein compare
Rv3139 -0.8 -4.1 Probable acyl-CoA dehydrogenase FadE24 compare
Rv0563 -0.8 -1.8 Probable protease transmembrane protein heat shock protein HtpX compare
Rv0242c -0.8 -1.9 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase) compare
Rv0769 -0.8 -2.1 Probable dehydrogenase/reductase compare
Rv0452 -0.8 -2.5 Possible transcriptional regulatory protein compare
Rv2047c -0.8 -4.7 Conserved hypothetical protein compare
Rv1019 -0.8 -5.3 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv1286 -0.8 -2.4 Probable bifunctional enzyme CysN/CysC: sulfate adenyltransferase (subunit 1) + adenylylsulfate kinase compare
Rv3823c -0.8 -5.0 Conserved integral membrane transport protein MmpL8 compare
Rv2468A -0.8 -3.1 Conserved protein compare
Rv0617 -0.8 -1.6 Possible toxin VapC29. Contains PIN domain. compare
Rv0049 -0.8 -1.7 Conserved hypothetical protein compare
Rv0820 -0.8 -2.2 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv3162c -0.7 -1.4 Possible integral membrane protein compare
Rv0017c -0.7 -3.2 Probable cell division protein RodA compare
Rv1798 -0.7 -0.9 ESX conserved component EccA5. ESX-5 type VII secretion system protein. compare
Rv3813c -0.7 -2.6 Conserved protein compare
Rv2942 -0.7 -5.1 Conserved transmembrane transport protein MmpL7 compare
Rv3131 -0.7 -1.3 Conserved protein compare
Rv0472c -0.7 -2.6 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv1272c -0.7 -3.4 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv0865 -0.7 -2.7 Probable molybdopterin biosynthesis Mog protein compare
Rv0916c -0.7 -1.3 PE family protein PE7 compare
Rv0949 -0.7 -0.6 Probable ATP-dependent DNA helicase II UvrD1 compare
Rv1640c -0.7 -3.7 Lysyl-tRNA synthetase 2 LysX compare
Rv2732c -0.7 -2.1 Probable conserved transmembrane protein compare
Rv0085 -0.7 -1.2 Possible hydrogenase HycP compare
Rv1284 -0.7 -0.6 Beta-carbonic anhydrase compare
Rv0243 -0.7 -3.8 Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase) compare
Rv2985 -0.7 -1.2 Possible hydrolase MutT1 compare
Rv0460 -0.7 -1.6 Conserved hydrophobic protein compare
Rv0609 -0.7 -0.6 Possible toxin VapC28. Contains PIN domain. compare
Rv2376c -0.7 -1.0 Low molecular weight antigen CFP2 (low molecular weight protein antigen 2) (CFP-2) compare
Rv3768 -0.7 -1.6 Unknown protein compare
Rv1096 -0.7 -0.5 Possible glycosyl hydrolase compare
Rv0773c -0.7 -2.3 Probable bifunctional acylase GgtA: cephalosporin acylase (GL-7ACA acylase) + gamma-glutamyltranspeptidase (GGT) compare
Rv0516c -0.7 -4.1 Possible anti-anti-sigma factor compare
Rv3273 -0.7 -5.2 Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) compare
Rv1955 -0.7 -1.6 Possible toxin HigB compare
Rv2230c -0.7 -1.0 Conserved protein compare
Rv2624c -0.7 -1.0 Universal stress protein family protein compare
Rv0986 -0.7 -1.9 Probable adhesion component transport ATP-binding protein ABC transporter compare
Rv2731 -0.7 -3.6 Conserved alanine and arginine rich protein compare
Rv0274 -0.7 -1.8 Conserved protein compare
Rv1128c -0.7 -1.4 Conserved hypothetical protein compare
Rv2937 -0.7 -4.9 Daunorubicin-dim-transport integral membrane protein ABC transporter DrrB compare
Rv1148c -0.7 -1.2 Conserved hypothetical protein compare
Rv0886 -0.7 -4.3 Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) compare
Rv2037c -0.7 -2.6 Conserved transmembrane protein compare
Rv2026c -0.7 -0.9 Universal stress protein family protein compare
Rv2938 -0.7 -5.0 Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC compare
Rv2936 -0.7 -4.9 Daunorubicin-dim-transport ATP-binding protein ABC transporter DrrA compare
Rv2855 -0.7 -1.8 NADPH-dependent mycothiol reductase Mtr compare
Rv3267 -0.7 -1.8 Conserved protein (CPSA-related protein) compare
Rv0280 -0.7 -4.7 PPE family protein PPE3 compare
Rv1334 -0.6 -3.6 Possible hydrolase compare
Rv0370c -0.6 -0.8 Possible oxidoreductase compare
Rv0653c -0.6 -2.9 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv1680 -0.6 -2.2 Hypothetical protein compare
Rv2544 -0.6 -1.9 Probable conserved lipoprotein LppB compare
Rv1051c -0.6 -1.7 Conserved hypothetical protein compare
Rv3922c -0.6 -1.9 Possible hemolysin compare
Rv0057 -0.6 -3.2 Hypothetical protein compare
Rv0093c -0.6 -0.8 Probable conserved membrane protein compare
Rv3614c -0.6 -1.9 ESX-1 secretion-associated protein EspD compare
Rv3193c -0.6 -1.1 Probable conserved transmembrane protein compare
Rv3445c -0.6 -1.5 ESAT-6 like protein EsxU compare
Rv2096c -0.6 -2.8 Proteasome accessory factor B PafB compare
Rv2899c -0.6 -1.0 Possible FdhD protein homolog compare
Rv2812 -0.6 -1.3 Probable transposase compare
Rv0503c -0.6 -4.7 Cyclopropane-fatty-acyl-phospholipid synthase 2 CmaA2 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic acid synthase 2) (mycolic acid trans-cyclopropane synthetase) compare
Rv1766 -0.6 -0.9 Conserved protein compare
Rv3492c -0.6 -1.5 Conserved hypothetical Mce associated protein compare
Rv3414c -0.6 -1.3 Probable alternative RNA polymerase sigma-D factor SigD compare
Rv2197c -0.6 -2.1 Probable conserved transmembrane protein compare
Rv1337 -0.6 -3.3 Probable integral membrane protein compare
Rv2048c -0.6 -2.4 Polyketide synthase Pks12 compare
Rv2466c -0.6 -1.5 Conserved protein compare
Rv1411c -0.6 -1.9 Conserved lipoprotein LprG compare
Rv0504c -0.6 -0.9 Conserved protein compare
Rv1531 -0.6 -1.3 Conserved protein compare
Rv0924c -0.6 -3.2 Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP) compare
Rv0202c -0.6 -3.2 Probable conserved transmembrane transport protein MmpL11 compare
Rv2871 -0.6 -1.6 Possible antitoxin VapB43 compare
Rv0868c -0.6 -1.1 Probable molybdenum cofactor biosynthesis protein D 2 MoaD2 (molybdopterin converting factor small subunit) (molybdopterin [MPT] converting factor, subunit 1) compare
Rv0634A -0.6 -3.5 Unknown protein compare
Rv3344c -0.6 -3.4 PE-PGRS family protein PE_PGRS49 compare
Rv1908c -0.6 -1.1 Catalase-peroxidase-peroxynitritase T KatG compare
Rv1273c -0.6 -2.8 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv3230c -0.6 -1.9 Hypothetical oxidoreductase compare
Rv2858c -0.6 -1.5 Probable aldehyde dehydrogenase AldC compare
Rv2427A -0.6 -1.2 'Transcriptional regulator OxyR', pseudogene' pseudogene=unknown transl_table=11 compare
Rv0745 -0.6 -1.6 Conserved hypothetical protein compare
Rv1516c -0.6 -1.2 Probable sugar transferase compare
Rv3842c -0.6 -3.2 Probable glycerophosphoryl diester phosphodiesterase GlpQ1 (glycerophosphodiester phosphodiesterase) compare
Rv3022A -0.6 -2.4 PE family protein PE29 compare
Rv1889c -0.6 -1.0 Conserved hypothetical protein compare
Rv1646 -0.6 -3.2 PE family protein PE17 compare
Rv0374c -0.6 -1.0 Probable carbon monoxyde dehydrogenase (small chain) compare
Rv1768 -0.6 -2.3 PE-PGRS family protein PE_PGRS31 compare
Rv1386 -0.6 -1.9 PE family protein PE15 compare
Rv1792 -0.6 -0.9 ESAT-6 like protein EsxM compare
Rv1514c -0.6 -1.8 Conserved hypothetical protein compare
Rv3020c -0.6 -2.3 ESAT-6 like protein EsxS compare
Rv0566c -0.6 -1.8 Conserved protein compare
Rv0346c -0.6 -3.8 Possible L-asparagine permease AnsP2 (L-asparagine transport protein) compare
Rv3486 -0.6 -1.0 Conserved protein compare
Rv3647c -0.6 -0.6 Conserved hypothetical protein compare
Rv2214c -0.5 -3.4 Possible short-chain dehydrogenase EphD compare
Rv0324 -0.5 -1.5 Possible transcriptional regulatory protein (possibly ArsR-family) compare
Rv3833 -0.5 -1.7 Transcriptional regulatory protein (probably AraC-family) compare
Rv1356c -0.5 -2.5 Hypothetical protein compare
Rv0037c -0.5 -3.9 Probable conserved integral membrane protein compare
Rv0464c -0.5 -2.3 Conserved protein compare
Rv0881 -0.5 -1.4 Possible rRNA methyltransferase (rRNA methylase) compare
Rv2569c -0.5 -2.5 Conserved hypothetical protein compare
Rv2072c -0.5 -0.8 Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL compare
Rv1840c -0.5 -1.7 PE-PGRS family protein PE_PGRS34 compare


Specific Phenotypes

For 6 genes in this experiment

For carbon source heptadecanoic acid in Mycobacterium tuberculosis H37Rv

For carbon source heptadecanoic acid across organisms