Experiment set2S604 for Mycobacterium tuberculosis H37Rv

Compare to:

Sodium L-Lactate 10 mM carbon source

200 most important genes:

  gene name fitness t score description  
Rv1512 -3.2 -1.0 Probable nucleotide-sugar epimerase EpiA compare
Rv1291c -2.9 -2.1 Conserved hypothetical secreted protein compare
Rv1127c -2.9 -2.2 Probable pyruvate, phosphate dikinase PpdK compare
Rv0929 -2.7 -3.7 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv1872c -2.4 -7.2 Possible L-lactate dehydrogenase (cytochrome) LldD2 conserved
Rv3101c -2.1 -2.6 Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter) compare
Rv1010 -2.0 -1.8 Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase) compare
Rv0758 -1.9 -3.8 Possible two component system response sensor kinase membrane associated PhoR compare
Rv1908c -1.9 -3.6 Catalase-peroxidase-peroxynitritase T KatG compare
Rv2047c -1.8 -7.7 Conserved hypothetical protein compare
Rv0241c -1.8 -4.0 Probable 3-hydroxyacyl-thioester dehydratase HtdX compare
Rv0242c -1.7 -3.5 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase) compare
Rv2702 -1.7 -0.9 Polyphosphate glucokinase PpgK (polyphosphate-glucose phosphotransferase) compare
Rv3400 -1.7 -8.1 Probable hydrolase compare
Rv3102c -1.7 -3.3 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv0007 -1.6 -0.9 Possible conserved membrane protein compare
Rv2898c -1.6 -1.0 Conserved hypothetical protein compare
Rv0247c -1.6 -0.9 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) compare
Rv3270 -1.5 -1.9 Probable metal cation-transporting P-type ATPase C CtpC compare
Rv1284 -1.5 -0.8 Beta-carbonic anhydrase compare
Rv0825c -1.5 -2.5 Conserved protein compare
Rv1410c -1.5 -7.3 Aminoglycosides/tetracycline-transport integral membrane protein compare
Rv3810 -1.5 -2.6 Exported repetitive protein precursor PirG (cell surface protein) (EXP53) compare
Rv2048c -1.5 -5.5 Polyketide synthase Pks12 compare
Rv2476c -1.5 -4.2 Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase) compare
Rv0928 -1.4 -3.3 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv2869c -1.4 -2.1 Membrane bound metalloprotease compare
Rv0930 -1.4 -7.9 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv0820 -1.3 -4.6 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv3919c -1.3 -2.7 Probable glucose-inhibited division protein B Gid compare
Rv3816c -1.3 -1.2 Possible acyltransferase compare
Rv0867c -1.3 -0.9 Possible resuscitation-promoting factor RpfA compare
Rv1159 -1.3 -2.0 Mannosyltransferase PimE compare
Rv3208A -1.3 -1.6 Conserved protein TB9.4 compare
Rv2003c -1.3 -1.7 Conserved hypothetical protein compare
Rv0129c -1.3 -5.6 Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) compare
Rv0819 -1.3 -3.4 GCN5-related N-acetyltransferase, MshD compare
Rv2982c -1.2 -4.2 Probable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA2 (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase) compare
Rv3066 -1.2 -4.4 Probable transcriptional regulatory protein (probably DeoR-family) compare
Rv0504c -1.2 -1.8 Conserved protein compare
Rv1590 -1.2 -3.3 Conserved hypothetical protein compare
Rv1570 -1.2 -1.4 Dethiobiotin synthetase BioD compare
Rv1798 -1.2 -0.9 ESX conserved component EccA5. ESX-5 type VII secretion system protein. compare
Rv1589 -1.2 -7.2 Probable biotin synthetase BioB compare
Rv0323c -1.2 -1.7 Conserved hypothetical protein compare
Rv0472c -1.2 -3.2 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv3045 -1.2 -3.5 Probable NADP-dependent alcohol dehydrogenase AdhC compare
Rv2661c -1.1 -1.4 Hypothetical protein compare
Rv3230c -1.1 -3.3 Hypothetical oxidoreductase compare
Rv1350 -1.1 -1.1 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) compare
Rv0497 -1.1 -1.2 Probable conserved transmembrane protein compare
Rv1273c -1.1 -5.3 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv1411c -1.1 -2.4 Conserved lipoprotein LprG compare
Rv3819 -1.1 -0.9 Unknown protein compare
Rv2606c -1.1 -4.0 Possible pyridoxine biosynthesis protein SnzP compare
Rv3046c -1.0 -0.8 Conserved protein compare
Rv0954 -1.0 -4.2 Probable conserved transmembrane protein compare
Rv0202c -1.0 -4.6 Probable conserved transmembrane transport protein MmpL11 compare
Rv2173 -1.0 -4.4 Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) compare
Rv3005c -1.0 -5.6 Conserved hypothetical protein compare
Rv2154c -1.0 -1.4 FtsW-like protein FtsW compare
Rv0040c -1.0 -4.5 Secreted proline rich protein Mtc28 (proline rich 28 kDa antigen) compare
Rv0009 -1.0 -0.7 Probable iron-regulated peptidyl-prolyl cis-trans isomerase A PpiA (PPIase A) (rotamase A) compare
Rv1829 -1.0 -3.7 Conserved protein compare
Rv0886 -1.0 -5.8 Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) compare
Rv3140 -1.0 -2.7 Probable acyl-CoA dehydrogenase FadE23 compare
Rv3413c -1.0 -1.2 Unknown alanine and proline rich protein compare
Rv1963c -1.0 -1.3 Probable transcriptional repressor (probably TetR-family) Mce3R compare
Rv1568 -0.9 -5.5 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA compare
Rv1620c -0.9 -2.7 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC compare
Rv3229c -0.9 -1.7 Possible linoleoyl-CoA desaturase (delta(6)-desaturase) compare
Rv2007c -0.9 -1.0 Ferredoxin FdxA compare
Rv0243 -0.9 -3.8 Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase) compare
Rv1693 -0.9 -1.1 Conserved hypothetical protein compare
Rv2170 -0.9 -1.2 GCN5-related N-acetyltransferase compare
Rv2798c -0.9 -2.1 Conserved hypothetical protein compare
Rv1745c -0.9 -2.7 Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase) compare
Rv3668c -0.9 -2.4 Possible protease compare
Rv2044c -0.9 -0.7 Conserved hypothetical protein compare
Rv2001 -0.8 -0.8 Conserved hypothetical protein compare
Rv3249c -0.8 -0.7 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv1565c -0.8 -4.4 Conserved hypothetical membrane protein compare
Rv3131 -0.8 -1.2 Conserved protein compare
Rv2237A -0.8 -0.7 Conserved protein compare
Rv1621c -0.8 -1.6 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD compare
Rv0204c -0.8 -2.5 Probable conserved transmembrane protein compare
Rv2317 -0.8 -0.9 Probable sugar-transport integral membrane protein ABC transporter UspB compare
Rv2736c -0.8 -1.1 Regulatory protein RecX compare
Rv3182 -0.8 -0.7 Conserved hypothetical protein compare
Rv0971c -0.8 -2.4 Probable enoyl-CoA hydratase EchA7 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv0949 -0.8 -0.8 Probable ATP-dependent DNA helicase II UvrD1 compare
Rv1324 -0.8 -1.1 Possible thioredoxin compare
Rv3803c -0.8 -3.4 Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) (85C) compare
Rv2588c -0.8 -1.3 Probable conserved membrane protein secretion factor YajC compare
Rv3766 -0.8 -2.8 Hypothetical protein compare
Rv3139 -0.8 -3.1 Probable acyl-CoA dehydrogenase FadE24 compare
Rv3405c -0.8 -0.9 Possible transcriptional regulatory protein compare
Rv0050 -0.7 -2.4 Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase) compare
Rv0361 -0.7 -0.8 Probable conserved membrane protein compare
Rv3136 -0.7 -3.6 PPE family protein PPE51 compare
Rv3513c -0.7 -0.9 Probable fatty-acid-CoA ligase FadD18 (fragment) (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv3672c -0.7 -1.0 Conserved hypothetical protein compare
Rv2148c -0.7 -1.6 Conserved protein compare
Rv1272c -0.7 -3.2 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv0658c -0.7 -1.2 Probable conserved integral membrane protein compare
Rv2331A -0.7 -0.8 Hypothetical protein compare
Rv3428c -0.7 -0.7 Possible transposase compare
Rv0769 -0.7 -2.2 Probable dehydrogenase/reductase compare
Rv0782 -0.7 -1.1 Probable protease II PtrBb [second part] (oligopeptidase B) compare
Rv1107c -0.7 -0.9 Probable exodeoxyribonuclease VII (small subunit) XseB (exonuclease VII small subunit) compare
Rv2497c -0.7 -3.5 Probable branched-chain keto acid dehydrogenase E1 component, alpha subunit BkdA compare
Rv1823 -0.7 -3.2 Conserved protein compare
Rv0994 -0.7 -3.8 Probable molybdopterin biosynthesis protein MoeA1 compare
Rv0088 -0.7 -0.7 Possible polyketide cyclase/dehydrase compare
Rv0437c -0.7 -0.6 Possible phosphatidylserine decarboxylase Psd (PS decarboxylase) compare
Rv0876c -0.7 -2.2 Possible conserved transmembrane protein compare
Rv2850c -0.7 -0.6 Possible magnesium chelatase compare
Rv3217c -0.7 -1.9 Probable conserved integral membrane protein compare
Rv1692 -0.7 -2.6 Probable phosphatase compare
Rv0280 -0.7 -4.3 PPE family protein PPE3 compare
Rv3691 -0.7 -0.7 Conserved protein compare
Rv2732c -0.7 -1.8 Probable conserved transmembrane protein compare
Rv3134c -0.7 -2.4 Universal stress protein family protein compare
Rv1930c -0.7 -0.5 Conserved hypothetical protein compare
Rv0984 -0.7 -1.7 Possible pterin-4-alpha-carbinolamine dehydratase MoaB2 (PHS) (4-alpha-hydroxy-tetrahydropterin dehydratase) (pterin-4-a-carbinolamine dehydratase) (phenylalanine hydroxylase-stimulating protein) (PHS) (pterin carbinolamine dehydratase) (PCD) compare
Rv0274 -0.7 -2.0 Conserved protein compare
Rv1935c -0.7 -1.7 Possible enoyl-CoA hydratase EchA13 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv1683 -0.6 -2.9 Possible bifunctional enzyme; long-chain acyl-CoA synthase and lipase. compare
Rv1247c -0.6 -1.1 Antitoxin RelB compare
Rv3305c -0.6 -0.8 Possible N-acyl-L-amino acid amidohydrolase AmiA1 (N-acyl-L-amino acid aminohydrolase) compare
Rv0220 -0.6 -1.8 Probable esterase LipC compare
Rv0610c -0.6 -0.7 Hypothetical protein compare
Rv0367c -0.6 -0.4 Hypothetical protein compare
Rv2583c -0.6 -1.6 Probable GTP pyrophosphokinase RelA (ATP:GTP 3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase) compare
Rv1234 -0.6 -1.6 Probable transmembrane protein compare
Rv3542c -0.6 -1.7 Conserved hypothetical protein compare
Rv3586 -0.6 -1.9 Conserved hypothetical protein compare
Rv0313 -0.6 -0.8 Conserved protein compare
Rv2680 -0.6 -1.1 Conserved protein compare
Rv3477 -0.6 -0.9 PE family protein PE31 compare
Rv2650c -0.6 -0.7 Possible PhiRv2 prophage protein compare
Rv0999 -0.6 -1.2 Unknown protein compare
Rv1598c -0.6 -1.7 Conserved protein compare
Rv2091c -0.6 -2.2 Probable membrane protein compare
Rv2018 -0.6 -2.3 Conserved protein compare
Rv3311 -0.6 -1.9 Conserved protein compare
Rv3267 -0.6 -1.0 Conserved protein (CPSA-related protein) compare
Rv0113 -0.6 -1.0 Probable sedoheptulose-7-phosphate isomerase GmhA (phosphoheptose isomerase) compare
Rv3553 -0.6 -1.2 Possible oxidoreductase compare
Rv3073c -0.6 -0.5 Conserved hypothetical protein compare
Rv3706c -0.6 -1.7 Conserved hypothetical proline rich protein compare
Rv3286c -0.6 -1.7 Alternative RNA polymerase sigma factor SigF compare
Rv1834 -0.6 -2.7 Probable hydrolase compare
Rv3192 -0.6 -2.8 Conserved hypothetical alanine and proline-rich protein compare
Rv0665 -0.6 -1.4 Possible toxin VapC8 compare
Rv3315c -0.6 -2.3 Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) compare
Rv2813 -0.6 -1.8 Conserved hypothetical protein compare
Rv3897c -0.6 -0.6 Conserved hypothetical protein compare
Rv2046 -0.6 -1.3 Probable lipoprotein LppI compare
Rv0502 -0.6 -2.9 Conserved protein compare
Rv0677c -0.6 -0.8 Possible conserved membrane protein MmpS5 compare
Rv2979c -0.6 -2.1 Probable resolvase compare
Rv3768 -0.6 -1.1 Unknown protein compare
Rv1766 -0.6 -1.5 Conserved protein compare
Rv2831 -0.6 -1.8 Probable enoyl-CoA hydratase EchA16 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv2224c -0.6 -4.6 Probable carboxylesterase CaeA compare
Rv3865 -0.6 -1.7 ESX-1 secretion-associated protein EspF compare
Rv2206 -0.6 -1.3 Probable conserved transmembrane protein compare
Rv0912 -0.6 -1.2 Probable conserved transmembrane protein compare
Rv0375c -0.5 -0.8 Probable carbon monoxyde dehydrogenase (medium chain) compare
Rv2248 -0.5 -0.9 Conserved hypothetical protein compare
Rv3868 -0.5 -3.5 ESX conserved component EccA1. ESX-1 type VII secretion system protein. compare
Rv3367 -0.5 -2.1 PE-PGRS family protein PE_PGRS51 compare
Rv1898 -0.5 -1.1 Conserved hypothetical protein compare
Rv1242 -0.5 -1.5 Possible toxin VapC33. Contains PIN domain. compare
Rv3559c -0.5 -0.7 Probable oxidoreductase compare
Rv3433c -0.5 -0.9 Conserved protein compare
Rv1269c -0.5 -1.6 Conserved probable secreted protein compare
Rv2292c -0.5 -0.5 Hypothetical protein compare
Rv0818 -0.5 -2.6 Transcriptional regulatory protein compare
Rv3321c -0.5 -1.5 Possible antitoxin VapB44 compare
Rv1569 -0.5 -2.1 Probable 8-amino-7-oxononanoate synthase BioF1 (AONS) (8-amino-7-ketopelargonate synthase) (7-keto-8-amino-pelargonic acid synthetase) (7-KAP synthetase) (L-alanine--pimelyl CoA ligase) compare
Rv2817c -0.5 -1.5 Conserved hypothetical protein compare
Rv1220c -0.5 -2.4 Probable methyltransferase compare
Rv1698 -0.5 -1.8 Outer membrane protein MctB compare
Rv1155 -0.5 -2.8 Possible pyridoxamine 5'-phosphate oxidase (PNP/PMP oxidase) (pyridoxinephosphate oxidase) (PNPOX) (pyridoxine 5'-phosphate oxidase) compare
Rv3478 -0.5 -1.6 PE family protein PPE60 compare
Rv2709 -0.5 -2.4 Probable conserved transmembrane protein compare
Rv3445c -0.5 -0.7 ESAT-6 like protein EsxU compare
Rv3251c -0.5 -1.7 Probable rubredoxin RubA compare
Rv0398c -0.5 -1.4 Possible secreted protein compare
Rv1825 -0.5 -1.7 Conserved protein compare
Rv1259 -0.5 -0.6 Probable uracil DNA glycosylase, UdgB compare
Rv1506c -0.5 -1.3 Hypothetical protein compare
Rv1237 -0.5 -2.0 Probable sugar-transport integral membrane protein ABC transporter SugB compare
Rv1271c -0.5 -1.2 Conserved hypothetical secreted protein compare
Rv3013 -0.5 -0.6 Conserved protein compare
Rv0473 -0.5 -2.3 Possible conserved transmembrane protein compare
Rv0661c -0.5 -1.1 Possible toxin VapC7 compare
Rv1959c -0.5 -2.5 Possible toxin ParE1 compare


Specific Phenotypes

For 1 genes in this experiment

For carbon source Sodium L-Lactate in Mycobacterium tuberculosis H37Rv

For carbon source Sodium L-Lactate across organisms