Experiment set2S601 for Mycobacterium tuberculosis H37Rv

Compare to:

Sodium D-Lactate 10 mM carbon source

200 most important genes:

  gene name fitness t score description  
Rv1257c -2.6 -6.6 Probable oxidoreductase conserved
Rv0487 -2.2 -7.1 Conserved hypothetical protein compare
Rv2476c -2.2 -5.3 Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase) compare
Rv1010 -2.0 -1.4 Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase) compare
Rv2702 -1.9 -1.0 Polyphosphate glucokinase PpgK (polyphosphate-glucose phosphotransferase) compare
Rv1538c -1.8 -9.3 Probable L-aparaginase AnsA compare
Rv3306c -1.7 -2.0 Probable amidohydrolase AmiB1 (aminohydrolase) compare
Rv2647 -1.6 -1.6 Hypothetical protein compare
Rv3819 -1.5 -1.2 Unknown protein compare
Rv0346c -1.5 -9.0 Possible L-asparagine permease AnsP2 (L-asparagine transport protein) compare
Rv2606c -1.5 -4.6 Possible pyridoxine biosynthesis protein SnzP compare
Rv3182 -1.5 -1.1 Conserved hypothetical protein compare
Rv3066 -1.4 -5.1 Probable transcriptional regulatory protein (probably DeoR-family) compare
Rv0472c -1.4 -3.4 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv0504c -1.4 -2.2 Conserved protein compare
Rv0280 -1.4 -9.0 PPE family protein PPE3 compare
Rv1798 -1.3 -0.8 ESX conserved component EccA5. ESX-5 type VII secretion system protein. compare
Rv0328 -1.2 -2.3 Possible transcriptional regulatory protein (possibly TetR/AcrR-family) compare
Rv0609 -1.2 -1.1 Possible toxin VapC28. Contains PIN domain. compare
Rv2154c -1.2 -1.9 FtsW-like protein FtsW compare
Rv1290A -1.2 -0.9 Hypothetical protein compare
Rv3267 -1.2 -4.1 Conserved protein (CPSA-related protein) compare
Rv0949 -1.2 -0.9 Probable ATP-dependent DNA helicase II UvrD1 compare
Rv3249c -1.2 -0.8 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv2444c -1.1 -2.6 Possible ribonuclease E Rne compare
Rv3102c -1.1 -3.1 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv1908c -1.1 -2.2 Catalase-peroxidase-peroxynitritase T KatG compare
Rv3400 -1.1 -6.3 Probable hydrolase compare
Rv3816c -1.1 -1.1 Possible acyltransferase compare
Rv2993c -1.0 -1.0 Possible 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) compare
Rv0758 -1.0 -1.7 Possible two component system response sensor kinase membrane associated PhoR compare
Rv0190 -1.0 -4.7 Conserved protein compare
Rv2661c -1.0 -1.4 Hypothetical protein compare
Rv3230c -1.0 -3.1 Hypothetical oxidoreductase compare
Rv1291c -1.0 -1.4 Conserved hypothetical secreted protein compare
Rv3559c -1.0 -1.2 Probable oxidoreductase compare
Rv2635 -1.0 -0.8 Hypothetical protein compare
Rv0819 -1.0 -2.7 GCN5-related N-acetyltransferase, MshD compare
Rv1242 -0.9 -3.0 Possible toxin VapC33. Contains PIN domain. compare
Rv2170 -0.9 -1.3 GCN5-related N-acetyltransferase compare
Rv3527 -0.9 -1.6 Hypothetical protein compare
Rv3610c -0.9 -1.8 Membrane-bound protease FtsH (cell division protein) compare
Rv3810 -0.9 -1.6 Exported repetitive protein precursor PirG (cell surface protein) (EXP53) compare
Rv1085c -0.9 -3.7 Possible hemolysin-like protein compare
Rv2222c -0.9 -3.0 Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) compare
Rv3229c -0.9 -2.3 Possible linoleoyl-CoA desaturase (delta(6)-desaturase) compare
Rv2047c -0.9 -5.3 Conserved hypothetical protein compare
Rv0157A -0.9 -1.5 Conserved protein compare
Rv1946c -0.9 -2.2 Possible lipoprotein compare
Rv0242c -0.8 -3.0 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase) compare
Rv2003c -0.8 -1.0 Conserved hypothetical protein compare
Rv1710 -0.8 -1.8 Possible segregation and condensation protein ScpB compare
Rv3013 -0.8 -1.0 Conserved protein compare
Rv1895 -0.8 -1.5 Possible dehydrogenase compare
Rv3114 -0.8 -0.9 Conserved hypothetical protein compare
Rv1821 -0.8 -3.4 Possible preprotein translocase ATPase SecA2 compare
Rv1590 -0.8 -2.5 Conserved hypothetical protein compare
Rv3667 -0.8 -4.9 Acetyl-coenzyme A synthetase Acs (acetate--CoA ligase) (acetyl-CoA synthetase) (acetyl-CoA synthase) (acyl-activating enzyme) (acetate thiokinase) (acetyl-activating enzyme) (acetate--coenzyme A ligase) (acetyl-coenzyme A synthase) compare
Rv2001 -0.8 -0.8 Conserved hypothetical protein compare
Rv3321c -0.8 -1.7 Possible antitoxin VapB44 compare
Rv3177 -0.8 -1.2 Possible peroxidase (non-haem peroxidase) compare
Rv3358 -0.8 -1.5 Toxin RelK compare
Rv0930 -0.8 -4.7 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv3193c -0.8 -1.2 Probable conserved transmembrane protein compare
Rv1234 -0.8 -2.1 Probable transmembrane protein compare
Rv0030 -0.8 -1.6 Conserved hypothetical protein compare
Rv3856c -0.8 -1.8 Conserved hypothetical protein compare
Rv2982c -0.8 -3.1 Probable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA2 (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase) compare
Rv0129c -0.8 -3.8 Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) compare
Rv2342 -0.8 -3.4 Conserved hypothetical protein compare
Rv1272c -0.8 -3.8 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv0693 -0.8 -2.8 Probable coenzyme PQQ synthesis protein E PqqE (coenzyme PQQ synthesis protein III) compare
Rv1159 -0.8 -1.7 Mannosyltransferase PimE compare
Rv2044c -0.8 -0.7 Conserved hypothetical protein compare
Rv3331 -0.8 -2.2 Probable sugar-transport integral membrane protein SugI compare
Rv0353 -0.8 -2.7 Probable heat shock protein transcriptional repressor HspR (MerR family) compare
Rv2989 -0.8 -0.5 Probable transcriptional regulatory protein compare
Rv0984 -0.7 -2.0 Possible pterin-4-alpha-carbinolamine dehydratase MoaB2 (PHS) (4-alpha-hydroxy-tetrahydropterin dehydratase) (pterin-4-a-carbinolamine dehydratase) (phenylalanine hydroxylase-stimulating protein) (PHS) (pterin carbinolamine dehydratase) (PCD) compare
Rv1693 -0.7 -1.0 Conserved hypothetical protein compare
Rv0745 -0.7 -2.0 Conserved hypothetical protein compare
Rv1496 -0.7 -2.6 Possible transport system kinase compare
Rv2922c -0.7 -2.2 Probable chromosome partition protein Smc compare
Rv1103c -0.7 -1.3 Possible antitoxin MazE3 compare
Rv1107c -0.7 -1.2 Probable exodeoxyribonuclease VII (small subunit) XseB (exonuclease VII small subunit) compare
Rv0893c -0.7 -1.5 Possible S-adenosylmethionine-dependent methyltransferase compare
Rv0007 -0.7 -0.5 Possible conserved membrane protein compare
Rv0275c -0.7 -1.4 Possible transcriptional regulatory protein (possibly TetR-family) compare
Rv0954 -0.7 -2.7 Probable conserved transmembrane protein compare
Rv1829 -0.7 -2.7 Conserved protein compare
Rv0696 -0.7 -2.5 Probable membrane sugar transferase compare
Rv0573c -0.7 -2.5 Nicotinic acid phosphoribosyltransferase PncB2 compare
Rv3600c -0.7 -2.0 Conserved protein compare
Rv1531 -0.7 -0.9 Conserved protein compare
Rv3478 -0.7 -2.0 PE family protein PPE60 compare
Rv2374c -0.7 -1.7 Probable heat shock protein transcriptional repressor HrcA compare
Rv1411c -0.7 -2.3 Conserved lipoprotein LprG compare
Rv0523c -0.7 -0.9 Conserved protein compare
Rv3650 -0.7 -0.5 PE family protein PE33 compare
Rv0944 -0.7 -1.5 Possible formamidopyrimidine-DNA glycosylase (FAPY-DNA glycosylase) compare
Rv3651 -0.7 -0.9 Conserved hypothetical protein compare
Rv0436c -0.7 -0.9 Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase) compare
Rv0247c -0.7 -0.5 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) compare
Rv3514 -0.6 -2.5 PE-PGRS family protein PE_PGRS57 compare
Rv0391 -0.6 -2.6 Probable O-succinylhomoserine sulfhydrylase MetZ (OSH sulfhydrylase) compare
Rv1890c -0.6 -0.9 Hypothetical protein compare
Rv1173 -0.6 -1.8 Probable F420 biosynthesis protein FbiC compare
Rv3516 -0.6 -1.3 Possible enoyl-CoA hydratase EchA19 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv0748 -0.6 -1.5 Possible antitoxin VapB31 compare
Rv0971c -0.6 -1.9 Probable enoyl-CoA hydratase EchA7 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv1273c -0.6 -3.0 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv1271c -0.6 -0.7 Conserved hypothetical secreted protein compare
Rv0370c -0.6 -1.4 Possible oxidoreductase compare
Rv1792 -0.6 -0.8 ESAT-6 like protein EsxM compare
Rv1410c -0.6 -3.3 Aminoglycosides/tetracycline-transport integral membrane protein compare
Rv1675c -0.6 -1.4 Probable transcriptional regulatory protein Cmr compare
Rv2048c -0.6 -3.2 Polyketide synthase Pks12 compare
Rv0473 -0.6 -2.4 Possible conserved transmembrane protein compare
Rv2721c -0.6 -4.1 Possible conserved transmembrane alanine and glycine rich protein compare
Rv3501c -0.6 -2.6 Conserved integral membrane protein YrbE4A. Possible ABC transporter. compare
Rv1239c -0.6 -3.7 Possible magnesium and cobalt transport transmembrane protein CorA compare
Rv1158c -0.6 -1.3 Conserved hypothetical ala-, pro-rich protein compare
Rv1055 -0.6 -0.7 Possible integrase (fragment) compare
Rv0782 -0.6 -1.8 Probable protease II PtrBb [second part] (oligopeptidase B) compare
Rv1049 -0.6 -0.9 Probable transcriptional repressor protein compare
Rv3301c -0.6 -2.3 Probable phosphate-transport system transcriptional regulatory protein PhoU homolog 1 PhoY1 compare
Rv0390 -0.6 -2.6 Conserved protein compare
Rv0928 -0.6 -1.4 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv2740 -0.6 -2.7 Epoxide hydrolase compare
Rv2251 -0.6 -1.8 Possible flavoprotein compare
Rv2869c -0.6 -1.1 Membrane bound metalloprotease compare
Rv2670c -0.6 -2.8 Conserved hypothetical protein compare
Rv1286 -0.6 -1.1 Probable bifunctional enzyme CysN/CysC: sulfate adenyltransferase (subunit 1) + adenylylsulfate kinase compare
Rv0388c -0.5 -2.4 PPE family protein PPE9 compare
Rv3140 -0.5 -2.3 Probable acyl-CoA dehydrogenase FadE23 compare
Rv2858c -0.5 -1.6 Probable aldehyde dehydrogenase AldC compare
Rv0207c -0.5 -1.8 Conserved hypothetical protein compare
Rv1220c -0.5 -2.6 Probable methyltransferase compare
Rv0757 -0.5 -1.0 Possible two component system response transcriptional positive regulator PhoP compare
Rv1729c -0.5 -2.2 Possible S-adenosylmethionine-dependent methyltransferase compare
Rv0531 -0.5 -0.8 Possible conserved membrane protein compare
Rv0820 -0.5 -2.3 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv0518 -0.5 -2.3 Possible exported protein compare
Rv0742 -0.5 -0.6 PE-PGRS family protein PE_PGRS8 compare
Rv2506 -0.5 -1.5 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv1671 -0.5 -1.4 Probable membrane protein compare
Rv0734 -0.5 -1.8 Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) compare
Rv3492c -0.5 -1.2 Conserved hypothetical Mce associated protein compare
Rv0825c -0.5 -1.2 Conserved protein compare
Rv1825 -0.5 -1.7 Conserved protein compare
Rv1657 -0.5 -0.8 Probable arginine repressor ArgR (AHRC) compare
Rv0395 -0.5 -1.4 Hypothetical protein compare
Rv3868 -0.5 -3.7 ESX conserved component EccA1. ESX-1 type VII secretion system protein. compare
Rv1554 -0.5 -2.0 Probable fumarate reductase [membrane anchor subunit] FrdC (fumarate dehydrogenase) (fumaric hydrogenase) compare
Rv2722 -0.5 -1.9 Conserved hypothetical protein compare
Rv3529c -0.5 -2.3 Conserved hypothetical protein compare
Rv3131 -0.5 -0.8 Conserved protein compare
Rv0177 -0.5 -0.7 Probable conserved Mce associated protein compare
Rv1455 -0.5 -3.4 Conserved protein compare
Rv2224c -0.5 -3.9 Probable carboxylesterase CaeA compare
Rv0069c -0.5 -1.0 Probable L-serine dehydratase SdaA (L-serine deaminase) (SDH) (L-SD) compare
Rv1683 -0.5 -2.4 Possible bifunctional enzyme; long-chain acyl-CoA synthase and lipase. compare
Rv2148c -0.5 -1.7 Conserved protein compare
Rv0661c -0.5 -1.3 Possible toxin VapC7 compare
Rv2522c -0.5 -2.5 Conserved hypothetical protein compare
Rv2583c -0.5 -1.1 Probable GTP pyrophosphokinase RelA (ATP:GTP 3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase) compare
Rv2132 -0.5 -1.5 Conserved hypothetical protein compare
Rv2462c -0.5 -1.5 Probable trigger factor (TF) protein Tig compare
Rv1087 -0.5 -3.1 PE-PGRS family protein PE_PGRS21 compare
Rv1909c -0.5 -1.3 Ferric uptake regulation protein FurA (fur) compare
Rv0037c -0.5 -3.5 Probable conserved integral membrane protein compare
Rv3328c -0.5 -1.4 Probable alternative RNA polymerase sigma factor (fragment) SigJ compare
Rv3867 -0.5 -2.8 ESX-1 secretion-associated protein EspH compare
Rv2280 -0.5 -1.7 Probable dehydrogenase compare
Rv1925 -0.5 -3.3 Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) compare
Rv0769 -0.5 -1.7 Probable dehydrogenase/reductase compare
Rv3586 -0.5 -1.2 Conserved hypothetical protein compare
Rv1701 -0.5 -1.2 Probable integrase/recombinase compare
Rv3173c -0.5 -1.9 Probable transcriptional regulatory protein (probably TetR/AcrR-family) compare
Rv1019 -0.5 -2.2 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv3886c -0.5 -1.7 Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-2) compare
Rv3093c -0.5 -1.7 Hypothetical oxidoreductase compare
Rv3897c -0.5 -0.5 Conserved hypothetical protein compare
Rv0300 -0.5 -1.6 Possible antitoxin VapB2 compare
Rv3664c -0.5 -1.6 Probable dipeptide-transport integral membrane protein ABC transporter DppC compare
Rv0671 -0.5 -1.6 Possible conserved lipoprotein LpqP compare
Rv0747 -0.5 -1.7 PE-PGRS family protein PE_PGRS10 compare
Rv3196A -0.5 -1.6 Unknown protein compare
Rv2415c -0.4 -1.2 Conserved hypothetical protein compare
Rv0508 -0.4 -1.4 Conserved hypothetical protein compare
Rv0324 -0.4 -1.6 Possible transcriptional regulatory protein (possibly ArsR-family) compare
Rv1269c -0.4 -1.4 Conserved probable secreted protein compare
Rv3286c -0.4 -1.5 Alternative RNA polymerase sigma factor SigF compare
Rv2252 -0.4 -0.6 Diacylglycerol kinase compare
Rv2051c -0.4 -1.9 Polyprenol-monophosphomannose synthase Ppm1 compare
Rv1823 -0.4 -2.3 Conserved protein compare
Rv1589 -0.4 -3.0 Probable biotin synthetase BioB compare
Rv0818 -0.4 -2.2 Transcriptional regulatory protein compare
Rv2660c -0.4 -1.9 Hypothetical protein compare
Rv2550c -0.4 -1.8 Possible antitoxin VapB20 compare
Rv3200c -0.4 -1.2 Possible transmembrane cation transporter compare


Specific Phenotypes

For 2 genes in this experiment

For carbon source Sodium D-Lactate in Mycobacterium tuberculosis H37Rv

For carbon source Sodium D-Lactate across organisms