Experiment set2S618 for Mycobacterium tuberculosis H37Rv

Compare to:

Sodium butyrate 10 mM carbon source

200 most important genes:

  gene name fitness t score description  
Rv0642c -3.2 -2.6 Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase) compare
Rv1159 -3.0 -3.4 Mannosyltransferase PimE compare
Rv3400 -3.0 -7.6 Probable hydrolase compare
Rv3810 -3.0 -3.9 Exported repetitive protein precursor PirG (cell surface protein) (EXP53) compare
Rv3816c -2.7 -1.5 Possible acyltransferase compare
Rv2476c -2.5 -6.5 Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase) compare
Rv1798 -2.4 -1.3 ESX conserved component EccA5. ESX-5 type VII secretion system protein. compare
Rv2869c -2.3 -2.3 Membrane bound metalloprotease compare
Rv1570 -2.3 -3.4 Dethiobiotin synthetase BioD compare
Rv1589 -2.2 -7.8 Probable biotin synthetase BioB compare
Rv0383c -2.2 -1.2 Possible conserved secreted protein compare
Rv2553c -2.1 -1.6 Probable conserved membrane protein compare
Rv3267 -2.1 -4.6 Conserved protein (CPSA-related protein) compare
Rv2606c -2.0 -5.8 Possible pyridoxine biosynthesis protein SnzP compare
Rv3631 -2.0 -1.4 Possible transferase (possibly glycosyltransferase) compare
Rv0367c -2.0 -1.4 Hypothetical protein compare
Rv2989 -1.8 -1.2 Probable transcriptional regulatory protein compare
Rv2850c -1.8 -1.1 Possible magnesium chelatase compare
Rv1590 -1.8 -5.1 Conserved hypothetical protein compare
Rv0819 -1.8 -4.5 GCN5-related N-acetyltransferase, MshD compare
Rv1568 -1.8 -10.6 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA compare
Rv1410c -1.7 -10.3 Aminoglycosides/tetracycline-transport integral membrane protein compare
Rv0472c -1.7 -4.8 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv0007 -1.7 -1.1 Possible conserved membrane protein compare
Rv2982c -1.6 -6.1 Probable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA2 (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase) compare
Rv1577c -1.6 -1.2 Probable PhiRv1 phage protein compare
Rv1411c -1.6 -3.0 Conserved lipoprotein LprG compare
Rv2851c -1.6 -5.8 GCN5-related N-acetyltransferase compare
Rv3575c -1.6 -7.9 Transcriptional regulatory protein (probably LacI-family) compare
Rv0204c -1.6 -5.2 Probable conserved transmembrane protein compare
Rv1291c -1.5 -1.9 Conserved hypothetical secreted protein compare
Rv2302 -1.5 -1.5 Conserved protein compare
Rv3102c -1.4 -3.0 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv2047c -1.4 -7.5 Conserved hypothetical protein compare
Rv3193c -1.4 -1.3 Probable conserved transmembrane protein compare
Rv3101c -1.4 -2.3 Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter) compare
Rv0825c -1.4 -1.7 Conserved protein compare
Rv3249c -1.3 -1.3 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv1851 -1.3 -1.7 Urease accessory protein UreF compare
Rv0949 -1.3 -0.9 Probable ATP-dependent DNA helicase II UvrD1 compare
Rv2048c -1.3 -4.6 Polyketide synthase Pks12 compare
Rv3139 -1.3 -5.2 Probable acyl-CoA dehydrogenase FadE24 compare
Rv1058 -1.2 -4.8 Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv2365c -1.2 -0.8 Conserved hypothetical protein compare
Rv1273c -1.2 -4.3 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv3140 -1.2 -3.5 Probable acyl-CoA dehydrogenase FadE23 compare
Rv0202c -1.2 -5.8 Probable conserved transmembrane transport protein MmpL11 compare
Rv3366 -1.2 -2.4 Probable tRNA/rRNA methylase SpoU (tRNA/rRNA methyltransferase) compare
Rv0820 -1.2 -3.6 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv3066 -1.1 -5.5 Probable transcriptional regulatory protein (probably DeoR-family) compare
Rv0563 -1.1 -2.9 Probable protease transmembrane protein heat shock protein HtpX compare
Rv3277 -1.1 -0.8 Probable conserved transmembrane protein compare
Rv0757 -1.1 -1.1 Possible two component system response transcriptional positive regulator PhoP compare
Rv0056 -1.1 -2.2 50S ribosomal protein L9 RplI compare
Rv0930 -1.1 -4.7 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv0243 -1.1 -6.5 Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase) compare
Rv1121 -1.1 -2.2 Probable glucose-6-phosphate 1-dehydrogenase Zwf1 (G6PD) compare
Rv1836c -1.1 -2.4 Conserved protein compare
Rv1565c -1.1 -5.5 Conserved hypothetical membrane protein compare
Rv2680 -1.1 -1.8 Conserved protein compare
Rv1821 -1.1 -3.5 Possible preprotein translocase ATPase SecA2 compare
Rv1013 -1.1 -4.8 Putative polyketide synthase Pks16 compare
Rv3305c -1.1 -2.0 Possible N-acyl-L-amino acid amidohydrolase AmiA1 (N-acyl-L-amino acid aminohydrolase) compare
Rv1421 -1.1 -2.2 Conserved protein compare
Rv3229c -1.0 -2.2 Possible linoleoyl-CoA desaturase (delta(6)-desaturase) compare
Rv0241c -1.0 -1.8 Probable 3-hydroxyacyl-thioester dehydratase HtdX compare
Rv3306c -1.0 -1.5 Probable amidohydrolase AmiB1 (aminohydrolase) compare
Rv1128c -1.0 -2.3 Conserved hypothetical protein compare
Rv1569 -1.0 -2.5 Probable 8-amino-7-oxononanoate synthase BioF1 (AONS) (8-amino-7-ketopelargonate synthase) (7-keto-8-amino-pelargonic acid synthetase) (7-KAP synthetase) (L-alanine--pimelyl CoA ligase) compare
Rv0929 -1.0 -1.3 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv0989c -1.0 -5.7 Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) compare
Rv1908c -1.0 -2.2 Catalase-peroxidase-peroxynitritase T KatG compare
Rv3497c -1.0 -5.6 Mce-family protein Mce4C compare
Rv3501c -1.0 -2.9 Conserved integral membrane protein YrbE4A. Possible ABC transporter. compare
Rv1621c -1.0 -3.4 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD compare
Rv3813c -1.0 -2.0 Conserved protein compare
Rv0248c -1.0 -4.6 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) compare
Rv0821c -1.0 -2.4 Probable phosphate-transport system transcriptional regulatory protein PhoY2 compare
Rv3768 -0.9 -2.2 Unknown protein compare
Rv1107c -0.9 -1.3 Probable exodeoxyribonuclease VII (small subunit) XseB (exonuclease VII small subunit) compare
Rv1010 -0.9 -1.1 Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase) compare
Rv0249c -0.9 -3.6 Probable succinate dehydrogenase [membrane anchor subunit] (succinic dehydrogenase) compare
Rv0504c -0.9 -1.1 Conserved protein compare
Rv0452 -0.9 -1.8 Possible transcriptional regulatory protein compare
Rv3650 -0.9 -0.7 PE family protein PE33 compare
Rv1072 -0.9 -0.9 Probable conserved transmembrane protein compare
Rv1234 -0.9 -1.6 Probable transmembrane protein compare
Rv2224c -0.9 -7.1 Probable carboxylesterase CaeA compare
Rv2206 -0.9 -2.4 Probable conserved transmembrane protein compare
Rv3311 -0.9 -3.7 Conserved protein compare
Rv1019 -0.9 -6.1 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv3614c -0.9 -2.7 ESX-1 secretion-associated protein EspD compare
Rv0531 -0.8 -1.1 Possible conserved membrane protein compare
Rv3438 -0.8 -2.2 Conserved protein compare
Rv2609c -0.8 -2.0 Probable conserved membrane protein compare
Rv2252 -0.8 -0.8 Diacylglycerol kinase compare
Rv2581c -0.8 -0.9 Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II) compare
Rv3492c -0.8 -1.8 Conserved hypothetical Mce associated protein compare
Rv2026c -0.8 -1.2 Universal stress protein family protein compare
Rv1272c -0.8 -3.7 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv0655 -0.8 -3.5 Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl compare
Rv3301c -0.8 -2.8 Probable phosphate-transport system transcriptional regulatory protein PhoU homolog 1 PhoY1 compare
Rv0200 -0.8 -1.9 Possible conserved transmembrane protein compare
Rv1657 -0.8 -1.9 Probable arginine repressor ArgR (AHRC) compare
Rv0436c -0.8 -1.0 Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase) compare
Rv0749 -0.8 -0.7 Possible toxin VapC31. Contains PIN domain. compare
Rv1951c -0.8 -1.9 Conserved hypothetical protein compare
Rv0539 -0.8 -2.0 Probable dolichyl-phosphate sugar synthase (dolichol-phosphate sugar synthetase) (dolichol-phosphate sugar transferase) (sugar phosphoryldolichol synthase) compare
Rv0003 -0.8 -2.6 DNA replication and repair protein RecF (single-strand DNA binding protein) compare
Rv0994 -0.8 -4.0 Probable molybdopterin biosynthesis protein MoeA1 compare
Rv1127c -0.8 -0.9 Probable pyruvate, phosphate dikinase PpdK compare
Rv3162c -0.7 -1.0 Possible integral membrane protein compare
Rv0280 -0.7 -5.2 PPE family protein PPE3 compare
Rv0876c -0.7 -1.5 Possible conserved transmembrane protein compare
Rv1829 -0.7 -4.2 Conserved protein compare
Rv3321c -0.7 -1.5 Possible antitoxin VapB44 compare
Rv1745c -0.7 -2.8 Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase) compare
Rv2732c -0.7 -2.0 Probable conserved transmembrane protein compare
Rv1825 -0.7 -2.1 Conserved protein compare
Rv0675 -0.7 -0.6 Probable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv2796c -0.7 -2.4 Probable conserved lipoprotein LppV compare
Rv0040c -0.7 -3.3 Secreted proline rich protein Mtc28 (proline rich 28 kDa antigen) compare
Rv3751 -0.7 -1.3 Probable integrase (fragment) compare
Rv3897c -0.7 -0.4 Conserved hypothetical protein compare
Rv1944c -0.7 -2.0 Conserved protein compare
Rv2154c -0.7 -1.3 FtsW-like protein FtsW compare
Rv3748 -0.7 -1.0 Conserved hypothetical protein compare
Rv3414c -0.7 -1.8 Probable alternative RNA polymerase sigma-D factor SigD compare
Rv1701 -0.7 -1.5 Probable integrase/recombinase compare
Rv2374c -0.7 -1.4 Probable heat shock protein transcriptional repressor HrcA compare
Rv1962A -0.7 -1.0 Possible antitoxin VapB35 compare
Rv1333 -0.7 -1.9 Probable hydrolase compare
Rv3496c -0.7 -5.2 Mce-family protein Mce4D compare
Rv3098c -0.7 -0.9 Hypothetical protein compare
Rv3417c -0.7 -1.6 60 kDa chaperonin 1 GroEL1 (protein CPN60-1) (GroEL protein 1) compare
Rv3500c -0.7 -4.1 Conserved integral membrane protein YrbE4B. Possible ABC transporter. compare
Rv3230c -0.7 -1.6 Hypothetical oxidoreductase compare
Rv2668 -0.7 -2.3 Possible exported alanine and valine rich protein compare
Rv0038 -0.7 -2.2 Conserved protein compare
Rv2376c -0.7 -1.0 Low molecular weight antigen CFP2 (low molecular weight protein antigen 2) (CFP-2) compare
Rv0242c -0.7 -1.1 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase) compare
Rv3553 -0.7 -1.3 Possible oxidoreductase compare
Rv2203 -0.7 -3.6 Possible conserved membrane protein compare
Rv0247c -0.7 -0.4 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) compare
Rv1332 -0.7 -0.7 Probable transcriptional regulatory protein compare
Rv3147 -0.7 -2.0 Probable NADH dehydrogenase I (chain C) NuoC (NADH-ubiquinone oxidoreductase chain C) compare
Rv2272 -0.7 -0.4 Probable conserved transmembrane protein compare
Rv2789c -0.7 -3.1 Probable acyl-CoA dehydrogenase FadE21 compare
Rv2691 -0.7 -2.8 TRK system potassium uptake protein CeoB compare
Rv2862c -0.7 -3.4 Conserved hypothetical protein compare
Rv2170 -0.6 -0.9 GCN5-related N-acetyltransferase compare
Rv1566c -0.6 -2.1 Possible Inv protein compare
Rv2437 -0.6 -1.5 Conserved transmembrane protein compare
Rv0954 -0.6 -2.6 Probable conserved transmembrane protein compare
Rv2718c -0.6 -3.0 Probable transcriptional regulatory protein NrdR compare
Rv0870c -0.6 -1.0 Possible conserved integral membrane protein compare
Rv3371 -0.6 -1.2 Possible triacylglycerol synthase (diacylglycerol acyltransferase) compare
Rv0971c -0.6 -2.9 Probable enoyl-CoA hydratase EchA7 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv2137c -0.6 -1.7 Conserved hypothetical protein compare
Rv3358 -0.6 -1.3 Toxin RelK compare
Rv1336 -0.6 -3.6 Cysteine synthase B CysM (CSASE B) (O-phosphoserine sulfhydrylase B) (O-phosphoserine (thiol)-lyase B) compare
Rv0924c -0.6 -3.6 Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP) compare
Rv2693c -0.6 -3.1 Probable conserved integral membrane alanine and leucine rich protein compare
Rv3392c -0.6 -1.6 Cyclopropane-fatty-acyl-phospholipid synthase 1 CmaA1 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic acid synthase 1) compare
Rv2086 -0.6 -1.8 Conserved hypothetical protein compare
Rv3005c -0.6 -4.7 Conserved hypothetical protein compare
Rv2550c -0.6 -3.1 Possible antitoxin VapB20 compare
Rv2384 -0.6 -1.6 Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase compare
Rv2091c -0.6 -3.1 Probable membrane protein compare
Rv3823c -0.6 -4.2 Conserved integral membrane transport protein MmpL8 compare
Rv2468A -0.6 -1.9 Conserved protein compare
Rv3256c -0.6 -1.0 Conserved protein compare
Rv3376 -0.6 -1.7 Conserved hypothetical protein compare
Rv1006 -0.6 -2.7 Unknown protein compare
Rv1671 -0.6 -1.5 Probable membrane protein compare
Rv1946c -0.6 -1.2 Possible lipoprotein compare
Rv3394c -0.6 -1.0 Conserved hypothetical protein compare
Rv0805 -0.6 -0.6 Class III cyclic nucleotide phosphodiesterase (cNMP PDE) compare
Rv0176 -0.6 -2.8 Probable conserved Mce associated transmembrane protein compare
Rv3073c -0.6 -0.9 Conserved hypothetical protein compare
Rv0886 -0.6 -3.5 Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) compare
Rv3214 -0.6 -0.9 Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) compare
Rv2462c -0.6 -2.4 Probable trigger factor (TF) protein Tig compare
Rv2707 -0.6 -4.3 Probable conserved transmembrane alanine and leucine rich protein compare
Rv0610c -0.6 -0.7 Hypothetical protein compare
Rv0379 -0.6 -0.5 Possible protein transport protein SecE2 compare
Rv2799 -0.6 -3.6 Probable membrane protein compare
Rv2474c -0.6 -0.9 Conserved hypothetical protein compare
Rv3477 -0.6 -0.7 PE family protein PE31 compare
Rv0918 -0.6 -1.2 Conserved protein compare
Rv0680c -0.6 -1.0 Probable conserved transmembrane protein compare
Rv0420c -0.5 -1.8 Possible transmembrane protein compare
Rv2586c -0.5 -0.8 Probable protein-export membrane protein SecF compare
Rv3770B -0.5 -1.0 Probable remnant of a transposase compare
Rv0190 -0.5 -1.9 Conserved protein compare
Rv0090 -0.5 -2.3 Possible membrane protein compare
Rv2696c -0.5 -0.9 Conserved alanine and glycine and valine rich protein compare
Rv0098 -0.5 -1.2 Probable fatty acyl CoA thioesterase type III FcoT compare
Rv1303 -0.5 -0.6 Conserved hypothetical transmembrane protein compare
Rv2185c -0.5 -1.4 Conserved protein TB16.3 compare


Specific Phenotypes

For 2 genes in this experiment

For carbon source Sodium butyrate in Mycobacterium tuberculosis H37Rv

For carbon source Sodium butyrate across organisms