Experiment set2S602 for Mycobacterium tuberculosis H37Rv

200 most important genes:

gene	name	fitness	t score	description
Rv1257c		-3.0	-7.0	Probable oxidoreductase	conserved
Rv1291c		-2.6	-2.1	Conserved hypothetical secreted protein
Rv0007		-2.6	-1.1	Possible conserved membrane protein
Rv0487		-2.3	-7.0	Conserved hypothetical protein
Rv2476c		-2.1	-6.8	Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase)
Rv1538c		-2.0	-6.7	Probable L-aparaginase AnsA
Rv0190		-1.6	-5.2	Conserved protein
Rv3066		-1.6	-4.3	Probable transcriptional regulatory protein (probably DeoR-family)
Rv2606c		-1.6	-7.4	Possible pyridoxine biosynthesis protein SnzP
Rv3249c		-1.5	-1.3	Possible transcriptional regulatory protein (probably TetR-family)
Rv2702		-1.4	-0.8	Polyphosphate glucokinase PpgK (polyphosphate-glucose phosphotransferase)
Rv0346c		-1.4	-9.9	Possible L-asparagine permease AnsP2 (L-asparagine transport protein)
Rv2982c		-1.4	-6.3	Probable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA2 (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase)
Rv3413c		-1.4	-1.3	Unknown alanine and proline rich protein
Rv3816c		-1.4	-1.2	Possible acyltransferase
Rv1798		-1.3	-0.8	ESX conserved component EccA5. ESX-5 type VII secretion system protein.
Rv0280		-1.3	-8.9	PPE family protein PPE3
Rv0129c		-1.2	-5.8	Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C)
Rv0955		-1.2	-1.3	Probable conserved integral membrane protein
Rv2047c		-1.2	-5.6	Conserved hypothetical protein
Rv0472c		-1.2	-3.1	Probable transcriptional regulatory protein (possibly TetR-family)
Rv2003c		-1.1	-1.2	Conserved hypothetical protein
Rv3267		-1.1	-3.7	Conserved protein (CPSA-related protein)
Rv3229c		-1.1	-2.6	Possible linoleoyl-CoA desaturase (delta(6)-desaturase)
Rv3810		-1.0	-1.7	Exported repetitive protein precursor PirG (cell surface protein) (EXP53)
Rv0531		-1.0	-1.3	Possible conserved membrane protein
Rv0867c		-1.0	-0.8	Possible resuscitation-promoting factor RpfA
Rv0391		-1.0	-4.7	Probable O-succinylhomoserine sulfhydrylase MetZ (OSH sulfhydrylase)
Rv3400		-1.0	-6.2	Probable hydrolase
Rv3140		-1.0	-3.5	Probable acyl-CoA dehydrogenase FadE23
Rv0949		-1.0	-0.7	Probable ATP-dependent DNA helicase II UvrD1
Rv2772c		-0.9	-1.5	Probable conserved transmembrane protein
Rv1495		-0.9	-1.0	Possible toxin MazF4
Rv0353		-0.9	-2.9	Probable heat shock protein transcriptional repressor HspR (MerR family)
Rv1173		-0.9	-2.5	Probable F420 biosynthesis protein FbiC
Rv3273		-0.9	-5.9	Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase)
Rv0436c		-0.9	-1.7	Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase)
Rv1657		-0.9	-1.7	Probable arginine repressor ArgR (AHRC)
Rv1003		-0.9	-0.7	Conserved protein
Rv1829		-0.9	-3.5	Conserved protein
Rv0825c		-0.9	-1.4	Conserved protein
Rv0928		-0.9	-3.1	Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1)
Rv0757		-0.9	-1.5	Possible two component system response transcriptional positive regulator PhoP
Rv2240c		-0.9	-1.4	Unknown protein
Rv1025		-0.9	-0.8	Conserved protein
Rv0693		-0.9	-3.0	Probable coenzyme PQQ synthesis protein E PqqE (coenzyme PQQ synthesis protein III)
Rv0451c		-0.9	-1.4	Probable conserved membrane protein MmpS4
Rv3667		-0.9	-4.6	Acetyl-coenzyme A synthetase Acs (acetate--CoA ligase) (acetyl-CoA synthetase) (acetyl-CoA synthase) (acyl-activating enzyme) (acetate thiokinase) (acetyl-activating enzyme) (acetate--coenzyme A ligase) (acetyl-coenzyme A synthase)
Rv3182		-0.8	-0.7	Conserved hypothetical protein
Rv0328		-0.8	-1.7	Possible transcriptional regulatory protein (possibly TetR/AcrR-family)
Rv1411c		-0.8	-2.5	Conserved lipoprotein LprG
Rv0758		-0.8	-2.0	Possible two component system response sensor kinase membrane associated PhoR
Rv3230c		-0.8	-2.2	Hypothetical oxidoreductase
Rv2774c		-0.8	-0.7	Hypothetical protein
Rv3114		-0.8	-0.9	Conserved hypothetical protein
Rv1446c		-0.8	-2.1	Putative OXPP cycle protein OpcA
Rv3919c		-0.8	-1.9	Probable glucose-inhibited division protein B Gid
Rv1203c		-0.8	-1.9	Hypothetical protein
Rv1364c		-0.8	-4.1	Possible sigma factor regulatory protein
Rv1366A		-0.8	-0.7	Conserved protein
Rv2001		-0.8	-0.8	Conserved hypothetical protein
Rv1745c		-0.8	-4.6	Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase)
Rv2154c		-0.8	-0.9	FtsW-like protein FtsW
Rv1410c		-0.8	-4.1	Aminoglycosides/tetracycline-transport integral membrane protein
Rv1693		-0.8	-1.0	Conserved hypothetical protein
Rv3768		-0.8	-1.2	Unknown protein
Rv2331A		-0.7	-0.9	Hypothetical protein
Rv2048c		-0.7	-3.6	Polyketide synthase Pks12
Rv1273c		-0.7	-2.5	Probable drugs-transport transmembrane ATP-binding protein ABC transporter
Rv0610c		-0.7	-0.8	Hypothetical protein
Rv1107c		-0.7	-1.2	Probable exodeoxyribonuclease VII (small subunit) XseB (exonuclease VII small subunit)
Rv1019		-0.7	-3.4	Probable transcriptional regulatory protein (probably TetR-family)
Rv2869c		-0.7	-1.3	Membrane bound metalloprotease
Rv3417c		-0.7	-2.6	60 kDa chaperonin 1 GroEL1 (protein CPN60-1) (GroEL protein 1)
Rv2044c		-0.7	-0.7	Conserved hypothetical protein
Rv2237A		-0.7	-0.7	Conserved protein
Rv1085c		-0.7	-2.6	Possible hemolysin-like protein
Rv2506		-0.7	-2.0	Probable transcriptional regulatory protein (probably TetR-family)
Rv0954		-0.7	-3.3	Probable conserved transmembrane protein
Rv0219		-0.7	-2.3	Probable conserved transmembrane protein
Rv3610c		-0.7	-2.6	Membrane-bound protease FtsH (cell division protein)
Rv1239c		-0.7	-3.2	Possible magnesium and cobalt transport transmembrane protein CorA
Rv0458		-0.7	-4.4	Probable aldehyde dehydrogenase
Rv0333		-0.7	-2.2	Unknown protein
Rv3478		-0.7	-2.8	PE family protein PPE60
Rv3321c		-0.7	-1.2	Possible antitoxin VapB44
Rv3055		-0.7	-2.3	Possible transcriptional regulatory protein (probably TetR-family)
Rv3897c		-0.7	-0.7	Conserved hypothetical protein
Rv3516		-0.7	-1.6	Possible enoyl-CoA hydratase EchA19 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv3331		-0.7	-1.8	Probable sugar-transport integral membrane protein SugI
Rv0694		-0.7	-2.3	Possible L-lactate dehydrogenase (cytochrome) LldD1
Rv3678A		-0.7	-2.2	Conserved hypothetical protein
Rv2583c		-0.7	-1.2	Probable GTP pyrophosphokinase RelA (ATP:GTP 3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase)
Rv0871		-0.7	-1.3	Probable cold shock-like protein B CspB
Rv0157A		-0.7	-1.1	Conserved protein
Rv0520		-0.7	-2.5	Possible methyltransferase/methylase (fragment)
Rv0395		-0.7	-1.7	Hypothetical protein
Rv3723		-0.7	-2.6	Probable conserved transmembrane protein
Rv1851		-0.7	-0.9	Urease accessory protein UreF
Rv2503c		-0.7	-1.8	Probable succinyl-CoA:3-ketoacid-coenzyme A transferase (beta subunit) ScoB (3-oxo-acid:CoA transferase) (OXCT B) (succinyl CoA:3-oxoacid CoA-transferase)
Rv3193c		-0.7	-0.9	Probable conserved transmembrane protein
Rv3693		-0.6	-1.4	Possible conserved membrane protein
Rv3556c		-0.6	-2.0	Probable acetyl-CoA acetyltransferase FadA6 (acetoacetyl-CoA thiolase)
Rv3340		-0.6	-2.2	Probable O-acetylhomoserine sulfhydrylase MetC (homocysteine synthase) (O-acetylhomoserine (thiol)-lyase) (OAH sulfhydrylase) (O-acetyl-L-homoserine sulfhydrylase)
Rv0940c		-0.6	-1.2	Possible oxidoreductase
Rv1010		-0.6	-0.9	Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase)
Rv2072c		-0.6	-0.8	Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL
Rv2798c		-0.6	-1.3	Conserved hypothetical protein
Rv2328		-0.6	-1.9	PE family protein PE23
Rv1272c		-0.6	-3.1	Probable drugs-transport transmembrane ATP-binding protein ABC transporter
Rv0518		-0.6	-2.2	Possible exported protein
Rv0930		-0.6	-3.2	Probable phosphate-transport integral membrane ABC transporter PstA1
Rv1220c		-0.6	-2.6	Probable methyltransferase
Rv3664c		-0.6	-2.0	Probable dipeptide-transport integral membrane protein ABC transporter DppC
Rv2014		-0.6	-1.1	Transposase
Rv0324		-0.6	-1.5	Possible transcriptional regulatory protein (possibly ArsR-family)
Rv0819		-0.6	-1.2	GCN5-related N-acetyltransferase, MshD
Rv0868c		-0.6	-1.2	Probable molybdenum cofactor biosynthesis protein D 2 MoaD2 (molybdopterin converting factor small subunit) (molybdopterin [MPT] converting factor, subunit 1)
Rv0437c		-0.6	-0.7	Possible phosphatidylserine decarboxylase Psd (PS decarboxylase)
Rv0504c		-0.6	-1.1	Conserved protein
Rv0390		-0.6	-2.2	Conserved protein
Rv2721c		-0.6	-4.0	Possible conserved transmembrane alanine and glycine rich protein
Rv1455		-0.6	-4.3	Conserved protein
Rv3358		-0.6	-0.7	Toxin RelK
Rv1286		-0.6	-1.1	Probable bifunctional enzyme CysN/CysC: sulfate adenyltransferase (subunit 1) + adenylylsulfate kinase
Rv3687c		-0.6	-0.5	Anti-anti-sigma factor RsfB (anti-sigma factor antagonist) (regulator of sigma F B)
Rv2657c		-0.6	-0.7	Probable PhiRv2 prophage protein
Rv1570		-0.6	-1.5	Dethiobiotin synthetase BioD
Rv3895c		-0.6	-2.1	ESX conserved component EccB2. ESX-2 type VII secretion system protein. Probable membrane protein.
Rv3891c		-0.6	-2.5	Possible ESAT-6 like protein EsxD
Rv3584		-0.6	-0.9	Possible conserved lipoprotein LpqE
Rv1234		-0.6	-1.5	Probable transmembrane protein
Rv0674		-0.6	-0.5	Conserved hypothetical protein
Rv0569		-0.6	-1.2	Conserved protein
Rv0671		-0.6	-2.1	Possible conserved lipoprotein LpqP
Rv2415c		-0.5	-1.8	Conserved hypothetical protein
Rv2855		-0.5	-1.2	NADPH-dependent mycothiol reductase Mtr
Rv3770B		-0.5	-1.0	Probable remnant of a transposase
Rv2623		-0.5	-1.4	Universal stress protein family protein TB31.7
Rv0692		-0.5	-2.7	Conserved hypothetical protein
Rv2897c		-0.5	-0.9	Conserved hypothetical protein
Rv2801c		-0.5	-0.7	Toxin MazF9
Rv3497c		-0.5	-2.8	Mce-family protein Mce4C
Rv3428c		-0.5	-0.7	Possible transposase
Rv1821		-0.5	-2.0	Possible preprotein translocase ATPase SecA2
Rv0113		-0.5	-0.9	Probable sedoheptulose-7-phosphate isomerase GmhA (phosphoheptose isomerase)
Rv3316		-0.5	-1.2	Probable succinate dehydrogenase (cytochrome B-556 subunit) SdhC (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase)
Rv0010c		-0.5	-3.8	Probable conserved membrane protein
Rv2405		-0.5	-2.6	Conserved protein
Rv0375c		-0.5	-0.6	Probable carbon monoxyde dehydrogenase (medium chain)
Rv0971c		-0.5	-1.5	Probable enoyl-CoA hydratase EchA7 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv1259		-0.5	-0.7	Probable uracil DNA glycosylase, UdgB
Rv2487c		-0.5	-1.4	PE-PGRS family protein PE_PGRS42
Rv1621c		-0.5	-1.0	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD
Rv1276c		-0.5	-1.6	Conserved hypothetical protein
Rv0043c		-0.5	-0.9	Probable transcriptional regulatory protein (probably GntR-family)
Rv3833		-0.5	-0.9	Transcriptional regulatory protein (probably AraC-family)
Rv0984		-0.5	-1.4	Possible pterin-4-alpha-carbinolamine dehydratase MoaB2 (PHS) (4-alpha-hydroxy-tetrahydropterin dehydratase) (pterin-4-a-carbinolamine dehydratase) (phenylalanine hydroxylase-stimulating protein) (PHS) (pterin carbinolamine dehydratase) (PCD)
Rv1280c		-0.5	-2.4	Probable periplasmic oligopeptide-binding lipoprotein OppA
Rv1589		-0.5	-3.3	Probable biotin synthetase BioB
Rv0200		-0.5	-0.7	Possible conserved transmembrane protein
Rv3376		-0.5	-2.0	Conserved hypothetical protein
Rv2475c		-0.5	-1.5	Conserved protein
Rv2989		-0.5	-0.4	Probable transcriptional regulatory protein
Rv0367c		-0.5	-0.3	Hypothetical protein
Rv3131		-0.5	-0.8	Conserved protein
Rv1062		-0.5	-0.5	Conserved hypothetical protein
Rv1565c		-0.5	-2.6	Conserved hypothetical membrane protein
Rv0573c		-0.5	-1.9	Nicotinic acid phosphoribosyltransferase PncB2
Rv2671		-0.5	-1.4	Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reductase (HTP reductase)
Rv2899c		-0.5	-0.8	Possible FdhD protein homolog
Rv1963c		-0.5	-1.0	Probable transcriptional repressor (probably TetR-family) Mce3R
Rv0088		-0.5	-0.6	Possible polyketide cyclase/dehydrase
Rv1473A		-0.5	-0.5	Possible transcriptional regulatory protein
Rv0037c		-0.5	-3.6	Probable conserved integral membrane protein
Rv0456B		-0.5	-2.3	Possible antitoxin MazE1
Rv2817c		-0.5	-1.0	Conserved hypothetical protein
Rv0983		-0.5	-2.3	Probable serine protease PepD (serine proteinase) (MTB32B)
Rv1046c		-0.5	-0.7	Hypothetical protein
Rv0040c		-0.5	-2.8	Secreted proline rich protein Mtc28 (proline rich 28 kDa antigen)
Rv2462c		-0.5	-1.9	Probable trigger factor (TF) protein Tig
Rv0473		-0.5	-1.8	Possible conserved transmembrane protein
Rv1271c		-0.5	-1.2	Conserved hypothetical secreted protein
Rv2277c		-0.5	-0.8	Possible glycerolphosphodiesterase
Rv3759c		-0.5	-1.7	Possible osmoprotectant (glycine betaine/carnitine/choline/L-proline) binding lipoprotein ProX
Rv3236c		-0.5	-1.0	Probable conserved integral membrane transport protein
Rv0188		-0.5	-1.3	Probable conserved transmembrane protein
Rv0642c		-0.5	-0.8	Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase)
Rv3026c		-0.5	-1.9	Conserved hypothetical protein
Rv0202c		-0.5	-2.8	Probable conserved transmembrane transport protein MmpL11
Rv3668c		-0.5	-1.6	Possible protease
Rv3852		-0.5	-2.6	Possible histone-like protein Hns
Rv2317		-0.5	-0.6	Probable sugar-transport integral membrane protein ABC transporter UspB
Rv1925		-0.4	-2.7	Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase)
Rv0655		-0.4	-2.1	Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl
Rv1679		-0.4	-0.5	Possible acyl-CoA dehydrogenase FadE16
Rv1448c		-0.4	-1.4	Probable transaldolase Tal
Rv2173		-0.4	-1.7	Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase)
Rv2148c		-0.4	-1.3	Conserved protein
Rv2224c		-0.4	-3.3	Probable carboxylesterase CaeA

Specific Phenotypes

For 2 genes in this experiment

For carbon source Sodium D-Lactate in Mycobacterium tuberculosis H37Rv

For carbon source Sodium D-Lactate across organisms