Experiment set2S596 for Mycobacterium tuberculosis H37Rv

200 most important genes:

gene	name	fitness	t score	description
Rv3208A		-3.3	-2.6	Conserved protein TB9.4
Rv2416c		-2.7	-6.8	Enhanced intracellular survival protein Eis,GCN5-related N-acetyltransferase
Rv2581c		-2.7	-1.5	Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II)
Rv3610c		-2.6	-3.9	Membrane-bound protease FtsH (cell division protein)
Rv0819		-2.5	-3.8	GCN5-related N-acetyltransferase, MshD
Rv0437c		-2.4	-1.4	Possible phosphatidylserine decarboxylase Psd (PS decarboxylase)
Rv0871		-2.3	-3.0	Probable cold shock-like protein B CspB
Rv0930		-2.3	-9.1	Probable phosphate-transport integral membrane ABC transporter PstA1
Rv0929		-2.2	-3.3	Phosphate-transport integral membrane ABC transporter PstC2
Rv1062		-1.8	-1.6	Conserved hypothetical protein
Rv1620c		-1.8	-3.9	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC
Rv1640c		-1.8	-8.9	Lysyl-tRNA synthetase 2 LysX
Rv1280c		-1.8	-7.0	Probable periplasmic oligopeptide-binding lipoprotein OppA
Rv1046c		-1.8	-1.9	Hypothetical protein
Rv3193c		-1.7	-1.7	Probable conserved transmembrane protein
Rv3249c		-1.7	-1.6	Possible transcriptional regulatory protein (probably TetR-family)
Rv1281c		-1.7	-5.9	Probable oligopeptide-transport ATP-binding protein ABC transporter OppD
Rv0928		-1.6	-3.9	Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1)
Rv0820		-1.6	-3.6	Probable phosphate-transport ATP-binding protein ABC transporter PhoT
Rv2206		-1.6	-2.8	Probable conserved transmembrane protein
Rv0241c		-1.5	-4.5	Probable 3-hydroxyacyl-thioester dehydratase HtdX
Rv1745c		-1.5	-4.3	Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase)
Rv2317		-1.5	-1.2	Probable sugar-transport integral membrane protein ABC transporter UspB
Rv2462c		-1.5	-4.8	Probable trigger factor (TF) protein Tig
Rv1072		-1.4	-1.1	Probable conserved transmembrane protein
Rv2691		-1.4	-6.3	TRK system potassium uptake protein CeoB
Rv0939		-1.4	-1.2	Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase
Rv0452		-1.4	-3.4	Possible transcriptional regulatory protein
Rv1112		-1.4	-1.3	Probable GTP binding protein
Rv1621c		-1.3	-3.7	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD
Rv0989c		-1.3	-5.8	Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase)
Rv1908c		-1.3	-2.0	Catalase-peroxidase-peroxynitritase T KatG
Rv3140		-1.2	-4.0	Probable acyl-CoA dehydrogenase FadE23
Rv0018c		-1.2	-4.3	Phosphoserine/threonine phosphatase PstP
Rv0007		-1.2	-0.7	Possible conserved membrane protein
Rv2569c		-1.2	-5.0	Conserved hypothetical protein
Rv1410c		-1.2	-5.1	Aminoglycosides/tetracycline-transport integral membrane protein
Rv3717		-1.2	-3.5	Conserved hypothetical protein
Rv3855		-1.2	-4.2	Transcriptional regulatory repressor protein (TetR-family) EthR
Rv3672c		-1.2	-1.7	Conserved hypothetical protein
Rv3033		-1.2	-0.8	Unknown protein
Rv3631		-1.2	-0.7	Possible transferase (possibly glycosyltransferase)
Rv0392c		-1.1	-1.4	Probable membrane NADH dehydrogenase NdhA
Rv2694c		-1.1	-2.7	Conserved protein
Rv0949		-1.1	-0.7	Probable ATP-dependent DNA helicase II UvrD1
Rv2224c		-1.1	-8.2	Probable carboxylesterase CaeA
Rv0924c		-1.1	-3.8	Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP)
Rv2500c		-1.1	-1.3	Possible acyl-CoA dehydrogenase FadE19 (MMGC)
Rv2707		-1.1	-7.5	Probable conserved transmembrane alanine and leucine rich protein
Rv2374c		-1.0	-1.9	Probable heat shock protein transcriptional repressor HrcA
Rv1283c		-1.0	-1.8	Probable oligopeptide-transport integral membrane protein ABC transporter OppB
Rv2945c		-1.0	-6.6	Probable conserved lipoprotein LppX
Rv1282c		-1.0	-2.7	Probable oligopeptide-transport integral membrane protein ABC transporter OppC
Rv3200c		-1.0	-2.1	Possible transmembrane cation transporter
Rv3658c		-1.0	-1.2	Probable conserved transmembrane protein
Rv0531		-1.0	-1.3	Possible conserved membrane protein
Rv1422		-1.0	-1.0	Conserved hypothetical protein
Rv0994		-1.0	-5.7	Probable molybdopterin biosynthesis protein MoeA1
Rv2154c		-1.0	-1.9	FtsW-like protein FtsW
Rv3311		-0.9	-4.2	Conserved protein
Rv0444c		-0.9	-3.6	Anti-sigma factor RskA (regulator of sigma K)
Rv3309c		-0.9	-1.3	Probable uracil phosphoribosyltransferase Upp (UMP pyrophosphorylase) (uprtase) (UMP diphosphorylase)
Rv2942		-0.9	-7.0	Conserved transmembrane transport protein MmpL7
Rv1019		-0.9	-4.5	Probable transcriptional regulatory protein (probably TetR-family)
Rv3810		-0.9	-1.1	Exported repetitive protein precursor PirG (cell surface protein) (EXP53)
Rv1946c		-0.9	-1.8	Possible lipoprotein
Rv2709		-0.9	-3.8	Probable conserved transmembrane protein
Rv0504c		-0.9	-1.3	Conserved protein
Rv0243		-0.9	-5.0	Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase)
Rv0990c		-0.9	-0.6	Hypothetical protein
Rv0242c		-0.9	-2.3	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase)
Rv3306c		-0.9	-1.2	Probable amidohydrolase AmiB1 (aminohydrolase)
Rv3204		-0.9	-0.7	Possible DNA-methyltransferase (modification methylase)
Rv2616		-0.9	-4.3	Conserved protein
Rv3720		-0.9	-4.3	Possible fatty acid synthase
Rv3486		-0.9	-1.4	Conserved protein
Rv3139		-0.9	-4.8	Probable acyl-CoA dehydrogenase FadE24
Rv0208c		-0.9	-2.9	Hypothetical methlytransferase (methylase)
Rv0157A		-0.9	-1.4	Conserved protein
Rv0530A		-0.9	-2.9	Conserved protein
Rv0375c		-0.8	-1.8	Probable carbon monoxyde dehydrogenase (medium chain)
Rv2635		-0.8	-0.9	Hypothetical protein
Rv3273		-0.8	-5.3	Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase)
Rv1244		-0.8	-3.0	Probable lipoprotein LpqZ
Rv2936		-0.8	-6.5	Daunorubicin-dim-transport ATP-binding protein ABC transporter DrrA
Rv2657c		-0.8	-0.9	Probable PhiRv2 prophage protein
Rv2912c		-0.8	-2.7	Probable transcriptional regulatory protein (probably TetR-family)
Rv0472c		-0.8	-2.9	Probable transcriptional regulatory protein (possibly TetR-family)
Rv0954		-0.8	-2.0	Probable conserved transmembrane protein
Rv0313		-0.8	-1.8	Conserved protein
Rv2801A		-0.8	-2.9	Possible antitoxin MazE9
Rv3270		-0.8	-1.1	Probable metal cation-transporting P-type ATPase C CtpC
Rv0135c		-0.8	-2.3	Possible transcriptional regulatory protein
Rv1730c		-0.8	-1.9	Possible penicillin-binding protein
Rv2938		-0.8	-5.4	Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC
Rv3222c		-0.8	-1.1	Conserved hypothetical protein
Rv2173		-0.8	-2.1	Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase)
Rv0818		-0.8	-2.6	Transcriptional regulatory protein
Rv2348c		-0.8	-0.5	Hypothetical protein
Rv3438		-0.8	-1.9	Conserved protein
Rv1751		-0.8	-1.7	Probable oxidoreductase
Rv0999		-0.8	-2.4	Unknown protein
Rv0933		-0.8	-1.3	Phosphate-transport ATP-binding protein ABC transporter PstB
Rv0200		-0.8	-1.3	Possible conserved transmembrane protein
Rv2937		-0.8	-5.7	Daunorubicin-dim-transport integral membrane protein ABC transporter DrrB
Rv2468c		-0.8	-3.1	Conserved protein
Rv2222c		-0.8	-1.6	Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II)
Rv3698		-0.8	-3.4	Conserved protein
Rv2879c		-0.7	-0.7	Conserved hypothetical protein
Rv1291c		-0.7	-1.1	Conserved hypothetical secreted protein
Rv3493c		-0.7	-2.4	Conserved hypothetical Mce associated alanine and valine rich protein
Rv0436c		-0.7	-1.1	Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase)
Rv0017c		-0.7	-3.0	Probable cell division protein RodA
Rv0016c		-0.7	-3.4	Probable penicillin-binding protein PbpA
Rv3304		-0.7	-2.4	Conserved protein
Rv2089c		-0.7	-1.0	Dipeptidase PepE
Rv2733c		-0.7	-1.7	Conserved hypothetical alanine, arginine-rich protein
Rv2855		-0.7	-1.5	NADPH-dependent mycothiol reductase Mtr
Rv0476		-0.7	-2.6	Possible conserved transmembrane protein
Rv0321		-0.7	-1.9	Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase)
Rv0019c		-0.7	-1.8	Conserved protein with FHA domain, FhaB
Rv0550c		-0.7	-0.9	Possible antitoxin VapB3
Rv0862c		-0.7	-2.2	Conserved protein
Rv1420		-0.7	-1.5	Probable excinuclease ABC (subunit C-nuclease) UvrC
Rv3697c		-0.7	-2.5	Possible toxin VapC48. Contains PIN domain.
Rv0328		-0.7	-0.9	Possible transcriptional regulatory protein (possibly TetR/AcrR-family)
Rv2871		-0.7	-1.6	Possible antitoxin VapB43
Rv0383c		-0.7	-0.6	Possible conserved secreted protein
Rv2687c		-0.7	-1.9	Antibiotic-transport integral membrane leucine and valine rich protein ABC transporter
Rv0494		-0.7	-2.1	Probable transcriptional regulatory protein (probably GntR-family)
Rv2427A		-0.7	-1.7	'Transcriptional regulator OxyR', pseudogene' pseudogene=unknown transl_table=11
Rv0379		-0.7	-0.4	Possible protein transport protein SecE2
Rv3414c		-0.7	-2.1	Probable alternative RNA polymerase sigma-D factor SigD
Rv2762c		-0.7	-0.7	Conserved hypothetical protein
Rv3358		-0.6	-1.5	Toxin RelK
Rv2798c		-0.6	-1.3	Conserved hypothetical protein
Rv1160		-0.6	-0.9	Probable mutator protein MutT2 (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase)
Rv3262		-0.6	-1.1	Probable F420 biosynthesis protein FbiB
Rv1173		-0.6	-1.3	Probable F420 biosynthesis protein FbiC
Rv0323c		-0.6	-0.8	Conserved hypothetical protein
Rv3715c		-0.6	-1.1	Probable recombination protein RecR
Rv3162c		-0.6	-0.9	Possible integral membrane protein
Rv3272		-0.6	-4.2	Conserved hypothetical protein
Rv0959		-0.6	-0.7	Conserved hypothetical protein
Rv1290A		-0.6	-0.7	Hypothetical protein
Rv0734		-0.6	-1.8	Methionine aminopeptidase MapA (map) (peptidase M) (MetAP)
Rv2850c		-0.6	-0.8	Possible magnesium chelatase
Rv2998		-0.6	-1.8	Hypothetical protein
Rv1840c		-0.6	-0.8	PE-PGRS family protein PE_PGRS34
Rv2618		-0.6	-2.6	Conserved hypothetical protein
Rv3564		-0.6	-1.7	Probable acyl-CoA dehydrogenase FadE33
Rv2176		-0.6	-2.8	Probable transmembrane serine/threonine-protein kinase L PknL (protein kinase L) (STPK L)
Rv2468A		-0.6	-2.6	Conserved protein
Rv0190		-0.6	-1.9	Conserved protein
Rv2567		-0.6	-2.6	Conserved hypothetical alanine and leucine rich protein
Rv0653c		-0.6	-2.3	Possible transcriptional regulatory protein (probably TetR-family)
Rv2260		-0.6	-1.0	Conserved hypothetical protein
Rv3223c		-0.6	-2.0	Alternative RNA polymerase sigma-E factor (sigma-24) SigH (RPOE)
Rv2923c		-0.6	-0.8	Conserved protein
Rv2042c		-0.6	-2.2	Conserved protein
Rv3683		-0.6	-3.7	Conserved protein
Rv3005c		-0.6	-3.5	Conserved hypothetical protein
Rv3174		-0.6	-0.7	Probable short-chain dehydrogenase/reductase
Rv2382c		-0.6	-0.7	Polyketide synthetase MbtC (polyketide synthase)
Rv3557c		-0.6	-2.8	Transcriptional regulatory protein (probably TetR-family)
Rv2650c		-0.6	-0.5	Possible PhiRv2 prophage protein
Rv3497c		-0.6	-2.9	Mce-family protein Mce4C
Rv1284		-0.6	-0.3	Beta-carbonic anhydrase
Rv2989		-0.6	-0.4	Probable transcriptional regulatory protein
Rv0362		-0.6	-2.9	Possible Mg2+ transport transmembrane protein MgtE
Rv0047c		-0.6	-1.8	Conserved protein
Rv3267		-0.5	-2.2	Conserved protein (CPSA-related protein)
Rv2404c		-0.5	-3.7	Probable GTP-binding protein LepA (GTP-binding elongation factor)
Rv3085		-0.5	-0.4	Probable short-chain type dehydrogenase/reductase
Rv0576		-0.5	-1.5	Probable transcriptional regulatory protein (possibly ArsR-family)
Rv3492c		-0.5	-1.3	Conserved hypothetical Mce associated protein
Rv1698		-0.5	-1.6	Outer membrane protein MctB
Rv3020c		-0.5	-1.3	ESAT-6 like protein EsxS
Rv2064		-0.5	-1.9	Precorrin-3B synthase CobG
Rv2181		-0.5	-3.4	Alpha(1->2)mannosyltransferase
Rv0309		-0.5	-1.9	Possible conserved exported protein
Rv1116A		-0.5	-0.8	Conserved hypothetical protein (fragment)
Rv0677c		-0.5	-1.1	Possible conserved membrane protein MmpS5
Rv2789c		-0.5	-1.5	Probable acyl-CoA dehydrogenase FadE21
Rv1234		-0.5	-1.2	Probable transmembrane protein
Rv2312		-0.5	-1.4	Hypothetical protein
Rv1109c		-0.5	-1.2	Conserved protein
Rv3773c		-0.5	-2.7	Conserved protein
Rv0535		-0.5	-1.4	Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase)
Rv2731		-0.5	-2.5	Conserved alanine and arginine rich protein
Rv1829		-0.5	-2.4	Conserved protein
Rv1111c		-0.5	-3.0	Conserved hypothetical protein
Rv2250c		-0.5	-1.4	Possible transcriptional regulatory protein
Rv0563		-0.5	-1.1	Probable protease transmembrane protein heat shock protein HtpX
Rv0955		-0.5	-0.7	Probable conserved integral membrane protein
Rv1911c		-0.5	-1.7	Probable lipoprotein LppC
Rv3513c		-0.5	-0.6	Probable fatty-acid-CoA ligase FadD18 (fragment) (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Rv2680		-0.5	-1.0	Conserved protein
Rv3070		-0.5	-2.2	Probable conserved integral membrane protein
Rv3500c		-0.5	-3.5	Conserved integral membrane protein YrbE4B. Possible ABC transporter.

Specific Phenotypes

For 4 genes in this experiment

For stress Hygromycin B in Mycobacterium tuberculosis H37Rv

For stress Hygromycin B across organisms