Experiment set2S608 for Mycobacterium tuberculosis H37Rv

Compare to:

D-Trehalose dihydrate 10 mM carbon source

200 most important genes:

  gene name fitness t score description  
Rv2003c -5.7 -3.0 Conserved hypothetical protein compare
Rv3816c -3.7 -1.6 Possible acyltransferase compare
Rv3010c -2.5 -7.4 Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) compare
Rv2989 -2.5 -1.0 Probable transcriptional regulatory protein compare
Rv1290A -2.2 -1.1 Hypothetical protein compare
Rv3400 -2.1 -9.9 Probable hydrolase compare
Rv0929 -2.1 -2.5 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv1235 -2.1 -4.6 Probable sugar-binding lipoprotein LpqY compare
Rv1824 -1.8 -2.0 Conserved hypothetical membrane protein compare
Rv1236 -1.8 -9.4 Probable sugar-transport integral membrane protein ABC transporter SugA conserved
Rv3306c -1.8 -1.8 Probable amidohydrolase AmiB1 (aminohydrolase) compare
Rv0504c -1.8 -2.2 Conserved protein compare
Rv2774c -1.7 -1.5 Hypothetical protein compare
Rv0497 -1.6 -2.0 Probable conserved transmembrane protein compare
Rv1238 -1.6 -6.1 Probable sugar-transport ATP-binding protein ABC transporter SugC conserved
Rv3033 -1.6 -0.8 Unknown protein compare
Rv1836c -1.6 -1.8 Conserved protein compare
Rv2047c -1.5 -7.8 Conserved hypothetical protein compare
Rv1237 -1.5 -4.2 Probable sugar-transport integral membrane protein ABC transporter SugB compare
Rv0928 -1.5 -4.2 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv2374c -1.4 -2.7 Probable heat shock protein transcriptional repressor HrcA compare
Rv1234 -1.4 -2.9 Probable transmembrane protein compare
Rv0379 -1.4 -1.1 Possible protein transport protein SecE2 compare
Rv1102c -1.4 -1.7 Toxin MazF3 compare
Rv2476c -1.4 -4.5 Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase) compare
Rv3066 -1.4 -4.6 Probable transcriptional regulatory protein (probably DeoR-family) compare
Rv1291c -1.4 -1.5 Conserved hypothetical secreted protein compare
Rv1332 -1.3 -1.1 Probable transcriptional regulatory protein compare
Rv3513c -1.3 -1.2 Probable fatty-acid-CoA ligase FadD18 (fragment) (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv0012 -1.3 -6.3 Probable conserved membrane protein compare
Rv1411c -1.2 -3.2 Conserved lipoprotein LprG compare
Rv1590 -1.2 -3.1 Conserved hypothetical protein compare
Rv3810 -1.2 -2.2 Exported repetitive protein precursor PirG (cell surface protein) (EXP53) compare
Rv2887 -1.2 -1.6 Probable transcriptional regulatory protein compare
Rv0819 -1.2 -3.3 GCN5-related N-acetyltransferase, MshD compare
Rv0242c -1.2 -2.7 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase) compare
Rv1324 -1.2 -1.4 Possible thioredoxin compare
Rv1328 -1.1 -4.7 Probable glycogen phosphorylase GlgP compare
Rv1107c -1.1 -1.6 Probable exodeoxyribonuclease VII (small subunit) XseB (exonuclease VII small subunit) compare
Rv0451c -1.1 -1.5 Probable conserved membrane protein MmpS4 compare
Rv0642c -1.1 -1.5 Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase) compare
Rv2048c -1.1 -4.4 Polyketide synthase Pks12 compare
Rv3316 -1.1 -1.4 Probable succinate dehydrogenase (cytochrome B-556 subunit) SdhC (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase) compare
Rv0472c -1.0 -3.4 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv3477 -1.0 -1.3 PE family protein PE31 compare
Rv2606c -1.0 -3.7 Possible pyridoxine biosynthesis protein SnzP compare
Rv3101c -1.0 -1.7 Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter) compare
Rv1538c -1.0 -6.3 Probable L-aparaginase AnsA compare
Rv1410c -1.0 -5.2 Aminoglycosides/tetracycline-transport integral membrane protein compare
Rv2647 -1.0 -1.1 Hypothetical protein compare
Rv1273c -1.0 -3.2 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv1620c -1.0 -2.7 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC compare
Rv0129c -1.0 -3.8 Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) compare
Rv0930 -0.9 -3.4 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv3267 -0.9 -3.3 Conserved protein (CPSA-related protein) compare
Rv0113 -0.9 -1.4 Probable sedoheptulose-7-phosphate isomerase GmhA (phosphoheptose isomerase) compare
Rv0437c -0.9 -1.0 Possible phosphatidylserine decarboxylase Psd (PS decarboxylase) compare
Rv2553c -0.9 -0.8 Probable conserved membrane protein compare
Rv0202c -0.9 -3.6 Probable conserved transmembrane transport protein MmpL11 compare
Rv2975c -0.9 -0.5 Conserved hypothetical protein compare
Rv1621c -0.9 -2.2 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD compare
Rv2226 -0.9 -2.2 Conserved protein compare
Rv1159 -0.9 -1.4 Mannosyltransferase PimE compare
Rv0040c -0.9 -5.5 Secreted proline rich protein Mtc28 (proline rich 28 kDa antigen) compare
Rv3311 -0.9 -3.6 Conserved protein compare
Rv0820 -0.9 -2.2 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv3766 -0.9 -2.3 Hypothetical protein compare
Rv2583c -0.9 -2.1 Probable GTP pyrophosphokinase RelA (ATP:GTP 3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase) compare
Rv0758 -0.9 -2.0 Possible two component system response sensor kinase membrane associated PhoR compare
Rv0436c -0.8 -1.1 Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase) compare
Rv1821 -0.8 -2.7 Possible preprotein translocase ATPase SecA2 compare
Rv3004 -0.8 -1.2 Low molecular weight protein antigen 6 (CFP-6) compare
Rv3433c -0.8 -1.7 Conserved protein compare
Rv2170 -0.8 -1.1 GCN5-related N-acetyltransferase compare
Rv0376c -0.8 -2.2 Conserved hypothetical protein compare
Rv2091c -0.8 -3.2 Probable membrane protein compare
Rv0876c -0.8 -1.8 Possible conserved transmembrane protein compare
Rv0867c -0.8 -0.6 Possible resuscitation-promoting factor RpfA compare
Rv0971c -0.8 -2.0 Probable enoyl-CoA hydratase EchA7 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv0007 -0.8 -0.5 Possible conserved membrane protein compare
Rv1569 -0.8 -3.3 Probable 8-amino-7-oxononanoate synthase BioF1 (AONS) (8-amino-7-ketopelargonate synthase) (7-keto-8-amino-pelargonic acid synthetase) (7-KAP synthetase) (L-alanine--pimelyl CoA ligase) compare
Rv0241c -0.8 -2.0 Probable 3-hydroxyacyl-thioester dehydratase HtdX compare
Rv1473A -0.8 -0.8 Possible transcriptional regulatory protein compare
Rv1568 -0.8 -4.2 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA compare
Rv1823 -0.8 -4.0 Conserved protein compare
Rv3614c -0.8 -1.9 ESX-1 secretion-associated protein EspD compare
Rv0243 -0.8 -5.0 Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase) compare
Rv2650c -0.8 -0.8 Possible PhiRv2 prophage protein compare
Rv1072 -0.8 -1.2 Probable conserved transmembrane protein compare
Rv3102c -0.8 -2.2 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv0949 -0.8 -0.6 Probable ATP-dependent DNA helicase II UvrD1 compare
Rv3177 -0.8 -1.0 Possible peroxidase (non-haem peroxidase) compare
Rv0069c -0.8 -1.3 Probable L-serine dehydratase SdaA (L-serine deaminase) (SDH) (L-SD) compare
Rv1566c -0.8 -1.6 Possible Inv protein compare
Rv0361 -0.8 -0.8 Probable conserved membrane protein compare
Rv1565c -0.8 -3.5 Conserved hypothetical membrane protein compare
Rv2772c -0.8 -1.1 Probable conserved transmembrane protein compare
Rv1280c -0.7 -4.7 Probable periplasmic oligopeptide-binding lipoprotein OppA compare
Rv1825 -0.7 -2.2 Conserved protein compare
Rv1259 -0.7 -0.8 Probable uracil DNA glycosylase, UdgB compare
Rv1941 -0.7 -1.0 Probable short-chain type dehydrogenase/reductase compare
Rv0112 -0.7 -2.4 Possible GDP-mannose 4,6-dehydratase Gca (GDP-D-mannose dehydratase) compare
Rv3068c -0.7 -4.7 Probable phosphoglucomutase PgmA (glucose phosphomutase) (PGM) compare
Rv3230c -0.7 -2.2 Hypothetical oxidoreductase compare
Rv3715c -0.7 -1.1 Probable recombination protein RecR compare
Rv3338 -0.7 -0.8 Conserved hypothetical protein compare
Rv3556c -0.7 -1.6 Probable acetyl-CoA acetyltransferase FadA6 (acetoacetyl-CoA thiolase) compare
Rv3040c -0.7 -2.7 Conserved protein compare
Rv3073c -0.7 -0.8 Conserved hypothetical protein compare
Rv0836c -0.7 -2.8 Hypothetical protein compare
Rv0886 -0.7 -4.4 Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) compare
Rv0939 -0.7 -0.7 Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase compare
Rv0499 -0.7 -1.7 Conserved hypothetical protein compare
Rv3833 -0.7 -1.9 Transcriptional regulatory protein (probably AraC-family) compare
Rv2051c -0.7 -2.0 Polyprenol-monophosphomannose synthase Ppm1 compare
Rv2046 -0.7 -1.7 Probable lipoprotein LppI compare
Rv2496c -0.7 -2.4 Probable branched-chain keto acid dehydrogenase E1 component, beta subunit BkdB compare
Rv3586 -0.7 -3.1 Conserved hypothetical protein compare
Rv1025 -0.7 -0.6 Conserved protein compare
Rv2173 -0.7 -2.5 Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) compare
Rv3610c -0.7 -1.3 Membrane-bound protease FtsH (cell division protein) compare
Rv2816c -0.7 -1.4 Conserved hypothetical protein compare
Rv1331 -0.7 -2.0 Conserved hypothetical protein compare
Rv2982c -0.7 -2.8 Probable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA2 (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase) compare
Rv1589 -0.7 -4.1 Probable biotin synthetase BioB compare
Rv3270 -0.7 -0.8 Probable metal cation-transporting P-type ATPase C CtpC compare
Rv1683 -0.7 -2.4 Possible bifunctional enzyme; long-chain acyl-CoA synthase and lipase. compare
Rv3140 -0.7 -2.4 Probable acyl-CoA dehydrogenase FadE23 compare
Rv3340 -0.7 -1.8 Probable O-acetylhomoserine sulfhydrylase MetC (homocysteine synthase) (O-acetylhomoserine (thiol)-lyase) (OAH sulfhydrylase) (O-acetyl-L-homoserine sulfhydrylase) compare
Rv3637 -0.7 -1.3 Possible transposase compare
Rv2240c -0.7 -1.0 Unknown protein compare
Rv2222c -0.7 -1.6 Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) compare
Rv1459c -0.7 -0.9 Possible conserved integral membrane protein compare
Rv3569c -0.6 -1.1 4,9-DHSA hydrolase compare
Rv3631 -0.6 -0.5 Possible transferase (possibly glycosyltransferase) compare
Rv2224c -0.6 -4.6 Probable carboxylesterase CaeA compare
Rv0805 -0.6 -0.6 Class III cyclic nucleotide phosphodiesterase (cNMP PDE) compare
Rv0757 -0.6 -0.9 Possible two component system response transcriptional positive regulator PhoP compare
Rv2232 -0.6 -1.6 Protein tyrosine kinase transcriptional regulatory protein PtkA compare
Rv2324 -0.6 -2.2 Probable transcriptional regulatory protein (probably AsnC-family) compare
Rv3527 -0.6 -1.0 Hypothetical protein compare
Rv3540c -0.6 -1.8 Probable lipid transfer protein or keto acyl-CoA thiolase Ltp2 compare
Rv0530A -0.6 -2.9 Conserved protein compare
Rv1570 -0.6 -1.5 Dethiobiotin synthetase BioD compare
Rv0672 -0.6 -2.8 Probable acyl-CoA dehydrogenase FadE8 compare
Rv0208c -0.6 -2.7 Hypothetical methlytransferase (methylase) compare
Rv1006 -0.6 -2.4 Unknown protein compare
Rv3563 -0.6 -1.2 Probable acyl-CoA dehydrogenase FadE32 compare
Rv0328 -0.6 -0.7 Possible transcriptional regulatory protein (possibly TetR/AcrR-family) compare
Rv3481c -0.6 -0.8 Probable integral membrane protein compare
Rv3249c -0.6 -0.7 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv0028 -0.6 -2.1 Conserved hypothetical protein compare
Rv2829c -0.6 -1.2 Possible toxin VapC22 compare
Rv1281c -0.6 -1.8 Probable oligopeptide-transport ATP-binding protein ABC transporter OppD compare
Rv2249c -0.6 -1.5 Probable glycerol-3-phosphate dehydrogenase GlpD1 compare
Rv0885 -0.6 -2.4 Conserved hypothetical protein compare
Rv2497c -0.6 -2.3 Probable branched-chain keto acid dehydrogenase E1 component, alpha subunit BkdA compare
Rv2154c -0.6 -1.4 FtsW-like protein FtsW compare
Rv2851c -0.6 -2.9 GCN5-related N-acetyltransferase compare
Rv1272c -0.6 -3.1 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv2237A -0.6 -0.5 Conserved protein compare
Rv2331A -0.6 -0.7 Hypothetical protein compare
Rv1581c -0.6 -1.2 Probable PhiRv1 phage protein compare
Rv3584 -0.6 -1.3 Possible conserved lipoprotein LpqE compare
Rv3286c -0.5 -1.3 Alternative RNA polymerase sigma factor SigF compare
Rv2581c -0.5 -0.4 Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II) compare
Rv2862A -0.5 -1.6 Possible antitoxin VapB23 compare
Rv0030 -0.5 -1.0 Conserved hypothetical protein compare
Rv3005c -0.5 -3.8 Conserved hypothetical protein compare
Rv1895 -0.5 -1.2 Possible dehydrogenase compare
Rv0204c -0.5 -2.0 Probable conserved transmembrane protein compare
Rv3770B -0.5 -1.0 Probable remnant of a transposase compare
Rv2216 -0.5 -2.3 Conserved protein compare
Rv3448 -0.5 -2.1 ESX conserved component EccD4. ESX-4 type VII secretion system protein. Probable integral membrane protein. compare
Rv0893c -0.5 -1.1 Possible S-adenosylmethionine-dependent methyltransferase compare
Rv0501 -0.5 -2.1 Possible UDP-glucose 4-epimerase GalE2 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridine diphospho-galactose 4-epimerase) compare
Rv1963c -0.5 -0.8 Probable transcriptional repressor (probably TetR-family) Mce3R compare
Rv0003 -0.5 -2.0 DNA replication and repair protein RecF (single-strand DNA binding protein) compare
Rv0769 -0.5 -2.3 Probable dehydrogenase/reductase compare
Rv3291c -0.5 -2.1 Probable transcriptional regulatory protein LrpA (Lrp/AsnC-family) compare
Rv3666c -0.5 -2.1 Probable periplasmic dipeptide-binding lipoprotein DppA compare
Rv3842c -0.5 -2.4 Probable glycerophosphoryl diester phosphodiesterase GlpQ1 (glycerophosphodiester phosphodiesterase) compare
Rv3376 -0.5 -2.5 Conserved hypothetical protein compare
Rv1946c -0.5 -1.1 Possible lipoprotein compare
Rv2798c -0.5 -1.3 Conserved hypothetical protein compare
Rv3647c -0.5 -0.5 Conserved hypothetical protein compare
Rv1215c -0.5 -2.4 Conserved protein compare
Rv3856c -0.5 -1.2 Conserved hypothetical protein compare
Rv2342 -0.5 -2.1 Conserved hypothetical protein compare
Rv1931c -0.5 -1.6 Probable transcriptional regulatory protein compare
Rv2148c -0.5 -1.1 Conserved protein compare
Rv2694c -0.5 -2.0 Conserved protein compare
Rv1140 -0.5 -1.0 Probable integral membrane protein compare
Rv0531 -0.5 -0.7 Possible conserved membrane protein compare
Rv2321c -0.5 -0.8 Probable ornithine aminotransferase (C-terminus part) RocD2 (ornithine--oxo-acid aminotransferase) compare
Rv3062 -0.5 -1.6 Probable ATP-dependent DNA ligase LigB (polydeoxyribonucleotide synthase [ATP]) (polynucleotide ligase [ATP]) (sealase) (DNA repair protein) (DNA joinase) compare
Rv1109c -0.5 -1.4 Conserved protein compare
Rv2230c -0.5 -0.6 Conserved protein compare
Rv1657 -0.5 -1.0 Probable arginine repressor ArgR (AHRC) compare
Rv0622 -0.5 -0.9 Possible membrane protein compare


Specific Phenotypes

For 2 genes in this experiment

For carbon source D-Trehalose dihydrate in Mycobacterium tuberculosis H37Rv

For carbon source D-Trehalose dihydrate across organisms