Experiment set2S604 for Mycobacterium tuberculosis H37Rv

200 most important genes:

gene	name	fitness	t score	description
Rv1291c		-2.9	-2.1	Conserved hypothetical secreted protein
Rv1127c		-2.9	-2.2	Probable pyruvate, phosphate dikinase PpdK
Rv0929		-2.7	-3.7	Phosphate-transport integral membrane ABC transporter PstC2
Rv1872c		-2.4	-7.2	Possible L-lactate dehydrogenase (cytochrome) LldD2	conserved
Rv3101c		-2.1	-2.6	Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter)
Rv1010		-2.0	-1.8	Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase)
Rv1908c		-1.9	-3.6	Catalase-peroxidase-peroxynitritase T KatG
Rv0758		-1.9	-3.8	Possible two component system response sensor kinase membrane associated PhoR
Rv2047c		-1.8	-7.7	Conserved hypothetical protein
Rv0241c		-1.8	-4.0	Probable 3-hydroxyacyl-thioester dehydratase HtdX
Rv0242c		-1.7	-3.5	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase)
Rv2702		-1.7	-0.9	Polyphosphate glucokinase PpgK (polyphosphate-glucose phosphotransferase)
Rv3400		-1.7	-8.1	Probable hydrolase
Rv3102c		-1.7	-3.3	Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter)
Rv0007		-1.6	-0.9	Possible conserved membrane protein
Rv0247c		-1.6	-0.9	Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase)
Rv3270		-1.5	-1.9	Probable metal cation-transporting P-type ATPase C CtpC
Rv1284		-1.5	-0.8	Beta-carbonic anhydrase
Rv0825c		-1.5	-2.5	Conserved protein
Rv1410c		-1.5	-7.3	Aminoglycosides/tetracycline-transport integral membrane protein
Rv3810		-1.5	-2.6	Exported repetitive protein precursor PirG (cell surface protein) (EXP53)
Rv2476c		-1.5	-4.2	Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase)
Rv2048c		-1.5	-5.5	Polyketide synthase Pks12
Rv0928		-1.5	-3.3	Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1)
Rv2869c		-1.4	-2.1	Membrane bound metalloprotease
Rv0930		-1.4	-7.9	Probable phosphate-transport integral membrane ABC transporter PstA1
Rv1159		-1.3	-1.8	Mannosyltransferase PimE
Rv3919c		-1.3	-2.7	Probable glucose-inhibited division protein B Gid
Rv0820		-1.3	-4.5	Probable phosphate-transport ATP-binding protein ABC transporter PhoT
Rv3816c		-1.3	-1.1	Possible acyltransferase
Rv0867c		-1.3	-0.9	Possible resuscitation-promoting factor RpfA
Rv3208A		-1.3	-1.6	Conserved protein TB9.4
Rv0129c		-1.3	-5.9	Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C)
Rv2003c		-1.3	-1.6	Conserved hypothetical protein
Rv3066		-1.3	-4.4	Probable transcriptional regulatory protein (probably DeoR-family)
Rv0819		-1.3	-3.3	GCN5-related N-acetyltransferase, MshD
Rv2982c		-1.3	-4.2	Probable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA2 (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase)
Rv0504c		-1.2	-1.7	Conserved protein
Rv1590		-1.2	-3.2	Conserved hypothetical protein
Rv1570		-1.2	-1.4	Dethiobiotin synthetase BioD
Rv1798		-1.2	-0.9	ESX conserved component EccA5. ESX-5 type VII secretion system protein.
Rv0323c		-1.2	-1.7	Conserved hypothetical protein
Rv1589		-1.2	-7.2	Probable biotin synthetase BioB
Rv0472c		-1.2	-3.2	Probable transcriptional regulatory protein (possibly TetR-family)
Rv3045		-1.2	-3.5	Probable NADP-dependent alcohol dehydrogenase AdhC
Rv2661c		-1.1	-1.4	Hypothetical protein
Rv2606c		-1.1	-4.5	Possible pyridoxine biosynthesis protein SnzP
Rv3230c		-1.1	-3.3	Hypothetical oxidoreductase
Rv1350		-1.1	-1.1	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase)
Rv0497		-1.1	-1.2	Probable conserved transmembrane protein
Rv1273c		-1.1	-5.3	Probable drugs-transport transmembrane ATP-binding protein ABC transporter
Rv1411c		-1.1	-2.4	Conserved lipoprotein LprG
Rv3819		-1.1	-0.9	Unknown protein
Rv3046c		-1.0	-0.8	Conserved protein
Rv0954		-1.0	-4.2	Probable conserved transmembrane protein
Rv0202c		-1.0	-4.6	Probable conserved transmembrane transport protein MmpL11
Rv2173		-1.0	-4.4	Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase)
Rv3005c		-1.0	-5.7	Conserved hypothetical protein
Rv2154c		-1.0	-1.4	FtsW-like protein FtsW
Rv0040c		-1.0	-4.6	Secreted proline rich protein Mtc28 (proline rich 28 kDa antigen)
Rv0009		-1.0	-0.7	Probable iron-regulated peptidyl-prolyl cis-trans isomerase A PpiA (PPIase A) (rotamase A)
Rv1829		-1.0	-3.7	Conserved protein
Rv1963c		-1.0	-1.3	Probable transcriptional repressor (probably TetR-family) Mce3R
Rv3140		-1.0	-2.6	Probable acyl-CoA dehydrogenase FadE23
Rv3413c		-1.0	-1.2	Unknown alanine and proline rich protein
Rv1568		-0.9	-5.5	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA
Rv1620c		-0.9	-2.7	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC
Rv3229c		-0.9	-1.7	Possible linoleoyl-CoA desaturase (delta(6)-desaturase)
Rv0886		-0.9	-5.2	Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase)
Rv2007c		-0.9	-1.0	Ferredoxin FdxA
Rv0243		-0.9	-3.9	Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase)
Rv2170		-0.9	-1.2	GCN5-related N-acetyltransferase
Rv1693		-0.9	-1.1	Conserved hypothetical protein
Rv2798c		-0.9	-2.1	Conserved hypothetical protein
Rv1745c		-0.9	-2.7	Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase)
Rv3668c		-0.9	-2.4	Possible protease
Rv2044c		-0.9	-0.7	Conserved hypothetical protein
Rv2001		-0.8	-0.8	Conserved hypothetical protein
Rv3249c		-0.8	-0.7	Possible transcriptional regulatory protein (probably TetR-family)
Rv1565c		-0.8	-4.4	Conserved hypothetical membrane protein
Rv3131		-0.8	-1.1	Conserved protein
Rv2237A		-0.8	-0.7	Conserved protein
Rv2317		-0.8	-0.9	Probable sugar-transport integral membrane protein ABC transporter UspB
Rv1621c		-0.8	-1.6	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD
Rv0971c		-0.8	-2.6	Probable enoyl-CoA hydratase EchA7 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv2736c		-0.8	-1.1	Regulatory protein RecX
Rv3182		-0.8	-0.7	Conserved hypothetical protein
Rv3766		-0.8	-3.2	Hypothetical protein
Rv0204c		-0.8	-2.3	Probable conserved transmembrane protein
Rv0999		-0.8	-1.6	Unknown protein
Rv1324		-0.8	-1.1	Possible thioredoxin
Rv3803c		-0.8	-3.5	Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) (85C)
Rv0050		-0.8	-2.5	Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase)
Rv3405c		-0.8	-0.9	Possible transcriptional regulatory protein
Rv0361		-0.7	-0.8	Probable conserved membrane protein
Rv3139		-0.7	-3.0	Probable acyl-CoA dehydrogenase FadE24
Rv3136		-0.7	-3.5	PPE family protein PPE51
Rv3513c		-0.7	-0.9	Probable fatty-acid-CoA ligase FadD18 (fragment) (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Rv3672c		-0.7	-1.0	Conserved hypothetical protein
Rv2148c		-0.7	-1.6	Conserved protein
Rv1272c		-0.7	-3.2	Probable drugs-transport transmembrane ATP-binding protein ABC transporter
Rv0658c		-0.7	-1.2	Probable conserved integral membrane protein
Rv2331A		-0.7	-0.8	Hypothetical protein
Rv0769		-0.7	-2.2	Probable dehydrogenase/reductase
Rv3428c		-0.7	-0.7	Possible transposase
Rv2588c		-0.7	-1.3	Probable conserved membrane protein secretion factor YajC
Rv0782		-0.7	-1.1	Probable protease II PtrBb [second part] (oligopeptidase B)
Rv1107c		-0.7	-0.9	Probable exodeoxyribonuclease VII (small subunit) XseB (exonuclease VII small subunit)
Rv0088		-0.7	-0.7	Possible polyketide cyclase/dehydrase
Rv1531		-0.7	-0.7	Conserved protein
Rv1823		-0.7	-3.2	Conserved protein
Rv0994		-0.7	-3.8	Probable molybdopterin biosynthesis protein MoeA1
Rv2497c		-0.7	-3.4	Probable branched-chain keto acid dehydrogenase E1 component, alpha subunit BkdA
Rv3586		-0.7	-2.1	Conserved hypothetical protein
Rv0437c		-0.7	-0.6	Possible phosphatidylserine decarboxylase Psd (PS decarboxylase)
Rv0876c		-0.7	-2.2	Possible conserved transmembrane protein
Rv3217c		-0.7	-1.9	Probable conserved integral membrane protein
Rv3691		-0.7	-0.7	Conserved protein
Rv1692		-0.7	-2.6	Probable phosphatase
Rv2850c		-0.7	-0.6	Possible magnesium chelatase
Rv0274		-0.7	-2.0	Conserved protein
Rv0984		-0.7	-1.7	Possible pterin-4-alpha-carbinolamine dehydratase MoaB2 (PHS) (4-alpha-hydroxy-tetrahydropterin dehydratase) (pterin-4-a-carbinolamine dehydratase) (phenylalanine hydroxylase-stimulating protein) (PHS) (pterin carbinolamine dehydratase) (PCD)
Rv2732c		-0.7	-1.8	Probable conserved transmembrane protein
Rv1930c		-0.7	-0.5	Conserved hypothetical protein
Rv1935c		-0.7	-1.8	Possible enoyl-CoA hydratase EchA13 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv0280		-0.6	-4.1	PPE family protein PPE3
Rv1683		-0.6	-2.8	Possible bifunctional enzyme; long-chain acyl-CoA synthase and lipase.
Rv0220		-0.6	-1.9	Probable esterase LipC
Rv3305c		-0.6	-0.8	Possible N-acyl-L-amino acid amidohydrolase AmiA1 (N-acyl-L-amino acid aminohydrolase)
Rv0367c		-0.6	-0.4	Hypothetical protein
Rv1242		-0.6	-1.9	Possible toxin VapC33. Contains PIN domain.
Rv1234		-0.6	-1.6	Probable transmembrane protein
Rv2583c		-0.6	-1.6	Probable GTP pyrophosphokinase RelA (ATP:GTP 3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase)
Rv0313		-0.6	-0.8	Conserved protein
Rv0610c		-0.6	-0.6	Hypothetical protein
Rv3134c		-0.6	-2.2	Universal stress protein family protein
Rv3542c		-0.6	-1.7	Conserved hypothetical protein
Rv3477		-0.6	-0.9	PE family protein PE31
Rv2650c		-0.6	-0.7	Possible PhiRv2 prophage protein
Rv2091c		-0.6	-2.2	Probable membrane protein
Rv1598c		-0.6	-1.7	Conserved protein
Rv2018		-0.6	-2.3	Conserved protein
Rv3311		-0.6	-1.9	Conserved protein
Rv0113		-0.6	-1.0	Probable sedoheptulose-7-phosphate isomerase GmhA (phosphoheptose isomerase)
Rv3267		-0.6	-1.0	Conserved protein (CPSA-related protein)
Rv3553		-0.6	-1.2	Possible oxidoreductase
Rv3367		-0.6	-2.3	PE-PGRS family protein PE_PGRS51
Rv3706c		-0.6	-1.7	Conserved hypothetical proline rich protein
Rv3286c		-0.6	-1.7	Alternative RNA polymerase sigma factor SigF
Rv1834		-0.6	-2.7	Probable hydrolase
Rv3192		-0.6	-2.8	Conserved hypothetical alanine and proline-rich protein
Rv0665		-0.6	-1.4	Possible toxin VapC8
Rv3315c		-0.6	-2.3	Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase)
Rv2046		-0.6	-1.3	Probable lipoprotein LppI
Rv0502		-0.6	-3.0	Conserved protein
Rv3897c		-0.6	-0.6	Conserved hypothetical protein
Rv2813		-0.6	-1.8	Conserved hypothetical protein
Rv0677c		-0.6	-0.8	Possible conserved membrane protein MmpS5
Rv3768		-0.6	-1.0	Unknown protein
Rv1766		-0.6	-1.4	Conserved protein
Rv3614c		-0.6	-1.6	ESX-1 secretion-associated protein EspD
Rv2224c		-0.6	-4.6	Probable carboxylesterase CaeA
Rv2206		-0.6	-1.4	Probable conserved transmembrane protein
Rv1269c		-0.6	-2.0	Conserved probable secreted protein
Rv2831		-0.6	-1.8	Probable enoyl-CoA hydratase EchA16 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv0375c		-0.6	-0.8	Probable carbon monoxyde dehydrogenase (medium chain)
Rv3865		-0.6	-1.7	ESX-1 secretion-associated protein EspF
Rv0912		-0.6	-1.2	Probable conserved transmembrane protein
Rv2248		-0.5	-0.9	Conserved hypothetical protein
Rv3559c		-0.5	-0.7	Probable oxidoreductase
Rv3868		-0.5	-3.5	ESX conserved component EccA1. ESX-1 type VII secretion system protein.
Rv1898		-0.5	-1.1	Conserved hypothetical protein
Rv3433c		-0.5	-0.9	Conserved protein
Rv2292c		-0.5	-0.4	Hypothetical protein
Rv3321c		-0.5	-1.5	Possible antitoxin VapB44
Rv1569		-0.5	-2.0	Probable 8-amino-7-oxononanoate synthase BioF1 (AONS) (8-amino-7-ketopelargonate synthase) (7-keto-8-amino-pelargonic acid synthetase) (7-KAP synthetase) (L-alanine--pimelyl CoA ligase)
Rv2817c		-0.5	-1.5	Conserved hypothetical protein
Rv0949		-0.5	-0.4	Probable ATP-dependent DNA helicase II UvrD1
Rv2979c		-0.5	-2.0	Probable resolvase
Rv1220c		-0.5	-2.4	Probable methyltransferase
Rv2487c		-0.5	-1.9	PE-PGRS family protein PE_PGRS42
Rv3073c		-0.5	-0.7	Conserved hypothetical protein
Rv1155		-0.5	-2.8	Possible pyridoxamine 5'-phosphate oxidase (PNP/PMP oxidase) (pyridoxinephosphate oxidase) (PNPOX) (pyridoxine 5'-phosphate oxidase)
Rv3478		-0.5	-1.6	PE family protein PPE60
Rv2708c		-0.5	-1.6	Conserved hypothetical protein
Rv1698		-0.5	-1.8	Outer membrane protein MctB
Rv3445c		-0.5	-0.7	ESAT-6 like protein EsxU
Rv1825		-0.5	-1.7	Conserved protein
Rv0672		-0.5	-2.7	Probable acyl-CoA dehydrogenase FadE8
Rv0398c		-0.5	-1.4	Possible secreted protein
Rv2709		-0.5	-2.4	Probable conserved transmembrane protein
Rv3013		-0.5	-0.6	Conserved protein
Rv3251c		-0.5	-1.6	Probable rubredoxin RubA
Rv1259		-0.5	-0.6	Probable uracil DNA glycosylase, UdgB
Rv1506c		-0.5	-1.3	Hypothetical protein
Rv1237		-0.5	-2.0	Probable sugar-transport integral membrane protein ABC transporter SugB
Rv1271c		-0.5	-1.2	Conserved hypothetical secreted protein
Rv0473		-0.5	-2.3	Possible conserved transmembrane protein
Rv1959c		-0.5	-2.5	Possible toxin ParE1
Rv0661c		-0.5	-1.1	Possible toxin VapC7

Specific Phenotypes

For 1 genes in this experiment

For carbon source Sodium L-Lactate in Mycobacterium tuberculosis H37Rv

For carbon source Sodium L-Lactate across organisms