Experiment set2S616 for Mycobacterium tuberculosis H37Rv

Compare to:

Valeric acid 10 mM carbon source

200 most important genes:

  gene name fitness t score description  
Rv1129c -3.6 -7.3 Probable transcriptional regulator protein compare
Rv3819 -3.5 -1.2 Unknown protein compare
Rv3400 -2.6 -10.2 Probable hydrolase compare
Rv0642c -2.2 -2.9 Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase) compare
Rv1130 -2.2 -4.6 Possible methylcitrate dehydratase PrpD compare
Rv0805 -2.1 -1.5 Class III cyclic nucleotide phosphodiesterase (cNMP PDE) compare
Rv2606c -2.0 -7.0 Possible pyridoxine biosynthesis protein SnzP compare
Rv1291c -1.9 -2.1 Conserved hypothetical secreted protein compare
Rv2237A -1.9 -1.5 Conserved protein compare
Rv2869c -1.8 -2.7 Membrane bound metalloprotease compare
Rv3810 -1.8 -3.4 Exported repetitive protein precursor PirG (cell surface protein) (EXP53) compare
Rv3816c -1.8 -1.4 Possible acyltransferase compare
Rv2630 -1.6 -1.5 Hypothetical protein compare
Rv0436c -1.6 -2.3 Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase) compare
Rv1131 -1.6 -3.3 Probable methylcitrate synthase PrpC compare
Rv0472c -1.6 -4.7 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv2365c -1.6 -0.9 Conserved hypothetical protein compare
Rv2302 -1.5 -1.8 Conserved protein compare
Rv3101c -1.5 -2.5 Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter) compare
Rv1538c -1.4 -4.8 Probable L-aparaginase AnsA compare
Rv1836c -1.4 -2.8 Conserved protein compare
Rv0820 -1.4 -3.4 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv2982c -1.4 -5.8 Probable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA2 (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase) compare
Rv3102c -1.4 -3.8 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv0018c -1.4 -3.5 Phosphoserine/threonine phosphatase PstP compare
Rv2476c -1.4 -4.4 Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase) compare
Rv3823c -1.2 -9.0 Conserved integral membrane transport protein MmpL8 compare
Rv0452 -1.2 -3.4 Possible transcriptional regulatory protein compare
Rv3650 -1.2 -0.9 PE family protein PE33 compare
Rv1072 -1.2 -1.1 Probable conserved transmembrane protein compare
Rv3726 -1.2 -1.9 Possible dehydrogenase compare
Rv2374c -1.1 -2.7 Probable heat shock protein transcriptional repressor HrcA compare
Rv1930c -1.1 -1.0 Conserved hypothetical protein compare
Rv0887c -1.1 -1.7 Conserved hypothetical protein compare
Rv2657c -1.1 -1.4 Probable PhiRv2 prophage protein compare
Rv3321c -1.1 -1.7 Possible antitoxin VapB44 compare
Rv3478 -1.1 -2.6 PE family protein PPE60 compare
Rv3229c -1.1 -2.6 Possible linoleoyl-CoA desaturase (delta(6)-desaturase) compare
Rv0129c -1.1 -4.3 Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) compare
Rv0346c -1.1 -7.3 Possible L-asparagine permease AnsP2 (L-asparagine transport protein) compare
Rv0383c -1.0 -0.8 Possible conserved secreted protein compare
Rv0964c -1.0 -1.6 Hypothetical protein compare
Rv2709 -1.0 -5.1 Probable conserved transmembrane protein compare
Rv1411c -1.0 -2.6 Conserved lipoprotein LprG compare
Rv0367c -1.0 -1.0 Hypothetical protein compare
Rv3143 -1.0 -0.9 Probable response regulator compare
Rv1459c -1.0 -1.2 Possible conserved integral membrane protein compare
Rv1025 -1.0 -0.8 Conserved protein compare
Rv3267 -1.0 -1.4 Conserved protein (CPSA-related protein) compare
Rv3162c -1.0 -1.1 Possible integral membrane protein compare
Rv1908c -1.0 -1.3 Catalase-peroxidase-peroxynitritase T KatG compare
Rv1951c -0.9 -2.6 Conserved hypothetical protein compare
Rv0989c -0.9 -6.9 Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) compare
Rv2275 -0.9 -1.3 Conserved hypothetical protein compare
Rv2879c -0.9 -0.6 Conserved hypothetical protein compare
Rv1272c -0.9 -5.4 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv3405c -0.9 -1.5 Possible transcriptional regulatory protein compare
Rv0390 -0.9 -3.2 Conserved protein compare
Rv1336 -0.9 -5.1 Cysteine synthase B CysM (CSASE B) (O-phosphoserine sulfhydrylase B) (O-phosphoserine (thiol)-lyase B) compare
Rv0497 -0.9 -1.2 Probable conserved transmembrane protein compare
Rv2173 -0.9 -3.7 Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) compare
Rv0655 -0.9 -3.6 Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl compare
Rv0929 -0.9 -1.7 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv1455 -0.9 -5.4 Conserved protein compare
Rv2635 -0.8 -0.9 Hypothetical protein compare
Rv1035c -0.8 -1.2 Probable transposase (fragment) compare
Rv1010 -0.8 -1.1 Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase) compare
Rv1829 -0.8 -3.8 Conserved protein compare
Rv3919c -0.8 -2.6 Probable glucose-inhibited division protein B Gid compare
Rv3140 -0.8 -2.9 Probable acyl-CoA dehydrogenase FadE23 compare
Rv0190 -0.8 -3.1 Conserved protein compare
Rv2680 -0.8 -1.5 Conserved protein compare
Rv0867c -0.8 -0.7 Possible resuscitation-promoting factor RpfA compare
Rv1112 -0.8 -1.1 Probable GTP binding protein compare
Rv3200c -0.8 -3.1 Possible transmembrane cation transporter compare
Rv3208A -0.8 -0.9 Conserved protein TB9.4 compare
Rv1926c -0.8 -2.4 Immunogenic protein Mpt63 (antigen Mpt63/MPB63) (16 kDa immunoprotective extracellular protein) compare
Rv3513c -0.8 -1.0 Probable fatty-acid-CoA ligase FadD18 (fragment) (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv1495 -0.8 -0.9 Possible toxin MazF4 compare
Rv0696 -0.8 -2.9 Probable membrane sugar transferase compare
Rv3139 -0.8 -3.5 Probable acyl-CoA dehydrogenase FadE24 compare
Rv1159 -0.8 -1.6 Mannosyltransferase PimE compare
Rv0769 -0.8 -2.6 Probable dehydrogenase/reductase compare
Rv2650c -0.8 -0.8 Possible PhiRv2 prophage protein compare
Rv2224c -0.8 -5.8 Probable carboxylesterase CaeA compare
Rv0924c -0.8 -2.6 Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP) compare
Rv0819 -0.7 -2.7 GCN5-related N-acetyltransferase, MshD compare
Rv1963c -0.7 -0.9 Probable transcriptional repressor (probably TetR-family) Mce3R compare
Rv1183 -0.7 -4.8 Probable conserved transmembrane transport protein MmpL10 compare
Rv0391 -0.7 -4.8 Probable O-succinylhomoserine sulfhydrylase MetZ (OSH sulfhydrylase) compare
Rv0135c -0.7 -2.3 Possible transcriptional regulatory protein compare
Rv2025c -0.7 -2.9 Conserved membrane protein compare
Rv1683 -0.7 -2.7 Possible bifunctional enzyme; long-chain acyl-CoA synthase and lipase. compare
Rv2821c -0.7 -2.2 Conserved hypothetical protein compare
Rv2376c -0.7 -1.0 Low molecular weight antigen CFP2 (low molecular weight protein antigen 2) (CFP-2) compare
Rv0204c -0.7 -2.9 Probable conserved transmembrane protein compare
Rv3564 -0.7 -2.6 Probable acyl-CoA dehydrogenase FadE33 compare
Rv1331 -0.7 -1.6 Conserved hypothetical protein compare
Rv3278c -0.7 -2.6 Probable conserved transmembrane protein compare
Rv1085c -0.7 -3.6 Possible hemolysin-like protein compare
Rv2581c -0.7 -0.8 Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II) compare
Rv3484 -0.7 -4.2 Possible conserved protein CpsA compare
Rv2175c -0.7 -1.7 Conserved regulatory protein compare
Rv0806c -0.7 -3.8 Possible UDP-glucose-4-epimerase CpsY (galactowaldenase) (UDP-galactose-4-epimerase) (uridine diphosphate galactose-4-epimerase) (uridine diphospho-galactose-4-epimerase) compare
Rv3045 -0.7 -1.9 Probable NADP-dependent alcohol dehydrogenase AdhC compare
Rv3204 -0.7 -0.6 Possible DNA-methyltransferase (modification methylase) compare
Rv1335 -0.7 -2.9 Sulfur carrier protein CysO compare
Rv2647 -0.7 -0.9 Hypothetical protein compare
Rv3283 -0.7 -2.0 Probable thiosulfate sulfurtransferase SseA (rhodanese) (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase) compare
Rv2707 -0.7 -4.8 Probable conserved transmembrane alanine and leucine rich protein compare
Rv1410c -0.7 -3.8 Aminoglycosides/tetracycline-transport integral membrane protein compare
Rv0113 -0.7 -1.1 Probable sedoheptulose-7-phosphate isomerase GmhA (phosphoheptose isomerase) compare
Rv3066 -0.7 -2.8 Probable transcriptional regulatory protein (probably DeoR-family) compare
Rv3311 -0.7 -3.1 Conserved protein compare
Rv1111c -0.7 -3.6 Conserved hypothetical protein compare
Rv0563 -0.7 -2.0 Probable protease transmembrane protein heat shock protein HtpX compare
Rv0049 -0.7 -2.2 Conserved hypothetical protein compare
Rv2317 -0.7 -0.9 Probable sugar-transport integral membrane protein ABC transporter UspB compare
Rv1121 -0.7 -0.7 Probable glucose-6-phosphate 1-dehydrogenase Zwf1 (G6PD) compare
Rv1170 -0.6 -1.9 N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) compare
Rv0248c -0.6 -2.9 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) compare
Rv3147 -0.6 -1.8 Probable NADH dehydrogenase I (chain C) NuoC (NADH-ubiquinone oxidoreductase chain C) compare
Rv0207c -0.6 -0.9 Conserved hypothetical protein compare
Rv3768 -0.6 -1.5 Unknown protein compare
Rv3150 -0.6 -3.4 Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) compare
Rv1058 -0.6 -2.2 Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv0928 -0.6 -2.2 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv2011c -0.6 -1.7 Conserved hypothetical protein, probable transcription repressor. compare
Rv1334 -0.6 -2.7 Possible hydrolase compare
Rv1013 -0.6 -3.4 Putative polyketide synthase Pks16 compare
Rv3445c -0.6 -0.9 ESAT-6 like protein EsxU compare
Rv0037c -0.6 -4.8 Probable conserved integral membrane protein compare
Rv0912 -0.6 -1.1 Probable conserved transmembrane protein compare
Rv2718c -0.6 -2.4 Probable transcriptional regulatory protein NrdR compare
Rv1566c -0.6 -1.6 Possible Inv protein compare
Rv3157 -0.6 -2.8 Probable NADH dehydrogenase I (chain M) NUOK (NADH-ubiquinone oxidoreductase chain M) compare
Rv2039c -0.6 -1.2 Probable sugar-transport integral membrane protein ABC transporter compare
Rv0520 -0.6 -1.5 Possible methyltransferase/methylase (fragment) compare
Rv0773c -0.6 -1.7 Probable bifunctional acylase GgtA: cephalosporin acylase (GL-7ACA acylase) + gamma-glutamyltranspeptidase (GGT) compare
Rv2550c -0.6 -2.0 Possible antitoxin VapB20 compare
Rv3167c -0.6 -1.2 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv0348 -0.6 -1.5 Possible transcriptional regulatory protein compare
Rv2206 -0.6 -1.5 Probable conserved transmembrane protein compare
Rv3304 -0.6 -3.0 Conserved protein compare
Rv3486 -0.6 -1.1 Conserved protein compare
Rv1003 -0.6 -0.4 Conserved protein compare
Rv0986 -0.6 -0.9 Probable adhesion component transport ATP-binding protein ABC transporter compare
Rv1435c -0.6 -1.9 Probable conserved proline, glycine, valine-rich secreted protein compare
Rv1946c -0.6 -0.8 Possible lipoprotein compare
Rv3145 -0.6 -2.9 Probable NADH dehydrogenase I (chain A) NuoA (NADH-ubiquinone oxidoreductase chain A) compare
Rv0955 -0.6 -0.6 Probable conserved integral membrane protein compare
Rv2702 -0.6 -0.5 Polyphosphate glucokinase PpgK (polyphosphate-glucose phosphotransferase) compare
Rv2037c -0.6 -1.6 Conserved transmembrane protein compare
Rv1657 -0.6 -1.4 Probable arginine repressor ArgR (AHRC) compare
Rv1128c -0.6 -1.1 Conserved hypothetical protein compare
Rv2154c -0.6 -0.6 FtsW-like protein FtsW compare
Rv0749 -0.6 -1.2 Possible toxin VapC31. Contains PIN domain. compare
Rv3419c -0.6 -1.0 Probable O-sialoglycoprotein endopeptidase Gcp (glycoprotease) compare
Rv2812 -0.6 -1.2 Probable transposase compare
Rv2047c -0.6 -3.1 Conserved hypothetical protein compare
Rv3687c -0.6 -0.7 Anti-anti-sigma factor RsfB (anti-sigma factor antagonist) (regulator of sigma F B) compare
Rv3414c -0.5 -1.5 Probable alternative RNA polymerase sigma-D factor SigD compare
Rv3416 -0.5 -1.2 Transcriptional regulatory protein WhiB-like WhiB3. Contains [4FE-4S] cluster. compare
Rv2955c -0.5 -3.6 Conserved protein compare
Rv3132c -0.5 -1.8 Two component sensor histidine kinase DevS compare
Rv2344c -0.5 -2.5 Probable deoxyguanosine triphosphate triphosphohydrolase Dgt (dGTPase) (dGTP triphosphohydrolase) compare
Rv3723 -0.5 -1.5 Probable conserved transmembrane protein compare
Rv3565 -0.5 -0.8 Possible aspartate aminotransferase AspB (transaminase A) (ASPAT) (glutamic--oxaloacetic transaminase) (glutamic--aspartic transaminase) compare
Rv3156 -0.5 -2.6 Probable NADH dehydrogenase I (chain L) NuoL (NADH-ubiquinone oxidoreductase chain L) compare
Rv0653c -0.5 -3.0 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv3647c -0.5 -0.6 Conserved hypothetical protein compare
Rv1621c -0.5 -1.2 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD compare
Rv1675c -0.5 -1.4 Probable transcriptional regulatory protein Cmr compare
Rv1337 -0.5 -3.0 Probable integral membrane protein compare
Rv1359 -0.5 -2.1 Probable transcriptional regulatory protein compare
Rv0892 -0.5 -0.9 Probable monooxygenase compare
Rv3908 -0.5 -1.0 Possible mutator protein MutT4 compare
Rv2668 -0.5 -1.2 Possible exported alanine and valine rich protein compare
Rv1745c -0.5 -1.5 Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase) compare
Rv0249c -0.5 -2.0 Probable succinate dehydrogenase [membrane anchor subunit] (succinic dehydrogenase) compare
Rv3497c -0.5 -2.4 Mce-family protein Mce4C compare
Rv0870c -0.5 -1.3 Possible conserved integral membrane protein compare
Rv1729c -0.5 -1.9 Possible S-adenosylmethionine-dependent methyltransferase compare
Rv1766 -0.5 -1.0 Conserved protein compare
Rv2043c -0.5 -2.0 Pyrazinamidase/nicotinamidase PncA (PZase) compare
Rv1579c -0.5 -1.7 Probable PhiRv1 phage protein compare
Rv1284 -0.5 -0.4 Beta-carbonic anhydrase compare
Rv1051c -0.5 -1.4 Conserved hypothetical protein compare
Rv3868 -0.5 -3.2 ESX conserved component EccA1. ESX-1 type VII secretion system protein. compare
Rv3575c -0.5 -2.5 Transcriptional regulatory protein (probably LacI-family) compare
Rv3146 -0.5 -2.5 Probable NADH dehydrogenase I (chain B) NuoB (NADH-ubiquinone oxidoreductase chain B) compare
Rv0689c -0.5 -1.7 Hypothetical protein compare
Rv0202c -0.5 -2.9 Probable conserved transmembrane transport protein MmpL11 compare
Rv0752c -0.5 -2.3 Probable acyl-CoA dehydrogenase FadE9 compare
Rv3340 -0.5 -1.2 Probable O-acetylhomoserine sulfhydrylase MetC (homocysteine synthase) (O-acetylhomoserine (thiol)-lyase) (OAH sulfhydrylase) (O-acetyl-L-homoserine sulfhydrylase) compare
Rv2331 -0.5 -2.0 Hypothetical protein compare
Rv3867 -0.5 -1.8 ESX-1 secretion-associated protein EspH compare
Rv0971c -0.5 -1.4 Probable enoyl-CoA hydratase EchA7 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv2048c -0.5 -2.6 Polyketide synthase Pks12 compare
Rv3217c -0.5 -1.6 Probable conserved integral membrane protein compare


Specific Phenotypes

For 2 genes in this experiment

For carbon source Valeric acid in Mycobacterium tuberculosis H37Rv

For carbon source Valeric acid across organisms