Experiment set2S595 for Mycobacterium tuberculosis H37Rv

200 most important genes:

gene	name	fitness	t score	description
Rv0949		-4.3	-1.3	Probable ATP-dependent DNA helicase II UvrD1
Rv2416c		-2.7	-5.3	Enhanced intracellular survival protein Eis,GCN5-related N-acetyltransferase
Rv0437c		-2.4	-1.5	Possible phosphatidylserine decarboxylase Psd (PS decarboxylase)
Rv0819		-2.2	-5.2	GCN5-related N-acetyltransferase, MshD
Rv0928		-2.1	-5.3	Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1)
Rv0990c		-2.1	-1.1	Hypothetical protein
Rv0871		-2.0	-2.8	Probable cold shock-like protein B CspB
Rv3610c		-2.0	-3.9	Membrane-bound protease FtsH (cell division protein)
Rv0930		-2.0	-8.4	Probable phosphate-transport integral membrane ABC transporter PstA1
Rv1072		-1.9	-1.9	Probable conserved transmembrane protein
Rv1281c		-1.9	-6.3	Probable oligopeptide-transport ATP-binding protein ABC transporter OppD
Rv0805		-1.9	-1.5	Class III cyclic nucleotide phosphodiesterase (cNMP PDE)
Rv0820		-1.8	-4.3	Probable phosphate-transport ATP-binding protein ABC transporter PhoT
Rv0929		-1.8	-2.3	Phosphate-transport integral membrane ABC transporter PstC2
Rv1280c		-1.7	-6.7	Probable periplasmic oligopeptide-binding lipoprotein OppA
Rv0955		-1.7	-1.9	Probable conserved integral membrane protein
Rv1025		-1.6	-1.2	Conserved protein
Rv1640c		-1.6	-8.6	Lysyl-tRNA synthetase 2 LysX
Rv1010		-1.6	-1.6	Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase)
Rv1908c		-1.6	-1.7	Catalase-peroxidase-peroxynitritase T KatG
Rv1062		-1.5	-1.4	Conserved hypothetical protein
Rv1745c		-1.5	-2.9	Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase)
Rv0989c		-1.5	-6.7	Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase)
Rv1282c		-1.4	-3.5	Probable oligopeptide-transport integral membrane protein ABC transporter OppC
Rv3162c		-1.4	-1.9	Possible integral membrane protein
Rv2224c		-1.3	-9.7	Probable carboxylesterase CaeA
Rv2140c		-1.3	-2.2	Conserved protein TB18.6
Rv1291c		-1.3	-1.6	Conserved hypothetical secreted protein
Rv0242c		-1.3	-2.7	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase)
Rv2887		-1.3	-1.4	Probable transcriptional regulatory protein
Rv2206		-1.3	-3.5	Probable conserved transmembrane protein
Rv1283c		-1.3	-2.1	Probable oligopeptide-transport integral membrane protein ABC transporter OppB
Rv1621c		-1.3	-3.5	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD
Rv2694c		-1.2	-2.2	Conserved protein
Rv1963c		-1.2	-2.0	Probable transcriptional repressor (probably TetR-family) Mce3R
Rv2691		-1.2	-4.8	TRK system potassium uptake protein CeoB
Rv3306c		-1.2	-1.6	Probable amidohydrolase AmiB1 (aminohydrolase)
Rv0452		-1.2	-3.3	Possible transcriptional regulatory protein
Rv3311		-1.2	-3.8	Conserved protein
Rv3655c		-1.2	-1.2	Conserved hypothetical protein
Rv0531		-1.1	-1.4	Possible conserved membrane protein
Rv1620c		-1.1	-3.0	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC
Rv0017c		-1.1	-4.3	Probable cell division protein RodA
Rv2374c		-1.1	-2.3	Probable heat shock protein transcriptional repressor HrcA
Rv1679		-1.1	-1.0	Possible acyl-CoA dehydrogenase FadE16
Rv2869c		-1.1	-1.2	Membrane bound metalloprotease
Rv3065		-1.1	-1.9	Multidrugs-transport integral membrane protein Mmr
Rv1411c		-1.1	-2.1	Conserved lipoprotein LprG
Rv3050c		-1.0	-2.3	Probable transcriptional regulatory protein (probably AsnC-family)
Rv0190		-1.0	-3.5	Conserved protein
Rv2462c		-1.0	-4.1	Probable trigger factor (TF) protein Tig
Rv2707		-1.0	-7.4	Probable conserved transmembrane alanine and leucine rich protein
Rv3139		-1.0	-4.9	Probable acyl-CoA dehydrogenase FadE24
Rv2468A		-1.0	-2.8	Conserved protein
Rv0018c		-1.0	-2.0	Phosphoserine/threonine phosphatase PstP
Rv2733c		-1.0	-1.9	Conserved hypothetical alanine, arginine-rich protein
Rv0361		-1.0	-1.1	Probable conserved membrane protein
Rv2007c		-0.9	-1.5	Ferredoxin FdxA
Rv0098		-0.9	-1.2	Probable fatty acyl CoA thioesterase type III FcoT
Rv3405c		-0.9	-1.1	Possible transcriptional regulatory protein
Rv3277		-0.9	-0.9	Probable conserved transmembrane protein
Rv3200c		-0.9	-2.3	Possible transmembrane cation transporter
Rv2680		-0.9	-1.7	Conserved protein
Rv3527		-0.9	-1.4	Hypothetical protein
Rv0954		-0.9	-2.6	Probable conserved transmembrane protein
Rv3140		-0.9	-2.9	Probable acyl-CoA dehydrogenase FadE23
Rv1410c		-0.9	-4.3	Aminoglycosides/tetracycline-transport integral membrane protein
Rv0818		-0.9	-3.1	Transcriptional regulatory protein
Rv1019		-0.9	-4.3	Probable transcriptional regulatory protein (probably TetR-family)
Rv3855		-0.9	-2.5	Transcriptional regulatory repressor protein (TetR-family) EthR
Rv0444c		-0.9	-4.3	Anti-sigma factor RskA (regulator of sigma K)
Rv2154c		-0.8	-1.7	FtsW-like protein FtsW
Rv2317		-0.8	-0.8	Probable sugar-transport integral membrane protein ABC transporter UspB
Rv0237		-0.8	-2.8	Probable conserved lipoprotein LpqI
Rv2173		-0.8	-2.6	Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase)
Rv1112		-0.8	-0.9	Probable GTP binding protein
Rv0321		-0.8	-2.3	Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase)
Rv0019c		-0.8	-2.5	Conserved protein with FHA domain, FhaB
Rv2037c		-0.8	-2.4	Conserved transmembrane protein
Rv2222c		-0.8	-2.1	Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II)
Rv1940		-0.8	-1.3	Probable riboflavin biosynthesis protein RibA1 (GTP cyclohydrolase II)
Rv0924c		-0.8	-3.3	Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP)
Rv1773c		-0.8	-1.7	Probable transcriptional regulatory protein
Rv0375c		-0.8	-1.4	Probable carbon monoxyde dehydrogenase (medium chain)
Rv1244		-0.8	-3.7	Probable lipoprotein LpqZ
Rv3237c		-0.8	-2.3	Conserved protein
Rv0418		-0.8	-2.7	Probable lipoprotein aminopeptidase LpqL
Rv0549c		-0.8	-1.3	Possible toxin VapC3
Rv2942		-0.8	-6.0	Conserved transmembrane transport protein MmpL7
Rv2938		-0.8	-6.0	Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC
Rv2650c		-0.8	-0.7	Possible PhiRv2 prophage protein
Rv2936		-0.8	-6.3	Daunorubicin-dim-transport ATP-binding protein ABC transporter DrrA
Rv3486		-0.8	-1.2	Conserved protein
Rv1829		-0.7	-3.2	Conserved protein
Rv3249c		-0.7	-0.7	Possible transcriptional regulatory protein (probably TetR-family)
Rv1422		-0.7	-0.9	Conserved hypothetical protein
Rv0362		-0.7	-4.1	Possible Mg2+ transport transmembrane protein MgtE
Rv2706c		-0.7	-0.8	Hypothetical protein
Rv3922c		-0.7	-1.7	Possible hemolysin
Rv3007c		-0.7	-2.4	Possible oxidoreductase
Rv1698		-0.7	-1.6	Outer membrane protein MctB
Rv1046c		-0.7	-1.2	Hypothetical protein
Rv1851		-0.7	-0.9	Urease accessory protein UreF
Rv2937		-0.7	-5.7	Daunorubicin-dim-transport integral membrane protein ABC transporter DrrB
Rv2772c		-0.7	-0.9	Probable conserved transmembrane protein
Rv2709		-0.7	-2.2	Probable conserved transmembrane protein
Rv1401		-0.7	-0.8	Possible membrane protein
Rv3720		-0.7	-4.2	Possible fatty acid synthase
Rv0056		-0.7	-1.7	50S ribosomal protein L9 RplI
Rv0991c		-0.7	-0.8	Conserved serine rich protein
Rv0353		-0.7	-2.5	Probable heat shock protein transcriptional repressor HspR (MerR family)
Rv2404c		-0.7	-3.6	Probable GTP-binding protein LepA (GTP-binding elongation factor)
Rv0615		-0.7	-1.0	Probable integral membrane protein
Rv0550c		-0.7	-1.3	Possible antitoxin VapB3
Rv0047c		-0.7	-3.5	Conserved protein
Rv1421		-0.7	-1.9	Conserved protein
Rv3766		-0.7	-1.7	Hypothetical protein
Rv3114		-0.7	-0.7	Conserved hypothetical protein
Rv2581c		-0.7	-0.9	Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II)
Rv0245		-0.7	-1.6	Possible oxidoreductase
Rv0135c		-0.7	-1.7	Possible transcriptional regulatory protein
Rv3005c		-0.7	-4.6	Conserved hypothetical protein
Rv3272		-0.7	-4.3	Conserved hypothetical protein
Rv0476		-0.7	-2.3	Possible conserved transmembrane protein
Rv1450c		-0.7	-1.5	PE-PGRS family protein PE_PGRS27
Rv0020c		-0.7	-3.5	Conserved protein with FHA domain, FhaA
Rv3438		-0.7	-1.9	Conserved protein
Rv2240c		-0.7	-1.1	Unknown protein
Rv2567		-0.6	-3.1	Conserved hypothetical alanine and leucine rich protein
Rv2319c		-0.6	-2.5	Universal stress protein family protein
Rv1070c		-0.6	-3.6	Probable enoyl-CoA hydratase EchA8 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv3273		-0.6	-3.4	Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase)
Rv1121		-0.6	-0.9	Probable glucose-6-phosphate 1-dehydrogenase Zwf1 (G6PD)
Rv0243		-0.6	-2.6	Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase)
Rv2046		-0.6	-1.7	Probable lipoprotein LppI
Rv0200		-0.6	-1.5	Possible conserved transmembrane protein
Rv0933		-0.6	-1.2	Phosphate-transport ATP-binding protein ABC transporter PstB
Rv0994		-0.6	-3.3	Probable molybdopterin biosynthesis protein MoeA1
Rv3033		-0.6	-0.5	Unknown protein
Rv3631		-0.6	-0.4	Possible transferase (possibly glycosyltransferase)
Rv0093c		-0.6	-0.9	Probable conserved membrane protein
Rv1496		-0.6	-1.7	Possible transport system kinase
Rv3818		-0.6	-3.2	Unknown protein
Rv1116A		-0.6	-0.9	Conserved hypothetical protein (fragment)
Rv0016c		-0.6	-2.6	Probable penicillin-binding protein PbpA
Rv3193c		-0.6	-0.8	Probable conserved transmembrane protein
Rv3102c		-0.6	-1.7	Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter)
Rv2813		-0.6	-1.8	Conserved hypothetical protein
Rv1444c		-0.6	-1.3	Unknown protein
Rv0049		-0.6	-1.5	Conserved hypothetical protein
Rv3693		-0.6	-1.2	Possible conserved membrane protein
Rv2322c		-0.6	-0.7	Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase)
Rv3304		-0.6	-1.7	Conserved protein
Rv2044c		-0.6	-0.4	Conserved hypothetical protein
Rv0825c		-0.6	-1.1	Conserved protein
Rv0688		-0.6	-2.2	Putative ferredoxin reductase
Rv2945c		-0.6	-2.3	Probable conserved lipoprotein LppX
Rv1955		-0.6	-2.1	Possible toxin HigB
Rv2029c		-0.6	-1.9	6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase)
Rv3687c		-0.6	-0.5	Anti-anti-sigma factor RsfB (anti-sigma factor antagonist) (regulator of sigma F B)
Rv1616		-0.5	-1.1	Conserved membrane protein
Rv3283		-0.5	-1.8	Probable thiosulfate sulfurtransferase SseA (rhodanese) (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase)
Rv0466		-0.5	-2.8	Conserved protein
Rv2731		-0.5	-1.9	Conserved alanine and arginine rich protein
Rv0208c		-0.5	-1.9	Hypothetical methlytransferase (methylase)
Rv2342		-0.5	-2.3	Conserved hypothetical protein
Rv3717		-0.5	-2.4	Conserved hypothetical protein
Rv1441c		-0.5	-2.4	PE-PGRS family protein PE_PGRS26
Rv2732c		-0.5	-1.4	Probable conserved transmembrane protein
Rv2997		-0.5	-1.3	Possible alanine rich dehydrogenase
Rv3358		-0.5	-0.8	Toxin RelK
Rv2644c		-0.5	-1.2	Hypothetical protein
Rv2696c		-0.5	-1.2	Conserved alanine and glycine and valine rich protein
Rv3291c		-0.5	-2.0	Probable transcriptional regulatory protein LrpA (Lrp/AsnC-family)
Rv1506c		-0.5	-1.2	Hypothetical protein
Rv2018		-0.5	-1.5	Conserved protein
Rv2003c		-0.5	-0.3	Conserved hypothetical protein
Rv2468c		-0.5	-2.7	Conserved protein
Rv2446c		-0.5	-2.4	Probable conserved integral membrane protein
Rv1946c		-0.5	-1.2	Possible lipoprotein
Rv3046c		-0.5	-0.4	Conserved protein
Rv0573c		-0.5	-1.9	Nicotinic acid phosphoribosyltransferase PncB2
Rv3334		-0.5	-1.4	Probable transcriptional regulatory protein (probably MerR-family)
Rv2205c		-0.5	-1.8	Conserved hypothetical protein
Rv3196A		-0.5	-1.0	Unknown protein
Rv0744c		-0.5	-2.1	Possible transcriptional regulatory protein
Rv2693c		-0.5	-1.8	Probable conserved integral membrane alanine and leucine rich protein
Rv0436c		-0.5	-0.7	Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase)
Rv1173		-0.5	-1.0	Probable F420 biosynthesis protein FbiC
Rv3589		-0.5	-1.8	Probable adenine glycosylase MutY
Rv2522c		-0.5	-2.0	Conserved hypothetical protein
Rv1898		-0.5	-1.1	Conserved hypothetical protein
Rv0892		-0.5	-1.3	Probable monooxygenase
Rv3910		-0.5	-0.9	Probable conserved transmembrane protein
Rv2979c		-0.5	-1.7	Probable resolvase
Rv1095		-0.5	-1.9	Probable PHOH-like protein PhoH2 (phosphate starvation-inducible protein PSIH)
Rv0241c		-0.5	-1.1	Probable 3-hydroxyacyl-thioester dehydratase HtdX
Rv3600c		-0.5	-1.4	Conserved protein
Rv1935c		-0.5	-1.7	Possible enoyl-CoA hydratase EchA13 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv0679c		-0.5	-0.9	Conserved threonine rich protein

Specific Phenotypes

For 4 genes in this experiment

For stress Hygromycin B in Mycobacterium tuberculosis H37Rv

For stress Hygromycin B across organisms