Experiment set2S607 for Mycobacterium tuberculosis H37Rv

Compare to:

D-Trehalose dihydrate 10 mM carbon source

200 most detrimental genes:

  gene name fitness t score description  
Rv1957 +1.7 2.1 Hypothetical protein compare
Rv2647 +1.4 2.5 Hypothetical protein compare
Rv0545c +1.3 5.3 Probable low-affinity inorganic phosphate transporter integral membrane protein PitA compare
Rv3777 +1.2 6.4 Probable oxidoreductase compare
Rv3920c +1.2 1.4 Conserved protein similar to jag protein compare
Rv2929 +1.1 3.6 Hypothetical protein compare
Rv2940c +1.1 10.0 Probable multifunctional mycocerosic acid synthase membrane-associated Mas compare
Rv0561c +1.1 2.3 Possible oxidoreductase compare
Rv1284 +1.1 1.1 Beta-carbonic anhydrase compare
Rv2939 +1.1 9.6 Possible conserved polyketide synthase associated protein PapA5 compare
Rv3486 +1.1 2.9 Conserved protein compare
Rv2975c +1.1 1.3 Conserved hypothetical protein compare
Rv2043c +1.1 2.6 Pyrazinamidase/nicotinamidase PncA (PZase) compare
Rv0642c +1.0 1.1 Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase) compare
Rv2941 +1.0 8.5 Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) compare
Rv3085 +1.0 1.2 Probable short-chain type dehydrogenase/reductase compare
Rv2935 +1.0 8.4 Phenolpthiocerol synthesis type-I polyketide synthase PpsE compare
Rv3771c +1.0 1.1 Conserved hypothetical protein compare
Rv3405c +1.0 1.9 Possible transcriptional regulatory protein compare
Rv1751 +1.0 2.9 Probable oxidoreductase compare
Rv1791 +0.9 1.8 PE family protein PE19 compare
Rv2932 +0.9 7.2 Phenolpthiocerol synthesis type-I polyketide synthase PpsB compare
Rv2930 +0.9 8.4 Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) compare
Rv1422 +0.9 1.6 Conserved hypothetical protein compare
Rv0544c +0.9 1.8 Possible conserved transmembrane protein compare
Rv2931 +0.9 8.0 Phenolpthiocerol synthesis type-I polyketide synthase PpsA compare
Rv0695 +0.9 4.1 Conserved hypothetical protein compare
Rv1577c +0.9 0.9 Probable PhiRv1 phage protein compare
Rv3885c +0.9 2.8 ESX conserved component EccE2. ESX-2 type VII secretion system protein. Possible membrane protein. compare
Rv2933 +0.9 7.3 Phenolpthiocerol synthesis type-I polyketide synthase PpsC compare
Rv3377c +0.9 6.9 Halimadienyl diphosphate synthase compare
Rv0135c +0.9 3.9 Possible transcriptional regulatory protein compare
Rv0725c +0.9 2.3 Conserved hypothetical protein compare
Rv3171c +0.9 1.2 Possible non-heme haloperoxidase Hpx compare
Rv3346c +0.9 1.5 Conserved transmembrane protein compare
Rv1278 +0.8 2.8 Hypothetical protein compare
Rv2292c +0.8 1.0 Hypothetical protein compare
Rv0857 +0.8 1.5 Conserved hypothetical protein compare
Rv0009 +0.8 0.8 Probable iron-regulated peptidyl-prolyl cis-trans isomerase A PpiA (PPIase A) (rotamase A) compare
Rv2867c +0.8 4.0 GCN5-related N-acetyltransferase compare
Rv0892 +0.8 2.1 Probable monooxygenase compare
Rv3848 +0.8 1.7 Probable conserved transmembrane protein compare
Rv0738 +0.7 1.2 Conserved protein compare
Rv0078 +0.7 1.8 Probable transcriptional regulatory protein compare
Rv2934 +0.7 6.1 Phenolpthiocerol synthesis type-I polyketide synthase PpsD compare
Rv1259 +0.7 1.3 Probable uracil DNA glycosylase, UdgB compare
Rv2231A +0.7 2.3 Possible toxin VapC16 compare
Rv3198c +0.7 1.0 Probable ATP-dependent DNA helicase II UvrD2 compare
Rv2581c +0.7 0.9 Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II) compare
Rv3305c +0.7 1.7 Possible N-acyl-L-amino acid amidohydrolase AmiA1 (N-acyl-L-amino acid aminohydrolase) compare
Rv2428 +0.7 0.8 Alkyl hydroperoxide reductase C protein AhpC (alkyl hydroperoxidase C) compare
Rv0250c +0.7 1.8 Conserved protein compare
Rv0093c +0.7 1.1 Probable conserved membrane protein compare
Rv2702 +0.7 0.7 Polyphosphate glucokinase PpgK (polyphosphate-glucose phosphotransferase) compare
Rv1669 +0.7 2.1 Hypothetical protein compare
Rv3716c +0.7 0.5 Conserved protein compare
Rv1210 +0.7 3.6 Probable DNA-3-methyladenine glycosylase I TagA (tag I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine glycosidase I) compare
Rv2468A +0.7 2.0 Conserved protein compare
Rv1055 +0.7 1.0 Possible integrase (fragment) compare
Rv3386 +0.7 1.1 Possible transposase compare
Rv0889c +0.6 3.3 Probable citrate synthase II CitA compare
Rv3188 +0.6 1.6 Conserved hypothetical protein compare
Rv1665 +0.6 1.5 Chalcone synthase Pks11 compare
Rv3565 +0.6 1.0 Possible aspartate aminotransferase AspB (transaminase A) (ASPAT) (glutamic--oxaloacetic transaminase) (glutamic--aspartic transaminase) compare
Rv3073c +0.6 0.8 Conserved hypothetical protein compare
Rv2319c +0.6 2.1 Universal stress protein family protein compare
Rv2976c +0.6 0.7 Probable uracil-DNA glycosylase Ung (UDG) compare
Rv1108c +0.6 2.9 Probable exodeoxyribonuclease VII (large subunit) XseA (exonuclease VII large subunit) compare
Rv1421 +0.6 2.7 Conserved protein compare
Rv1929c +0.6 2.1 Conserved hypothetical protein compare
Rv2750 +0.6 1.6 Probable dehydrogenase compare
Rv3431c +0.6 4.3 Possible transposase (fragment) compare
Rv2506 +0.6 2.5 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv2739c +0.6 1.5 Possible alanine rich transferase compare
Rv0598c +0.6 1.9 Possible toxin VapC27. Contains PIN domain. compare
Rv1350 +0.6 0.6 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) compare
Rv2752c +0.6 2.1 Conserved hypothetical protein compare
Rv2558 +0.6 1.8 Conserved protein compare
Rv0916c +0.6 1.0 PE family protein PE7 compare
Rv3697c +0.6 2.4 Possible toxin VapC48. Contains PIN domain. compare
Rv3176c +0.6 2.0 Probable epoxide hydrolase MesT (epoxide hydratase) (arene-oxide hydratase) compare
Rv3719 +0.6 3.5 Conserved protein compare
Rv0070c +0.6 1.0 Serine hydroxymethyltransferase GlyA2 (serine methylase 2) (SHMT 2) compare
Rv0234c +0.6 2.0 Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 compare
Rv2898c +0.6 0.6 Conserved hypothetical protein compare
Rv0554 +0.6 4.7 Possible peroxidase BpoC (non-haem peroxidase) compare
Rv0905 +0.6 1.3 Possible enoyl-CoA hydratase EchA6 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv0468 +0.6 0.9 3-hydroxybutyryl-CoA dehydrogenase FadB2 (beta-hydroxybutyryl-CoA dehydrogenase) (BHBD) compare
Rv2721c +0.6 4.1 Possible conserved transmembrane alanine and glycine rich protein compare
Rv0199 +0.6 2.3 Probable conserved membrane protein compare
Rv0841 +0.6 1.1 Probable conserved transmembrane protein compare
Rv2335 +0.6 1.2 Probable serine acetyltransferase CysE (sat) compare
Rv1717 +0.6 0.8 Conserved hypothetical protein compare
Rv2681 +0.6 3.2 Conserved hypothetical alanine rich protein compare
Rv0762c +0.6 2.3 Conserved hypothetical protein compare
Rv0773c +0.6 1.3 Probable bifunctional acylase GgtA: cephalosporin acylase (GL-7ACA acylase) + gamma-glutamyltranspeptidase (GGT) compare
Rv3825c +0.6 4.8 Polyketide synthase Pks2 compare
Rv1614 +0.5 2.0 Possible prolipoprotein diacylglyceryl transferases Lgt compare
Rv1286 +0.5 1.8 Probable bifunctional enzyme CysN/CysC: sulfate adenyltransferase (subunit 1) + adenylylsulfate kinase compare
Rv2026c +0.5 0.7 Universal stress protein family protein compare
Rv1914c +0.5 1.4 Unknown protein compare
Rv0201c +0.5 0.9 Conserved protein compare
Rv0117 +0.5 2.6 Oxidative stress response regulatory protein OxyS compare
Rv0356c +0.5 2.0 Conserved protein compare
Rv2876 +0.5 0.5 Possible conserved transmembrane protein compare
Rv3720 +0.5 3.2 Possible fatty acid synthase compare
Rv1773c +0.5 1.3 Probable transcriptional regulatory protein compare
Rv1364c +0.5 2.0 Possible sigma factor regulatory protein compare
Rv3334 +0.5 1.7 Probable transcriptional regulatory protein (probably MerR-family) compare
Rv0680c +0.5 1.2 Probable conserved transmembrane protein compare
Rv3826 +0.5 3.4 Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) compare
Rv2417c +0.5 1.0 Conserved protein compare
Rv3559c +0.5 0.9 Probable oxidoreductase compare
Rv0084 +0.5 0.9 Possible formate hydrogenlyase HycD (FHL) compare
Rv1168c +0.5 2.6 PPE family protein PPE17 compare
Rv1035c +0.5 0.7 Probable transposase (fragment) compare
Rv1366A +0.5 0.6 Conserved protein compare
Rv3207c +0.5 1.5 Conserved protein compare
Rv0675 +0.5 0.4 Probable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv1955 +0.5 2.0 Possible toxin HigB compare
Rv2657c +0.5 0.8 Probable PhiRv2 prophage protein compare
Rv3076 +0.5 1.1 Conserved hypothetical protein compare
Rv0174 +0.5 3.2 Mce-family protein Mce1F compare
Rv0608 +0.5 0.9 Possible antitoxin VapB28 compare
Rv1994c +0.5 1.9 Metal sensor transcriptional regulator CmtR (ArsR-SmtB family) compare
Rv3419c +0.5 0.9 Probable O-sialoglycoprotein endopeptidase Gcp (glycoprotease) compare
Rv2745c +0.5 1.1 Transcriptional regulatory protein ClgR compare
Rv0396 +0.5 1.6 Hypothetical protein compare
Rv0065 +0.5 1.0 Possible toxin VapC1 compare
Rv1897c +0.5 0.8 Conserved hypothetical protein compare
Rv0309 +0.5 2.5 Possible conserved exported protein compare
Rv0933 +0.5 1.0 Phosphate-transport ATP-binding protein ABC transporter PstB compare
Rv2731 +0.5 2.3 Conserved alanine and arginine rich protein compare
Rv0786c +0.5 2.1 Conserved protein compare
Rv3162c +0.5 0.6 Possible integral membrane protein compare
Rv0118c +0.5 2.0 Probable oxalyl-CoA decarboxylase OxcA compare
Rv3145 +0.5 2.4 Probable NADH dehydrogenase I (chain A) NuoA (NADH-ubiquinone oxidoreductase chain A) compare
Rv0321 +0.5 1.4 Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase) compare
Rv3830c +0.5 0.7 Transcriptional regulatory protein (probably TetR-family) compare
Rv2621c +0.5 0.6 Possible transcriptional regulatory protein compare
Rv3702c +0.5 2.2 Conserved hypothetical protein compare
Rv1137c +0.5 1.7 Hypothetical protein compare
Rv2967c +0.5 2.6 Probable pyruvate carboxylase Pca (pyruvic carboxylase) compare
Rv0295c +0.5 1.6 Conserved protein compare
Rv0968 +0.5 1.5 Conserved protein compare
Rv2023A +0.5 1.9 Hypothetical protein, pseudogene compare
Rv0564c +0.5 1.1 Probable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA1 (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase) (NAD(P)H-dependent dihydroxyacetone-phosphate reductase) compare
Rv0870c +0.5 0.8 Possible conserved integral membrane protein compare
Rv0470c +0.4 1.6 Mycolic acid synthase PcaA (cyclopropane synthase) compare
Rv2042c +0.4 1.2 Conserved protein compare
Rv3416 +0.4 1.4 Transcriptional regulatory protein WhiB-like WhiB3. Contains [4FE-4S] cluster. compare
Rv2616 +0.4 1.8 Conserved protein compare
Rv1049 +0.4 0.9 Probable transcriptional repressor protein compare
Rv3149 +0.4 2.4 Probable NADH dehydrogenase I (chain E) NuoE (NADH-ubiquinone oxidoreductase chain E) compare
Rv3331 +0.4 1.3 Probable sugar-transport integral membrane protein SugI compare
Rv3820c +0.4 3.6 Possible conserved polyketide synthase associated protein PapA2 compare
Rv2819c +0.4 1.7 Hypothetical protein compare
Rv0424c +0.4 2.4 Hypothetical protein compare
Rv3174 +0.4 0.8 Probable short-chain dehydrogenase/reductase compare
Rv3824c +0.4 2.7 Conserved polyketide synthase associated protein PapA1 compare
Rv3890c +0.4 2.6 ESAT-6 like protein EsxC (ESAT-6 like protein 11) compare
Rv1998c +0.4 1.4 Conserved protein compare
Rv3663c +0.4 0.6 Probable dipeptide-transport ATP-binding protein ABC transporter DppD compare
Rv2432c +0.4 0.7 Hypothetical protein compare
Rv3706c +0.4 0.9 Conserved hypothetical proline rich protein compare
Rv1180 +0.4 1.2 Probable polyketide beta-ketoacyl synthase Pks3 compare
Rv3022A +0.4 1.9 PE family protein PE29 compare
Rv3643 +0.4 0.6 Hypothetical protein compare
Rv1678 +0.4 1.2 Probable integral membrane protein compare
Rv3263 +0.4 3.0 Probable DNA methylase (modification methylase) (methyltransferase) compare
Rv0353 +0.4 0.9 Probable heat shock protein transcriptional repressor HspR (MerR family) compare
Rv1578c +0.4 0.3 Probable PhiRv1 phage protein compare
Rv0270 +0.4 2.0 Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv0590 +0.4 1.3 Mce-family protein Mce2B compare
Rv2378c +0.4 1.2 Lysine-N-oxygenase MbtG (L-lysine 6-monooxygenase) (lysine N6-hydroxylase) compare
Rv2598 +0.4 1.2 Conserved hypothetical protein compare
Rv0566c +0.4 1.8 Conserved protein compare
Rv0614 +0.4 1.8 Conserved hypothetical protein compare
Rv2544 +0.4 1.3 Probable conserved lipoprotein LppB compare
Rv2991 +0.4 1.2 Conserved protein compare
Rv3133c +0.4 1.1 Two component transcriptional regulatory protein DevR (probably LuxR/UhpA-family) compare
Rv2857c +0.4 1.7 Probable short-chain type dehydrogenase/reductase compare
Rv0310c +0.4 0.8 Conserved protein compare
Rv1724c +0.4 1.5 Hypothetical protein compare
Rv0099 +0.4 1.1 Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv2270 +0.4 0.8 Probable lipoprotein LppN compare
Rv3533c +0.4 2.1 PPE family protein PPE62 compare
Rv1679 +0.4 0.6 Possible acyl-CoA dehydrogenase FadE16 compare
Rv0606 +0.4 0.9 Possible transposase (fragment) compare
Rv3631 +0.4 0.4 Possible transferase (possibly glycosyltransferase) compare
Rv3099c +0.4 1.4 Conserved protein compare
Rv1694 +0.4 0.9 2'-O-methyltransferase TlyA compare
Rv2084 +0.4 3.0 Hypothetical protein compare
Rv3705A +0.4 1.9 Conserved hypothetical proline rich protein compare
Rv2137c +0.4 1.2 Conserved hypothetical protein compare
Rv3564 +0.4 1.3 Probable acyl-CoA dehydrogenase FadE33 compare
Rv3364c +0.4 0.6 Conserved protein compare
Rv0311 +0.4 1.1 Unknown protein compare
Rv3397c +0.4 2.0 Probable phytoene synthase PhyA compare
Rv3647c +0.4 0.5 Conserved hypothetical protein compare


Specific Phenotypes

For 1 genes in this experiment

For carbon source D-Trehalose dihydrate in Mycobacterium tuberculosis H37Rv

For carbon source D-Trehalose dihydrate across organisms